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The map label for this gene is proA

Identifier: 220915357

GI number: 220915357

Start: 250862

End: 252145

Strand: Direct

Name: proA

Synonym: A2cp1_0236

Alternate gene names: 220915357

Gene position: 250862-252145 (Clockwise)

Preceding gene: 220915356

Following gene: 220915358

Centisome position: 4.99

GC content: 75.0

Gene sequence:

>1284_bases
ATGCGCAAGGAGAAGTCGCTGGGCCTCGCCGCCGAGATGCGGAAGCTGGCGGAGGCCTCTCGCGAGGCCGCCCGGGCCCT
CTCGCACGCCGACCCCCGCCGCAAGGACGCCGCGCTGCGCGCCGCCGCCGAGGCCATCGGCCGCCGCGAGAAGCGGATCC
TCTCCGAGAACGCGCGCGATGTCGCCGCGGCCCGCGCGGCCGGGCAGAACGCCGCCTACCTCGACCGGCTGCGGCTCGAC
CCGAAGCGGCTCGCCGGCATCGGCGCGGCGCTGCACGAGATCGCCGGGCTGCGCGACCCGGTGGGCGAGGTGACCGCGAG
CTGGCGGAGGCCGAACGGCCTCGAGATCCGCAAGGTCCGCATCCCGCTCGGCGTGGTCCTGATGGTGTACGAGGCCCGGC
CCAACGTGACCGTCGACGCGGCCGCGCTGTGCCTGAAGAGCGGCAACGCGGCCATCCTCCGCCCCGGCTCCGACGCGCTC
CGCTCGTCGCTCGCGCTCGCCGCGGCGTTCGCCGAGGGGCTCGAGAAGGCCGGGCTGCCCGCCGCCAGCGCGCAGGTGGT
GCCCACCCCGGATCGCGAGGCCACCTACGAGCTGCTCGCGCTCGACGACCTCATCGACCTCGCCATCCCGCGCGGCGGGC
CGTCGCTCATCCGCGCGGTGGCGGCGCGCTCCCGCGTGCCGGTGCTGAAGCACTACCAGGGCGTGTGCCACCTGTACCTC
GACGCGTCGGCCCCGCCGCAGCAGGCGGTGGACCTCGCGCTGAACGGCAAGGTGCAGCGCCCCGGCGTGTGCAACGCGAC
CGAGTGCCTGCTCGTGCACCGCGGCGCCGCCGGCAAGCTCCTGCCGCCGGTGGGGCGCGCGCTCGCCGACGCCGGGGTGG
AGCTGCGCTGCGATCCCACCGCGCTCACCATCCTGAAGCGCGCCGGGGTGGCGGCGGTGCCCGCCCGCCCGGACGACTTC
GGCAAGGAGTTCCTGGACAAGATCCTGGCCGTGCGGGTGGTCGCGGATCTCGACGGCGCGCTCGACCACATCGCGCGCTA
CGGCTCGCTCCACACCGAGGCGATCGTCACCCGCGATCTCGCGAGCGCGCGGCGCTTCCAGCGCGAGGTGGACGCGAGCG
CGGTGATGGTCAACGCGTCCACCCGCTTCAACGACGGCGGCGAGCTGGGGCTCGGCGCCGAGATCGGCATCTCCACCACC
AAGCTCCACGCGTTCGGGCCCATGGGGCTCGCCGAGCTCACCACCCAGAAGTTCCTGGTCGAGGGCGAAGGGCACGTGCG
GTAG

Upstream 100 bases:

>100_bases
TGAAGACCGGCGAGATCGAGCGCGCGCTCGGGTATAAGTACCTCGACGAGATCGTCCACCGGAACGACCTGGTGGTCCTC
GAGACCGGCCGGGAGTGAGC

Downstream 100 bases:

>100_bases
CGAGAGGAACCTGATGGCGACGAAGAAGAAGGCAGCCGGCAAGAAGCCGTTCGCGAAGAAGACCCCCTCGAAGCGCGCCC
CCGCGCGCCGCGGGCCGCCC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MRKEKSLGLAAEMRKLAEASREAARALSHADPRRKDAALRAAAEAIGRREKRILSENARDVAAARAAGQNAAYLDRLRLD
PKRLAGIGAALHEIAGLRDPVGEVTASWRRPNGLEIRKVRIPLGVVLMVYEARPNVTVDAAALCLKSGNAAILRPGSDAL
RSSLALAAAFAEGLEKAGLPAASAQVVPTPDREATYELLALDDLIDLAIPRGGPSLIRAVAARSRVPVLKHYQGVCHLYL
DASAPPQQAVDLALNGKVQRPGVCNATECLLVHRGAAGKLLPPVGRALADAGVELRCDPTALTILKRAGVAAVPARPDDF
GKEFLDKILAVRVVADLDGALDHIARYGSLHTEAIVTRDLASARRFQREVDASAVMVNASTRFNDGGELGLGAEIGISTT
KLHAFGPMGLAELTTQKFLVEGEGHVR

Sequences:

>Translated_427_residues
MRKEKSLGLAAEMRKLAEASREAARALSHADPRRKDAALRAAAEAIGRREKRILSENARDVAAARAAGQNAAYLDRLRLD
PKRLAGIGAALHEIAGLRDPVGEVTASWRRPNGLEIRKVRIPLGVVLMVYEARPNVTVDAAALCLKSGNAAILRPGSDAL
RSSLALAAAFAEGLEKAGLPAASAQVVPTPDREATYELLALDDLIDLAIPRGGPSLIRAVAARSRVPVLKHYQGVCHLYL
DASAPPQQAVDLALNGKVQRPGVCNATECLLVHRGAAGKLLPPVGRALADAGVELRCDPTALTILKRAGVAAVPARPDDF
GKEFLDKILAVRVVADLDGALDHIARYGSLHTEAIVTRDLASARRFQREVDASAVMVNASTRFNDGGELGLGAEIGISTT
KLHAFGPMGLAELTTQKFLVEGEGHVR
>Mature_427_residues
MRKEKSLGLAAEMRKLAEASREAARALSHADPRRKDAALRAAAEAIGRREKRILSENARDVAAARAAGQNAAYLDRLRLD
PKRLAGIGAALHEIAGLRDPVGEVTASWRRPNGLEIRKVRIPLGVVLMVYEARPNVTVDAAALCLKSGNAAILRPGSDAL
RSSLALAAAFAEGLEKAGLPAASAQVVPTPDREATYELLALDDLIDLAIPRGGPSLIRAVAARSRVPVLKHYQGVCHLYL
DASAPPQQAVDLALNGKVQRPGVCNATECLLVHRGAAGKLLPPVGRALADAGVELRCDPTALTILKRAGVAAVPARPDDF
GKEFLDKILAVRVVADLDGALDHIARYGSLHTEAIVTRDLASARRFQREVDASAVMVNASTRFNDGGELGLGAEIGISTT
KLHAFGPMGLAELTTQKFLVEGEGHVR

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=416, Percent_Identity=35.8173076923077, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI21361368, Length=416, Percent_Identity=35.8173076923077, Blast_Score=236, Evalue=2e-62,
Organism=Escherichia coli, GI1786438, Length=415, Percent_Identity=43.6144578313253, Blast_Score=347, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI17569969, Length=417, Percent_Identity=36.21103117506, Blast_Score=254, Evalue=9e-68,
Organism=Caenorhabditis elegans, GI17569967, Length=417, Percent_Identity=36.21103117506, Blast_Score=254, Evalue=9e-68,
Organism=Saccharomyces cerevisiae, GI6324899, Length=430, Percent_Identity=33.4883720930233, Blast_Score=233, Evalue=6e-62,
Organism=Drosophila melanogaster, GI21357643, Length=413, Percent_Identity=36.5617433414044, Blast_Score=249, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_ANAD2 (B8J8Z7)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002490661.1
- ProteinModelPortal:   B8J8Z7
- SMR:   B8J8Z7
- GeneID:   7298471
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_0236
- HOGENOM:   HBG318080
- ProtClustDB:   PRK00197
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45199; Mature: 45199

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKEKSLGLAAEMRKLAEASREAARALSHADPRRKDAALRAAAEAIGRREKRILSENARD
CCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VAAARAAGQNAAYLDRLRLDPKRLAGIGAALHEIAGLRDPVGEVTASWRRPNGLEIRKVR
HHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEE
IPLGVVLMVYEARPNVTVDAAALCLKSGNAAILRPGSDALRSSLALAAAFAEGLEKAGLP
CCCEEEEEEEECCCCCCHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCC
AASAQVVPTPDREATYELLALDDLIDLAIPRGGPSLIRAVAARSRVPVLKHYQGVCHLYL
CCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHCCCEEEEEE
DASAPPQQAVDLALNGKVQRPGVCNATECLLVHRGAAGKLLPPVGRALADAGVELRCDPT
CCCCCHHHHHHHHCCCCCCCCCCCCHHHEEEEECCCCCCCCCHHHHHHHHCCCEEEECHH
ALTILKRAGVAAVPARPDDFGKEFLDKILAVRVVADLDGALDHIARYGSLHTEAIVTRDL
HHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
ASARRFQREVDASAVMVNASTRFNDGGELGLGAEIGISTTKLHAFGPMGLAELTTQKFLV
HHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHEE
EGEGHVR
CCCCCCC
>Mature Secondary Structure
MRKEKSLGLAAEMRKLAEASREAARALSHADPRRKDAALRAAAEAIGRREKRILSENARD
CCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VAAARAAGQNAAYLDRLRLDPKRLAGIGAALHEIAGLRDPVGEVTASWRRPNGLEIRKVR
HHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEE
IPLGVVLMVYEARPNVTVDAAALCLKSGNAAILRPGSDALRSSLALAAAFAEGLEKAGLP
CCCEEEEEEEECCCCCCHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCC
AASAQVVPTPDREATYELLALDDLIDLAIPRGGPSLIRAVAARSRVPVLKHYQGVCHLYL
CCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHCCCEEEEEE
DASAPPQQAVDLALNGKVQRPGVCNATECLLVHRGAAGKLLPPVGRALADAGVELRCDPT
CCCCCHHHHHHHHCCCCCCCCCCCCHHHEEEEECCCCCCCCCHHHHHHHHCCCEEEECHH
ALTILKRAGVAAVPARPDDFGKEFLDKILAVRVVADLDGALDHIARYGSLHTEAIVTRDL
HHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
ASARRFQREVDASAVMVNASTRFNDGGELGLGAEIGISTTKLHAFGPMGLAELTTQKFLV
HHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHEE
EGEGHVR
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA