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The map label for this gene is ygcA [C]

Identifier: 220905512

GI number: 220905512

Start: 2711111

End: 2712763

Strand: Direct

Name: ygcA [C]

Synonym: Ddes_2251

Alternate gene names: 220905512

Gene position: 2711111-2712763 (Clockwise)

Preceding gene: 220905507

Following gene: 220905513

Centisome position: 94.35

GC content: 66.42

Gene sequence:

>1653_bases
ATGAACGATACCATTACCCTTCAGATAGAAAGCCTGACCCATGACGGTCGCGGCCTGGCCCGCGCCCACGGCGACGCGAT
TTCCATATCCGGCTCCGCTCCGGCGGGCGGTCGGGCCTCCGGGCGCACCCGCAACCGTGGCACTGTTGTTTTTGTGACCG
GCGGCCTGCCCGGGCAGACCGTGCGTGCGCGCATCACCCGCCGCAAATCCAGCTTCTGTGAAGCCGAAATGCTGGAAGTC
CTGCAGGATGCCCCGCGCTCTGCACCGCCCGCCTGTACCCACCACGGCGACTGTGGCGGATGCCCGCTGCAGACCATGCC
GTACGATATGCAGTTGCAGTGGAAGCGCCGCATCGCCCTTGATGCCATGAGCCGCATCGGCGGCCTGGACGCCGGGCTTG
TGGAGAGCCTGTTTACCAGTGTCCTGCCTTCTCCCGCGCTTGAACAGTACCGCAACAAGATGGAACTGGCCTTTGCCGGC
AGCGGCACGGAGGGCGACCCCCTGATACTCGGCCTGCGCCGCCGGAACGGGCGCGGCGTGGTTTCTGTGCCTCAATGCGC
CCTGCTGCCCGCCGCAGCCCGTGACATTGTCCGCATGGCGGCTGATCTGGCGGCACAAAGCGGACTGCCGGCGCATACCC
CACGCGATCAGGCCCGCTACAGGCAAGCGCCCCAGGAAGACACTGCGCACCACGGCAAGCCGGACGGCAAAGGCAGGCGC
GGCTCACGCCCGGCCCGCCGTGCACCCGCAAACAGCATCGCAGCAGCAGCTATGGCCGCAGAAGCAGTGCAGAACAACGG
CTTCTGGCGTTTCCTCGTTTTGCGGCGCGGGCTTTCCGCCGACCTGCGCACTCCCGGCTGGTGGGCACTTTGCATCACCA
GCCCGGGCAGCCATGAAGAGCAGGAAAAAGTACGAACTGTGGGCCAGAAGCTGCTCCAGTCCTTTCCCGCGCTGGCCGGA
TTCATTCACGAAGAACGCGCCAGTGAAGACGCCCTGGCCCAAGGGCAGAAGCGCATCGCCAGCCTGGACAGGACCGGCGC
GCACAATCCGGCCTCGGCCCGCTTTTGGCAGCCCCTTGGCGGGCGCCATTTCGCCCTGGATGCCGCATCGTTTTTTCAGG
TCAATACCGCTGCGGCGCAGGTGCTGGCAGACACGGCACTGGGCATGCTCAAGCGGCATGTCAGCCAGGAATCTCCCGCG
CTGCTCGATCTCTACTGCGGCGTGGGCGCTCCGGGCCTGCTCATGGCAGACCGCTGCGGCCGCCTGCTCGGCCTGGAACA
GGACGCAAAAGCTGTTGCCCTGGCACAGGCCAACGCCGCCGCCATGGGCTTTACCCATTGCTCCTACGTGGCCGGCGACG
CCGCCCAGCGGCTGGACAGACTTGCCCCCGCGCACGAAAATTACTGGCACCCCACGGAAACATGGGACGCCGTGCTGGTG
GACCCGCCGCGCGCGGGCCTTGCCCCCCGCGCCCTGAATGCACTGCTGCGGCTCAATGCCCACACCATACTTTATGTGTC
ATGTAATCCGGCCACGCTGGCCCGGGACGCGGCCCGGCTTCGCGGGGCCTACCGGCTGGTGGAAATGGCCGCAGTGGACC
TGTTTCCGCATACACCGCATGTGGAATGCCTGACCCTGTGGCAAAGCCTGTAA

Upstream 100 bases:

>100_bases
GTCCCACAAGCGCGTTCTTGCAGCATATACAGCCAAACCCATAGTTTTTCCTGCGAGTTTTCCTTGGCATACTGCCCTTG
CGCTGCTATGTTTTGCGGCG

Downstream 100 bases:

>100_bases
GGCCATGCGCCATGCATATTTCCGCGTAAAGTCATTGACGCGGCGCGAAGGCTGTGATAATTTACACAGCGTTGGGGTTT
ATAACGTCCATCCCTGTAAC

Product: (Uracil-5)-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MNDTITLQIESLTHDGRGLARAHGDAISISGSAPAGGRASGRTRNRGTVVFVTGGLPGQTVRARITRRKSSFCEAEMLEV
LQDAPRSAPPACTHHGDCGGCPLQTMPYDMQLQWKRRIALDAMSRIGGLDAGLVESLFTSVLPSPALEQYRNKMELAFAG
SGTEGDPLILGLRRRNGRGVVSVPQCALLPAAARDIVRMAADLAAQSGLPAHTPRDQARYRQAPQEDTAHHGKPDGKGRR
GSRPARRAPANSIAAAAMAAEAVQNNGFWRFLVLRRGLSADLRTPGWWALCITSPGSHEEQEKVRTVGQKLLQSFPALAG
FIHEERASEDALAQGQKRIASLDRTGAHNPASARFWQPLGGRHFALDAASFFQVNTAAAQVLADTALGMLKRHVSQESPA
LLDLYCGVGAPGLLMADRCGRLLGLEQDAKAVALAQANAAAMGFTHCSYVAGDAAQRLDRLAPAHENYWHPTETWDAVLV
DPPRAGLAPRALNALLRLNAHTILYVSCNPATLARDAARLRGAYRLVEMAAVDLFPHTPHVECLTLWQSL

Sequences:

>Translated_550_residues
MNDTITLQIESLTHDGRGLARAHGDAISISGSAPAGGRASGRTRNRGTVVFVTGGLPGQTVRARITRRKSSFCEAEMLEV
LQDAPRSAPPACTHHGDCGGCPLQTMPYDMQLQWKRRIALDAMSRIGGLDAGLVESLFTSVLPSPALEQYRNKMELAFAG
SGTEGDPLILGLRRRNGRGVVSVPQCALLPAAARDIVRMAADLAAQSGLPAHTPRDQARYRQAPQEDTAHHGKPDGKGRR
GSRPARRAPANSIAAAAMAAEAVQNNGFWRFLVLRRGLSADLRTPGWWALCITSPGSHEEQEKVRTVGQKLLQSFPALAG
FIHEERASEDALAQGQKRIASLDRTGAHNPASARFWQPLGGRHFALDAASFFQVNTAAAQVLADTALGMLKRHVSQESPA
LLDLYCGVGAPGLLMADRCGRLLGLEQDAKAVALAQANAAAMGFTHCSYVAGDAAQRLDRLAPAHENYWHPTETWDAVLV
DPPRAGLAPRALNALLRLNAHTILYVSCNPATLARDAARLRGAYRLVEMAAVDLFPHTPHVECLTLWQSL
>Mature_550_residues
MNDTITLQIESLTHDGRGLARAHGDAISISGSAPAGGRASGRTRNRGTVVFVTGGLPGQTVRARITRRKSSFCEAEMLEV
LQDAPRSAPPACTHHGDCGGCPLQTMPYDMQLQWKRRIALDAMSRIGGLDAGLVESLFTSVLPSPALEQYRNKMELAFAG
SGTEGDPLILGLRRRNGRGVVSVPQCALLPAAARDIVRMAADLAAQSGLPAHTPRDQARYRQAPQEDTAHHGKPDGKGRR
GSRPARRAPANSIAAAAMAAEAVQNNGFWRFLVLRRGLSADLRTPGWWALCITSPGSHEEQEKVRTVGQKLLQSFPALAG
FIHEERASEDALAQGQKRIASLDRTGAHNPASARFWQPLGGRHFALDAASFFQVNTAAAQVLADTALGMLKRHVSQESPA
LLDLYCGVGAPGLLMADRCGRLLGLEQDAKAVALAQANAAAMGFTHCSYVAGDAAQRLDRLAPAHENYWHPTETWDAVLV
DPPRAGLAPRALNALLRLNAHTILYVSCNPATLARDAARLRGAYRLVEMAAVDLFPHTPHVECLTLWQSL

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=485, Percent_Identity=27.4226804123711, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI51173878, Length=485, Percent_Identity=27.4226804123711, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI269784680, Length=191, Percent_Identity=36.1256544502618, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI269784676, Length=191, Percent_Identity=36.1256544502618, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI20149688, Length=191, Percent_Identity=36.1256544502618, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI269784678, Length=191, Percent_Identity=36.1256544502618, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI1789148, Length=193, Percent_Identity=32.1243523316062, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1787083, Length=177, Percent_Identity=35.5932203389831, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1790403, Length=155, Percent_Identity=31.6129032258064, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24666579, Length=482, Percent_Identity=23.4439834024896, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 59037; Mature: 59037

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS50926 TRAM ; PS01230 TRMA_1 ; PS01231 TRMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDTITLQIESLTHDGRGLARAHGDAISISGSAPAGGRASGRTRNRGTVVFVTGGLPGQT
CCCEEEEEEECCCCCCCCHHHHCCCEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCHH
VRARITRRKSSFCEAEMLEVLQDAPRSAPPACTHHGDCGGCPLQTMPYDMQLQWKRRIAL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
DAMSRIGGLDAGLVESLFTSVLPSPALEQYRNKMELAFAGSGTEGDPLILGLRRRNGRGV
HHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHCCEEEEEECCCCCCCCEEEEEEECCCCCE
VSVPQCALLPAAARDIVRMAADLAAQSGLPAHTPRDQARYRQAPQEDTAHHGKPDGKGRR
EECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHCCCCCCCCCCCC
GSRPARRAPANSIAAAAMAAEAVQNNGFWRFLVLRRGLSADLRTPGWWALCITSPGSHEE
CCCCHHHCCCHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCCCCCCCEEEEEEECCCCCHH
QEKVRTVGQKLLQSFPALAGFIHEERASEDALAQGQKRIASLDRTGAHNPASARFWQPLG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCC
GRHFALDAASFFQVNTAAAQVLADTALGMLKRHVSQESPALLDLYCGVGAPGLLMADRCG
CCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHH
RLLGLEQDAKAVALAQANAAAMGFTHCSYVAGDAAQRLDRLAPAHENYWHPTETWDAVLV
HHHCCCCCCCEEEHHHCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEE
DPPRAGLAPRALNALLRLNAHTILYVSCNPATLARDAARLRGAYRLVEMAAVDLFPHTPH
CCCCCCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VECLTLWQSL
HHHHHHHHCC
>Mature Secondary Structure
MNDTITLQIESLTHDGRGLARAHGDAISISGSAPAGGRASGRTRNRGTVVFVTGGLPGQT
CCCEEEEEEECCCCCCCCHHHHCCCEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCHH
VRARITRRKSSFCEAEMLEVLQDAPRSAPPACTHHGDCGGCPLQTMPYDMQLQWKRRIAL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
DAMSRIGGLDAGLVESLFTSVLPSPALEQYRNKMELAFAGSGTEGDPLILGLRRRNGRGV
HHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHCCEEEEEECCCCCCCCEEEEEEECCCCCE
VSVPQCALLPAAARDIVRMAADLAAQSGLPAHTPRDQARYRQAPQEDTAHHGKPDGKGRR
EECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHCCCCCCCCCCCC
GSRPARRAPANSIAAAAMAAEAVQNNGFWRFLVLRRGLSADLRTPGWWALCITSPGSHEE
CCCCHHHCCCHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCCCCCCCEEEEEEECCCCCHH
QEKVRTVGQKLLQSFPALAGFIHEERASEDALAQGQKRIASLDRTGAHNPASARFWQPLG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCC
GRHFALDAASFFQVNTAAAQVLADTALGMLKRHVSQESPALLDLYCGVGAPGLLMADRCG
CCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHH
RLLGLEQDAKAVALAQANAAAMGFTHCSYVAGDAAQRLDRLAPAHENYWHPTETWDAVLV
HHHCCCCCCCEEEHHHCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEE
DPPRAGLAPRALNALLRLNAHTILYVSCNPATLARDAARLRGAYRLVEMAAVDLFPHTPH
CCCCCCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VECLTLWQSL
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA