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The map label for this gene is lpxC [H]

Identifier: 220916126

GI number: 220916126

Start: 1139342

End: 1140268

Strand: Direct

Name: lpxC [H]

Synonym: A2cp1_1013

Alternate gene names: 220916126

Gene position: 1139342-1140268 (Clockwise)

Preceding gene: 220916124

Following gene: 220916127

Centisome position: 22.65

GC content: 72.28

Gene sequence:

>927_bases
ATGGCTTCCTGGAATCAGCGAACGGTCGCGAAGCGGGTCTCCTGCACGGGGGTGGGCCTCCACTCCGGCCGGCCCGCGAC
CCTGACGCTCGCGCCCGCCCCGGCCGACGCCGGCATCACGTTCGTCCGCATGGACCTCGGCGTCGAGATCCCCGCGCGCA
ACGAGCACGTGGTCGACACGATGCTCTCGACCTCGCTCGGCCGCGGCAGCGCCCGCGTGGCCACGGTCGAGCACGTCATG
GCCGCGCTGCACGGCATGGGCATCGACAACTGCCGCGTCGAGGTGGACGGCCCGGAGATCCCGATCCTGGACGGCTCCGC
CGCGCCGTTCACCTGCCTCGTGCAGGAGGCCGGCGTGAAGGTGCAGCCCGCCGGCAAGCGCTACCTGGTCGTCGACCAGG
CCGTCGAGATCCGCGACGGCGACAAGCTGGCGCGCCTCGAGCCCGCGGAGGGCTTCTCGGTCTCCTTCACCGCGGACTTC
GGCCACCCGCTCATCACCGACCAGTCGTTCCAGGTGAAGCTGGGCGAGCGCGCCTTCGAGCGCGAGGTGGCCCGCGCGCG
CACGTTCTGCTTCCGGCGCGACATCGAGAAGATGCAGGCGATGGGGCTGGCCAGGGGCGGCAGCCTCGAGAACGCCATCG
TGGTGGACGAGTTCTCGATCCTGAACCCCGAGGGGCTGCGCTTCCCGGACGAGTTCGCGCGGCACAAGGTGCTCGACGCG
ATCGGCGACCTGGCGCTGTTCGGGCTCCCGGTGGTGGGCGCGCTCGTCGCGGTGAAGAGCGGCCACGCCATGAACCAGGC
GCTGGTGAAGAAGGTCCTGGCCGACCCCGCCTCGCATCGCGTGGTCCGGGTGACCGGCGAGGCCGACGCGCCGGCGCTCC
GCGCGAAGGTGCCGGCCCTCGCGATCCACGAGGGCTCCGCGGCCTAG

Upstream 100 bases:

>100_bases
AGTGCCGCGGACCCATGAAGTGCCCGGAAATCGGGTTGATTGGCACGTCGATTGCTCGGAAGGGGGCCGCCCGGGCGACG
CGCCCAGAACGGACTTGGAC

Downstream 100 bases:

>100_bases
CGGCTGCGCCGCCCCGGCGCGCGCACGCGTTGGGGCGCGTCCGCCCGGGCCGCCCCGGCGCGCCGCGCCCGGCGGTACGC
TCGCGGCGTGGACCTCGCGC

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MASWNQRTVAKRVSCTGVGLHSGRPATLTLAPAPADAGITFVRMDLGVEIPARNEHVVDTMLSTSLGRGSARVATVEHVM
AALHGMGIDNCRVEVDGPEIPILDGSAAPFTCLVQEAGVKVQPAGKRYLVVDQAVEIRDGDKLARLEPAEGFSVSFTADF
GHPLITDQSFQVKLGERAFEREVARARTFCFRRDIEKMQAMGLARGGSLENAIVVDEFSILNPEGLRFPDEFARHKVLDA
IGDLALFGLPVVGALVAVKSGHAMNQALVKKVLADPASHRVVRVTGEADAPALRAKVPALAIHEGSAA

