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The map label for this gene is phoA [H]

Identifier: 220916153

GI number: 220916153

Start: 1164602

End: 1166008

Strand: Reverse

Name: phoA [H]

Synonym: A2cp1_1040

Alternate gene names: 220916153

Gene position: 1166008-1164602 (Counterclockwise)

Preceding gene: 220916154

Following gene: 220916152

Centisome position: 23.18

GC content: 73.13

Gene sequence:

>1407_bases
ATGCACGCACGCACCCTCGCGGCGCTCGCGCTCGCGCTCTCCGCCGGCGACGCCGTCGCCGCCGGCCCGGCCAAGAACGT
CATCTTCTTCCTCGGCGACGGGATGGGTCCCACCACCGTGACCGCCGCACGCATCTTCGCGCACGGCGAGGCCGGCGCCC
TCGCCATGGACGGCCTCGGCCGCACGGCCCGGGTCAAGACCTACTCCGCGAACGCCCAGACCACCGACAGCGCGCCCTCC
ATGTCGGCGTACATGACCGGCGTGAAGATGAACAACGAGGTGGTCTCGATGTCCGCGGAGACCTCCGCGGCGGACCTGTC
CGTCACCCCGCCGGCCCCTTACGTCTCCGGCGCGGACTCCACCTGCCCCGAGACCGGCAACGGCTCGCCGGTGACCACGC
TGCTCGAGCTCGCCAAGGCCGCCGGCAAGGCGGTCGGCGCGGTGACCACCACCCGCGTCACCCACGCCACCCCGGCCGCG
ACGTACTCGCACCTCTGCCACCGCGACGGCGAGAACACCATCGCGGAGCAGGTGACCCCGGGGCATCCGGGCTTCAACCC
CGCCCTGGGCGCCGGTGTGGACGTGCTGCTCGGCGGCGGCTGGCGGCACTTCGTCCCCAGCACCACCACCGGCAGCAAGC
GGTCCGACGCGACCGACCTCACCGCGCTGTTCACCGGGGCCGGCTACACCTACGTCACCAGCGGCAGCGCGCTCGCGGCG
GTGGACCCCGCCGCGACCACCCGCCTCCTGGGCCTGTTCAACCGCGATCACCTGTCGTACGAGCTGGACCGTGTCGCGAA
CGGCGCCGACGAGCCCAGCCTCGCGGACATGACCGAGAAGGCCATCCGCATCCTCTCCAGGGACGGCGACGGCTTCTTCC
TCATGGTCGAGGGCGGCCGCATCGACCACGCGCTCCACGGGACGAACGCGCGGCGCGCGCTCGAGGACACGGTCGCGTTC
GACGACGCCATCGCGCGGGCGCTCGCGCTCGTGGACCCTGCCGACACGCTCATCGTGGTCACCGCCGACCACGACCACAC
CCTCGCGTTCAACGGCTATGCCCACCGCGGCAATCCGGTGCTCGGCCTCTCCACCGACCTCAAGCAGACCGCGGTGACCG
GCGCACCCGTCCCGGCGCTCGCCGCCGACGGCCGGGCGTACACGACGCTCGTCTTCGGCAACGGCGGCACGCCCCGGAAC
GCCGACCGGGCCGACCCGAGCCTGGTCGACACCACCGCCCCCGGCTACCTGCAGGACGTCGGCGTCCAGCTCGGCACCCC
GGGTTCCGAGACGCACGGCGGCGGCGACGTGATGCTGTTCGCGAAGGGCGCCGGGAGCGCCGGGTTCAAGGGGACGATCG
ACAACACGCGCGTGTTCGGCCTGGTGCGCGCGGCGATGGGGCTGTAG

Upstream 100 bases:

>100_bases
CGGCGCGGAGCGCTTCACCGGGGTCATCGACAACACCGCCGTCTTCACGCTGGTCCGCCGGGCCGCGGGCCTCTAGCCCT
CGCTCCCAGGAGACACTCCC

Downstream 100 bases:

>100_bases
CGATGCGCCGGATGATCGCCTGCACCCTCGCGATCGGGGTGGCCTCGGCCGCGGCCCTGCCCGCGGCCGGCGTCGCCTCC
CCGCCGCCGCTGGACCTCGA

Product: Alkaline phosphatase

Products: NA

Alternate protein names: APase [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MHARTLAALALALSAGDAVAAGPAKNVIFFLGDGMGPTTVTAARIFAHGEAGALAMDGLGRTARVKTYSANAQTTDSAPS
MSAYMTGVKMNNEVVSMSAETSAADLSVTPPAPYVSGADSTCPETGNGSPVTTLLELAKAAGKAVGAVTTTRVTHATPAA
TYSHLCHRDGENTIAEQVTPGHPGFNPALGAGVDVLLGGGWRHFVPSTTTGSKRSDATDLTALFTGAGYTYVTSGSALAA
VDPAATTRLLGLFNRDHLSYELDRVANGADEPSLADMTEKAIRILSRDGDGFFLMVEGGRIDHALHGTNARRALEDTVAF
DDAIARALALVDPADTLIVVTADHDHTLAFNGYAHRGNPVLGLSTDLKQTAVTGAPVPALAADGRAYTTLVFGNGGTPRN
ADRADPSLVDTTAPGYLQDVGVQLGTPGSETHGGGDVMLFAKGAGSAGFKGTIDNTRVFGLVRAAMGL

Sequences:

>Translated_468_residues
MHARTLAALALALSAGDAVAAGPAKNVIFFLGDGMGPTTVTAARIFAHGEAGALAMDGLGRTARVKTYSANAQTTDSAPS
MSAYMTGVKMNNEVVSMSAETSAADLSVTPPAPYVSGADSTCPETGNGSPVTTLLELAKAAGKAVGAVTTTRVTHATPAA
TYSHLCHRDGENTIAEQVTPGHPGFNPALGAGVDVLLGGGWRHFVPSTTTGSKRSDATDLTALFTGAGYTYVTSGSALAA
VDPAATTRLLGLFNRDHLSYELDRVANGADEPSLADMTEKAIRILSRDGDGFFLMVEGGRIDHALHGTNARRALEDTVAF
DDAIARALALVDPADTLIVVTADHDHTLAFNGYAHRGNPVLGLSTDLKQTAVTGAPVPALAADGRAYTTLVFGNGGTPRN
ADRADPSLVDTTAPGYLQDVGVQLGTPGSETHGGGDVMLFAKGAGSAGFKGTIDNTRVFGLVRAAMGL
>Mature_468_residues
MHARTLAALALALSAGDAVAAGPAKNVIFFLGDGMGPTTVTAARIFAHGEAGALAMDGLGRTARVKTYSANAQTTDSAPS
MSAYMTGVKMNNEVVSMSAETSAADLSVTPPAPYVSGADSTCPETGNGSPVTTLLELAKAAGKAVGAVTTTRVTHATPAA
TYSHLCHRDGENTIAEQVTPGHPGFNPALGAGVDVLLGGGWRHFVPSTTTGSKRSDATDLTALFTGAGYTYVTSGSALAA
VDPAATTRLLGLFNRDHLSYELDRVANGADEPSLADMTEKAIRILSRDGDGFFLMVEGGRIDHALHGTNARRALEDTVAF
DDAIARALALVDPADTLIVVTADHDHTLAFNGYAHRGNPVLGLSTDLKQTAVTGAPVPALAADGRAYTTLVFGNGGTPRN
ADRADPSLVDTTAPGYLQDVGVQLGTPGSETHGGGDVMLFAKGAGSAGFKGTIDNTRVFGLVRAAMGL

Specific function: Unknown

COG id: COG1785

COG function: function code P; Alkaline phosphatase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alkaline phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI116734717, Length=449, Percent_Identity=38.9755011135858, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI94721246, Length=488, Percent_Identity=36.6803278688525, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI157266296, Length=488, Percent_Identity=36.4754098360656, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI157266292, Length=471, Percent_Identity=37.1549893842887, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI294660770, Length=444, Percent_Identity=38.2882882882883, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI294660772, Length=400, Percent_Identity=37, Blast_Score=209, Evalue=3e-54,
Organism=Escherichia coli, GI48994877, Length=377, Percent_Identity=31.8302387267904, Blast_Score=142, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6320689, Length=363, Percent_Identity=32.5068870523416, Blast_Score=138, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21355981, Length=460, Percent_Identity=36.7391304347826, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI21358067, Length=457, Percent_Identity=37.636761487965, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI21355151, Length=462, Percent_Identity=34.6320346320346, Blast_Score=238, Evalue=8e-63,
Organism=Drosophila melanogaster, GI21355149, Length=485, Percent_Identity=35.4639175257732, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI19921912, Length=492, Percent_Identity=34.9593495934959, Blast_Score=234, Evalue=8e-62,
Organism=Drosophila melanogaster, GI18859923, Length=450, Percent_Identity=35.7777777777778, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI85725200, Length=452, Percent_Identity=34.2920353982301, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI85815833, Length=452, Percent_Identity=34.2920353982301, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24585213, Length=474, Percent_Identity=33.1223628691983, Blast_Score=212, Evalue=5e-55,
Organism=Drosophila melanogaster, GI24651554, Length=480, Percent_Identity=33.5416666666667, Blast_Score=205, Evalue=5e-53,
Organism=Drosophila melanogaster, GI24657827, Length=473, Percent_Identity=34.0380549682875, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24651556, Length=469, Percent_Identity=32.8358208955224, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24657835, Length=465, Percent_Identity=32.0430107526882, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24657842, Length=475, Percent_Identity=31.5789473684211, Blast_Score=181, Evalue=9e-46,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR001952
- InterPro:   IPR018299
- InterPro:   IPR017850 [H]

Pfam domain/function: PF00245 Alk_phosphatase [H]

EC number: =3.1.3.1 [H]

Molecular weight: Translated: 47706; Mature: 47706

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHARTLAALALALSAGDAVAAGPAKNVIFFLGDGMGPTTVTAARIFAHGEAGALAMDGLG
CCHHHHHHHHHHHHCCCCEECCCCCCEEEEEECCCCCHHHEEEEEEECCCCCEEEECCCC
RTARVKTYSANAQTTDSAPSMSAYMTGVKMNNEVVSMSAETSAADLSVTPPAPYVSGADS
CEEEEEEEECCCCCCCCCCCCCCEEEEEEECCEEEEEECCCCCCEEEECCCCCCCCCCCC
TCPETGNGSPVTTLLELAKAAGKAVGAVTTTRVTHATPAATYSHLCHRDGENTIAEQVTP
CCCCCCCCCHHHHHHHHHHHHCCHHCCEEEEEEECCCCHHHHHHHHHCCCCCHHHHCCCC
GHPGFNPALGAGVDVLLGGGWRHFVPSTTTGSKRSDATDLTALFTGAGYTYVTSGSALAA
CCCCCCCCCCCCCEEEECCCCHHCCCCCCCCCCCCCCHHEEEEEECCCEEEEECCCEEEE
VDPAATTRLLGLFNRDHLSYELDRVANGADEPSLADMTEKAIRILSRDGDGFFLMVEGGR
ECCHHHHHHHHHHCCCCCCEEHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCC
IDHALHGTNARRALEDTVAFDDAIARALALVDPADTLIVVTADHDHTLAFNGYAHRGNPV
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEECCCCCCCCEE
LGLSTDLKQTAVTGAPVPALAADGRAYTTLVFGNGGTPRNADRADPSLVDTTAPGYLQDV
EEECCCHHHHHCCCCCCCCEECCCCEEEEEEECCCCCCCCCCCCCCCEEECCCCCHHHHC
GVQLGTPGSETHGGGDVMLFAKGAGSAGFKGTIDNTRVFGLVRAAMGL
CEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MHARTLAALALALSAGDAVAAGPAKNVIFFLGDGMGPTTVTAARIFAHGEAGALAMDGLG
CCHHHHHHHHHHHHCCCCEECCCCCCEEEEEECCCCCHHHEEEEEEECCCCCEEEECCCC
RTARVKTYSANAQTTDSAPSMSAYMTGVKMNNEVVSMSAETSAADLSVTPPAPYVSGADS
CEEEEEEEECCCCCCCCCCCCCCEEEEEEECCEEEEEECCCCCCEEEECCCCCCCCCCCC
TCPETGNGSPVTTLLELAKAAGKAVGAVTTTRVTHATPAATYSHLCHRDGENTIAEQVTP
CCCCCCCCCHHHHHHHHHHHHCCHHCCEEEEEEECCCCHHHHHHHHHCCCCCHHHHCCCC
GHPGFNPALGAGVDVLLGGGWRHFVPSTTTGSKRSDATDLTALFTGAGYTYVTSGSALAA
CCCCCCCCCCCCCEEEECCCCHHCCCCCCCCCCCCCCHHEEEEEECCCEEEEECCCEEEE
VDPAATTRLLGLFNRDHLSYELDRVANGADEPSLADMTEKAIRILSRDGDGFFLMVEGGR
ECCHHHHHHHHHHCCCCCCEEHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCC
IDHALHGTNARRALEDTVAFDDAIARALALVDPADTLIVVTADHDHTLAFNGYAHRGNPV
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEECCCCCCCCEE
LGLSTDLKQTAVTGAPVPALAADGRAYTTLVFGNGGTPRNADRADPSLVDTTAPGYLQDV
EEECCCHHHHHCCCCCCCCEECCCCEEEEEEECCCCCCCCCCCCCCCEEECCCCCHHHHC
GVQLGTPGSETHGGGDVMLFAKGAGSAGFKGTIDNTRVFGLVRAAMGL
CEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2129542 [H]