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The map label for this gene is tlpA [H]

Identifier: 220915827

GI number: 220915827

Start: 797520

End: 800003

Strand: Direct

Name: tlpA [H]

Synonym: A2cp1_0710

Alternate gene names: 220915827

Gene position: 797520-800003 (Clockwise)

Preceding gene: 220915822

Following gene: 220915844

Centisome position: 15.86

GC content: 78.02

Gene sequence:

>2484_bases
ATGCGCTTCGGTTGGCGGCTGGTCCGGAACGTCGCGTCGATGATCCTGCTCGGCACGGCGCTGGGGTGGTGGGTGACGCA
GGCGTTCCCGCTCTCCGCGCCCCAGCGCGAGGCGCTGCGGTGGGCGCTCCTCGCGAGCGTGGCGCTGGAGTGGGCCGCGG
CGGGCGGGGCCGTCTGGGCCCTGTCGCGGCCGCTGCGCGCCGCCGACGACGCGCACCGCGGCGCCGGCGCCATCCCGACG
CCGCTCGCGCTGCGCGCCGCCGCCACCGGCCACCGGCTGCCTGCCTACACCGCCGCGGTGGTGCTCGCCGCCGGCGTGCT
CGCCACGGTGGTGCTGACCGCGCTGGCCCGCGCGCGCGGGGTCCCGCTCGACCTCGGCCTGGCCGGCGCCGCGGTGGGCT
TCGCCAGCGCCTCGCTCGCGGCGATGCTCTGCTACGCGCTCGCCGGCACCGCCGCCGGCGAGGTGTTCGAGCGGCTCGGC
CCGGACGCCGAGGTCGCCGTCCAGGGCACGGTGCGCGGGAAGATCCTGATCCTCGCGCTCGGCCTCATCACCATCTGCGT
GCTCCTCTTCGCCGCCACCGGCTACGTCCGCTACCGGGGCGACATCGATCGCGAGTACGTCGCCACCGCCGCCCACGCGC
AGGAGAGCGCGGTCGCCTCCGGCGTGGCCGCGAGCGACGCGGAGCTGGCCGAGCACCTCTGGCTCGTGACCGGCACGCCC
TCGGCCGTGCTCGGCCCCGGCGGCGCGGTGGTGGCGCGCTTCGGCGCGGGCCGGGTCCCGTTCGAGGGCGCGGCCGCTGC
GGCCGCGGGCGCGCTCCGGGTCGAGGACGGCTGGCTCGTGTCGCGCGCCACCGCCTCGGGCGGGCGCGTGGTCTCGTGGC
TCCCGGAGGAGCCGGTGCGCGCGCGGCGGCGCGCGTTCTGGGGCGCGCTCGCCGTCAGCGCCCTGGTGGTCTACGCGGCG
ACCGCGCTGCTCGCCTGGCTCGCCGCCAGCGCCATCACGCTCCCGTTCCGGACGCTCGGCCGCGCCGCGGACCGCATCGC
CTCGGGCGACCTCGCCGCCAGCCCGCCGTCGGTCTCGCGCGACGAGATGGGCCAGCTCGCCGCCGACTTCCGGCGCATGG
CGCAGGGGTTGAAGGCGCTGGTCGTGGACGTGCAATCGGCGAGCGAGGGCGTCTCGGCCGGCGCGCGCGAGGCGGGCGCC
ATCGGCGAGCGGGTGCGGGCCGGCGCGCTGGACCAGCACGCCGGGGCGGTGGCGGCGCAGGGCGCGGTGGAGGCGATGGA
GGGCTCGATCGCGCTGGTGGCGCGCGGGGTCGGCGGCCTGTCGGAGTACGTCTCGGCGACCACGCAGCAGGTGGGCGAGA
TGGCGTCCGGCCTGGACGAGGTGCGGCGGAAGGGGGCCGAGCTGGAGCGCGCCATGGCGGTCGCGCTCCGCGACGTGGAG
TCGCTCGCGCACGCGGGCCGCGACGCCGACGCCACGCTCGCCGAGCTGGAGCAGCACGCCGGCCATGCCGCCGGGACGCT
CTCGGCGGTGCGGTCGTCCATCGGGACGCTGGAGCGCGCCGCCGAGGAGAGCGAGCGCACCGCCGGGATGGTGGCCGACG
TGGCCGAGCGGGCCGGCGGGGTGGTGGAGGAGACGGTGCACGGGATCGAGGCGCTGCGCGCGGCGGTCGCCGACGCGCAC
CGCCGCGTGGCGGCGCTGGGGCGGCGCTCCGACGACATCGACCAGGTGGTGGACTTCATCTCGGAGGTGGCCGGGCGCAC
CAGCCTGCTGTCGCTCAACGCCTCCATCATCGCCTCGCAGGCGGGCGAGCACGGCAAGGGCTTCGCGGTGGTGGCCGAGC
AGATCCGCGAGCTGGCGGCGCAGATCGCCCGCTCGACCACGTCGATCGGCGACATCGTCCGCGCGGTGCGCGACGACGTG
GAGGGCACCGCCGCCCTCATCGACCGCGGCGACGCGCTCGCCGGCGAGGGCGTGAAGCTGGCCCGCAACTCGCTCGAGGC
GCTCGGCGAGATCCGCCGCTCCACCGCGCAGGGGCGCGAGACCGCCGCCGCGATCCGGGCGGCGGTCGGCTCGCACGCAC
AGTCCACGCACGAGGTCTCGCTGCTGGTGGAGTCGGTGGCGGAGGGCTCTCGCGCGGTCGCGGCCGCGGTGCAGCTGGTG
GGCCGCAGCGCCGCCGGGGTGAACACCGCGTCGCGCAGCGTGAACGCGATGGCCGACCAGGTGGCGCGCGCGCTGGAGGA
CCAGTCCACGCGGGGCCGGCAGCAGCTGGAGAGCCTCGGGCGCGTGGAGCGGATGCTCGCGGAGATCGGGCGCGCGGTGG
AGCACCACAACGCGGCCACGCGCCGGGTCCGCGAGGGGCTGCGGGCGCTCTCGCAGACGGCCGGCGACCACGAGCGCGCG
GTGGAGGGGCTGTCCGGCCTGGCCGAGCGGCTCGGCTCCCGCTCGCGCGCGCTGGCGGAGCGGGTGGGGCGCTTCAAGGT
CTAG

Upstream 100 bases:

>100_bases
ACCCGTTTCCCATGGGGAAACGCGACCTTGCGTTGCCTGACGTGTATGGCCGCCCAGGGGCAGCGCCAGCGCGCTCCCCC
GGGATACACTCCCGGGCCAC

Downstream 100 bases:

>100_bases
CGGGCGGGCGGTCCCCCCCGGCTACTCCTCGTCGCCGCCGCCCATGGGCGCGCGGCCCTGCCCCGGCGTCAGCACGATGC
GCGGGTGTCCGAGCGTCCCC

Product: methyl-accepting chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 827; Mature: 827

Protein sequence:

>827_residues
MRFGWRLVRNVASMILLGTALGWWVTQAFPLSAPQREALRWALLASVALEWAAAGGAVWALSRPLRAADDAHRGAGAIPT
PLALRAAATGHRLPAYTAAVVLAAGVLATVVLTALARARGVPLDLGLAGAAVGFASASLAAMLCYALAGTAAGEVFERLG
PDAEVAVQGTVRGKILILALGLITICVLLFAATGYVRYRGDIDREYVATAAHAQESAVASGVAASDAELAEHLWLVTGTP
SAVLGPGGAVVARFGAGRVPFEGAAAAAAGALRVEDGWLVSRATASGGRVVSWLPEEPVRARRRAFWGALAVSALVVYAA
TALLAWLAASAITLPFRTLGRAADRIASGDLAASPPSVSRDEMGQLAADFRRMAQGLKALVVDVQSASEGVSAGAREAGA
IGERVRAGALDQHAGAVAAQGAVEAMEGSIALVARGVGGLSEYVSATTQQVGEMASGLDEVRRKGAELERAMAVALRDVE
SLAHAGRDADATLAELEQHAGHAAGTLSAVRSSIGTLERAAEESERTAGMVADVAERAGGVVEETVHGIEALRAAVADAH
RRVAALGRRSDDIDQVVDFISEVAGRTSLLSLNASIIASQAGEHGKGFAVVAEQIRELAAQIARSTTSIGDIVRAVRDDV
EGTAALIDRGDALAGEGVKLARNSLEALGEIRRSTAQGRETAAAIRAAVGSHAQSTHEVSLLVESVAEGSRAVAAAVQLV
GRSAAGVNTASRSVNAMADQVARALEDQSTRGRQQLESLGRVERMLAEIGRAVEHHNAATRRVREGLRALSQTAGDHERA
VEGLSGLAERLGSRSRALAERVGRFKV

Sequences:

>Translated_827_residues
MRFGWRLVRNVASMILLGTALGWWVTQAFPLSAPQREALRWALLASVALEWAAAGGAVWALSRPLRAADDAHRGAGAIPT
PLALRAAATGHRLPAYTAAVVLAAGVLATVVLTALARARGVPLDLGLAGAAVGFASASLAAMLCYALAGTAAGEVFERLG
PDAEVAVQGTVRGKILILALGLITICVLLFAATGYVRYRGDIDREYVATAAHAQESAVASGVAASDAELAEHLWLVTGTP
SAVLGPGGAVVARFGAGRVPFEGAAAAAAGALRVEDGWLVSRATASGGRVVSWLPEEPVRARRRAFWGALAVSALVVYAA
TALLAWLAASAITLPFRTLGRAADRIASGDLAASPPSVSRDEMGQLAADFRRMAQGLKALVVDVQSASEGVSAGAREAGA
IGERVRAGALDQHAGAVAAQGAVEAMEGSIALVARGVGGLSEYVSATTQQVGEMASGLDEVRRKGAELERAMAVALRDVE
SLAHAGRDADATLAELEQHAGHAAGTLSAVRSSIGTLERAAEESERTAGMVADVAERAGGVVEETVHGIEALRAAVADAH
RRVAALGRRSDDIDQVVDFISEVAGRTSLLSLNASIIASQAGEHGKGFAVVAEQIRELAAQIARSTTSIGDIVRAVRDDV
EGTAALIDRGDALAGEGVKLARNSLEALGEIRRSTAQGRETAAAIRAAVGSHAQSTHEVSLLVESVAEGSRAVAAAVQLV
GRSAAGVNTASRSVNAMADQVARALEDQSTRGRQQLESLGRVERMLAEIGRAVEHHNAATRRVREGLRALSQTAGDHERA
VEGLSGLAERLGSRSRALAERVGRFKV
>Mature_827_residues
MRFGWRLVRNVASMILLGTALGWWVTQAFPLSAPQREALRWALLASVALEWAAAGGAVWALSRPLRAADDAHRGAGAIPT
PLALRAAATGHRLPAYTAAVVLAAGVLATVVLTALARARGVPLDLGLAGAAVGFASASLAAMLCYALAGTAAGEVFERLG
PDAEVAVQGTVRGKILILALGLITICVLLFAATGYVRYRGDIDREYVATAAHAQESAVASGVAASDAELAEHLWLVTGTP
SAVLGPGGAVVARFGAGRVPFEGAAAAAAGALRVEDGWLVSRATASGGRVVSWLPEEPVRARRRAFWGALAVSALVVYAA
TALLAWLAASAITLPFRTLGRAADRIASGDLAASPPSVSRDEMGQLAADFRRMAQGLKALVVDVQSASEGVSAGAREAGA
IGERVRAGALDQHAGAVAAQGAVEAMEGSIALVARGVGGLSEYVSATTQQVGEMASGLDEVRRKGAELERAMAVALRDVE
SLAHAGRDADATLAELEQHAGHAAGTLSAVRSSIGTLERAAEESERTAGMVADVAERAGGVVEETVHGIEALRAAVADAH
RRVAALGRRSDDIDQVVDFISEVAGRTSLLSLNASIIASQAGEHGKGFAVVAEQIRELAAQIARSTTSIGDIVRAVRDDV
EGTAALIDRGDALAGEGVKLARNSLEALGEIRRSTAQGRETAAAIRAAVGSHAQSTHEVSLLVESVAEGSRAVAAAVQLV
GRSAAGVNTASRSVNAMADQVARALEDQSTRGRQQLESLGRVERMLAEIGRAVEHHNAATRRVREGLRALSQTAGDHERA
VEGLSGLAERLGSRSRALAERVGRFKV

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1789453, Length=239, Percent_Identity=24.2677824267782, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1788194, Length=399, Percent_Identity=23.8095238095238, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 85051; Mature: 85051

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFGWRLVRNVASMILLGTALGWWVTQAFPLSAPQREALRWALLASVALEWAAAGGAVWA
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHH
LSRPLRAADDAHRGAGAIPTPLALRAAATGHRLPAYTAAVVLAAGVLATVVLTALARARG
HCCCHHHCCHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
VPLDLGLAGAAVGFASASLAAMLCYALAGTAAGEVFERLGPDAEVAVQGTVRGKILILAL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHH
GLITICVLLFAATGYVRYRGDIDREYVATAAHAQESAVASGVAASDAELAEHLWLVTGTP
HHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHEEEEECCC
SAVLGPGGAVVARFGAGRVPFEGAAAAAAGALRVEDGWLVSRATASGGRVVSWLPEEPVR
CCCCCCCHHHHHHCCCCCCCCCCHHHHHHCCEEECCCCEEEECCCCCCCEEEECCCCHHH
ARRRAFWGALAVSALVVYAATALLAWLAASAITLPFRTLGRAADRIASGDLAASPPSVSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
DEMGQLAADFRRMAQGLKALVVDVQSASEGVSAGAREAGAIGERVRAGALDQHAGAVAAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHCCHHHHH
GAVEAMEGSIALVARGVGGLSEYVSATTQQVGEMASGLDEVRRKGAELERAMAVALRDVE
HHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLAHAGRDADATLAELEQHAGHAAGTLSAVRSSIGTLERAAEESERTAGMVADVAERAGG
HHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VVEETVHGIEALRAAVADAHRRVAALGRRSDDIDQVVDFISEVAGRTSLLSLNASIIASQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHEEEHHHHHHHHC
AGEHGKGFAVVAEQIRELAAQIARSTTSIGDIVRAVRDDVEGTAALIDRGDALAGEGVKL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHH
ARNSLEALGEIRRSTAQGRETAAAIRAAVGSHAQSTHEVSLLVESVAEGSRAVAAAVQLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
GRSAAGVNTASRSVNAMADQVARALEDQSTRGRQQLESLGRVERMLAEIGRAVEHHNAAT
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRVREGLRALSQTAGDHERAVEGLSGLAERLGSRSRALAERVGRFKV
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MRFGWRLVRNVASMILLGTALGWWVTQAFPLSAPQREALRWALLASVALEWAAAGGAVWA
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHH
LSRPLRAADDAHRGAGAIPTPLALRAAATGHRLPAYTAAVVLAAGVLATVVLTALARARG
HCCCHHHCCHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
VPLDLGLAGAAVGFASASLAAMLCYALAGTAAGEVFERLGPDAEVAVQGTVRGKILILAL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHH
GLITICVLLFAATGYVRYRGDIDREYVATAAHAQESAVASGVAASDAELAEHLWLVTGTP
HHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHEEEEECCC
SAVLGPGGAVVARFGAGRVPFEGAAAAAAGALRVEDGWLVSRATASGGRVVSWLPEEPVR
CCCCCCCHHHHHHCCCCCCCCCCHHHHHHCCEEECCCCEEEECCCCCCCEEEECCCCHHH
ARRRAFWGALAVSALVVYAATALLAWLAASAITLPFRTLGRAADRIASGDLAASPPSVSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
DEMGQLAADFRRMAQGLKALVVDVQSASEGVSAGAREAGAIGERVRAGALDQHAGAVAAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHCCHHHHH
GAVEAMEGSIALVARGVGGLSEYVSATTQQVGEMASGLDEVRRKGAELERAMAVALRDVE
HHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLAHAGRDADATLAELEQHAGHAAGTLSAVRSSIGTLERAAEESERTAGMVADVAERAGG
HHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VVEETVHGIEALRAAVADAHRRVAALGRRSDDIDQVVDFISEVAGRTSLLSLNASIIASQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHEEEHHHHHHHHC
AGEHGKGFAVVAEQIRELAAQIARSTTSIGDIVRAVRDDVEGTAALIDRGDALAGEGVKL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHH
ARNSLEALGEIRRSTAQGRETAAAIRAAVGSHAQSTHEVSLLVESVAEGSRAVAAAVQLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
GRSAAGVNTASRSVNAMADQVARALEDQSTRGRQQLESLGRVERMLAEIGRAVEHHNAAT
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRVREGLRALSQTAGDHERAVEGLSGLAERLGSRSRALAERVGRFKV
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]