Sequences:

>Translated_308_residues
MASWNQRTVAKRVSCTGVGLHSGRPATLTLAPAPADAGITFVRMDLGVEIPARNEHVVDTMLSTSLGRGSARVATVEHVM
AALHGMGIDNCRVEVDGPEIPILDGSAAPFTCLVQEAGVKVQPAGKRYLVVDQAVEIRDGDKLARLEPAEGFSVSFTADF
GHPLITDQSFQVKLGERAFEREVARARTFCFRRDIEKMQAMGLARGGSLENAIVVDEFSILNPEGLRFPDEFARHKVLDA
IGDLALFGLPVVGALVAVKSGHAMNQALVKKVLADPASHRVVRVTGEADAPALRAKVPALAIHEGSAA
>Mature_307_residues
ASWNQRTVAKRVSCTGVGLHSGRPATLTLAPAPADAGITFVRMDLGVEIPARNEHVVDTMLSTSLGRGSARVATVEHVMA
ALHGMGIDNCRVEVDGPEIPILDGSAAPFTCLVQEAGVKVQPAGKRYLVVDQAVEIRDGDKLARLEPAEGFSVSFTADFG
HPLITDQSFQVKLGERAFEREVARARTFCFRRDIEKMQAMGLARGGSLENAIVVDEFSILNPEGLRFPDEFARHKVLDAI
GDLALFGLPVVGALVAVKSGHAMNQALVKKVLADPASHRVVRVTGEADAPALRAKVPALAIHEGSAA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=302, Percent_Identity=48.3443708609272, Blast_Score=285, Evalue=3e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 32769; Mature: 32638

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASWNQRTVAKRVSCTGVGLHSGRPATLTLAPAPADAGITFVRMDLGVEIPARNEHVVDT
CCCCCHHHHHHHHEEEEEECCCCCCEEEEEECCCCCCCEEEEEEECCEECCCCCCHHHHH
MLSTSLGRGSARVATVEHVMAALHGMGIDNCRVEVDGPEIPILDGSAAPFTCLVQEAGVK
HHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEECCCCCCEEEEEECCCEE
VQPAGKRYLVVDQAVEIRDGDKLARLEPAEGFSVSFTADFGHPLITDQSFQVKLGERAFE
ECCCCCEEEEEECEEEECCCCCEEEECCCCCCEEEEEECCCCCEECCCCEEEEECHHHHH
REVARARTFCFRRDIEKMQAMGLARGGSLENAIVVDEFSILNPEGLRFPDEFARHKVLDA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHH
IGDLALFGLPVVGALVAVKSGHAMNQALVKKVLADPASHRVVRVTGEADAPALRAKVPAL
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHCCCEE
AIHEGSAA
EEECCCCC
>Mature Secondary Structure 
ASWNQRTVAKRVSCTGVGLHSGRPATLTLAPAPADAGITFVRMDLGVEIPARNEHVVDT
CCCCHHHHHHHHEEEEEECCCCCCEEEEEECCCCCCCEEEEEEECCEECCCCCCHHHHH
MLSTSLGRGSARVATVEHVMAALHGMGIDNCRVEVDGPEIPILDGSAAPFTCLVQEAGVK
HHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEECCCCCCEEEEEECCCEE
VQPAGKRYLVVDQAVEIRDGDKLARLEPAEGFSVSFTADFGHPLITDQSFQVKLGERAFE
ECCCCCEEEEEECEEEECCCCCEEEECCCCCCEEEEEECCCCCEECCCCEEEEECHHHHH
REVARARTFCFRRDIEKMQAMGLARGGSLENAIVVDEFSILNPEGLRFPDEFARHKVLDA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHH
IGDLALFGLPVVGALVAVKSGHAMNQALVKKVLADPASHRVVRVTGEADAPALRAKVPAL
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHCCCEE
AIHEGSAA
EEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA