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The map label for this gene is zraS [H]

Identifier: 220915791

GI number: 220915791

Start: 751537

End: 752658

Strand: Direct

Name: zraS [H]

Synonym: A2cp1_0672

Alternate gene names: 220915791

Gene position: 751537-752658 (Clockwise)

Preceding gene: 220915790

Following gene: 220915792

Centisome position: 14.94

GC content: 78.79

Gene sequence:

>1122_bases
ATGCGGCGCGTGGGCCTGGTGCTCCTGCTCGATCTCGTCGCCGCCGCGGCGGCGGGCGCGACGCTCCTGCTCGCGCTGGG
GGTTCCCTCCGCGGCCCGCGGCGCGCTCGGCCCCGGGCCGCTGCTGCTCCTGGCGGGCGTCGCCGCGGCGGCGACCATCG
CCGTGGGCGTGGTGCTGCTCGGCCGCTCGGTGGCCCGGCCCGTGGAACGGCTGCTCGCGTCCGCGCAGAGGCTCGGCCAC
GCCGGCGGCGGCCTGCCGGTGCTCGCGCCGCCGGGCGAGCCGGAGGATCGCTCACTCGCGCGCGCGGCGGTGGCCTTCGA
GCGCGTGGCCGAGGCGCTCTCGGAGGAGCGCGCCCGCCTCGCGGCCAAGATCGACGAGCTGGAGGGCGCGAACCACGCGC
TCGCGGAGGCGCGCGCGTCCTGGCTCCGCTCCGAGCAGCTCGCCGCAGTGGGGCGGCTCGCGTCGGGGGTGGCCCATGAG
GTGGGCAACCCGCTCGGCGCCATCGCGGGCTACGCCGAGCTGGCGCGCGGCCGCATCCGAGCGGGCGAGGCGGCGCAGGC
CGACGACCTGGTGGCGCGGATCGCGGTGGAGGCCGGGCGCATCGACGCGATCGTGCGCGATCTCCTGGAGCTGGCGCGCC
CCTCGGCGCCCGCGGTCGCGCCGATCGCGCTGTCCGGGCCGGTGGACGCGGCGCTGCGGCTCGCGCGCGTGCAGGCGCGG
CTCCGGGACGTGCGCGCCGAGCTCGACCTGCCGGCCGACCTCCCGCCGGTGCTCGCGGACGAGGCGCGGCTCGCGCAGGT
GTTCCTCAACCTGTTCCTGAACGCGGGCGACGCCATGGGCGGCCGCGGCACGCTCCGCGTGACGGCGCGTGAGGTGCAGG
ATCGGGTGGAGATCGACGTCGCCGATCAAGGGCCCGGCATCGGACCGGAGGACCTGCCGCGCGTCTTCGATCCGTTCTTC
ACCACCAAGCCGCCCGGCGCCGGAACCGGCCTCGGGCTGTCGGTGAGCCACCGCCTGATGGAGGCGATGGGCGGCGCCAT
CTCCGCCGCCAACGCGCCGGGCGGCGGGGCGGTGTTCCGCCTGCGGCTGCGGCGCGGCGGCCCGCCCGCCGCCCCGTGCT
AG

Upstream 100 bases:

>100_bases
CCCGTTCGGCCCGTTCCTGGCGGCCGGGGCGCTGGAGTGGCTGTACCTGGGGGACCTCATCGTGCGCGGCGTCCCCTCCC
TCGGCATCTTCCGGTGATCG

Downstream 100 bases:

>100_bases
AGTCGCGCCGTGGGCTTGCGAAACGTCCTCGTCGTGGACGACGAGGCCTCCATCCGTCACCTGCTCTCCGTGATCCTGGT
GGACCACGGCTACGACCCGC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MRRVGLVLLLDLVAAAAAGATLLLALGVPSAARGALGPGPLLLLAGVAAAATIAVGVVLLGRSVARPVERLLASAQRLGH
AGGGLPVLAPPGEPEDRSLARAAVAFERVAEALSEERARLAAKIDELEGANHALAEARASWLRSEQLAAVGRLASGVAHE
VGNPLGAIAGYAELARGRIRAGEAAQADDLVARIAVEAGRIDAIVRDLLELARPSAPAVAPIALSGPVDAALRLARVQAR
LRDVRAELDLPADLPPVLADEARLAQVFLNLFLNAGDAMGGRGTLRVTAREVQDRVEIDVADQGPGIGPEDLPRVFDPFF
TTKPPGAGTGLGLSVSHRLMEAMGGAISAANAPGGGAVFRLRLRRGGPPAAPC

Sequences:

>Translated_373_residues
MRRVGLVLLLDLVAAAAAGATLLLALGVPSAARGALGPGPLLLLAGVAAAATIAVGVVLLGRSVARPVERLLASAQRLGH
AGGGLPVLAPPGEPEDRSLARAAVAFERVAEALSEERARLAAKIDELEGANHALAEARASWLRSEQLAAVGRLASGVAHE
VGNPLGAIAGYAELARGRIRAGEAAQADDLVARIAVEAGRIDAIVRDLLELARPSAPAVAPIALSGPVDAALRLARVQAR
LRDVRAELDLPADLPPVLADEARLAQVFLNLFLNAGDAMGGRGTLRVTAREVQDRVEIDVADQGPGIGPEDLPRVFDPFF
TTKPPGAGTGLGLSVSHRLMEAMGGAISAANAPGGGAVFRLRLRRGGPPAAPC
>Mature_373_residues
MRRVGLVLLLDLVAAAAAGATLLLALGVPSAARGALGPGPLLLLAGVAAAATIAVGVVLLGRSVARPVERLLASAQRLGH
AGGGLPVLAPPGEPEDRSLARAAVAFERVAEALSEERARLAAKIDELEGANHALAEARASWLRSEQLAAVGRLASGVAHE
VGNPLGAIAGYAELARGRIRAGEAAQADDLVARIAVEAGRIDAIVRDLLELARPSAPAVAPIALSGPVDAALRLARVQAR
LRDVRAELDLPADLPPVLADEARLAQVFLNLFLNAGDAMGGRGTLRVTAREVQDRVEIDVADQGPGIGPEDLPRVFDPFF
TTKPPGAGTGLGLSVSHRLMEAMGGAISAANAPGGGAVFRLRLRRGGPPAAPC

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=221, Percent_Identity=41.6289592760181, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1788549, Length=225, Percent_Identity=38.6666666666667, Blast_Score=141, Evalue=6e-35,
Organism=Escherichia coli, GI87081816, Length=350, Percent_Identity=30.5714285714286, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI48994928, Length=223, Percent_Identity=29.1479820627803, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789149, Length=355, Percent_Identity=23.0985915492958, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788393, Length=264, Percent_Identity=27.6515151515151, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786912, Length=273, Percent_Identity=26.3736263736264, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790346, Length=225, Percent_Identity=27.5555555555556, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI145693157, Length=330, Percent_Identity=25.1515151515152, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787894, Length=342, Percent_Identity=25.4385964912281, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082128, Length=233, Percent_Identity=25.3218884120172, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790300, Length=224, Percent_Identity=29.0178571428571, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786783, Length=241, Percent_Identity=25.7261410788382, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 37978; Mature: 37978

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVGLVLLLDLVAAAAAGATLLLALGVPSAARGALGPGPLLLLAGVAAAATIAVGVVLL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GRSVARPVERLLASAQRLGHAGGGLPVLAPPGEPEDRSLARAAVAFERVAEALSEERARL
HHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AAKIDELEGANHALAEARASWLRSEQLAAVGRLASGVAHEVGNPLGAIAGYAELARGRIR
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
AGEAAQADDLVARIAVEAGRIDAIVRDLLELARPSAPAVAPIALSGPVDAALRLARVQAR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHH
LRDVRAELDLPADLPPVLADEARLAQVFLNLFLNAGDAMGGRGTLRVTAREVQDRVEIDV
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHEEEE
ADQGPGIGPEDLPRVFDPFFTTKPPGAGTGLGLSVSHRLMEAMGGAISAANAPGGGAVFR
CCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHCCCCCCCCCCEEE
LRLRRGGPPAAPC
EEEECCCCCCCCC
>Mature Secondary Structure
MRRVGLVLLLDLVAAAAAGATLLLALGVPSAARGALGPGPLLLLAGVAAAATIAVGVVLL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GRSVARPVERLLASAQRLGHAGGGLPVLAPPGEPEDRSLARAAVAFERVAEALSEERARL
HHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AAKIDELEGANHALAEARASWLRSEQLAAVGRLASGVAHEVGNPLGAIAGYAELARGRIR
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
AGEAAQADDLVARIAVEAGRIDAIVRDLLELARPSAPAVAPIALSGPVDAALRLARVQAR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHH
LRDVRAELDLPADLPPVLADEARLAQVFLNLFLNAGDAMGGRGTLRVTAREVQDRVEIDV
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHEEEE
ADQGPGIGPEDLPRVFDPFFTTKPPGAGTGLGLSVSHRLMEAMGGAISAANAPGGGAVFR
CCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHCCCCCCCCCCEEE
LRLRRGGPPAAPC
EEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]