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The map label for this gene is lpxA

Identifier: 220916319

GI number: 220916319

Start: 1362960

End: 1363733

Strand: Direct

Name: lpxA

Synonym: A2cp1_1213

Alternate gene names: 220916319

Gene position: 1362960-1363733 (Clockwise)

Preceding gene: 220916318

Following gene: 220916320

Centisome position: 27.1

GC content: 71.96

Gene sequence:

>774_bases
ATGGCAATCCACCCCACCGCCATCGTCGAGGCCGGCGCGCAGGTCGATCCGTCCTGCGACATCGGCCCGTACGCCGTGAT
CGGCCCGCTGGTTCGCATGGGCCCCGGCAACTCGGTCGGCGCGCACGCGGTCGTGACCGGCCGGACCACGCTCGGCGCGT
CGAACCGGATCTTCCCGCACGCGGTCATCGGCGGCATCCCGCAGGACCTGAAGTACCGGGGCGAGGACACCGCGCTCGTC
ATCGGCGACCGCAACACGTTCCGCGAGTTCGCCACCGTGAACCTCGGGACCGCCGGCGGCGGCGGGGTGACCCGCATCGG
CTCGGGCGGCCTGTTCATGGCGAGCAGCCACATCGGCCACGACTGCCAGGTGGGCGACGGGGCCATCATCGCGAACTCGG
TCGCCATCGCCGGCCACGTGCTCATCGAGGACCACGTGCACTTCGGCGGCCTGTCCGCGTCGCACCAGTTCTGCCGCGTC
GGGCGGCTCGCGTTCGTGGGCGGCATGACCGGCGTCGCCATGGACGTCGCGCCGTACTGCACCGTGGCGGGCGCGCGCGG
CGAGCTGGCCGGGCTGAACACCATCGGCATGCAGCGCGCGGGCATGACCGAGGAGCAGGTCGGCCGCGTGAAGCAGGCAT
ACAAGATCGTGTTCCGGTCGAGCCTCGGCCTGGCCGAGGCCATCGCGCAGCTCGAGGCGGAGCTCGCCGGCCACCCCGAG
ACCGACCACTTCATCGCGTTCCTGAAGGGCTCGCAGCGCGGCATCACCCGCTAG

Upstream 100 bases:

>100_bases
GGCGTCGCGCGCGTCGACGGCCAGGTGGTCGCCGAGGCCGAGTTCATGGCGATGCTCGCCGACCGCGAGCGGTAGCAGAC
GATCGAGGAGCACGGGCGTC

Downstream 100 bases:

>100_bases
CCGTGGCGACCATCGGCCTCATCGCCGGCGGCGGGCGGTTCCCGCTCCTGTTCGCGGAGAGCGCGCGCCGCGCCGGCCAC
CGCGTGGTGGCGGTGGCGCA

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MAIHPTAIVEAGAQVDPSCDIGPYAVIGPLVRMGPGNSVGAHAVVTGRTTLGASNRIFPHAVIGGIPQDLKYRGEDTALV
IGDRNTFREFATVNLGTAGGGGVTRIGSGGLFMASSHIGHDCQVGDGAIIANSVAIAGHVLIEDHVHFGGLSASHQFCRV
GRLAFVGGMTGVAMDVAPYCTVAGARGELAGLNTIGMQRAGMTEEQVGRVKQAYKIVFRSSLGLAEAIAQLEAELAGHPE
TDHFIAFLKGSQRGITR

Sequences:

>Translated_257_residues
MAIHPTAIVEAGAQVDPSCDIGPYAVIGPLVRMGPGNSVGAHAVVTGRTTLGASNRIFPHAVIGGIPQDLKYRGEDTALV
IGDRNTFREFATVNLGTAGGGGVTRIGSGGLFMASSHIGHDCQVGDGAIIANSVAIAGHVLIEDHVHFGGLSASHQFCRV
GRLAFVGGMTGVAMDVAPYCTVAGARGELAGLNTIGMQRAGMTEEQVGRVKQAYKIVFRSSLGLAEAIAQLEAELAGHPE
TDHFIAFLKGSQRGITR
>Mature_256_residues
AIHPTAIVEAGAQVDPSCDIGPYAVIGPLVRMGPGNSVGAHAVVTGRTTLGASNRIFPHAVIGGIPQDLKYRGEDTALVI
GDRNTFREFATVNLGTAGGGGVTRIGSGGLFMASSHIGHDCQVGDGAIIANSVAIAGHVLIEDHVHFGGLSASHQFCRVG
RLAFVGGMTGVAMDVAPYCTVAGARGELAGLNTIGMQRAGMTEEQVGRVKQAYKIVFRSSLGLAEAIAQLEAELAGHPET
DHFIAFLKGSQRGITR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=256, Percent_Identity=44.140625, Blast_Score=220, Evalue=6e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_ANAD2 (B8JFW9)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002491623.1
- ProteinModelPortal:   B8JFW9
- SMR:   B8JFW9
- GeneID:   7299079
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_1213
- HOGENOM:   HBG659295
- ProtClustDB:   PRK05289
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 26480; Mature: 26348

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIHPTAIVEAGAQVDPSCDIGPYAVIGPLVRMGPGNSVGAHAVVTGRTTLGASNRIFPH
CCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCEECCCCCCCCCH
AVIGGIPQDLKYRGEDTALVIGDRNTFREFATVNLGTAGGGGVTRIGSGGLFMASSHIGH
HHHCCCCHHHEECCCCCEEEEECCHHHHHHEEEECCCCCCCCEEEECCCCEEEEECCCCC
DCQVGDGAIIANSVAIAGHVLIEDHVHFGGLSASHQFCRVGRLAFVGGMTGVAMDVAPYC
CCCCCCCEEEECCEEEEEEEEEECCEEECCCCCCHHHHHHHHHHEECCCCHHHHHHCCCE
TVAGARGELAGLNTIGMQRAGMTEEQVGRVKQAYKIVFRSSLGLAEAIAQLEAELAGHPE
EEECCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
TDHFIAFLKGSQRGITR
CCEEEEEEECCCCCCCC
>Mature Secondary Structure 
AIHPTAIVEAGAQVDPSCDIGPYAVIGPLVRMGPGNSVGAHAVVTGRTTLGASNRIFPH
CCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCEECCCCCCCCCH
AVIGGIPQDLKYRGEDTALVIGDRNTFREFATVNLGTAGGGGVTRIGSGGLFMASSHIGH
HHHCCCCHHHEECCCCCEEEEECCHHHHHHEEEECCCCCCCCEEEECCCCEEEEECCCCC
DCQVGDGAIIANSVAIAGHVLIEDHVHFGGLSASHQFCRVGRLAFVGGMTGVAMDVAPYC
CCCCCCCEEEECCEEEEEEEEEECCEEECCCCCCHHHHHHHHHHEECCCCHHHHHHCCCE
TVAGARGELAGLNTIGMQRAGMTEEQVGRVKQAYKIVFRSSLGLAEAIAQLEAELAGHPE
EEECCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
TDHFIAFLKGSQRGITR
CCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA