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The map label for this gene is gyrB [H]

Identifier: 220915127

GI number: 220915127

Start: 4659

End: 7046

Strand: Direct

Name: gyrB [H]

Synonym: A2cp1_0004

Alternate gene names: 220915127

Gene position: 4659-7046 (Clockwise)

Preceding gene: 220915126

Following gene: 220915128

Centisome position: 0.09

GC content: 69.1

Gene sequence:

>2388_bases
GTGCTCGAGGGCCTCGAGGCCGTGCGCAAGCGGCCGCACATGTACATCGGCGACGTGGGCGCCCGCGGCCTGCACCACCT
CGTCTACGAGGTCGTCGACAACTCGGTCGACGAGGCCATGGCCGGCCGCGCCAACGAGATCAACGTCGCCATCCACGCCG
ACAACTCCATCACCGTGCTCGACAACGGCTCGGGCATCCCCATCGGCCCGCACCCGACGGTGAAGGGGATGGACACGCTC
GACGTGGTGCTGACGAAGCTCCACGCCGGCGGCAAGTTCGAGTCGAACGCGTACAAGGTCTCCGGCGGCCTGCACGGCGT
GGGCGTGACCTGCGTGAACGCGCTCTCGGAGTGGCTGAAGGCCGAGGTGTACCGCGACGGCAAGGTCTGGGCGCAGCGCT
ACGAGCGCGGCACGCCCGCCGGCAAGGTCACCGCCATCGGCGAGACCCAGCGGCGCGGGACCCGCATCACGTTCAAGCCC
GACGCGACCATCTTCGAGGTGACCGAGTACAGCTTCGAGACGCTGTCCGGCCGCCTGCGCGAGCTCGCCTTCCTGAACGC
CGGCCTCAAGATCACCATCGAGGACGAGCGGCACGGCAAGAAGCACGAGTTCCTGTTCAAGGACGGCATCCGCGAGTTCG
TCGCGTTCCTGAACAAGAGCCGCGAGGTGCTGTTCCAGCCGCCCATCGCGCTGCGCCAGGAGGTCGAGACCGAGCGCGGC
GCGGCGCTGGTCGAGATCGCCCTGCAGTGGAACGACGGCTACGACGAGAAGGTCTTCGCGTTCGCCAACAACATCCACAA
CCACGAGGGCGGCACGCACCTCATCGGCTTCAAGGCGGCGCTGACGCGCACCATCAACGCCTACGGCCAGAAGAACAACC
TGTTCAAGGACCTGAAGGACGAGCTGCCGAGCGGCGACGACATGCGCGAGGGGCTCGCCGCGGTGATCTCGGTCCGCCTC
CCCGGCGCGAGCTTCGAGGGACAGACCAAGACCAAGCTCTCCAACACCGAGGCGAAGAGCATGGTCGAGACCATGCTCAA
CGAGCGGCTCTCCGCGTTCCTCGAGGAGAACCCGAACGTCGCGAAGCGGATCTGCGGCAAGGTCGCCGAGGCGGCCCGCG
CCCGGATCGCGGCGCGCAAGGCGCGCGAGACGGTCCGCCGCAAGGGCGCGCTCGACAGCGCCTCGCTCCCGGGCAAGCTC
GCCGACTGCCAGTCGCGGGATCCGAAGGAGTCGGAGCTGTACCTGGTGGAGGGCGACTCCGCCGGCGGCTCGGCGAAGCA
GGGGCGCGACCGGCGCACCCAGGCCATCCTGCCGCTCCGCGGCAAGATCCTGAACGTCGAGAAGGCCCGCTTCGACAAGA
TGCTCGGGTCGGCGGAGATCGCGACCATCATCACCGCGCTCGGGACCGGCATCGGCCCCGAGGAGTTCGACGTCGAGAAG
ATCCGCTACCACAAGATCGTGATCATGACGGACGCGGACGTGGACGGGTCGCACATCCGGACGCTGCTCCTCACGTTCTT
CTTCCGGCAGATGCCGAGCGTGATCGAGCGCGGGCTCGTCTACATCGCGCAGCCGCCGCTGTTCCGGGTCGCGAAGGGCA
AGAAGGAGAGCTACCTCAAGGACGAGGCGGCGCTCGACGAGTACCTGCTCGCGCTCGGGACCGACCGGACCCGGCTCGTG
GCCGGCGACACGGTCATCGAGGGTCGCGACCTCGCGCGGCTCGCCCGCGACGCCATCGCCTACCGGGCGTTGCTCGCGCG
GGTGGACCGCCGGCGCGACAGCCGCATCGTGGACGCCGCCATCCAGCTCGGCGATCTCGACCTCGACCTGCTGAAGCACC
ACGAGCAGGTGAAGGAGCAGGTGCAGAAGATCTTCGACAAGGCGCAGAAGCTCCACCCCGAGCTCCAGGTCCGCATCGCC
AAGATCGAGCGCGACGAGGAGCACGGCTGCGACGCGCTCGTCTACCAGACCAGCATGGCCGGCGCGCCGCGCGACACCCG
CCTCGACCACGACTACCTGTCGGGCGCGGAGTGGGGCGAGCTGGCGGCGCTGCACGCCGCCATCGCCGAGCTCGGGCCCG
GGCCGTTCCGCCTCGAGACGCCGGAGGGCGCCGAGGAGGTGCTCGACGTGTTCGAGGCGGTCGAGGCGGTGAAGAAGGCC
GCCGGCCAGGGCCAGACCATCCAGCGCTACAAGGGGCTCGGCGAGATGAACCCCGAGCAGCTCTGGGAGACCACCATGGA
CCCGGCCCGGCGGACCATGCTGCAGGTGCGCGTGGACGACACGGTCGAGGCCGACGAGGTGTTCTCGATCCTGATGGGCG
ACGCGGTGGAGCCGCGCCGCGAGTTCATCGAGAAGCACGCGCTCGACGTGCAGAACCTGGACATCTGA

Upstream 100 bases:

>100_bases
CCTTTCAGAGAAACGAGCGAGGACCCCCCTGGAAACCGCCGAGCAGAGCCCCCGTCCCGCGGCTCCCGCGGATGACGACT
ACGGGACCGACACCATCAAG

Downstream 100 bases:

>100_bases
GGAGGAGCCGCCCATGCCCCGCGCCGCCATCGTCGCCCTCGGCACGCACGTCCCCGACCGCGTGGTCACGAACGAAGAGC
TCACGAAGCACATGGAGACC

Product: DNA gyrase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 795; Mature: 795

Protein sequence:

>795_residues
MLEGLEAVRKRPHMYIGDVGARGLHHLVYEVVDNSVDEAMAGRANEINVAIHADNSITVLDNGSGIPIGPHPTVKGMDTL
DVVLTKLHAGGKFESNAYKVSGGLHGVGVTCVNALSEWLKAEVYRDGKVWAQRYERGTPAGKVTAIGETQRRGTRITFKP
DATIFEVTEYSFETLSGRLRELAFLNAGLKITIEDERHGKKHEFLFKDGIREFVAFLNKSREVLFQPPIALRQEVETERG
AALVEIALQWNDGYDEKVFAFANNIHNHEGGTHLIGFKAALTRTINAYGQKNNLFKDLKDELPSGDDMREGLAAVISVRL
PGASFEGQTKTKLSNTEAKSMVETMLNERLSAFLEENPNVAKRICGKVAEAARARIAARKARETVRRKGALDSASLPGKL
ADCQSRDPKESELYLVEGDSAGGSAKQGRDRRTQAILPLRGKILNVEKARFDKMLGSAEIATIITALGTGIGPEEFDVEK
IRYHKIVIMTDADVDGSHIRTLLLTFFFRQMPSVIERGLVYIAQPPLFRVAKGKKESYLKDEAALDEYLLALGTDRTRLV
AGDTVIEGRDLARLARDAIAYRALLARVDRRRDSRIVDAAIQLGDLDLDLLKHHEQVKEQVQKIFDKAQKLHPELQVRIA
KIERDEEHGCDALVYQTSMAGAPRDTRLDHDYLSGAEWGELAALHAAIAELGPGPFRLETPEGAEEVLDVFEAVEAVKKA
AGQGQTIQRYKGLGEMNPEQLWETTMDPARRTMLQVRVDDTVEADEVFSILMGDAVEPRREFIEKHALDVQNLDI

Sequences:

>Translated_795_residues
MLEGLEAVRKRPHMYIGDVGARGLHHLVYEVVDNSVDEAMAGRANEINVAIHADNSITVLDNGSGIPIGPHPTVKGMDTL
DVVLTKLHAGGKFESNAYKVSGGLHGVGVTCVNALSEWLKAEVYRDGKVWAQRYERGTPAGKVTAIGETQRRGTRITFKP
DATIFEVTEYSFETLSGRLRELAFLNAGLKITIEDERHGKKHEFLFKDGIREFVAFLNKSREVLFQPPIALRQEVETERG
AALVEIALQWNDGYDEKVFAFANNIHNHEGGTHLIGFKAALTRTINAYGQKNNLFKDLKDELPSGDDMREGLAAVISVRL
PGASFEGQTKTKLSNTEAKSMVETMLNERLSAFLEENPNVAKRICGKVAEAARARIAARKARETVRRKGALDSASLPGKL
ADCQSRDPKESELYLVEGDSAGGSAKQGRDRRTQAILPLRGKILNVEKARFDKMLGSAEIATIITALGTGIGPEEFDVEK
IRYHKIVIMTDADVDGSHIRTLLLTFFFRQMPSVIERGLVYIAQPPLFRVAKGKKESYLKDEAALDEYLLALGTDRTRLV
AGDTVIEGRDLARLARDAIAYRALLARVDRRRDSRIVDAAIQLGDLDLDLLKHHEQVKEQVQKIFDKAQKLHPELQVRIA
KIERDEEHGCDALVYQTSMAGAPRDTRLDHDYLSGAEWGELAALHAAIAELGPGPFRLETPEGAEEVLDVFEAVEAVKKA
AGQGQTIQRYKGLGEMNPEQLWETTMDPARRTMLQVRVDDTVEADEVFSILMGDAVEPRREFIEKHALDVQNLDI
>Mature_795_residues
MLEGLEAVRKRPHMYIGDVGARGLHHLVYEVVDNSVDEAMAGRANEINVAIHADNSITVLDNGSGIPIGPHPTVKGMDTL
DVVLTKLHAGGKFESNAYKVSGGLHGVGVTCVNALSEWLKAEVYRDGKVWAQRYERGTPAGKVTAIGETQRRGTRITFKP
DATIFEVTEYSFETLSGRLRELAFLNAGLKITIEDERHGKKHEFLFKDGIREFVAFLNKSREVLFQPPIALRQEVETERG
AALVEIALQWNDGYDEKVFAFANNIHNHEGGTHLIGFKAALTRTINAYGQKNNLFKDLKDELPSGDDMREGLAAVISVRL
PGASFEGQTKTKLSNTEAKSMVETMLNERLSAFLEENPNVAKRICGKVAEAARARIAARKARETVRRKGALDSASLPGKL
ADCQSRDPKESELYLVEGDSAGGSAKQGRDRRTQAILPLRGKILNVEKARFDKMLGSAEIATIITALGTGIGPEEFDVEK
IRYHKIVIMTDADVDGSHIRTLLLTFFFRQMPSVIERGLVYIAQPPLFRVAKGKKESYLKDEAALDEYLLALGTDRTRLV
AGDTVIEGRDLARLARDAIAYRALLARVDRRRDSRIVDAAIQLGDLDLDLLKHHEQVKEQVQKIFDKAQKLHPELQVRIA
KIERDEEHGCDALVYQTSMAGAPRDTRLDHDYLSGAEWGELAALHAAIAELGPGPFRLETPEGAEEVLDVFEAVEAVKKA
AGQGQTIQRYKGLGEMNPEQLWETTMDPARRTMLQVRVDDTVEADEVFSILMGDAVEPRREFIEKHALDVQNLDI

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=593, Percent_Identity=25.8010118043845, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI19913406, Length=587, Percent_Identity=26.2350936967632, Blast_Score=123, Evalue=8e-28,
Organism=Escherichia coli, GI48994957, Length=799, Percent_Identity=50.6883604505632, Blast_Score=751, Evalue=0.0,
Organism=Escherichia coli, GI1789408, Length=546, Percent_Identity=37.7289377289377, Blast_Score=360, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI212645845, Length=516, Percent_Identity=25.1937984496124, Blast_Score=132, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17535065, Length=553, Percent_Identity=24.5931283905967, Blast_Score=126, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI212645657, Length=143, Percent_Identity=34.965034965035, Blast_Score=79, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6324241, Length=582, Percent_Identity=25.7731958762887, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI17136538, Length=542, Percent_Identity=26.7527675276753, Blast_Score=132, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 88148; Mature: 88148

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEGLEAVRKRPHMYIGDVGARGLHHLVYEVVDNSVDEAMAGRANEINVAIHADNSITVL
CCCCHHHHHHCCCEEEECCCHHHHHHHHHHHHHCHHHHHHCCCCCEEEEEEECCCEEEEE
DNGSGIPIGPHPTVKGMDTLDVVLTKLHAGGKFESNAYKVSGGLHGVGVTCVNALSEWLK
ECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHH
AEVYRDGKVWAQRYERGTPAGKVTAIGETQRRGTRITFKPDATIFEVTEYSFETLSGRLR
HHHHCCHHHHHHHHHCCCCCCCEEECCCHHCCCCEEEECCCCCEEEEHHHHHHHHHHHHH
ELAFLNAGLKITIEDERHGKKHEFLFKDGIREFVAFLNKSREVLFQPPIALRQEVETERG
HHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHCC
AALVEIALQWNDGYDEKVFAFANNIHNHEGGTHLIGFKAALTRTINAYGQKNNLFKDLKD
CEEEEEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHCCCCCHHHHHHH
ELPSGDDMREGLAAVISVRLPGASFEGQTKTKLSNTEAKSMVETMLNERLSAFLEENPNV
HCCCCCHHHHHHHHHHEEECCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCH
AKRICGKVAEAARARIAARKARETVRRKGALDSASLPGKLADCQSRDPKESELYLVEGDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCEEEEEECCC
AGGSAKQGRDRRTQAILPLRGKILNVEKARFDKMLGSAEIATIITALGTGIGPEEFDVEK
CCCCCCCCCCHHHHEECCCCCCEECHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHE
IRYHKIVIMTDADVDGSHIRTLLLTFFFRQMPSVIERGLVYIAQPPLFRVAKGKKESYLK
EEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHCCCHHHHHH
DEAALDEYLLALGTDRTRLVAGDTVIEGRDLARLARDAIAYRALLARVDRRRDSRIVDAA
HHHHHHHHHHHHCCCCCEEEECCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQLGDLDLDLLKHHEQVKEQVQKIFDKAQKLHPELQVRIAKIERDEEHGCDALVYQTSMA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEEEEECCCCCCCCCCEEEEEHHCC
GAPRDTRLDHDYLSGAEWGELAALHAAIAELGPGPFRLETPEGAEEVLDVFEAVEAVKKA
CCCCCCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHH
AGQGQTIQRYKGLGEMNPEQLWETTMDPARRTMLQVRVDDTVEADEVFSILMGDAVEPRR
CCCCCHHHHHCCCCCCCHHHHHHHHCCHHHHHEEEEEECCCCCHHHHHHHHHCCCCCHHH
EFIEKHALDVQNLDI
HHHHHHCCCCCCCCC
>Mature Secondary Structure
MLEGLEAVRKRPHMYIGDVGARGLHHLVYEVVDNSVDEAMAGRANEINVAIHADNSITVL
CCCCHHHHHHCCCEEEECCCHHHHHHHHHHHHHCHHHHHHCCCCCEEEEEEECCCEEEEE
DNGSGIPIGPHPTVKGMDTLDVVLTKLHAGGKFESNAYKVSGGLHGVGVTCVNALSEWLK
ECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHH
AEVYRDGKVWAQRYERGTPAGKVTAIGETQRRGTRITFKPDATIFEVTEYSFETLSGRLR
HHHHCCHHHHHHHHHCCCCCCCEEECCCHHCCCCEEEECCCCCEEEEHHHHHHHHHHHHH
ELAFLNAGLKITIEDERHGKKHEFLFKDGIREFVAFLNKSREVLFQPPIALRQEVETERG
HHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHCC
AALVEIALQWNDGYDEKVFAFANNIHNHEGGTHLIGFKAALTRTINAYGQKNNLFKDLKD
CEEEEEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHCCCCCHHHHHHH
ELPSGDDMREGLAAVISVRLPGASFEGQTKTKLSNTEAKSMVETMLNERLSAFLEENPNV
HCCCCCHHHHHHHHHHEEECCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCH
AKRICGKVAEAARARIAARKARETVRRKGALDSASLPGKLADCQSRDPKESELYLVEGDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCEEEEEECCC
AGGSAKQGRDRRTQAILPLRGKILNVEKARFDKMLGSAEIATIITALGTGIGPEEFDVEK
CCCCCCCCCCHHHHEECCCCCCEECHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHE
IRYHKIVIMTDADVDGSHIRTLLLTFFFRQMPSVIERGLVYIAQPPLFRVAKGKKESYLK
EEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHCCCHHHHHH
DEAALDEYLLALGTDRTRLVAGDTVIEGRDLARLARDAIAYRALLARVDRRRDSRIVDAA
HHHHHHHHHHHHCCCCCEEEECCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQLGDLDLDLLKHHEQVKEQVQKIFDKAQKLHPELQVRIAKIERDEEHGCDALVYQTSMA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEEEEECCCCCCCCCCEEEEEHHCC
GAPRDTRLDHDYLSGAEWGELAALHAAIAELGPGPFRLETPEGAEEVLDVFEAVEAVKKA
CCCCCCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHH
AGQGQTIQRYKGLGEMNPEQLWETTMDPARRTMLQVRVDDTVEADEVFSILMGDAVEPRR
CCCCCHHHHHCCCCCCCHHHHHHHHCCHHHHHEEEEEECCCCCHHHHHHHHHCCCCCHHH
EFIEKHALDVQNLDI
HHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9639935 [H]