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The map label for this gene is prlC [H]

Identifier: 220915545

GI number: 220915545

Start: 479778

End: 481724

Strand: Direct

Name: prlC [H]

Synonym: A2cp1_0426

Alternate gene names: 220915545

Gene position: 479778-481724 (Clockwise)

Preceding gene: 220915544

Following gene: 220915546

Centisome position: 9.54

GC content: 74.88

Gene sequence:

>1947_bases
ATGTCCGAGCCCCTGCGCCCCGAGGCCTCCCGCGAGCTGACCGGCACGCCGCCCGCCTTCACGGAGGGTTGCCGCCGCGA
CATGGACCGCGCCCGCGCCGAGGCCGCCCGGGCCCGCGCGCTCGGGCCGGCGGGCGGCCTGGCCACGCTGGAGGCGTTCG
ACGCGGCGTTCGCGGCGCTCTCCGAGGCCGCCTCGCGCGCGAGCCTGGCGCGCAACGTCCACCCGGATCCGGCGCTGCGC
GACGCGGCCGAGGCCGCGGAGCGCGAGGTGGACGCGCTCTCCACCGAGCTGTCGCTCGACCGCGGCCTGTACGACGCGCT
CGCGGGGCTCGACCCCTCGGGCCTCGACGCCCCCACCCGCCACCTCGTGGAGAAGAGCCTGCGCGACTTCCGCCGGGCCG
GCGTGGACCGCGACGACGCCACCCGCGCGCGCGTGAAGGCGCTCCGCGAGGAGCTGGTGCGGGTGGGGCAGGAGTTCGGG
CGCAACATCAAGGACGACGTGCGCCGGCTGGAGGTCGAGCCGGCCGCGCTGGACGGGCTCCCCGAGGACTGGCGCCGCGC
GCACGCGCCCGGGCCGGACGGCCGGGTGACGCTCACCACCGACAACACCGACTACGTGCCGTTCCTGACGTACGCGCGGA
GCGCGGCGGCGCGCGAGGCGCTCTGGCGGCTCTACCGGCTGCGCGGCCACCCGCGCAACCTCGAGGTCCTCTCGCGCATG
CTGGCGCGGCGCGCCGACCTGGCGCGGCTGCTCGGGTACCCGAGCTGGGCCGCCTACGTCACCGAGGACAAGATGATCGG
GAGCGACGGCGCCGCGGCCGACTTCATCGAGCGGATCGCGCGCGCCGCCGAGGCGCGCATGCGGCGGGACCACGCCCAGC
TCCTCGAGCGCAAGCGCGAGGAGCGCCCCGACGCCGACCGCGTCGAGCCCTGGGACTCGGCCTGGCTCCAGGAGCGGGTG
AAGGCGGAGCGCTACGGCTTCGACTCGCAGTCGGTGCGGCCGTACTTCGAGTACCAGCGCGTGAAGCAGGGGGTGCTGGA
CGTCACCGGGCGGATCTTCGGCATCGCCTACCGCCGCGCGCCGGACGCGCCGGTGTGGCACCCGGAGGTCGAGGCCTGGG
ACGTGATCGAGGACGGCGCGCTGCTCGGCCGCGTGTACCTCGACATGCACCCGCGCGACGGCAAGTACAAGCACTACGCC
CAGTTCACGCTCGCGTCGGGCCAGGCCGGCCGGCGGCTGCCGGAGGGCGTGCTGGTGTGCAACTTCCCGCGCCCGGCCCC
GGGCGCGCCGGCGCTCATGGAGCACGGCGACGTCCGCACGTTCTTCCACGAGTTCGGCCACCTGCTGCACCACGTGCTCG
GCGGGCACACGCGCTGGGCGGGCCAGTCCGGCGTCGCGACCGAGTGGGACTTCGTGGAGGCGCCCTCGCAGATGCTGGAG
GAGTGGGTGTGGGACCCGGAGGTCCTCGCCACCTTCGCGCGCCACGTCGACACCGGCGAGCCCATCCCCGCCGAGCTCGT
GGCGCGGATGAAGGCGGCCGACGAGTACGGCAAGGGCCTGATGGTGCGGCAGCAGATGTTCTACGCCGCGACCAGCCTCG
AGCTGCACCGGCGCGATCCCGGCGCGCTCGACACCACCGCGCTCGTCGCCGAGCTGCAGGAGCGCTACACGCCGTTCCGC
CACGTGCCGGGGACCTACTTCCAGGAGTCCTTCGGGCACCTCGACGGGTACAGCGCCATTTACTATACGTACATGTGGTC
GCTCGTGATCGCGAAGGACCTGTTCGGCCCGTTCCGCGAGGCCGGGCTGCTCGATCCCGCCCCCGCCCGCCGCTACCGCC
GGGCCGTGCTGGAGCCGGGCGGCTCCAAGCCCGCGGCGGAGCTGGTGAAGGACTTCCTCGGTCGGCCGCACGCCTTCGAC
GCGTTCGCCGCCTGGCTCGAGGCCTGA

Upstream 100 bases:

>100_bases
CGCGCACGGGGACCGCGCCGCCGTGGCCCCGCGCGCACCGCGGGTGCGGTCCCGCACCGGCCCCGTGCGGATCGGCCCGG
GGCGAAGTACACATGAGGCC

Downstream 100 bases:

>100_bases
GAGCACGTGAACCCATCCCCTCCCGTCGCCGCGGCGGCCGATCCGCGTCGCATCGCGTCGTTGCTCCTCCCTCACATGCC
GACGGGCATGCTCGGTCGTC

Product: Thimet oligopeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 648; Mature: 647

Protein sequence:

>648_residues
MSEPLRPEASRELTGTPPAFTEGCRRDMDRARAEAARARALGPAGGLATLEAFDAAFAALSEAASRASLARNVHPDPALR
DAAEAAEREVDALSTELSLDRGLYDALAGLDPSGLDAPTRHLVEKSLRDFRRAGVDRDDATRARVKALREELVRVGQEFG
RNIKDDVRRLEVEPAALDGLPEDWRRAHAPGPDGRVTLTTDNTDYVPFLTYARSAAAREALWRLYRLRGHPRNLEVLSRM
LARRADLARLLGYPSWAAYVTEDKMIGSDGAAADFIERIARAAEARMRRDHAQLLERKREERPDADRVEPWDSAWLQERV
KAERYGFDSQSVRPYFEYQRVKQGVLDVTGRIFGIAYRRAPDAPVWHPEVEAWDVIEDGALLGRVYLDMHPRDGKYKHYA
QFTLASGQAGRRLPEGVLVCNFPRPAPGAPALMEHGDVRTFFHEFGHLLHHVLGGHTRWAGQSGVATEWDFVEAPSQMLE
EWVWDPEVLATFARHVDTGEPIPAELVARMKAADEYGKGLMVRQQMFYAATSLELHRRDPGALDTTALVAELQERYTPFR
HVPGTYFQESFGHLDGYSAIYYTYMWSLVIAKDLFGPFREAGLLDPAPARRYRRAVLEPGGSKPAAELVKDFLGRPHAFD
AFAAWLEA

Sequences:

>Translated_648_residues
MSEPLRPEASRELTGTPPAFTEGCRRDMDRARAEAARARALGPAGGLATLEAFDAAFAALSEAASRASLARNVHPDPALR
DAAEAAEREVDALSTELSLDRGLYDALAGLDPSGLDAPTRHLVEKSLRDFRRAGVDRDDATRARVKALREELVRVGQEFG
RNIKDDVRRLEVEPAALDGLPEDWRRAHAPGPDGRVTLTTDNTDYVPFLTYARSAAAREALWRLYRLRGHPRNLEVLSRM
LARRADLARLLGYPSWAAYVTEDKMIGSDGAAADFIERIARAAEARMRRDHAQLLERKREERPDADRVEPWDSAWLQERV
KAERYGFDSQSVRPYFEYQRVKQGVLDVTGRIFGIAYRRAPDAPVWHPEVEAWDVIEDGALLGRVYLDMHPRDGKYKHYA
QFTLASGQAGRRLPEGVLVCNFPRPAPGAPALMEHGDVRTFFHEFGHLLHHVLGGHTRWAGQSGVATEWDFVEAPSQMLE
EWVWDPEVLATFARHVDTGEPIPAELVARMKAADEYGKGLMVRQQMFYAATSLELHRRDPGALDTTALVAELQERYTPFR
HVPGTYFQESFGHLDGYSAIYYTYMWSLVIAKDLFGPFREAGLLDPAPARRYRRAVLEPGGSKPAAELVKDFLGRPHAFD
AFAAWLEA
>Mature_647_residues
SEPLRPEASRELTGTPPAFTEGCRRDMDRARAEAARARALGPAGGLATLEAFDAAFAALSEAASRASLARNVHPDPALRD
AAEAAEREVDALSTELSLDRGLYDALAGLDPSGLDAPTRHLVEKSLRDFRRAGVDRDDATRARVKALREELVRVGQEFGR
NIKDDVRRLEVEPAALDGLPEDWRRAHAPGPDGRVTLTTDNTDYVPFLTYARSAAAREALWRLYRLRGHPRNLEVLSRML
ARRADLARLLGYPSWAAYVTEDKMIGSDGAAADFIERIARAAEARMRRDHAQLLERKREERPDADRVEPWDSAWLQERVK
AERYGFDSQSVRPYFEYQRVKQGVLDVTGRIFGIAYRRAPDAPVWHPEVEAWDVIEDGALLGRVYLDMHPRDGKYKHYAQ
FTLASGQAGRRLPEGVLVCNFPRPAPGAPALMEHGDVRTFFHEFGHLLHHVLGGHTRWAGQSGVATEWDFVEAPSQMLEE
WVWDPEVLATFARHVDTGEPIPAELVARMKAADEYGKGLMVRQQMFYAATSLELHRRDPGALDTTALVAELQERYTPFRH
VPGTYFQESFGHLDGYSAIYYTYMWSLVIAKDLFGPFREAGLLDPAPARRYRRAVLEPGGSKPAAELVKDFLGRPHAFDA
FAAWLEA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=615, Percent_Identity=30.4065040650407, Blast_Score=309, Evalue=7e-84,
Organism=Homo sapiens, GI14149738, Length=642, Percent_Identity=27.5700934579439, Blast_Score=278, Evalue=9e-75,
Organism=Homo sapiens, GI156105687, Length=634, Percent_Identity=28.391167192429, Blast_Score=250, Evalue=4e-66,
Organism=Escherichia coli, GI1789913, Length=660, Percent_Identity=31.3636363636364, Blast_Score=289, Evalue=3e-79,
Organism=Escherichia coli, GI1787819, Length=658, Percent_Identity=29.483282674772, Blast_Score=216, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI32565901, Length=573, Percent_Identity=21.4659685863874, Blast_Score=112, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6319793, Length=677, Percent_Identity=26.1447562776957, Blast_Score=244, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6322715, Length=653, Percent_Identity=24.5022970903522, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI20129717, Length=631, Percent_Identity=27.7337559429477, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI21356111, Length=596, Percent_Identity=24.6644295302013, Blast_Score=146, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 72685; Mature: 72553

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPLRPEASRELTGTPPAFTEGCRRDMDRARAEAARARALGPAGGLATLEAFDAAFAAL
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
SEAASRASLARNVHPDPALRDAAEAAEREVDALSTELSLDRGLYDALAGLDPSGLDAPTR
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
HLVEKSLRDFRRAGVDRDDATRARVKALREELVRVGQEFGRNIKDDVRRLEVEPAALDGL
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHCCC
PEDWRRAHAPGPDGRVTLTTDNTDYVPFLTYARSAAAREALWRLYRLRGHPRNLEVLSRM
CHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LARRADLARLLGYPSWAAYVTEDKMIGSDGAAADFIERIARAAEARMRRDHAQLLERKRE
HHHHHHHHHHHCCCCHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERPDADRVEPWDSAWLQERVKAERYGFDSQSVRPYFEYQRVKQGVLDVTGRIFGIAYRRA
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
PDAPVWHPEVEAWDVIEDGALLGRVYLDMHPRDGKYKHYAQFTLASGQAGRRLPEGVLVC
CCCCCCCCCCCHHHHHHCCHHEEEHEEEECCCCCCCHHHHEEEECCCCCCCCCCCCCEEE
NFPRPAPGAPALMEHGDVRTFFHEFGHLLHHVLGGHTRWAGQSGVATEWDFVEAPSQMLE
CCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
EWVWDPEVLATFARHVDTGEPIPAELVARMKAADEYGKGLMVRQQMFYAATSLELHRRDP
HHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
GALDTTALVAELQERYTPFRHVPGTYFQESFGHLDGYSAIYYTYMWSLVIAKDLFGPFRE
CCHHHHHHHHHHHHHCCCHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AGLLDPAPARRYRRAVLEPGGSKPAAELVKDFLGRPHAFDAFAAWLEA
CCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SEPLRPEASRELTGTPPAFTEGCRRDMDRARAEAARARALGPAGGLATLEAFDAAFAAL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
SEAASRASLARNVHPDPALRDAAEAAEREVDALSTELSLDRGLYDALAGLDPSGLDAPTR
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
HLVEKSLRDFRRAGVDRDDATRARVKALREELVRVGQEFGRNIKDDVRRLEVEPAALDGL
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHCCC
PEDWRRAHAPGPDGRVTLTTDNTDYVPFLTYARSAAAREALWRLYRLRGHPRNLEVLSRM
CHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LARRADLARLLGYPSWAAYVTEDKMIGSDGAAADFIERIARAAEARMRRDHAQLLERKRE
HHHHHHHHHHHCCCCHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERPDADRVEPWDSAWLQERVKAERYGFDSQSVRPYFEYQRVKQGVLDVTGRIFGIAYRRA
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
PDAPVWHPEVEAWDVIEDGALLGRVYLDMHPRDGKYKHYAQFTLASGQAGRRLPEGVLVC
CCCCCCCCCCCHHHHHHCCHHEEEHEEEECCCCCCCHHHHEEEECCCCCCCCCCCCCEEE
NFPRPAPGAPALMEHGDVRTFFHEFGHLLHHVLGGHTRWAGQSGVATEWDFVEAPSQMLE
CCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
EWVWDPEVLATFARHVDTGEPIPAELVARMKAADEYGKGLMVRQQMFYAATSLELHRRDP
HHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
GALDTTALVAELQERYTPFRHVPGTYFQESFGHLDGYSAIYYTYMWSLVIAKDLFGPFRE
CCHHHHHHHHHHHHHCCCHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AGLLDPAPARRYRRAVLEPGGSKPAAELVKDFLGRPHAFDAFAAWLEA
CCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]