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The map label for this gene is atoS [H]

Identifier: 220915444

GI number: 220915444

Start: 363887

End: 365359

Strand: Direct

Name: atoS [H]

Synonym: A2cp1_0323

Alternate gene names: 220915444

Gene position: 363887-365359 (Clockwise)

Preceding gene: 220915442

Following gene: 220915445

Centisome position: 7.24

GC content: 76.37

Gene sequence:

>1473_bases
ATGATGCACGCCACCGGTACCGCCAAGCGGCTCGCCCTCGGGCTCGGGGCGCTCGTGCTGTTGCTGGCGATCGCGTCCGC
GGCGGCGATCATCGGCTCCGCCCGCATCCACCGCGGCATCGCCGAGACCATGCGGCGCGAGGAGGGCGTGCGCCTCTCCC
TCGAGCTGGCGAGCGCGGTGCGCGACCAGTACGCGCACCAGGCGCACACCATCATCATCGGCGACGGCAGCCACCTCGGC
TTCTACGCCGAGTCGCGCGACACGGTGCTGCGGCTCACCCGCGCGCTCCGGCAGGCGGCCGACCGCCCCGAGGAGCGCTC
GCTCGTCGATCGCATCGAGGCGGAGAGCGGCCGCCTCGACCGCATCTTCCGCGACTCGATCGTGCCCGCGGTGCTCCGCG
GCGAGCGCCAGAGCGTGCAGGAGGAGCACGGGCGGGCGCAGCTCGTGGTGACGCACATCCAGGACCTCACCCAGGAGCTG
GTCTCGCGCTTCGAGGCGCAGATCGCGCAGGCGCGCGCCGGCGCCGACCAGGCCGAGCGGCGCACGCTCGCGGTGCTGGT
CGCGATCCTGGTGGCGGCGCCGCTCGTGGCCGCGGCGGTGAGCCTCGCCATCGGACGGTCCATCGCGGTGCCGGTGGCGC
AGCTCCAGGCGGGCGCGGCCCGGATCGCGGAGGGCGACCTCGACACGCGCATCGAGGTGCGCGGCGCGCCGGAGCTGGTG
TCGCTGGCGCGGCGCTGGAACGAGATGACCGCGGCGGTGCGCGACCACCAGGAGCAGCTCGTCCGCTCGGAGAAGCTGGC
CGGCATCGGCCGCCTCGCCGCCGGGGTGGCCCACGAGATCAACAACCCGCTCGGCGTGATCCTCGGCTACGCGAAGCTCC
TGCGGAAGAAGGCCGACGGCGCGCTCGCCGAGGACCTGGCGGTGGTGGAGGAGGAGGCGCTCCGCGCCAAGCACATCGTG
GACGGGCTGCTCGACCTCTCCCGGCCGCTCCCCCCGCCCTCGGAGCAGGTGGACCTGCGCGCGCTCGCGGAGGACGTGGT
GGCGCGGCTGCGCGAGGCGCGGCTGCTGGAGGGCGTGTCGGCGGAGGTGGAGGGCGAGGCGAGCGCGCCCGGCCACGCCG
AGAAGCTGCGACAGGTGCTCGTGAACCTGGTGCGGAACGCCGGTGAGGCCTCCGGGCCGGGCGGGCGCGTGGCGGTGCGG
CTGCGCGAGCGGGACGGCGTGGCGGAGCTCACCGTGCGGGACTCCGGCCCGGGCATCCCCGCCGCGGCCCGCGGGAAGAT
GTTCGAGCCGTTCTTCACCACCAAGCCGCGCGGCACGGGCCTGGGGCTCGCGGTGTCGCGCGCCATCGCGCGCGCCCACG
GCGGCGAGCTGGCGGTCGCGGCGGCGGCGGAGGGCGGCGCCTGCTTCGCGCTCACGCTGCCCACGGCGCCCGCGGCGGCC
CGGCGGCGGGCCGCGGGAGGAGCGAAGCCATGA

Upstream 100 bases:

>100_bases
CCGCGCCCCGCGGCCACCCAGGGCGCCCGGAAGTCCGCCTGGACGCCGCCGGTTCGGATCCTGCAAAGCCGTCGAGGCGA
CGCCCGAGAGACCTCCCGCG

Downstream 100 bases:

>100_bases
CGGGCGGGCCGGTGCGCGTGCTGGTGGCGGACGACAAGGAGAACATGCGCAAGCTGCTCGCGAAGATCCTCGCGGACGGC
TACGCGGTGGAGGAGGCCGA

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MMHATGTAKRLALGLGALVLLLAIASAAAIIGSARIHRGIAETMRREEGVRLSLELASAVRDQYAHQAHTIIIGDGSHLG
FYAESRDTVLRLTRALRQAADRPEERSLVDRIEAESGRLDRIFRDSIVPAVLRGERQSVQEEHGRAQLVVTHIQDLTQEL
VSRFEAQIAQARAGADQAERRTLAVLVAILVAAPLVAAAVSLAIGRSIAVPVAQLQAGAARIAEGDLDTRIEVRGAPELV
SLARRWNEMTAAVRDHQEQLVRSEKLAGIGRLAAGVAHEINNPLGVILGYAKLLRKKADGALAEDLAVVEEEALRAKHIV
DGLLDLSRPLPPPSEQVDLRALAEDVVARLREARLLEGVSAEVEGEASAPGHAEKLRQVLVNLVRNAGEASGPGGRVAVR
LRERDGVAELTVRDSGPGIPAAARGKMFEPFFTTKPRGTGLGLAVSRAIARAHGGELAVAAAAEGGACFALTLPTAPAAA
RRRAAGGAKP

Sequences:

>Translated_490_residues
MMHATGTAKRLALGLGALVLLLAIASAAAIIGSARIHRGIAETMRREEGVRLSLELASAVRDQYAHQAHTIIIGDGSHLG
FYAESRDTVLRLTRALRQAADRPEERSLVDRIEAESGRLDRIFRDSIVPAVLRGERQSVQEEHGRAQLVVTHIQDLTQEL
VSRFEAQIAQARAGADQAERRTLAVLVAILVAAPLVAAAVSLAIGRSIAVPVAQLQAGAARIAEGDLDTRIEVRGAPELV
SLARRWNEMTAAVRDHQEQLVRSEKLAGIGRLAAGVAHEINNPLGVILGYAKLLRKKADGALAEDLAVVEEEALRAKHIV
DGLLDLSRPLPPPSEQVDLRALAEDVVARLREARLLEGVSAEVEGEASAPGHAEKLRQVLVNLVRNAGEASGPGGRVAVR
LRERDGVAELTVRDSGPGIPAAARGKMFEPFFTTKPRGTGLGLAVSRAIARAHGGELAVAAAAEGGACFALTLPTAPAAA
RRRAAGGAKP
>Mature_490_residues
MMHATGTAKRLALGLGALVLLLAIASAAAIIGSARIHRGIAETMRREEGVRLSLELASAVRDQYAHQAHTIIIGDGSHLG
FYAESRDTVLRLTRALRQAADRPEERSLVDRIEAESGRLDRIFRDSIVPAVLRGERQSVQEEHGRAQLVVTHIQDLTQEL
VSRFEAQIAQARAGADQAERRTLAVLVAILVAAPLVAAAVSLAIGRSIAVPVAQLQAGAARIAEGDLDTRIEVRGAPELV
SLARRWNEMTAAVRDHQEQLVRSEKLAGIGRLAAGVAHEINNPLGVILGYAKLLRKKADGALAEDLAVVEEEALRAKHIV
DGLLDLSRPLPPPSEQVDLRALAEDVVARLREARLLEGVSAEVEGEASAPGHAEKLRQVLVNLVRNAGEASGPGGRVAVR
LRERDGVAELTVRDSGPGIPAAARGKMFEPFFTTKPRGTGLGLAVSRAIARAHGGELAVAAAAEGGACFALTLPTAPAAA
RRRAAGGAKP

Specific function: Member of the two-component regulatory system AtoS/AtoC; may activate AtoC by phosphorylation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=230, Percent_Identity=37.8260869565217, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1790436, Length=226, Percent_Identity=39.8230088495575, Blast_Score=129, Evalue=6e-31,
Organism=Escherichia coli, GI1790300, Length=241, Percent_Identity=35.2697095435685, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI87081816, Length=392, Percent_Identity=27.8061224489796, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788393, Length=281, Percent_Identity=27.7580071174377, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI48994928, Length=236, Percent_Identity=28.3898305084746, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=28.310502283105, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790346, Length=309, Percent_Identity=26.537216828479, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786912, Length=224, Percent_Identity=30.3571428571429, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1789808, Length=270, Percent_Identity=29.2592592592593, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87082128, Length=300, Percent_Identity=25.3333333333333, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786783, Length=308, Percent_Identity=26.6233766233766, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789149, Length=337, Percent_Identity=23.7388724035608, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787894, Length=307, Percent_Identity=26.7100977198697, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51791; Mature: 51791

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMHATGTAKRLALGLGALVLLLAIASAAAIIGSARIHRGIAETMRREEGVRLSLELASAV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHH
RDQYAHQAHTIIIGDGSHLGFYAESRDTVLRLTRALRQAADRPEERSLVDRIEAESGRLD
HHHHHHHCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHH
RIFRDSIVPAVLRGERQSVQEEHGRAQLVVTHIQDLTQELVSRFEAQIAQARAGADQAER
HHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
RTLAVLVAILVAAPLVAAAVSLAIGRSIAVPVAQLQAGAARIAEGDLDTRIEVRGAPELV
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHH
SLARRWNEMTAAVRDHQEQLVRSEKLAGIGRLAAGVAHEINNPLGVILGYAKLLRKKADG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
ALAEDLAVVEEEALRAKHIVDGLLDLSRPLPPPSEQVDLRALAEDVVARLREARLLEGVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
AEVEGEASAPGHAEKLRQVLVNLVRNAGEASGPGGRVAVRLRERDGVAELTVRDSGPGIP
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCC
AAARGKMFEPFFTTKPRGTGLGLAVSRAIARAHGGELAVAAAAEGGACFALTLPTAPAAA
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCCHHH
RRRAAGGAKP
HHHCCCCCCC
>Mature Secondary Structure
MMHATGTAKRLALGLGALVLLLAIASAAAIIGSARIHRGIAETMRREEGVRLSLELASAV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHH
RDQYAHQAHTIIIGDGSHLGFYAESRDTVLRLTRALRQAADRPEERSLVDRIEAESGRLD
HHHHHHHCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHH
RIFRDSIVPAVLRGERQSVQEEHGRAQLVVTHIQDLTQELVSRFEAQIAQARAGADQAER
HHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
RTLAVLVAILVAAPLVAAAVSLAIGRSIAVPVAQLQAGAARIAEGDLDTRIEVRGAPELV
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHH
SLARRWNEMTAAVRDHQEQLVRSEKLAGIGRLAAGVAHEINNPLGVILGYAKLLRKKADG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
ALAEDLAVVEEEALRAKHIVDGLLDLSRPLPPPSEQVDLRALAEDVVARLREARLLEGVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
AEVEGEASAPGHAEKLRQVLVNLVRNAGEASGPGGRVAVRLRERDGVAELTVRDSGPGIP
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCC
AAARGKMFEPFFTTKPRGTGLGLAVSRAIARAHGGELAVAAAAEGGACFALTLPTAPAAA
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCCHHH
RRRAAGGAKP
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8346225; 9097040; 9278503 [H]