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The map label for this gene is nrdZ [H]

Identifier: 220916577

GI number: 220916577

Start: 1641735

End: 1643522

Strand: Direct

Name: nrdZ [H]

Synonym: A2cp1_1471

Alternate gene names: 220916577

Gene position: 1641735-1643522 (Clockwise)

Preceding gene: 220916573

Following gene: 220916578

Centisome position: 32.64

GC content: 76.06

Gene sequence:

>1788_bases
ATGGTCCGGCTCGGCGAGAACGCCCGGCACGTGCTCGAGCGGCGCTACCTGCTGCGCGACGAGGGCGGGCAGGTGATCGA
GACCCCCGAGGCGATGTTCCGCCGCGTGGCGCAGGCGGTTGCGGCGGCCGAGCACCCGGCGGCGCGGGCGCTCTGGGCGG
AGCGGTTCGAGGCGCGGATGGCGGCGCTCGAGCTGCTGCCGAACTCGCCCACCCTCATGAACGCCGGGCGGGCGCACGGC
CAGCTCGCCGCCTGCTTCGTGCTGCCGGTGGACGACGACCTCGCCGCCATCTTCGACGCGCTGAAGTGGGCGGCGCTCAT
CCACCAGTCCGGCGGCGGCACCGGGTTCTCGTTCTCGCGCCTCCGGCCACGCGGCGACGTGGTGAAGACCACGCACGGCG
TGGCGAGCGGGCCGGTGTCCTTCATGCGCGTCTACGACGCCGCGACCGAGATCATCAAGCAGGGCGGCGTGCGGCGCGGC
GCGAACATGGCGGTGCTCGCCGCCGACCACCCGGACGTGCTCGAGTTCGTGGACGCGAAGCGCGCCGCGGGGCTGGAGAA
CTTCAACATCTCGGTGTCCGCGCCGGACGCGCTCTTCCACGCGGCCGCGCGCAGCGGAGGCTGGGCGCTGCGCCACCCGC
GCGGCGGCGCGGTGGTGCGCGAGGTGGACGCGGCCGGGCTGCTGGAGCGCATCGCCGCCTCGGCCTGGGCCTCGGGCGAG
CCGGGCCTGGTGTTCCTCGATCGCGTCGAGGCGGCCAACCCCACCCCGGACCTGGGGCGGTTCGAGGCGGTGAACCCGTG
CGGCGAGCAGCCGCTGCTGCCGTTCGAGGCGTGCACGCTCGGCTCGGTGAACCTGGCGCGGTTCGAGCGCGGCGGGCGGG
TGGACCTCGAGCGGCTGGGCGCGTGCGTGCGCGACGGCGTGCGGCTGCTCGACGACGTGCTCGACGTGAACGTCTGGCCG
CTGCCGCAGATCGCGGAGATCTCGCGGCGCAACCGGAAGATCGGGCTCGGGGTGATGGGCTGGGCGGACCTGCTCGTCGC
GCTCGGGATCCCCTACGACGCGCCGGAGGCGCTGGCGCTCGCGGGCGAGGTGATGGGGTTCGTGCAGCGCGAGGCGCACG
CGGCGAGCGAGGCGCTCGCCGCCGAGCGCGGGGCGTTCCCGGGCTTCGCGAGCAGCGCGCCCGCGCGCTCGGGCGGCCGT
CCCCGGCGCAACGCCACCGTCACCACCATCGCGCCCACCGGCACGCTCGCCATCATCGCGGGCTGCTCCTCGGGCATCGA
GCCGCTGTTCGCGCTCACGTACGTGCGGCACGCGCTCGACGACGCGGCGCTGCCGGAGGAGCACCCGGCGCTCGGCCGCG
CGCTCCGCGCCGCGGGGGCCGAGGCGGCGCTGCCCGCGGTGCGCGCGGCCGGCCGGGCGCGGGGCGTGGCCGGCGTGCCG
GACGCGGTGGCGCGGGTGTTCGCGACCGCGCACGACGTGACCCCCGAGGCGCACGTGCGCATGCAGGCCGCCTTCCAGCG
CCACGTGGACAACGGCGTCTCGAAGACCATCAACCTGCCGCGCACCGCGTCGGTCGAGGACGTGGCGTGCGCCTACCGGC
TCGCGTTCGAGCTGGGGTGCAAGGGCATCACGGTCTACCGCGACGGCTCGCGGGAGAAGCAGGTGCTGGTGAGCGGCGCC
ACCCGCAACGGCGAGCTCTGCCCGCAGTGCGAGGGGCCGGTGTCGCTCTCCGGCGGCTGCCGCACCTGCCCGCGCTGCGG
CTGGGGGAGCTGCGAGACCACCGAGTAG

Upstream 100 bases:

>100_bases
GTGCGGCAAGGGCGCGCGCCTCCTTCCGGCGCGGGACCGGCCGGGCCCTCGGCGCGCGTGCCCCCGGCGGCGGGCCCGCC
ACCCGGCTACATTCCCCCTC

Downstream 100 bases:

>100_bases
CGCATGATCCAGCGCTTCCCCATCCCTGCGCTGCGGCCGTTCGTGGCGCGGCTCTGGGCGTCCGAGGACGCCGACGCGGC
CGCGCCCGGGAGCGCCGGCC

Product: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 595; Mature: 595

Protein sequence:

>595_residues
MVRLGENARHVLERRYLLRDEGGQVIETPEAMFRRVAQAVAAAEHPAARALWAERFEARMAALELLPNSPTLMNAGRAHG
QLAACFVLPVDDDLAAIFDALKWAALIHQSGGGTGFSFSRLRPRGDVVKTTHGVASGPVSFMRVYDAATEIIKQGGVRRG
ANMAVLAADHPDVLEFVDAKRAAGLENFNISVSAPDALFHAAARSGGWALRHPRGGAVVREVDAAGLLERIAASAWASGE
PGLVFLDRVEAANPTPDLGRFEAVNPCGEQPLLPFEACTLGSVNLARFERGGRVDLERLGACVRDGVRLLDDVLDVNVWP
LPQIAEISRRNRKIGLGVMGWADLLVALGIPYDAPEALALAGEVMGFVQREAHAASEALAAERGAFPGFASSAPARSGGR
PRRNATVTTIAPTGTLAIIAGCSSGIEPLFALTYVRHALDDAALPEEHPALGRALRAAGAEAALPAVRAAGRARGVAGVP
DAVARVFATAHDVTPEAHVRMQAAFQRHVDNGVSKTINLPRTASVEDVACAYRLAFELGCKGITVYRDGSREKQVLVSGA
TRNGELCPQCEGPVSLSGGCRTCPRCGWGSCETTE

Sequences:

>Translated_595_residues
MVRLGENARHVLERRYLLRDEGGQVIETPEAMFRRVAQAVAAAEHPAARALWAERFEARMAALELLPNSPTLMNAGRAHG
QLAACFVLPVDDDLAAIFDALKWAALIHQSGGGTGFSFSRLRPRGDVVKTTHGVASGPVSFMRVYDAATEIIKQGGVRRG
ANMAVLAADHPDVLEFVDAKRAAGLENFNISVSAPDALFHAAARSGGWALRHPRGGAVVREVDAAGLLERIAASAWASGE
PGLVFLDRVEAANPTPDLGRFEAVNPCGEQPLLPFEACTLGSVNLARFERGGRVDLERLGACVRDGVRLLDDVLDVNVWP
LPQIAEISRRNRKIGLGVMGWADLLVALGIPYDAPEALALAGEVMGFVQREAHAASEALAAERGAFPGFASSAPARSGGR
PRRNATVTTIAPTGTLAIIAGCSSGIEPLFALTYVRHALDDAALPEEHPALGRALRAAGAEAALPAVRAAGRARGVAGVP
DAVARVFATAHDVTPEAHVRMQAAFQRHVDNGVSKTINLPRTASVEDVACAYRLAFELGCKGITVYRDGSREKQVLVSGA
TRNGELCPQCEGPVSLSGGCRTCPRCGWGSCETTE
>Mature_595_residues
MVRLGENARHVLERRYLLRDEGGQVIETPEAMFRRVAQAVAAAEHPAARALWAERFEARMAALELLPNSPTLMNAGRAHG
QLAACFVLPVDDDLAAIFDALKWAALIHQSGGGTGFSFSRLRPRGDVVKTTHGVASGPVSFMRVYDAATEIIKQGGVRRG
ANMAVLAADHPDVLEFVDAKRAAGLENFNISVSAPDALFHAAARSGGWALRHPRGGAVVREVDAAGLLERIAASAWASGE
PGLVFLDRVEAANPTPDLGRFEAVNPCGEQPLLPFEACTLGSVNLARFERGGRVDLERLGACVRDGVRLLDDVLDVNVWP
LPQIAEISRRNRKIGLGVMGWADLLVALGIPYDAPEALALAGEVMGFVQREAHAASEALAAERGAFPGFASSAPARSGGR
PRRNATVTTIAPTGTLAIIAGCSSGIEPLFALTYVRHALDDAALPEEHPALGRALRAAGAEAALPAVRAAGRARGVAGVP
DAVARVFATAHDVTPEAHVRMQAAFQRHVDNGVSKTINLPRTASVEDVACAYRLAFELGCKGITVYRDGSREKQVLVSGA
TRNGELCPQCEGPVSLSGGCRTCPRCGWGSCETTE

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=576, Percent_Identity=26.2152777777778, Blast_Score=187, Evalue=3e-47,
Organism=Escherichia coli, GI1789030, Length=641, Percent_Identity=25.8970358814353, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17555242, Length=577, Percent_Identity=24.6100519930676, Blast_Score=177, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6322123, Length=576, Percent_Identity=24.8263888888889, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6320914, Length=578, Percent_Identity=24.9134948096886, Blast_Score=164, Evalue=5e-41,
Organism=Drosophila melanogaster, GI17352481, Length=575, Percent_Identity=24.1739130434783, Blast_Score=166, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 62865; Mature: 62865

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRLGENARHVLERRYLLRDEGGQVIETPEAMFRRVAQAVAAAEHPAARALWAERFEARM
CCCCCHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
AALELLPNSPTLMNAGRAHGQLAACFVLPVDDDLAAIFDALKWAALIHQSGGGTGFSFSR
HHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCHHC
LRPRGDVVKTTHGVASGPVSFMRVYDAATEIIKQGGVRRGANMAVLAADHPDVLEFVDAK
CCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHH
RAAGLENFNISVSAPDALFHAAARSGGWALRHPRGGAVVREVDAAGLLERIAASAWASGE
HHCCCCCCEEEEECCHHHHHHHHCCCCEEEECCCCCCCEEHHHHHHHHHHHHHHHCCCCC
PGLVFLDRVEAANPTPDLGRFEAVNPCGEQPLLPFEACTLGSVNLARFERGGRVDLERLG
CCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHCCCCCCCHHHHH
ACVRDGVRLLDDVLDVNVWPLPQIAEISRRNRKIGLGVMGWADLLVALGIPYDAPEALAL
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEECEEHHHHHHHHHHHCCCCCCHHHHHH
AGEVMGFVQREAHAASEALAAERGAFPGFASSAPARSGGRPRRNATVTTIAPTGTLAIIA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEE
GCSSGIEPLFALTYVRHALDDAALPEEHPALGRALRAAGAEAALPAVRAAGRARGVAGVP
CCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
DAVARVFATAHDVTPEAHVRMQAAFQRHVDNGVSKTINLPRTASVEDVACAYRLAFELGC
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHCC
KGITVYRDGSREKQVLVSGATRNGELCPQCEGPVSLSGGCRTCPRCGWGSCETTE
CEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVRLGENARHVLERRYLLRDEGGQVIETPEAMFRRVAQAVAAAEHPAARALWAERFEARM
CCCCCHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
AALELLPNSPTLMNAGRAHGQLAACFVLPVDDDLAAIFDALKWAALIHQSGGGTGFSFSR
HHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCHHC
LRPRGDVVKTTHGVASGPVSFMRVYDAATEIIKQGGVRRGANMAVLAADHPDVLEFVDAK
CCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHH
RAAGLENFNISVSAPDALFHAAARSGGWALRHPRGGAVVREVDAAGLLERIAASAWASGE
HHCCCCCCEEEEECCHHHHHHHHCCCCEEEECCCCCCCEEHHHHHHHHHHHHHHHCCCCC
PGLVFLDRVEAANPTPDLGRFEAVNPCGEQPLLPFEACTLGSVNLARFERGGRVDLERLG
CCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHCCCCCCCHHHHH
ACVRDGVRLLDDVLDVNVWPLPQIAEISRRNRKIGLGVMGWADLLVALGIPYDAPEALAL
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEECEEHHHHHHHHHHHCCCCCCHHHHHH
AGEVMGFVQREAHAASEALAAERGAFPGFASSAPARSGGRPRRNATVTTIAPTGTLAIIA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEE
GCSSGIEPLFALTYVRHALDDAALPEEHPALGRALRAAGAEAALPAVRAAGRARGVAGVP
CCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
DAVARVFATAHDVTPEAHVRMQAAFQRHVDNGVSKTINLPRTASVEDVACAYRLAFELGC
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHCC
KGITVYRDGSREKQVLVSGATRNGELCPQCEGPVSLSGGCRTCPRCGWGSCETTE
CEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]