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The map label for this gene is glpA [H]

Identifier: 220916525

GI number: 220916525

Start: 1586891

End: 1588528

Strand: Direct

Name: glpA [H]

Synonym: A2cp1_1419

Alternate gene names: 220916525

Gene position: 1586891-1588528 (Clockwise)

Preceding gene: 220916524

Following gene: 220916526

Centisome position: 31.55

GC content: 76.13

Gene sequence:

>1638_bases
ATGGGCGAGCACGACGTCATCATCGTCGGCGGCGGCGTGAACGGGACCGGCACCGCCCGCGACTGCGCCATGCGCGGGCT
GCGGGTGCTGCTGCTGGAGAGGTCGGACTTCGGCGTCGGCGCGAGCGGCAACAGCTCGGGCATGATCCACGGCGGCATCC
GGTACATGCTCTCCGACCGGAAGGTCACCGAGCTGGCCTGCCGGGACTCCGGGTTCATCCAGCGGATCGCCCCGCACCTG
CTGTTCCGCATCCCGTTCCTGATGCCGTTCGGCTCGCGCGCCGAGGCCGCCACGCTCGCCGAGCGCGCCGCCTGGTACGC
CACCGAGGTCTACGTCGGCACCTACGACCAGTACCAGCCGCTGAAGCGCGGGAGGCCCTCCACCCGGCTGACCGCCGAGG
AGCTGTACCGCCTCGAGCCCGGCCTGCGCCCCGGCCTGCACGGCGCGGTGACGCTGGACGAGTGGGGCATCGACGCGTTC
CGGCTCTGCGTGCTGAACGCGCTCTCCGCCCGCACGCACGGCGCCGAGCTGCGCACCTGGACGGAGGTCCGCCAGCTCCT
CGTCGAGGGCGGCCGGGTGCGCGGCGTCCGGTGGCGCGACGCGCTCACCGGCGAGGAGGGCGAGGCGCGCGCGCCGGTGG
TGTTCAACGCGGCCGGCGCGTGGTCCCCGGCGCTGGCGCGGGCGAGCGGCGTGCGGGTGCCGATGCGCCCGGGCAAGGGC
GTGCACCTCACGCTCGACCGCCGCTGGTCCAGCTACGGCGTGATCTGCACCGCGGTCGACGGGCGGCAGATGTTCCTCAT
GCCGCACGAGAACGAGTCGATCGTCGGCACCACCGACGACGACTGGTACGGCGACCCGGACGACCTCGAGGCGACCCAGG
ACGAGGTGGAGTACCTGCTGGAGGGCGCCGCCTCCCTGGTCCCCGGCGTGCGGCGGGCGCGGATCACCCGGGCCTGGTGC
GGCCTGCGCACCACCCTGTACGCGTACGGGCCGAACGAGGACGCGCTCTCGCGCGAGCACCAGTTGCTCGACGGCGCCGC
GGACGGCGCGGCCGGGCTGCTCTCCATCGTGGGCGGGAAGCTCGCCTCGTACCGCGCCCAGTCCGAGGAGGCCGCCGACC
GGATCGAGGCGCTGCTCGGCCGGCCGGTCACGCCCTGCCGCACGCACCAGGAGCCGCTGCCCGGCGGCGACGAGGTGCCC
GACCCGGCCGCGCTGGCGCGCGAGTTCCCGGTGGCCGCGGCGGTGGCTGCGCGGCTGGTGTACCGGCACGGCGGCCGCGC
GCGGGAGATCTGCGCCATGATCCGCGACGACCGGCGCCTGGGCCTGGTGCTGTGCCGCGACGAGGCGATCCTCGCCGCCG
AGGTGGTCTACTGCGCGCGCCACGAGCAGGTGCGCCGCCTCCAGGACCTGCGGCGCCGCTGCCGGCTCTCGGTGGGCGCC
TGCGGCGGCCTCGACTGCGCGCGGGTGGGCGCGCAGCTCGTCGGGCGCGAGCTGTCCTGGCCGCCGGAGCGCGTGCGCGC
CGAGCTCTCCGACCTGCTCGACCAGGGCTGGCGCGAGCGGCGGCCGGTGCTGGACGGCGCCCAGCTCGCCGCCGAGGAGC
TGCTGCGCGGCGGGTGCGGCCCGTGGGAGGCGCCGTGA

Upstream 100 bases:

>100_bases
CCCGCGGCGCGCCGCCGCGGCCCCGCGCCCGGAGGCGCCTCACCTTTCGCGCGACCGCGCCCCCGGTCCGGGCTACGCTT
CGGAGCCGGGGGCGCGCGCG

Downstream 100 bases:

>100_bases
CCGCGTCGCGCACGGTGCGGGCCGACGTGCTGGTGGTGGGCGGCGGCATGGCCGGGGCGATGGCGGCGCTCTCGGCGCGG
GCGGCAGGCTGCGAGGTCGC

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: G-3-P dehydrogenase [H]

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MGEHDVIIVGGGVNGTGTARDCAMRGLRVLLLERSDFGVGASGNSSGMIHGGIRYMLSDRKVTELACRDSGFIQRIAPHL
LFRIPFLMPFGSRAEAATLAERAAWYATEVYVGTYDQYQPLKRGRPSTRLTAEELYRLEPGLRPGLHGAVTLDEWGIDAF
RLCVLNALSARTHGAELRTWTEVRQLLVEGGRVRGVRWRDALTGEEGEARAPVVFNAAGAWSPALARASGVRVPMRPGKG
VHLTLDRRWSSYGVICTAVDGRQMFLMPHENESIVGTTDDDWYGDPDDLEATQDEVEYLLEGAASLVPGVRRARITRAWC
GLRTTLYAYGPNEDALSREHQLLDGAADGAAGLLSIVGGKLASYRAQSEEAADRIEALLGRPVTPCRTHQEPLPGGDEVP
DPAALAREFPVAAAVAARLVYRHGGRAREICAMIRDDRRLGLVLCRDEAILAAEVVYCARHEQVRRLQDLRRRCRLSVGA
CGGLDCARVGAQLVGRELSWPPERVRAELSDLLDQGWRERRPVLDGAQLAAEELLRGGCGPWEAP

Sequences:

>Translated_545_residues
MGEHDVIIVGGGVNGTGTARDCAMRGLRVLLLERSDFGVGASGNSSGMIHGGIRYMLSDRKVTELACRDSGFIQRIAPHL
LFRIPFLMPFGSRAEAATLAERAAWYATEVYVGTYDQYQPLKRGRPSTRLTAEELYRLEPGLRPGLHGAVTLDEWGIDAF
RLCVLNALSARTHGAELRTWTEVRQLLVEGGRVRGVRWRDALTGEEGEARAPVVFNAAGAWSPALARASGVRVPMRPGKG
VHLTLDRRWSSYGVICTAVDGRQMFLMPHENESIVGTTDDDWYGDPDDLEATQDEVEYLLEGAASLVPGVRRARITRAWC
GLRTTLYAYGPNEDALSREHQLLDGAADGAAGLLSIVGGKLASYRAQSEEAADRIEALLGRPVTPCRTHQEPLPGGDEVP
DPAALAREFPVAAAVAARLVYRHGGRAREICAMIRDDRRLGLVLCRDEAILAAEVVYCARHEQVRRLQDLRRRCRLSVGA
CGGLDCARVGAQLVGRELSWPPERVRAELSDLLDQGWRERRPVLDGAQLAAEELLRGGCGPWEAP
>Mature_544_residues
GEHDVIIVGGGVNGTGTARDCAMRGLRVLLLERSDFGVGASGNSSGMIHGGIRYMLSDRKVTELACRDSGFIQRIAPHLL
FRIPFLMPFGSRAEAATLAERAAWYATEVYVGTYDQYQPLKRGRPSTRLTAEELYRLEPGLRPGLHGAVTLDEWGIDAFR
LCVLNALSARTHGAELRTWTEVRQLLVEGGRVRGVRWRDALTGEEGEARAPVVFNAAGAWSPALARASGVRVPMRPGKGV
HLTLDRRWSSYGVICTAVDGRQMFLMPHENESIVGTTDDDWYGDPDDLEATQDEVEYLLEGAASLVPGVRRARITRAWCG
LRTTLYAYGPNEDALSREHQLLDGAADGAAGLLSIVGGKLASYRAQSEEAADRIEALLGRPVTPCRTHQEPLPGGDEVPD
PAALAREFPVAAAVAARLVYRHGGRAREICAMIRDDRRLGLVLCRDEAILAAEVVYCARHEQVRRLQDLRRRCRLSVGAC
GGLDCARVGAQLVGRELSWPPERVRAELSDLLDQGWRERRPVLDGAQLAAEELLRGGCGPWEAP

Specific function: Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor [H]

COG id: COG0578

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=Loosely bound to the cytoplasmic membrane often occurring in vesicles associated with fumarate reductase (By similarity) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI285002233, Length=547, Percent_Identity=26.691042047532, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI285002231, Length=547, Percent_Identity=26.691042047532, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1788574, Length=528, Percent_Identity=33.7121212121212, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI2367226, Length=498, Percent_Identity=30.1204819277108, Blast_Score=118, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI115534726, Length=556, Percent_Identity=29.3165467625899, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17509253, Length=543, Percent_Identity=28.3609576427256, Blast_Score=138, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6322036, Length=591, Percent_Identity=25.8883248730964, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI161077125, Length=584, Percent_Identity=26.541095890411, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24653942, Length=584, Percent_Identity=26.541095890411, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24653944, Length=584, Percent_Identity=26.541095890411, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI20130025, Length=584, Percent_Identity=26.541095890411, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24586295, Length=404, Percent_Identity=28.4653465346535, Blast_Score=118, Evalue=9e-27,
Organism=Drosophila melanogaster, GI19921278, Length=539, Percent_Identity=25.0463821892393, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI45550977, Length=388, Percent_Identity=22.9381443298969, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007419
- InterPro:   IPR006076
- InterPro:   IPR017752
- InterPro:   IPR000447 [H]

Pfam domain/function: PF01266 DAO; PF04324 Fer2_BFD [H]

EC number: =1.1.5.3 [H]

Molecular weight: Translated: 59596; Mature: 59464

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00977 FAD_G3PDH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEHDVIIVGGGVNGTGTARDCAMRGLRVLLLERSDFGVGASGNSSGMIHGGIRYMLSDR
CCCCCEEEEECCCCCCCCHHHHHHHCCEEEEEECCCCCCCCCCCCCCEEECCHHEEECCC
KVTELACRDSGFIQRIAPHLLFRIPFLMPFGSRAEAATLAERAAWYATEVYVGTYDQYQP
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEEEEEECCHHHHH
LKRGRPSTRLTAEELYRLEPGLRPGLHGAVTLDEWGIDAFRLCVLNALSARTHGAELRTW
HHCCCCCCCCCHHHHHHHCCCCCCCCCCEEEEHHCCCHHHHHHHHHHHHHCCCCCHHHHH
TEVRQLLVEGGRVRGVRWRDALTGEEGEARAPVVFNAAGAWSPALARASGVRVPMRPGKG
HHHHHHHHCCCCCCCEEEHHCCCCCCCCCCCCEEEECCCCCCHHHHHHCCCEEECCCCCC
VHLTLDRRWSSYGVICTAVDGRQMFLMPHENESIVGTTDDDWYGDPDDLEATQDEVEYLL
EEEEEECCCCCCCEEEEEECCCEEEEEECCCCCEEECCCCCCCCCCCCCCCCHHHHHHHH
EGAASLVPGVRRARITRAWCGLRTTLYAYGPNEDALSREHQLLDGAADGAAGLLSIVGGK
HHHHHHCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LASYRAQSEEAADRIEALLGRPVTPCRTHQEPLPGGDEVPDPAALAREFPVAAAVAARLV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHH
YRHGGRAREICAMIRDDRRLGLVLCRDEAILAAEVVYCARHEQVRRLQDLRRRCRLSVGA
HHCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
CGGLDCARVGAQLVGRELSWPPERVRAELSDLLDQGWRERRPVLDGAQLAAEELLRGGCG
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
PWEAP
CCCCC
>Mature Secondary Structure 
GEHDVIIVGGGVNGTGTARDCAMRGLRVLLLERSDFGVGASGNSSGMIHGGIRYMLSDR
CCCCEEEEECCCCCCCCHHHHHHHCCEEEEEECCCCCCCCCCCCCCEEECCHHEEECCC
KVTELACRDSGFIQRIAPHLLFRIPFLMPFGSRAEAATLAERAAWYATEVYVGTYDQYQP
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEEEEEECCHHHHH
LKRGRPSTRLTAEELYRLEPGLRPGLHGAVTLDEWGIDAFRLCVLNALSARTHGAELRTW
HHCCCCCCCCCHHHHHHHCCCCCCCCCCEEEEHHCCCHHHHHHHHHHHHHCCCCCHHHHH
TEVRQLLVEGGRVRGVRWRDALTGEEGEARAPVVFNAAGAWSPALARASGVRVPMRPGKG
HHHHHHHHCCCCCCCEEEHHCCCCCCCCCCCCEEEECCCCCCHHHHHHCCCEEECCCCCC
VHLTLDRRWSSYGVICTAVDGRQMFLMPHENESIVGTTDDDWYGDPDDLEATQDEVEYLL
EEEEEECCCCCCCEEEEEECCCEEEEEECCCCCEEECCCCCCCCCCCCCCCCHHHHHHHH
EGAASLVPGVRRARITRAWCGLRTTLYAYGPNEDALSREHQLLDGAADGAAGLLSIVGGK
HHHHHHCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LASYRAQSEEAADRIEALLGRPVTPCRTHQEPLPGGDEVPDPAALAREFPVAAAVAARLV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHH
YRHGGRAREICAMIRDDRRLGLVLCRDEAILAAEVVYCARHEQVRRLQDLRRRCRLSVGA
HHCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
CGGLDCARVGAQLVGRELSWPPERVRAELSDLLDQGWRERRPVLDGAQLAAEELLRGGCG
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
PWEAP
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]