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The map label for this gene is zraR [H]

Identifier: 220915445

GI number: 220915445

Start: 365356

End: 366753

Strand: Direct

Name: zraR [H]

Synonym: A2cp1_0324

Alternate gene names: 220915445

Gene position: 365356-366753 (Clockwise)

Preceding gene: 220915444

Following gene: 220915446

Centisome position: 7.26

GC content: 75.39

Gene sequence:

>1398_bases
ATGACGGGCGGGCCGGTGCGCGTGCTGGTGGCGGACGACAAGGAGAACATGCGCAAGCTGCTCGCGAAGATCCTCGCGGA
CGGCTACGCGGTGGAGGAGGCCGAGGACGGCGCCCGCGCGCTCTCCCTCGTCGCCACGCGTCCGTACGACGTGGTCGTCA
CCGACATCCGCATGCCGGGCGCGGACGGGTTCGAGCTGCTCGGCGCGGTGAAGGCGCGCGCGCCCGACACCGAGGTGGTG
ATGATGACCGGCTACGCCACCATCGCCGACGCGGTGCGGGCCATGCGCATGGGCGCGTTCGACTACCTCGAGAAGCCGTT
CGACCCCGACGCGGCGCTGGCCGTGGTGGCGCGCGCGGCCGAGCACAAGCGCCTCGCCGACGCCGCCCGGCGCGACGACG
CCTCCGGCGGCGAGCCGTCCTCCTTCCACAACCTGGTGGGCCGCAGCGCGCGCATGCGCGCCGTCTACGGGCTCCTCGAC
AAGGCGGCCGGGCTCGACATCACCGTCCTGCTGCTGGGCGAGACCGGCACCGGCAAGGAGCTGGCGGCCCGCGCCATCCA
CTACCACTCGGCCCGGCGCGAGCGGCGCTTCGTGCCGGTGAACTGCGGGGCGCTCCCGGCGGAGCTGGTGGAGAGCGAGC
TGTTCGGGCACGCGCGCGGCGCGTTCACCGGCGCCGCCGCGGCGAAGGCCGGCCTGTTCGAGGAGGCGCAGGGCGGGTCG
CTGTTCCTCGACGAGGTGGGCGAGCTGCCGCTCCCGGCCCAGGTGAAGCTGAACCGCGCGCTGCAGGAGCGGGAGATCCG
GCGGGTGGGCGACACGCAGCCGCTCAAGGTGGACGTGCGCGTCATCGCCGCCACGCACCGCGATCTCCGCGAGGAGGTGC
GGGCCGGCCGCTTCCGCGAGGACCTGTTCTACCGGCTGCACGTGTTCCCGGTGACGCTCCCGCCGCTCCGCGAGCGGGCC
GAGGACGTGCCGCTGCTCGCGCAGCACTTCCTCGCGAAGCACGCGCGCGCGCTCCGGCGCGAGCTGGCCGGCGGGTTCGA
CCCGGAGGCGCTCCGGCGCCTGGCGGGCTATCCGTGGCCCGGCAACGTGCGCGAGCTCGAGAACGCGGTCGAGCGGGCGG
TGGCGGTCTCGTCGGGCGACCGCGTCCGCGTCGCCGACCTCCCGGCCGAGGTGGCCGGCGCGGCGCCGGCCGGGCCGGAG
CCGGCGGATCTCGCGAAGCTCCCGTACAAGGAGGCGGTGGCGGAGGCGCGCGACCGCACCTCGCGCGAGTACCTGGTGGC
GCTGCTGGCCGAGTTCGGCGGCAACGTGACCCGCGCCGCCGAGCGCGCCGGCATGGAGCGCGAGAGCCTCCACCGGCTGC
TGCGCCGGTACGGGCTCCGCTCCGACGACTTCAAGTAG

Upstream 100 bases:

>100_bases
TGGCGGTCGCGGCGGCGGCGGAGGGCGGCGCCTGCTTCGCGCTCACGCTGCCCACGGCGCCCGCGGCGGCCCGGCGGCGG
GCCGCGGGAGGAGCGAAGCC

Downstream 100 bases:

>100_bases
GCGGTCCGCGCCCGGAGCCGCGCGCGCCGGCGCCGGTGGACGGCGCGGTCTCGGCGCGGCATACCGGAGGCGGAGGTGGC
GATGGAGATCCTGCTCTACG

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MTGGPVRVLVADDKENMRKLLAKILADGYAVEEAEDGARALSLVATRPYDVVVTDIRMPGADGFELLGAVKARAPDTEVV
MMTGYATIADAVRAMRMGAFDYLEKPFDPDAALAVVARAAEHKRLADAARRDDASGGEPSSFHNLVGRSARMRAVYGLLD
KAAGLDITVLLLGETGTGKELAARAIHYHSARRERRFVPVNCGALPAELVESELFGHARGAFTGAAAAKAGLFEEAQGGS
LFLDEVGELPLPAQVKLNRALQEREIRRVGDTQPLKVDVRVIAATHRDLREEVRAGRFREDLFYRLHVFPVTLPPLRERA
EDVPLLAQHFLAKHARALRRELAGGFDPEALRRLAGYPWPGNVRELENAVERAVAVSSGDRVRVADLPAEVAGAAPAGPE
PADLAKLPYKEAVAEARDRTSREYLVALLAEFGGNVTRAAERAGMERESLHRLLRRYGLRSDDFK

Sequences:

>Translated_465_residues
MTGGPVRVLVADDKENMRKLLAKILADGYAVEEAEDGARALSLVATRPYDVVVTDIRMPGADGFELLGAVKARAPDTEVV
MMTGYATIADAVRAMRMGAFDYLEKPFDPDAALAVVARAAEHKRLADAARRDDASGGEPSSFHNLVGRSARMRAVYGLLD
KAAGLDITVLLLGETGTGKELAARAIHYHSARRERRFVPVNCGALPAELVESELFGHARGAFTGAAAAKAGLFEEAQGGS
LFLDEVGELPLPAQVKLNRALQEREIRRVGDTQPLKVDVRVIAATHRDLREEVRAGRFREDLFYRLHVFPVTLPPLRERA
EDVPLLAQHFLAKHARALRRELAGGFDPEALRRLAGYPWPGNVRELENAVERAVAVSSGDRVRVADLPAEVAGAAPAGPE
PADLAKLPYKEAVAEARDRTSREYLVALLAEFGGNVTRAAERAGMERESLHRLLRRYGLRSDDFK
>Mature_464_residues
TGGPVRVLVADDKENMRKLLAKILADGYAVEEAEDGARALSLVATRPYDVVVTDIRMPGADGFELLGAVKARAPDTEVVM
MTGYATIADAVRAMRMGAFDYLEKPFDPDAALAVVARAAEHKRLADAARRDDASGGEPSSFHNLVGRSARMRAVYGLLDK
AAGLDITVLLLGETGTGKELAARAIHYHSARRERRFVPVNCGALPAELVESELFGHARGAFTGAAAAKAGLFEEAQGGSL
FLDEVGELPLPAQVKLNRALQEREIRRVGDTQPLKVDVRVIAATHRDLREEVRAGRFREDLFYRLHVFPVTLPPLRERAE
DVPLLAQHFLAKHARALRRELAGGFDPEALRRLAGYPWPGNVRELENAVERAVAVSSGDRVRVADLPAEVAGAAPAGPEP
ADLAKLPYKEAVAEARDRTSREYLVALLAEFGGNVTRAAERAGMERESLHRLLRRYGLRSDDFK

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=460, Percent_Identity=42.8260869565217, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1790437, Length=457, Percent_Identity=43.7636761487965, Blast_Score=345, Evalue=3e-96,
Organism=Escherichia coli, GI1790299, Length=471, Percent_Identity=41.8259023354565, Blast_Score=337, Evalue=1e-93,
Organism=Escherichia coli, GI1788905, Length=458, Percent_Identity=40.3930131004367, Blast_Score=331, Evalue=5e-92,
Organism=Escherichia coli, GI1789087, Length=323, Percent_Identity=48.297213622291, Blast_Score=272, Evalue=3e-74,
Organism=Escherichia coli, GI87082117, Length=323, Percent_Identity=47.3684210526316, Blast_Score=271, Evalue=7e-74,
Organism=Escherichia coli, GI87082152, Length=334, Percent_Identity=46.4071856287425, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI1789233, Length=322, Percent_Identity=40.9937888198758, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1786524, Length=246, Percent_Identity=49.1869918699187, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI87081872, Length=321, Percent_Identity=39.8753894080997, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1787583, Length=325, Percent_Identity=37.8461538461538, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1789828, Length=315, Percent_Identity=33.6507936507937, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI87081858, Length=307, Percent_Identity=30.6188925081433, Blast_Score=132, Evalue=6e-32,
Organism=Escherichia coli, GI87082012, Length=122, Percent_Identity=31.1475409836066, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786784, Length=103, Percent_Identity=28.1553398058252, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50642; Mature: 50511

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGGPVRVLVADDKENMRKLLAKILADGYAVEEAEDGARALSLVATRPYDVVVTDIRMPG
CCCCCEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCC
ADGFELLGAVKARAPDTEVVMMTGYATIADAVRAMRMGAFDYLEKPFDPDAALAVVARAA
CCHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHCHHHHHCCCCCCHHHHHHHHHHH
EHKRLADAARRDDASGGEPSSFHNLVGRSARMRAVYGLLDKAAGLDITVLLLGETGTGKE
HHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHH
LAARAIHYHSARRERRFVPVNCGALPAELVESELFGHARGAFTGAAAAKAGLFEEAQGGS
HHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCHHHCCCCC
LFLDEVGELPLPAQVKLNRALQEREIRRVGDTQPLKVDVRVIAATHRDLREEVRAGRFRE
EEHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEHHHHHHHHHHHHHCCHHH
DLFYRLHVFPVTLPPLRERAEDVPLLAQHFLAKHARALRRELAGGFDPEALRRLAGYPWP
HHHEEEEEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCC
GNVRELENAVERAVAVSSGDRVRVADLPAEVAGAAPAGPEPADLAKLPYKEAVAEARDRT
CCHHHHHHHHHHHHHHCCCCEEEEECCCHHHCCCCCCCCCCHHHHHCCHHHHHHHHHHHH
SREYLVALLAEFGGNVTRAAERAGMERESLHRLLRRYGLRSDDFK
HHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TGGPVRVLVADDKENMRKLLAKILADGYAVEEAEDGARALSLVATRPYDVVVTDIRMPG
CCCCEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCC
ADGFELLGAVKARAPDTEVVMMTGYATIADAVRAMRMGAFDYLEKPFDPDAALAVVARAA
CCHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHCHHHHHCCCCCCHHHHHHHHHHH
EHKRLADAARRDDASGGEPSSFHNLVGRSARMRAVYGLLDKAAGLDITVLLLGETGTGKE
HHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHH
LAARAIHYHSARRERRFVPVNCGALPAELVESELFGHARGAFTGAAAAKAGLFEEAQGGS
HHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCHHHCCCCC
LFLDEVGELPLPAQVKLNRALQEREIRRVGDTQPLKVDVRVIAATHRDLREEVRAGRFRE
EEHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEHHHHHHHHHHHHHCCHHH
DLFYRLHVFPVTLPPLRERAEDVPLLAQHFLAKHARALRRELAGGFDPEALRRLAGYPWP
HHHEEEEEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCC
GNVRELENAVERAVAVSSGDRVRVADLPAEVAGAAPAGPEPADLAKLPYKEAVAEARDRT
CCHHHHHHHHHHHHHHCCCCEEEEECCCHHHCCCCCCCCCCHHHHHCCHHHHHHHHHHHH
SREYLVALLAEFGGNVTRAAERAGMERESLHRLLRRYGLRSDDFK
HHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]