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The map label for this gene is atoC [H]

Identifier: 220915792

GI number: 220915792

Start: 752668

End: 754044

Strand: Direct

Name: atoC [H]

Synonym: A2cp1_0673

Alternate gene names: 220915792

Gene position: 752668-754044 (Clockwise)

Preceding gene: 220915791

Following gene: 220915793

Centisome position: 14.97

GC content: 73.49

Gene sequence:

>1377_bases
GTGGGCTTGCGAAACGTCCTCGTCGTGGACGACGAGGCCTCCATCCGTCACCTGCTCTCCGTGATCCTGGTGGACCACGG
CTACGACCCGCGCGCCGTCGCGACCGGCGAGGAGGCGCTGAAGGAGCTCGCCGTCCGCGAGTACGATCTCGTGCTCACCG
ACGTGCGCATGCCCGGGATGGGCGGGCTCGGGCTGCTCCGCGAGATCCAGCGCACCGCGCCCGAGCTGATGGTCATCGTG
ATGAGCGCCTACGGCGCGCACGACGCGGCCATCGAGGCGATGAAGACCGGCGCCTACGACTACCTCTCGAAGCCGTTCAA
GCCGGACGAGGTGGTGCTGGTGCTCCGCAAGGCGGAGGAGCGCGAGCGGCTGGCGCGCGAGAACCGCCGGCTGCGCACCG
AGCTGTCGGCCGGGTACAGCCCGGAGCACATGGTGGGGACCTCCGAGCCGATGCGCGAGGTGTCCCGGCAGATCCGCAAG
ATCGCGCAGCAGAAGACCACCGTGCTGGTGCAGGGCGAGTCGGGCACCGGGAAGGAGCTGGTGGCGCGCGCCATCCACCA
GCTCTCTCCGCGCGCGGCCCTCCCGTTCGTGGCGGTCAACTGCGGGGCCATCCCCCCGGAGCTGATCGAGTCCGAGCTGT
TCGGGCACGTGAAGGGCGCCTTCACCGACGCGATCCGGGCGAAGAAGGGGCTCGCGGTCGAGGCGGACGGCGGGACGCTG
TTCCTGGACGAGATCGGCGAGCTGCCGCTCGGGCTCCAGGTGAAGCTGCTGCGCTTCCTCCAGGAGGAGGAGGTGCGGCC
GGTGGGCGACACCCGCCTCCGCCGCGTGGACGTGCGCGTCATCGCCGCGACCGCGGTCGATCTCCGCGCCGCCGTGGCGG
CGGGGCGGTTCCGGGAGGATCTCTACTGGCGCCTCGACGTGGTCGGGGTGCGCCTCCCGCCGCTGCGGGAGCGGCGGGAG
GACGTCCCCGCGCTGCTGGACCACTTCCTGGCCCGGTTCCGCCACCTCCGCCCGGAGCTGCCCGGGCTGGCGCTGTCGGA
CGAGGCTCGCGCGGCCCTGCTCGCCCACGGCTGGCCCGGCAACGTGCGCGAGCTGGAGCACGCGGTGGAGCGGGCGGTGG
TGCTCGCCGACGGGCCGGTGCTGCGCGAGGAGGACCTGCCCGAGACGGTGCGCGCGACCGCGCGCCCCGCGACCGGGCCG
GCCGAGGCCGGCGCCGAGGGCTCCCTCTCCGTGAAGCGTGCCACCCGTGCGCTGGAGGAGCGGCTCATCCGCGCGGCGCT
GGAGCGGACCGGCGGCAACCGCACCCGGGCCGCCGAGCTGCTGGAGCTCTCCTACGGGGCGCTCCTCTACAAGATCAAGG
AGTACGGGGTCGGATAG

Upstream 100 bases:

>100_bases
CGGCGCCATCTCCGCCGCCAACGCGCCGGGCGGCGGGGCGGTGTTCCGCCTGCGGCTGCGGCGCGGCGGCCCGCCCGCCG
CCCCGTGCTAGAGTCGCGCC

Downstream 100 bases:

>100_bases
CGCGCCGCCGGACCGCCCCTCCACAGCGGCCGACCGGCCGCTCGCCCGCTCCTCCACGCAACGTATGACGCATAACTACG
CATCACTTCGCGCCAGCTAG

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MGLRNVLVVDDEASIRHLLSVILVDHGYDPRAVATGEEALKELAVREYDLVLTDVRMPGMGGLGLLREIQRTAPELMVIV
MSAYGAHDAAIEAMKTGAYDYLSKPFKPDEVVLVLRKAEERERLARENRRLRTELSAGYSPEHMVGTSEPMREVSRQIRK
IAQQKTTVLVQGESGTGKELVARAIHQLSPRAALPFVAVNCGAIPPELIESELFGHVKGAFTDAIRAKKGLAVEADGGTL
FLDEIGELPLGLQVKLLRFLQEEEVRPVGDTRLRRVDVRVIAATAVDLRAAVAAGRFREDLYWRLDVVGVRLPPLRERRE
DVPALLDHFLARFRHLRPELPGLALSDEARAALLAHGWPGNVRELEHAVERAVVLADGPVLREEDLPETVRATARPATGP
AEAGAEGSLSVKRATRALEERLIRAALERTGGNRTRAAELLELSYGALLYKIKEYGVG

Sequences:

>Translated_458_residues
MGLRNVLVVDDEASIRHLLSVILVDHGYDPRAVATGEEALKELAVREYDLVLTDVRMPGMGGLGLLREIQRTAPELMVIV
MSAYGAHDAAIEAMKTGAYDYLSKPFKPDEVVLVLRKAEERERLARENRRLRTELSAGYSPEHMVGTSEPMREVSRQIRK
IAQQKTTVLVQGESGTGKELVARAIHQLSPRAALPFVAVNCGAIPPELIESELFGHVKGAFTDAIRAKKGLAVEADGGTL
FLDEIGELPLGLQVKLLRFLQEEEVRPVGDTRLRRVDVRVIAATAVDLRAAVAAGRFREDLYWRLDVVGVRLPPLRERRE
DVPALLDHFLARFRHLRPELPGLALSDEARAALLAHGWPGNVRELEHAVERAVVLADGPVLREEDLPETVRATARPATGP
AEAGAEGSLSVKRATRALEERLIRAALERTGGNRTRAAELLELSYGALLYKIKEYGVG
>Mature_457_residues
GLRNVLVVDDEASIRHLLSVILVDHGYDPRAVATGEEALKELAVREYDLVLTDVRMPGMGGLGLLREIQRTAPELMVIVM
SAYGAHDAAIEAMKTGAYDYLSKPFKPDEVVLVLRKAEERERLARENRRLRTELSAGYSPEHMVGTSEPMREVSRQIRKI
AQQKTTVLVQGESGTGKELVARAIHQLSPRAALPFVAVNCGAIPPELIESELFGHVKGAFTDAIRAKKGLAVEADGGTLF
LDEIGELPLGLQVKLLRFLQEEEVRPVGDTRLRRVDVRVIAATAVDLRAAVAAGRFREDLYWRLDVVGVRLPPLRERRED
VPALLDHFLARFRHLRPELPGLALSDEARAALLAHGWPGNVRELEHAVERAVVLADGPVLREEDLPETVRATARPATGPA
EAGAEGSLSVKRATRALEERLIRAALERTGGNRTRAAELLELSYGALLYKIKEYGVG

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=456, Percent_Identity=43.640350877193, Blast_Score=381, Evalue=1e-107,
Organism=Escherichia coli, GI1790437, Length=450, Percent_Identity=45.1111111111111, Blast_Score=345, Evalue=3e-96,
Organism=Escherichia coli, GI1790299, Length=471, Percent_Identity=42.6751592356688, Blast_Score=328, Evalue=3e-91,
Organism=Escherichia coli, GI1788905, Length=440, Percent_Identity=40.4545454545455, Blast_Score=298, Evalue=4e-82,
Organism=Escherichia coli, GI87082152, Length=323, Percent_Identity=47.0588235294118, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI87082117, Length=263, Percent_Identity=50.1901140684411, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI1789233, Length=361, Percent_Identity=40.9972299168975, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI1789087, Length=304, Percent_Identity=45.3947368421053, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI1787583, Length=338, Percent_Identity=39.3491124260355, Blast_Score=212, Evalue=5e-56,
Organism=Escherichia coli, GI87081872, Length=330, Percent_Identity=37.2727272727273, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1786524, Length=349, Percent_Identity=38.6819484240688, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1789828, Length=292, Percent_Identity=36.986301369863, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI87081858, Length=300, Percent_Identity=34, Blast_Score=138, Evalue=8e-34,
Organism=Escherichia coli, GI1786599, Length=111, Percent_Identity=32.4324324324324, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1789809, Length=118, Percent_Identity=31.3559322033898, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788222, Length=121, Percent_Identity=35.5371900826446, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788394, Length=127, Percent_Identity=31.496062992126, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1786911, Length=120, Percent_Identity=36.6666666666667, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50399; Mature: 50268

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLRNVLVVDDEASIRHLLSVILVDHGYDPRAVATGEEALKELAVREYDLVLTDVRMPGM
CCCCCEEEECCCHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHEEEEEECCCCC
GGLGLLREIQRTAPELMVIVMSAYGAHDAAIEAMKTGAYDYLSKPFKPDEVVLVLRKAEE
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHCCCCCCCCEEEEEHHHHH
RERLARENRRLRTELSAGYSPEHMVGTSEPMREVSRQIRKIAQQKTTVLVQGESGTGKEL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHH
VARAIHQLSPRAALPFVAVNCGAIPPELIESELFGHVKGAFTDAIRAKKGLAVEADGGTL
HHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEE
FLDEIGELPLGLQVKLLRFLQEEEVRPVGDTRLRRVDVRVIAATAVDLRAAVAAGRFRED
EHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHEEEEHHHHHHHHHHHHHHHHHH
LYWRLDVVGVRLPPLRERREDVPALLDHFLARFRHLRPELPGLALSDEARAALLAHGWPG
HEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCEEEEECCCCC
NVRELEHAVERAVVLADGPVLREEDLPETVRATARPATGPAEAGAEGSLSVKRATRALEE
CHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
RLIRAALERTGGNRTRAAELLELSYGALLYKIKEYGVG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GLRNVLVVDDEASIRHLLSVILVDHGYDPRAVATGEEALKELAVREYDLVLTDVRMPGM
CCCCEEEECCCHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHEEEEEECCCCC
GGLGLLREIQRTAPELMVIVMSAYGAHDAAIEAMKTGAYDYLSKPFKPDEVVLVLRKAEE
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHCCCCCCCCEEEEEHHHHH
RERLARENRRLRTELSAGYSPEHMVGTSEPMREVSRQIRKIAQQKTTVLVQGESGTGKEL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHH
VARAIHQLSPRAALPFVAVNCGAIPPELIESELFGHVKGAFTDAIRAKKGLAVEADGGTL
HHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEE
FLDEIGELPLGLQVKLLRFLQEEEVRPVGDTRLRRVDVRVIAATAVDLRAAVAAGRFRED
EHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHEEEEHHHHHHHHHHHHHHHHHH
LYWRLDVVGVRLPPLRERREDVPALLDHFLARFRHLRPELPGLALSDEARAALLAHGWPG
HEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCEEEEECCCCC
NVRELEHAVERAVVLADGPVLREEDLPETVRATARPATGPAEAGAEGSLSVKRATRALEE
CHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
RLIRAALERTGGNRTRAAELLELSYGALLYKIKEYGVG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]