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The map label for this gene is pyrD [H]

Identifier: 220905462

GI number: 220905462

Start: 2652719

End: 2653645

Strand: Direct

Name: pyrD [H]

Synonym: Ddes_2200

Alternate gene names: 220905462

Gene position: 2652719-2653645 (Clockwise)

Preceding gene: 220905461

Following gene: 220905463

Centisome position: 92.32

GC content: 63.32

Gene sequence:

>927_bases
ATGGACCTTTCTGTTACGCTGAACGGGCAAACACACGATCTGCCCCTCAAAAATCCCATACTTACGGCTTCCGGCACGTT
TGGCTACGGTGTGGAATTCGCCAGCTACGGCGACCTTGCCGGTCTTGGCGGCATGGTGGTCAAGGGGCTTTCCCTCGAGC
CGCGCGAGGGCAATCCCACCCCGCGCATCGTGGAGACCGTCTCCGGCATGCTCAATGCCGTTGGCCTGCAAAATGACGGC
GTGGATGTTTTCTGCACGCAAAAGCTTCCCCTGCTGCCCTGGCAGGAGACTGCCGTTATCGCCAACATTTACGCCTCTTC
TGCCGAAGAATTCGGCCGTCTGGCCGCCCGCCTCAATGACGAGGAAGGCGTGGCCGCCCTGGAGGTGAACGTATCCTGCC
CCAACGTGCGCGAAGGCGGCGTGGCCTTCGGCCAGGACCCGGGCATGATCGCCCAGGTCACGTCCATCGTGCGCCACGCG
GCCCCCGGCAAGCACATCATGGTCAAACTTTCGCCCAACGTCACCGACATCACGGTTATGGCACGCGCGGCGGAAGACGC
CGGGGCAGACAGCATATCCTGCATCAACACCCTGCTGGGTATGGCCGTGGACCTGCAAACCCGCCGTCCGTCACTGGCAA
ACGTGGTGGGCGGGCTTTCCGGCCCGGCCATCAAGCCTGTGGCCCTGCGCTGCGTATGGCAGGTGGCCCGCGCGGTCAAG
ATTCCCGTAATCGGCGTGGGCGGTATCTCCTGCGTGGAAGACGTGCTGGAATTCATCCTGGCAGGCGCGCACGCGGTTCA
GATCGGCACGGCAAGCTTCATGCGGCCGGACTGCGCCTTTGACCTTGTACAGCAACTGCCCGAAGCCTGCGAACGTCTGG
GCATCACCTCGCTGCAAGAGCTGCGCGGCAGCCTGCAAGTGGACTGA

Upstream 100 bases:

>100_bases
ATGGCGGACACGCCCCGGCGGGCACAAAACACCTTGCCACCCCCGCCCGGCGCATGGATGTGCGCCCCGGCGGGTCTGCG
TGGTTACTGGAGAATGCGGT

Downstream 100 bases:

>100_bases
TTTATGGCGCTTAACGTCATTGCAGCCCGGTCCGAGGCGGAAACAGGCCAGTTTCTGGACCTGCCCTGGAGCATTTATGC
CCAAAGCCCCCTGTGGACCC

Product: dihydroorotate dehydrogenase family protein

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MDLSVTLNGQTHDLPLKNPILTASGTFGYGVEFASYGDLAGLGGMVVKGLSLEPREGNPTPRIVETVSGMLNAVGLQNDG
VDVFCTQKLPLLPWQETAVIANIYASSAEEFGRLAARLNDEEGVAALEVNVSCPNVREGGVAFGQDPGMIAQVTSIVRHA
APGKHIMVKLSPNVTDITVMARAAEDAGADSISCINTLLGMAVDLQTRRPSLANVVGGLSGPAIKPVALRCVWQVARAVK
IPVIGVGGISCVEDVLEFILAGAHAVQIGTASFMRPDCAFDLVQQLPEACERLGITSLQELRGSLQVD

Sequences:

>Translated_308_residues
MDLSVTLNGQTHDLPLKNPILTASGTFGYGVEFASYGDLAGLGGMVVKGLSLEPREGNPTPRIVETVSGMLNAVGLQNDG
VDVFCTQKLPLLPWQETAVIANIYASSAEEFGRLAARLNDEEGVAALEVNVSCPNVREGGVAFGQDPGMIAQVTSIVRHA
APGKHIMVKLSPNVTDITVMARAAEDAGADSISCINTLLGMAVDLQTRRPSLANVVGGLSGPAIKPVALRCVWQVARAVK
IPVIGVGGISCVEDVLEFILAGAHAVQIGTASFMRPDCAFDLVQQLPEACERLGITSLQELRGSLQVD
>Mature_308_residues
MDLSVTLNGQTHDLPLKNPILTASGTFGYGVEFASYGDLAGLGGMVVKGLSLEPREGNPTPRIVETVSGMLNAVGLQNDG
VDVFCTQKLPLLPWQETAVIANIYASSAEEFGRLAARLNDEEGVAALEVNVSCPNVREGGVAFGQDPGMIAQVTSIVRHA
APGKHIMVKLSPNVTDITVMARAAEDAGADSISCINTLLGMAVDLQTRRPSLANVVGGLSGPAIKPVALRCVWQVARAVK
IPVIGVGGISCVEDVLEFILAGAHAVQIGTASFMRPDCAFDLVQQLPEACERLGITSLQELRGSLQVD

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=294, Percent_Identity=32.9931972789116, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI45006951, Length=311, Percent_Identity=26.0450160771704, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI87082059, Length=328, Percent_Identity=27.7439024390244, Blast_Score=96, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71984108, Length=170, Percent_Identity=34.1176470588235, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322633, Length=321, Percent_Identity=27.4143302180685, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24640763, Length=187, Percent_Identity=39.572192513369, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI18858217, Length=187, Percent_Identity=39.572192513369, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI281361352, Length=320, Percent_Identity=28.125, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17137316, Length=320, Percent_Identity=28.125, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 32240; Mature: 32240

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00911 DHODEHASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLSVTLNGQTHDLPLKNPILTASGTFGYGVEFASYGDLAGLGGMVVKGLSLEPREGNPT
CCEEEEECCCCCCCCCCCCEEEECCCCCCCEEECCCCCCCCCCHHHHCCCCCCCCCCCCC
PRIVETVSGMLNAVGLQNDGVDVFCTQKLPLLPWQETAVIANIYASSAEEFGRLAARLND
HHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
EEGVAALEVNVSCPNVREGGVAFGQDPGMIAQVTSIVRHAAPGKHIMVKLSPNVTDITVM
CCCEEEEEEECCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEE
ARAAEDAGADSISCINTLLGMAVDLQTRRPSLANVVGGLSGPAIKPVALRCVWQVARAVK
EEHHHHCCCCHHHHHHHHHHHHEECCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHC
IPVIGVGGISCVEDVLEFILAGAHAVQIGTASFMRPDCAFDLVQQLPEACERLGITSLQE
CCEEECCCHHHHHHHHHHHHCCCHHEEECCHHHCCCHHHHHHHHHHHHHHHHCCCHHHHH
LRGSLQVD
HHHCCCCC
>Mature Secondary Structure
MDLSVTLNGQTHDLPLKNPILTASGTFGYGVEFASYGDLAGLGGMVVKGLSLEPREGNPT
CCEEEEECCCCCCCCCCCCEEEECCCCCCCEEECCCCCCCCCCHHHHCCCCCCCCCCCCC
PRIVETVSGMLNAVGLQNDGVDVFCTQKLPLLPWQETAVIANIYASSAEEFGRLAARLND
HHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
EEGVAALEVNVSCPNVREGGVAFGQDPGMIAQVTSIVRHAAPGKHIMVKLSPNVTDITVM
CCCEEEEEEECCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEE
ARAAEDAGADSISCINTLLGMAVDLQTRRPSLANVVGGLSGPAIKPVALRCVWQVARAVK
EEHHHHCCCCHHHHHHHHHHHHEECCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHC
IPVIGVGGISCVEDVLEFILAGAHAVQIGTASFMRPDCAFDLVQQLPEACERLGITSLQE
CCEEECCCHHHHHHHHHHHHCCCHHEEECCHHHCCCHHHHHHHHHHHHHHHHCCCHHHHH
LRGSLQVD
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA