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The map label for this gene is zraS [H]

Identifier: 220916811

GI number: 220916811

Start: 1900191

End: 1901579

Strand: Direct

Name: zraS [H]

Synonym: A2cp1_1707

Alternate gene names: 220916811

Gene position: 1900191-1901579 (Clockwise)

Preceding gene: 220916810

Following gene: 220916812

Centisome position: 37.78

GC content: 75.45

Gene sequence:

>1389_bases
ATGGTCAGAGTCCTCTCCGCCGGCCCGGATCTTGCCTTTCGCTCCGGGGACGTGGTCGCCCCTCCGCGCACACACCCGCT
GGTCGCCTCCGCGCCGCCCTGCCCGATGACGGCGGCCGCGCCGTCGCGGGAGCGCGCCGACCGGTGGCCGCGCCGGGAGG
ACCTGTTCGCGATCGCCTACTACCTCGCGGCGGCGGGGGTGCTCGCGTGGGCGGGCTACGCGCCCTGGAGGATCGGCGTG
GTGCTGGCGGGCGGCGCCGTGCAGCAGGTGGGCGTGCGCGGCTGCCGGCGGGGCGACGCCAGCCGGTGCGTGAACGCGAC
CTTCGACCGGATCGCCCTCTACGTCGTCCTGGGACAGGCGTCGTTCTTCCTGACGACCGCGCTCGCGGCGGCGGTGACCG
GCGGCGAGCAGAGCCCGCTCATCCTCCCGTTCCTCGGGTCGTACTTCGTGGCGGTCTCGGTGGTGGGGGACCGCGTCGCC
ACGCGCGGGCTGCTCGCCGCGACGGCGCTCGGCGGCGCCGTGCTGGCGCTCCTGCCGGACGCGGTCGCCGGTCCGGAGCT
GCCCGCGCTCCAGCGCGGCGTGCTCACGGTGGTGAGCGTGCTCGGCGTCGGCGCGCTGCTCGCGCCGGCGCACGCGGAGA
CGCGGCGCAAGCGCGACCAGGTGGCCCGCGCCCGCGCCGAGATGGTGTCCGACGCGCTCAGCCGGGCGCAGGGGCTGGAG
CAGGTCGGCGCCAAGGTGGCGCACGAGCTGAAGAACCCGCTCACCGGCGTGAAGGCGCTCGTCCAGCTCGGGCTGCGCAG
CCCGGCGGAGGCGGCCTCGCACGAGCGGCTCGAGGTGGTGGACCGCGAGGTCACGCGGATGCAGGAGATCATCCAGAACT
ACCTCTCGTTCAACCGGCCGCTCCAGTCGGTCAACCCGCGGCAGGTGGCGCTCGGGCCGCTCGTCTCCGACACGCTGCTG
GTCCTCTCCGCCCGCGCCGACGAGGCGCGGGTGCGGCTCTACGCGCGCGGCGACGCGTCGCTCGAGGCGGACCCGCGCCG
CCTGAAGGAGGCGCTGCTGAACCTGGTGGCGAACGCGATCGAGGCGACGCCGGCCGGCGGCGAGGTGGTGGTGGAGGCGC
GCGAGCTGTCCGGGGACGACATCGAGCTGGTGGTGCGGGACACCGGGCGCGGGATGCCGCCGGAGACGCTCCGGCGCATC
GGCACCCCGTTCTTCACCACCCGCGACGACGGCACCGGGCTGGGCGTGGTGCTGGCGCGGGCGGTGATCGTGCAGCACGG
TGGTACCCTGCGCTACGAGAGCGAGCCGGGGAGCGGGACGAAGGTGCTCGTCACGTTGCCGCGCGCCGCGAAGAGGAGCG
GGGATGTCGCGCGTGCTGCTGGTGGATGA

Upstream 100 bases:

>100_bases
GAGCAGGTTGTTGGAGTTCTGCGCGGCGAGGCGGAAACGGCCGTTGGTCACGTTCCGGGGCGAGCGCGTGCGTTCAGGGC
CGGGTTAATCGAGCTGGGCC

Downstream 100 bases:

>100_bases
CGAGCCGTCGGTCCGCGCCGCGCTCAAGGAGCTGGTGCAGGGCCGCGGCTGGGAGCCGGTGCTCGCGTGCTCGGCCTCGG
AGGCGCTGGAGCAGCTCGAG

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MVRVLSAGPDLAFRSGDVVAPPRTHPLVASAPPCPMTAAAPSRERADRWPRREDLFAIAYYLAAAGVLAWAGYAPWRIGV
VLAGGAVQQVGVRGCRRGDASRCVNATFDRIALYVVLGQASFFLTTALAAAVTGGEQSPLILPFLGSYFVAVSVVGDRVA
TRGLLAATALGGAVLALLPDAVAGPELPALQRGVLTVVSVLGVGALLAPAHAETRRKRDQVARARAEMVSDALSRAQGLE
QVGAKVAHELKNPLTGVKALVQLGLRSPAEAASHERLEVVDREVTRMQEIIQNYLSFNRPLQSVNPRQVALGPLVSDTLL
VLSARADEARVRLYARGDASLEADPRRLKEALLNLVANAIEATPAGGEVVVEARELSGDDIELVVRDTGRGMPPETLRRI
GTPFFTTRDDGTGLGVVLARAVIVQHGGTLRYESEPGSGTKVLVTLPRAAKRSGDVARAAGG

Sequences:

>Translated_462_residues
MVRVLSAGPDLAFRSGDVVAPPRTHPLVASAPPCPMTAAAPSRERADRWPRREDLFAIAYYLAAAGVLAWAGYAPWRIGV
VLAGGAVQQVGVRGCRRGDASRCVNATFDRIALYVVLGQASFFLTTALAAAVTGGEQSPLILPFLGSYFVAVSVVGDRVA
TRGLLAATALGGAVLALLPDAVAGPELPALQRGVLTVVSVLGVGALLAPAHAETRRKRDQVARARAEMVSDALSRAQGLE
QVGAKVAHELKNPLTGVKALVQLGLRSPAEAASHERLEVVDREVTRMQEIIQNYLSFNRPLQSVNPRQVALGPLVSDTLL
VLSARADEARVRLYARGDASLEADPRRLKEALLNLVANAIEATPAGGEVVVEARELSGDDIELVVRDTGRGMPPETLRRI
GTPFFTTRDDGTGLGVVLARAVIVQHGGTLRYESEPGSGTKVLVTLPRAAKRSGDVARAAGG
>Mature_462_residues
MVRVLSAGPDLAFRSGDVVAPPRTHPLVASAPPCPMTAAAPSRERADRWPRREDLFAIAYYLAAAGVLAWAGYAPWRIGV
VLAGGAVQQVGVRGCRRGDASRCVNATFDRIALYVVLGQASFFLTTALAAAVTGGEQSPLILPFLGSYFVAVSVVGDRVA
TRGLLAATALGGAVLALLPDAVAGPELPALQRGVLTVVSVLGVGALLAPAHAETRRKRDQVARARAEMVSDALSRAQGLE
QVGAKVAHELKNPLTGVKALVQLGLRSPAEAASHERLEVVDREVTRMQEIIQNYLSFNRPLQSVNPRQVALGPLVSDTLL
VLSARADEARVRLYARGDASLEADPRRLKEALLNLVANAIEATPAGGEVVVEARELSGDDIELVVRDTGRGMPPETLRRI
GTPFFTTRDDGTGLGVVLARAVIVQHGGTLRYESEPGSGTKVLVTLPRAAKRSGDVARAAGG

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=248, Percent_Identity=34.2741935483871, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI1790436, Length=232, Percent_Identity=33.6206896551724, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1789149, Length=287, Percent_Identity=28.2229965156794, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790300, Length=233, Percent_Identity=30.4721030042918, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI145693157, Length=254, Percent_Identity=29.1338582677165, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1786783, Length=236, Percent_Identity=26.6949152542373, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786600, Length=243, Percent_Identity=24.6913580246914, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790346, Length=233, Percent_Identity=29.6137339055794, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI48994928, Length=256, Percent_Identity=25.390625, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87081816, Length=237, Percent_Identity=29.1139240506329, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87082128, Length=228, Percent_Identity=27.1929824561404, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788713, Length=256, Percent_Identity=23.046875, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48579; Mature: 48579

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRVLSAGPDLAFRSGDVVAPPRTHPLVASAPPCPMTAAAPSRERADRWPRREDLFAIAY
CEEEEECCCCCEECCCCEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHH
YLAAAGVLAWAGYAPWRIGVVLAGGAVQQVGVRGCRRGDASRCVNATFDRIALYVVLGQA
HHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCH
SFFLTTALAAAVTGGEQSPLILPFLGSYFVAVSVVGDRVATRGLLAATALGGAVLALLPD
HHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
AVAGPELPALQRGVLTVVSVLGVGALLAPAHAETRRKRDQVARARAEMVSDALSRAQGLE
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVGAKVAHELKNPLTGVKALVQLGLRSPAEAASHERLEVVDREVTRMQEIIQNYLSFNRP
HHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LQSVNPRQVALGPLVSDTLLVLSARADEARVRLYARGDASLEADPRRLKEALLNLVANAI
HHCCCCCCEECCHHHHHHHHHEECCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
EATPAGGEVVVEARELSGDDIELVVRDTGRGMPPETLRRIGTPFFTTRDDGTGLGVVLAR
HCCCCCCEEEEEEHHCCCCCEEEEEECCCCCCCHHHHHHCCCCCEEECCCCCCHHHHHHH
AVIVQHGGTLRYESEPGSGTKVLVTLPRAAKRSGDVARAAGG
HHHHHCCCEEEECCCCCCCCEEEEECCHHHCCCCCCHHCCCC
>Mature Secondary Structure
MVRVLSAGPDLAFRSGDVVAPPRTHPLVASAPPCPMTAAAPSRERADRWPRREDLFAIAY
CEEEEECCCCCEECCCCEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHH
YLAAAGVLAWAGYAPWRIGVVLAGGAVQQVGVRGCRRGDASRCVNATFDRIALYVVLGQA
HHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCH
SFFLTTALAAAVTGGEQSPLILPFLGSYFVAVSVVGDRVATRGLLAATALGGAVLALLPD
HHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
AVAGPELPALQRGVLTVVSVLGVGALLAPAHAETRRKRDQVARARAEMVSDALSRAQGLE
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVGAKVAHELKNPLTGVKALVQLGLRSPAEAASHERLEVVDREVTRMQEIIQNYLSFNRP
HHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LQSVNPRQVALGPLVSDTLLVLSARADEARVRLYARGDASLEADPRRLKEALLNLVANAI
HHCCCCCCEECCHHHHHHHHHEECCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
EATPAGGEVVVEARELSGDDIELVVRDTGRGMPPETLRRIGTPFFTTRDDGTGLGVVLAR
HCCCCCCEEEEEEHHCCCCCEEEEEECCCCCCCHHHHHHCCCCCEEECCCCCCHHHHHHH
AVIVQHGGTLRYESEPGSGTKVLVTLPRAAKRSGDVARAAGG
HHHHHCCCEEEECCCCCCCCEEEEECCHHHCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]