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The map label for this gene is hisA

Identifier: 220915869

GI number: 220915869

Start: 844089

End: 844805

Strand: Direct

Name: hisA

Synonym: A2cp1_0752

Alternate gene names: 220915869

Gene position: 844089-844805 (Clockwise)

Preceding gene: 220915868

Following gene: 220915870

Centisome position: 16.78

GC content: 76.29

Gene sequence:

>717_bases
ATGCTCGTCATCCCAGCGATCGATCTCATCGGCGGCGAGGTGGTCCGGCTGGAGAAGGGCGACTTCGCCCGCAAGACCGT
GTACGCGCGCGACCCGGCCGAGAAGGCCGCCGAGCTGGTGCGCGACGGCGCGAGCCTCATCCACGTGGTGGACCTCGACG
GCGCGAAGGCCGGCTGGCCGGTGAACCTCGACGCGGTCCGCGCCATCTGCGCGGTGCCGGGGGCGGAGGTGGAGCTGGGC
GGCGGGCTGCGCTCGCTGCCGGACATCGAGAAGGTGCTCGAGCTGGGCGTGCGGTACGTGGTGCTCGGCACCGCGGCGGT
GGAGCGGCTCGACCTGGTCCGCCAGGCCTGCGCCCGCTTCCCCGGGCGCGTGCGCAGCGGCATCGACGCGCGCAACGGCG
AGGTGAAGATCGCCGGCTGGCTGGAGGGCACCGGGCTCGGCGCGGCCGAGGTGGCGCGCCGGGTGAAGGAGGCCGGGGTC
GGGCTGGTGGAGTACACCGACGTCGGCCGCGACGGCATGTTCACCGGGGTGGACGCCGAGGGCGCGGCGCGGCTGCAGGC
CGAGGCCGGCGTGCAGGTGGTCGCCTCGGGCGGCGTGGCCGGCCTCGACGACGTGCGCGCCTGCCGCGCCGCCGGGCTGG
CCGGCGTGATCGTCGGCAAGGCGCTGTACGAGGGCCGGATCGCGCTCGCCGAGGCGGTGCGCGCCGCGGCGGAGTAG

Upstream 100 bases:

>100_bases
GGAGCGCGGCAACCTGTTCGCGGTGCAGTTCCACCCTGAGAAGAGCCAGCGCGTGGGCCTGGCCCTGCTCGAGCGGTTCG
TCTCCACCTAGGCGGGGGCC

Downstream 100 bases:

>100_bases
GAGAGGGAAGGGCACCGCATGCCGGCGAAGCGCATCATCCCCTGCCTCGACGTGAAGGCCGGACGCGTGGTCAAGGGGGT
CAAGTTCCAGAACCTGCGCG

Product: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MLVIPAIDLIGGEVVRLEKGDFARKTVYARDPAEKAAELVRDGASLIHVVDLDGAKAGWPVNLDAVRAICAVPGAEVELG
GGLRSLPDIEKVLELGVRYVVLGTAAVERLDLVRQACARFPGRVRSGIDARNGEVKIAGWLEGTGLGAAEVARRVKEAGV
GLVEYTDVGRDGMFTGVDAEGAARLQAEAGVQVVASGGVAGLDDVRACRAAGLAGVIVGKALYEGRIALAEAVRAAAE

Sequences:

>Translated_238_residues
MLVIPAIDLIGGEVVRLEKGDFARKTVYARDPAEKAAELVRDGASLIHVVDLDGAKAGWPVNLDAVRAICAVPGAEVELG
GGLRSLPDIEKVLELGVRYVVLGTAAVERLDLVRQACARFPGRVRSGIDARNGEVKIAGWLEGTGLGAAEVARRVKEAGV
GLVEYTDVGRDGMFTGVDAEGAARLQAEAGVQVVASGGVAGLDDVRACRAAGLAGVIVGKALYEGRIALAEAVRAAAE
>Mature_238_residues
MLVIPAIDLIGGEVVRLEKGDFARKTVYARDPAEKAAELVRDGASLIHVVDLDGAKAGWPVNLDAVRAICAVPGAEVELG
GGLRSLPDIEKVLELGVRYVVLGTAAVERLDLVRQACARFPGRVRSGIDARNGEVKIAGWLEGTGLGAAEVARRVKEAGV
GLVEYTDVGRDGMFTGVDAEGAARLQAEAGVQVVASGGVAGLDDVRACRAAGLAGVIVGKALYEGRIALAEAVRAAAE

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=239, Percent_Identity=35.1464435146443, Blast_Score=134, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_ANAD2 (B8JDL2)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002491173.1
- ProteinModelPortal:   B8JDL2
- GeneID:   7299137
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_0752
- HOGENOM:   HBG541613
- ProtClustDB:   CLSK945204
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 24530; Mature: 24530

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVIPAIDLIGGEVVRLEKGDFARKTVYARDPAEKAAELVRDGASLIHVVDLDGAKAGWP
CEEECCHHHCCCEEEEECCCCCHHHEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCCC
VNLDAVRAICAVPGAEVELGGGLRSLPDIEKVLELGVRYVVLGTAAVERLDLVRQACARF
CCHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHC
PGRVRSGIDARNGEVKIAGWLEGTGLGAAEVARRVKEAGVGLVEYTDVGRDGMFTGVDAE
CHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCEECCCCC
GAARLQAEAGVQVVASGGVAGLDDVRACRAAGLAGVIVGKALYEGRIALAEAVRAAAE
CCHHHHHHCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHCC
>Mature Secondary Structure
MLVIPAIDLIGGEVVRLEKGDFARKTVYARDPAEKAAELVRDGASLIHVVDLDGAKAGWP
CEEECCHHHCCCEEEEECCCCCHHHEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCCC
VNLDAVRAICAVPGAEVELGGGLRSLPDIEKVLELGVRYVVLGTAAVERLDLVRQACARF
CCHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHC
PGRVRSGIDARNGEVKIAGWLEGTGLGAAEVARRVKEAGVGLVEYTDVGRDGMFTGVDAE
CHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCEECCCCC
GAARLQAEAGVQVVASGGVAGLDDVRACRAAGLAGVIVGKALYEGRIALAEAVRAAAE
CCHHHHHHCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA