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The map label for this gene is mtnA

Identifier: 220905573

GI number: 220905573

Start: 2779820

End: 2780956

Strand: Reverse

Name: mtnA

Synonym: Ddes_2312

Alternate gene names: 220905573

Gene position: 2780956-2779820 (Counterclockwise)

Preceding gene: 220905579

Following gene: 220905572

Centisome position: 96.78

GC content: 64.29

Gene sequence:

>1137_bases
ATGGACGACCACATACGTTTTGACCACCAGACTTTTGAATTGCACCTGCTGGACCAGCGGCTTCTACCCGCACAGGAGGC
CGACTTTGTCTGCCGCTCGGTGGAAGACGTGGTTTACGCCCTGCAAACTATGGTGGTACGCGGTGCGCCCGCCATTGGCG
TTACGGCGGCCTGGGGCTGCGTGCTGGCGCTCAGGGAGGCCCAGGGGCCGGACTGGGCGGCAAGGCTTGAGCAGGGTATG
GAGCGCATCGCCGCGGCCAGGCCCACGGCCGTCAACCTGCGCTGGGCCGTTGAGCGCATGCGCGGCGTGTGGCTTGCGGC
GGGCGGTGAGGCGGGTGATCCCGCGCCCCTGCTGACGGCTTTTGCCCACGCGGCCCAGACCATGCAGGATGAAGACGTGG
CCGTTTGCAAAACTCTGGGCCGTCACGGCGCGGCCTGTATTGAAGACGGCGACTGTGTACTTACGCACTGCAATGCCGGG
GCGCTGGCAACGGCAGGCTACGGTACTGCCCTCGGGGTCATCCGCGCTGCGGTGGAGGCGGGCAAGAAGGTCAGCGTCAT
CGCTGACGAGACCCGCCCCTTTCTTCAGGGCGCACGCCTGACCGCCTGGGAGCTTGAACGGGACGGCATCCCCGTGACAG
TGGCCTGCGACAATGCCTGCGCCCTGCTCATGAGCCGCGGGCTGGTGCAGCGTGTGGTGGTGGGGGCCGACCGCATCGCC
GCTAACGGCGACACCGCAAACAAGATAGGAACCTATGGCGTGGCGCTGCTGGCCAGGCATTTTCATATTCCTTTTTATGT
GGCTGCGCCGCTTTCCACCATTGACCCGGCCACGCCTGACGGGGCGGGCATTCCCATTGAAGAGCGCCCGGAGCTTGAGG
TGACCCATATGGGAGAAACGCGGTTGTGTCCGGAAAACGTCCCTGTTCTCAATTTTGCCTTTGACGTGACGCCTGCGGAA
TATATAAGCGGCATCATTACAGAAAAAGGTGTTCTCTATCCGCCTTACGGTCTGTCCATATGGGCGGCGCTCAACGATTT
GAGCACGGGGCGCAGCGCGGGCATCAGCGCCGGACCCCTGCGGGACGAGGATGACGCCCCCGATGCGGAGCCTGACTGGA
GCCGGGAGCGCTCATGA

Upstream 100 bases:

>100_bases
GGGTGCTGGCATGCCGTTCCCGAGGTCCACCCGCACCCTATCATCTTTGCTTTCAGGCTATTGTGGTGTATGATCCGGGG
GTACGCCACCGGAGGAAAGC

Downstream 100 bases:

>100_bases
AGGAGCTTATACTCATAGCCGGACCGGTTGCTCCTGATCTGGGACCATGCCCGGTCAATCCCGAAAGCTTCAGGGGCGGC
GCCGCGCAGACCGTTGTGCA

Product: translation initiation factor, aIF-2BI family

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MDDHIRFDHQTFELHLLDQRLLPAQEADFVCRSVEDVVYALQTMVVRGAPAIGVTAAWGCVLALREAQGPDWAARLEQGM
ERIAAARPTAVNLRWAVERMRGVWLAAGGEAGDPAPLLTAFAHAAQTMQDEDVAVCKTLGRHGAACIEDGDCVLTHCNAG
ALATAGYGTALGVIRAAVEAGKKVSVIADETRPFLQGARLTAWELERDGIPVTVACDNACALLMSRGLVQRVVVGADRIA
ANGDTANKIGTYGVALLARHFHIPFYVAAPLSTIDPATPDGAGIPIEERPELEVTHMGETRLCPENVPVLNFAFDVTPAE
YISGIITEKGVLYPPYGLSIWAALNDLSTGRSAGISAGPLRDEDDAPDAEPDWSRERS

Sequences:

>Translated_378_residues
MDDHIRFDHQTFELHLLDQRLLPAQEADFVCRSVEDVVYALQTMVVRGAPAIGVTAAWGCVLALREAQGPDWAARLEQGM
ERIAAARPTAVNLRWAVERMRGVWLAAGGEAGDPAPLLTAFAHAAQTMQDEDVAVCKTLGRHGAACIEDGDCVLTHCNAG
ALATAGYGTALGVIRAAVEAGKKVSVIADETRPFLQGARLTAWELERDGIPVTVACDNACALLMSRGLVQRVVVGADRIA
ANGDTANKIGTYGVALLARHFHIPFYVAAPLSTIDPATPDGAGIPIEERPELEVTHMGETRLCPENVPVLNFAFDVTPAE
YISGIITEKGVLYPPYGLSIWAALNDLSTGRSAGISAGPLRDEDDAPDAEPDWSRERS
>Mature_378_residues
MDDHIRFDHQTFELHLLDQRLLPAQEADFVCRSVEDVVYALQTMVVRGAPAIGVTAAWGCVLALREAQGPDWAARLEQGM
ERIAAARPTAVNLRWAVERMRGVWLAAGGEAGDPAPLLTAFAHAAQTMQDEDVAVCKTLGRHGAACIEDGDCVLTHCNAG
ALATAGYGTALGVIRAAVEAGKKVSVIADETRPFLQGARLTAWELERDGIPVTVACDNACALLMSRGLVQRVVVGADRIA
ANGDTANKIGTYGVALLARHFHIPFYVAAPLSTIDPATPDGAGIPIEERPELEVTHMGETRLCPENVPVLNFAFDVTPAE
YISGIITEKGVLYPPYGLSIWAALNDLSTGRSAGISAGPLRDEDDAPDAEPDWSRERS

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=343, Percent_Identity=41.1078717201166, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI23943880, Length=146, Percent_Identity=53.4246575342466, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4503503, Length=201, Percent_Identity=31.8407960199005, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI7657058, Length=192, Percent_Identity=30.2083333333333, Blast_Score=69, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17557462, Length=338, Percent_Identity=35.5029585798817, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17557123, Length=182, Percent_Identity=29.6703296703297, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6325375, Length=395, Percent_Identity=33.4177215189873, Blast_Score=178, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6322878, Length=296, Percent_Identity=27.027027027027, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357667, Length=344, Percent_Identity=45.3488372093023, Blast_Score=262, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24651647, Length=344, Percent_Identity=45.3488372093023, Blast_Score=262, Evalue=3e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_DESDA (B8J4S7)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002480885.1
- ProteinModelPortal:   B8J4S7
- GeneID:   7286030
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_2312
- HOGENOM:   HBG682649
- ProtClustDB:   CLSK704399
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 40338; Mature: 40338

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: ACT_SITE 237-237 BINDING 87-87 BINDING 196-196

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDHIRFDHQTFELHLLDQRLLPAQEADFVCRSVEDVVYALQTMVVRGAPAIGVTAAWGC
CCCCEECCCCEEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
VLALREAQGPDWAARLEQGMERIAAARPTAVNLRWAVERMRGVWLAAGGEAGDPAPLLTA
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCEEEEECCCCCCCHHHHHH
FAHAAQTMQDEDVAVCKTLGRHGAACIEDGDCVLTHCNAGALATAGYGTALGVIRAAVEA
HHHHHHHCCCCHHHHHHHHCCCCCCEEECCCEEEEECCCCCEEECCCHHHHHHHHHHHHC
GKKVSVIADETRPFLQGARLTAWELERDGIPVTVACDNACALLMSRGLVQRVVVGADRIA
CCEEEEEECCCCHHHCCCCCEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHC
ANGDTANKIGTYGVALLARHFHIPFYVAAPLSTIDPATPDGAGIPIEERPELEVTHMGET
CCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCC
RLCPENVPVLNFAFDVTPAEYISGIITEKGVLYPPYGLSIWAALNDLSTGRSAGISAGPL
CCCCCCCCEEEEEEECCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHCCCCCCCCCCCCC
RDEDDAPDAEPDWSRERS
CCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDDHIRFDHQTFELHLLDQRLLPAQEADFVCRSVEDVVYALQTMVVRGAPAIGVTAAWGC
CCCCEECCCCEEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
VLALREAQGPDWAARLEQGMERIAAARPTAVNLRWAVERMRGVWLAAGGEAGDPAPLLTA
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCEEEEECCCCCCCHHHHHH
FAHAAQTMQDEDVAVCKTLGRHGAACIEDGDCVLTHCNAGALATAGYGTALGVIRAAVEA
HHHHHHHCCCCHHHHHHHHCCCCCCEEECCCEEEEECCCCCEEECCCHHHHHHHHHHHHC
GKKVSVIADETRPFLQGARLTAWELERDGIPVTVACDNACALLMSRGLVQRVVVGADRIA
CCEEEEEECCCCHHHCCCCCEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHC
ANGDTANKIGTYGVALLARHFHIPFYVAAPLSTIDPATPDGAGIPIEERPELEVTHMGET
CCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCC
RLCPENVPVLNFAFDVTPAEYISGIITEKGVLYPPYGLSIWAALNDLSTGRSAGISAGPL
CCCCCCCCEEEEEEECCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHCCCCCCCCCCCCC
RDEDDAPDAEPDWSRERS
CCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA