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The map label for this gene is Dml [H]

Identifier: 220914817

GI number: 220914817

Start: 177974

End: 178840

Strand: Reverse

Name: Dml [H]

Synonym: Mnod_7954

Alternate gene names: 220914817

Gene position: 178840-177974 (Counterclockwise)

Preceding gene: 220914820

Following gene: 220914816

Centisome position: 39.04

GC content: 69.55

Gene sequence:

>867_bases
ATGCGAGCCACACAGACCCTGAAATCCATCCTGGCGCGCCGCGAGGCGGTCAGTGTGCCGGGCGCTGCGAACGCCCTGTT
CGCCCGCGTCATCGAGGATCTCGGGTTCGAGGCGGTCTATGTGACCGGCGCAGGCGTCGCGAACATGCAGCTCGGCGCGC
CCGACATCGGGCTGACCAGCATCACCGAGGTCGCGAGCACGGTCGCGGCCGTGGCCGATGCGGTGGCGCTCCCGATCATC
GTCGATGCCGACACCGGATTCGGCAACGCCGTCAACATGATCCGGACGGTGCGGCTGCTGGAGCGCGCCGGCGCCGCCGG
AATCCAGATCGAGGACCAGGTCTTTCCCAAGAAGTGCGGCCACTTCACCGGCAAGGACGTCATCCCGCGGGACGAGATGG
TGCAGAAGGTGAAGGCGGCGGTCGATGCGCGGCGCGACGGCGACCTTCAGATCATCGCCCGGACCGATGCCCGGGCGGTG
GAAGGGCTGGAACGCGCGATCGAGCGGGCGCAGGCTTACATCGAGGCGGGCGCCGATGCGACCTTCGTGGAGGCGCCCGT
GTCGGCCGAGGAACTCGGCCGCATCGCCCGCGACCTGAAGGTTCCGCAGGTCGCCAACATCGTGTTCGGCGGGAAGACGC
CCGACCCGGGGCGCGAGCGCTTGGCCGAGATGGGGTTCTCGATCGTCCTCTACGCCAACGCGGCCCTGCAGGCGGCCCTG
AAGGCCTCCTACGAGGTGCTCGGGGCGCTCAAGCGAGACGGCTCGCTGTCCGCTGTCGCCGACCGGCTCGCCTCATTCGA
GGAGCGTCAGCGGGCGGTCGCCAAGGATGAATGGGACGCGCTCGAAGCCCGCTACCGGGCAGCCTGA

Upstream 100 bases:

>100_bases
GCTGAGGATGCACGAACCTGCTCGCGAGAACAGGGCGCCAGTCGCCCAAGAGCGCCGCCGCAAGGGACGGCCGCAGCAAG
CGTGAGGACAACGCCCGGTG

Downstream 100 bases:

>100_bases
GGAGGCCGGGGATGGACCGCAAGCCGTGGGACGGCCTGATCTCCGAGGAGGAGCAGCGGGCCTACAACGCCGCCGGGTTC
GGCCGTGCGACCGGCCTCGG

Product: carboxyvinyl-carboxyphosphonate phosphorylmutase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MRATQTLKSILARREAVSVPGAANALFARVIEDLGFEAVYVTGAGVANMQLGAPDIGLTSITEVASTVAAVADAVALPII
VDADTGFGNAVNMIRTVRLLERAGAAGIQIEDQVFPKKCGHFTGKDVIPRDEMVQKVKAAVDARRDGDLQIIARTDARAV
EGLERAIERAQAYIEAGADATFVEAPVSAEELGRIARDLKVPQVANIVFGGKTPDPGRERLAEMGFSIVLYANAALQAAL
KASYEVLGALKRDGSLSAVADRLASFEERQRAVAKDEWDALEARYRAA

Sequences:

>Translated_288_residues
MRATQTLKSILARREAVSVPGAANALFARVIEDLGFEAVYVTGAGVANMQLGAPDIGLTSITEVASTVAAVADAVALPII
VDADTGFGNAVNMIRTVRLLERAGAAGIQIEDQVFPKKCGHFTGKDVIPRDEMVQKVKAAVDARRDGDLQIIARTDARAV
EGLERAIERAQAYIEAGADATFVEAPVSAEELGRIARDLKVPQVANIVFGGKTPDPGRERLAEMGFSIVLYANAALQAAL
KASYEVLGALKRDGSLSAVADRLASFEERQRAVAKDEWDALEARYRAA
>Mature_288_residues
MRATQTLKSILARREAVSVPGAANALFARVIEDLGFEAVYVTGAGVANMQLGAPDIGLTSITEVASTVAAVADAVALPII
VDADTGFGNAVNMIRTVRLLERAGAAGIQIEDQVFPKKCGHFTGKDVIPRDEMVQKVKAAVDARRDGDLQIIARTDARAV
EGLERAIERAQAYIEAGADATFVEAPVSAEELGRIARDLKVPQVANIVFGGKTPDPGRERLAEMGFSIVLYANAALQAAL
KASYEVLGALKRDGSLSAVADRLASFEERQRAVAKDEWDALEARYRAA

Specific function: Catalyzes the formation of proponate and pyruvate from (2R,3S)-2,3-dimethylmalate. Has no activity toward dimethylmaleate, malate, citramalate, isocitrate and citrate [H]

COG id: COG2513

COG function: function code G; PEP phosphonomutase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786525, Length=276, Percent_Identity=38.0434782608696, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1790445, Length=220, Percent_Identity=30.4545454545455, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320908, Length=111, Percent_Identity=35.1351351351351, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.32 [H]

Molecular weight: Translated: 30575; Mature: 30575

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRATQTLKSILARREAVSVPGAANALFARVIEDLGFEAVYVTGAGVANMQLGAPDIGLTS
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCEEECCCCCCCCCHHH
ITEVASTVAAVADAVALPIIVDADTGFGNAVNMIRTVRLLERAGAAGIQIEDQVFPKKCG
HHHHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHC
HFTGKDVIPRDEMVQKVKAAVDARRDGDLQIIARTDARAVEGLERAIERAQAYIEAGADA
CCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCC
TFVEAPVSAEELGRIARDLKVPQVANIVFGGKTPDPGRERLAEMGFSIVLYANAALQAAL
EEEECCCCHHHHHHHHHHCCCCHHHHEEECCCCCCHHHHHHHHCCCEEEEEHHHHHHHHH
KASYEVLGALKRDGSLSAVADRLASFEERQRAVAKDEWDALEARYRAA
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRATQTLKSILARREAVSVPGAANALFARVIEDLGFEAVYVTGAGVANMQLGAPDIGLTS
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCEEECCCCCCCCCHHH
ITEVASTVAAVADAVALPIIVDADTGFGNAVNMIRTVRLLERAGAAGIQIEDQVFPKKCG
HHHHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHC
HFTGKDVIPRDEMVQKVKAAVDARRDGDLQIIARTDARAVEGLERAIERAQAYIEAGADA
CCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCC
TFVEAPVSAEELGRIARDLKVPQVANIVFGGKTPDPGRERLAEMGFSIVLYANAALQAAL
EEEECCCCHHHHHHHHHHCCCCHHHHEEECCCCCCHHHHHHHHCCCEEEEEHHHHHHHHH
KASYEVLGALKRDGSLSAVADRLASFEERQRAVAKDEWDALEARYRAA
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA