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The map label for this gene is sufS [H]

Identifier: 220916010

GI number: 220916010

Start: 1015528

End: 1016817

Strand: Direct

Name: sufS [H]

Synonym: A2cp1_0896

Alternate gene names: 220916010

Gene position: 1015528-1016817 (Clockwise)

Preceding gene: 220916009

Following gene: 220916011

Centisome position: 20.19

GC content: 75.74

Gene sequence:

>1290_bases
ATGAGCACGGCGGAGGCACAGGCGGCCGGCGGGCGGGCGGCGCGGCCGGAGGCGCGCGAGGGCGCGCGCGGCGCGTTCGA
CGTCGAGCGGGTGCGGGCCGAGTTCCCCATCCTGGCGCGGCCGGTGCGGGGCAAGCCGCTCGCGTACCTGGACAGCGCCG
CCACCGCGCAGAAGCCGCGCGCGGTGATCGACGCGGTCCGCCGCTACTACGAGGAGGACAACGCGAACGTGCACCGCGGG
GTCCACCTGCTCTCCGAGCGCGCCACCCGCCTCTACGACGGGGCGCGCGTGAAGGTGGCCCGGTTCCTGGGGGCGAGCGA
TCCGCACGAGGTGGTGTTCGTGCGCGGCACGACCGAGGCGGTGAACCTGGTGGCGCAGACGTTCGGGCGCCAGCGGGTCG
GGCCCGGCGACGAGATCCTCGTCACCGAGCTCGAGCACCACTCGAACATCGTGCCGTGGCAGCTCCTCTGCCAGGAGAAG
GGCGCCACGCTGCGCGCCGCGCCGGTGTCGGACGCGGGCGACCTCGACGTGGAGGCGCTCGACCGGATGATCGGGCCGCG
CACGCGCCTCGTGGCGGTGGCCCACGTCTCGAACGCGCTCGGCACGGTGAACCCGGTGGCCGAGATCGTGGCGCGCGCGC
ACGCGAAGGGCGTGCCGGTGCTGGTGGACGGCGCCCAGGCGGTGCCGCACCTCGCGGTGGACCTGCCCGCGCTCGGCGCC
GACTTCTACGCGTTCAGCGGCCACAAGCTGTACGGGCCGACCGGCATCGGGGTGCTGTGGGGGCGCAAGGCGCTCCTCGA
CGCGCTGCCGCCGTGGCAGGGCGGCGGCGACATGATCCTCTCGGTCTCCTTCGAGAAGACCACGTTCAACGCGGTCCCGC
ACCGGTTCGAGGCCGGCACGCCGAACATCGCGGGCGCGGTCGGGCTCGCGGCCGCCATCGACTGGCTCTCCGCGGTCGGG
CTGGAGGCGGCGGCGGCGCACGAGGACGCGCTCATCGCCCACGCGCTGGACGCGCTCCGCGAGGTCCCCGGGATCCGCCT
GATCGGCACGCCGCGGCGGCGGGCCGGCGTCATCTCGTTCCTCCCGGGCGACGTCCACCCGCACGACGCCGGCACCATCC
TCGATCGCCACGGGGTGGCGGTCCGCGCCGGGCACCACTGCGCCCAGCCGCTCATGCGGCGCATGGGCGTGGCGGCCACG
GTGCGCGCCTCCTTCGCCGCGTACAGCACGCGGGCCGACGTGGACGCGCTCGTCCGCGGCCTGCACGCGGTCCGGGAGGT
GTTCGCGTGA

Upstream 100 bases:

>100_bases
AGATGGTGGACCTGGTGCGGCCGGCCGGCCTGCACGCGCGCGCGCGGGAGCTCGTCGCGGCGCGGCTGCCGGCGGGGCGG
AAGGTGCTGGAGGCGGCGGC

Downstream 100 bases:

>100_bases
CCGCGTCCCGTCGCCGCCGACCGTCCCAGGGAGCCTGCCCGTGTCGGAGCTGAGCGATCTGTACCAGGAGGTGGTCCTCG
ACCACGGCAAGCGGCCGCGC

Product: SufS subfamily cysteine desulfurase

Products: NA

Alternate protein names: Selenocysteine beta-lyase; SCL; Selenocysteine lyase; Selenocysteine reductase [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MSTAEAQAAGGRAARPEAREGARGAFDVERVRAEFPILARPVRGKPLAYLDSAATAQKPRAVIDAVRRYYEEDNANVHRG
VHLLSERATRLYDGARVKVARFLGASDPHEVVFVRGTTEAVNLVAQTFGRQRVGPGDEILVTELEHHSNIVPWQLLCQEK
GATLRAAPVSDAGDLDVEALDRMIGPRTRLVAVAHVSNALGTVNPVAEIVARAHAKGVPVLVDGAQAVPHLAVDLPALGA
DFYAFSGHKLYGPTGIGVLWGRKALLDALPPWQGGGDMILSVSFEKTTFNAVPHRFEAGTPNIAGAVGLAAAIDWLSAVG
LEAAAAHEDALIAHALDALREVPGIRLIGTPRRRAGVISFLPGDVHPHDAGTILDRHGVAVRAGHHCAQPLMRRMGVAAT
VRASFAAYSTRADVDALVRGLHAVREVFA

Sequences:

>Translated_429_residues
MSTAEAQAAGGRAARPEAREGARGAFDVERVRAEFPILARPVRGKPLAYLDSAATAQKPRAVIDAVRRYYEEDNANVHRG
VHLLSERATRLYDGARVKVARFLGASDPHEVVFVRGTTEAVNLVAQTFGRQRVGPGDEILVTELEHHSNIVPWQLLCQEK
GATLRAAPVSDAGDLDVEALDRMIGPRTRLVAVAHVSNALGTVNPVAEIVARAHAKGVPVLVDGAQAVPHLAVDLPALGA
DFYAFSGHKLYGPTGIGVLWGRKALLDALPPWQGGGDMILSVSFEKTTFNAVPHRFEAGTPNIAGAVGLAAAIDWLSAVG
LEAAAAHEDALIAHALDALREVPGIRLIGTPRRRAGVISFLPGDVHPHDAGTILDRHGVAVRAGHHCAQPLMRRMGVAAT
VRASFAAYSTRADVDALVRGLHAVREVFA
>Mature_428_residues
STAEAQAAGGRAARPEAREGARGAFDVERVRAEFPILARPVRGKPLAYLDSAATAQKPRAVIDAVRRYYEEDNANVHRGV
HLLSERATRLYDGARVKVARFLGASDPHEVVFVRGTTEAVNLVAQTFGRQRVGPGDEILVTELEHHSNIVPWQLLCQEKG
ATLRAAPVSDAGDLDVEALDRMIGPRTRLVAVAHVSNALGTVNPVAEIVARAHAKGVPVLVDGAQAVPHLAVDLPALGAD
FYAFSGHKLYGPTGIGVLWGRKALLDALPPWQGGGDMILSVSFEKTTFNAVPHRFEAGTPNIAGAVGLAAAIDWLSAVGL
EAAAAHEDALIAHALDALREVPGIRLIGTPRRRAGVISFLPGDVHPHDAGTILDRHGVAVRAGHHCAQPLMRRMGVAATV
RASFAAYSTRADVDALVRGLHAVREVFA

Specific function: Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=232, Percent_Identity=31.0344827586207, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI156713448, Length=422, Percent_Identity=27.0142180094787, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1787970, Length=404, Percent_Identity=52.2277227722772, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1789175, Length=403, Percent_Identity=44.4168734491315, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI48994898, Length=217, Percent_Identity=32.7188940092166, Blast_Score=104, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI25143064, Length=215, Percent_Identity=31.1627906976744, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI193211090, Length=407, Percent_Identity=26.044226044226, Blast_Score=101, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6319831, Length=228, Percent_Identity=30.7017543859649, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI20129463, Length=264, Percent_Identity=32.1969696969697, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7; =4.4.1.16 [H]

Molecular weight: Translated: 45517; Mature: 45386

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTAEAQAAGGRAARPEAREGARGAFDVERVRAEFPILARPVRGKPLAYLDSAATAQKPR
CCCCCCHHCCCCCCCCCHHCCCCCCHHHHHHHHCCCCEECCCCCCCHHHHCCHHHCCCCH
AVIDAVRRYYEEDNANVHRGVHLLSERATRLYDGARVKVARFLGASDPHEVVFVRGTTEA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEECCHHH
VNLVAQTFGRQRVGPGDEILVTELEHHSNIVPWQLLCQEKGATLRAAPVSDAGDLDVEAL
HHHHHHHHCCCCCCCCCCEEEEEHHHCCCCCCHHHHHHHCCCEEEECCCCCCCCCCHHHH
DRMIGPRTRLVAVAHVSNALGTVNPVAEIVARAHAKGVPVLVDGAQAVPHLAVDLPALGA
HHHHCCHHHEEEEEHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHEECCCCCC
DFYAFSGHKLYGPTGIGVLWGRKALLDALPPWQGGGDMILSVSFEKTTFNAVPHRFEAGT
CEEEECCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHCCCCCCCCC
PNIAGAVGLAAAIDWLSAVGLEAAAAHEDALIAHALDALREVPGIRLIGTPRRRAGVISF
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHCCEEEE
LPGDVHPHDAGTILDRHGVAVRAGHHCAQPLMRRMGVAATVRASFAAYSTRADVDALVRG
CCCCCCCCCCCCEECCCCCEEECCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHH
LHAVREVFA
HHHHHHHHC
>Mature Secondary Structure 
STAEAQAAGGRAARPEAREGARGAFDVERVRAEFPILARPVRGKPLAYLDSAATAQKPR
CCCCCHHCCCCCCCCCHHCCCCCCHHHHHHHHCCCCEECCCCCCCHHHHCCHHHCCCCH
AVIDAVRRYYEEDNANVHRGVHLLSERATRLYDGARVKVARFLGASDPHEVVFVRGTTEA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEECCHHH
VNLVAQTFGRQRVGPGDEILVTELEHHSNIVPWQLLCQEKGATLRAAPVSDAGDLDVEAL
HHHHHHHHCCCCCCCCCCEEEEEHHHCCCCCCHHHHHHHCCCEEEECCCCCCCCCCHHHH
DRMIGPRTRLVAVAHVSNALGTVNPVAEIVARAHAKGVPVLVDGAQAVPHLAVDLPALGA
HHHHCCHHHEEEEEHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHEECCCCCC
DFYAFSGHKLYGPTGIGVLWGRKALLDALPPWQGGGDMILSVSFEKTTFNAVPHRFEAGT
CEEEECCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHCCCCCCCCC
PNIAGAVGLAAAIDWLSAVGLEAAAAHEDALIAHALDALREVPGIRLIGTPRRRAGVISF
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHCCEEEE
LPGDVHPHDAGTILDRHGVAVRAGHHCAQPLMRRMGVAATVRASFAAYSTRADVDALVRG
CCCCCCCCCCCCEECCCCCEEECCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHH
LHAVREVFA
HHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11251816 [H]