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The map label for this gene is atpA

Identifier: 220905448

GI number: 220905448

Start: 2636447

End: 2637955

Strand: Direct

Name: atpA

Synonym: Ddes_2186

Alternate gene names: 220905448

Gene position: 2636447-2637955 (Clockwise)

Preceding gene: 220905447

Following gene: 220905449

Centisome position: 91.75

GC content: 61.9

Gene sequence:

>1509_bases
ATGCAGATCAAAGCGGAAGAGATAAGCAAGATCATTGAGGATCAAATCCAGAACTACGAGCAGCGCGTAGAAATGAGCGA
AACCGGCACCGTGCTTTATGTTGGTGACGGCATCGCCCGCGTCTACGGCGTGCAGAACGCCATGTCGATGGAACTGCTGG
AATTTCCCGGCGGCATCATGGGCATGGTGCTCAACCTCGAAGAGGACAACGTGGGTGTCGCTCTGCTCGGTTCGGACGTG
GGCATCAAAGAAGGCGACCCGGTCAAACGTACCGGCAAGATCTTCTCCGTGCCTGTTGGCGACGGCGTTATGGGCCGCGT
GCTCAACCCCCTGGGTGAGCCGATCGACGGCCTCGGCCCCATCGATGCAGCCGAAGTGCGCCCGGTGGAAATCAAGGCCC
CCGGCATCATTGCCCGCAAAAGCGTGCATGAGCCCATGCCCACGGGTCTGAAGGCCATTGACGCCATGACTCCTATTGGC
CGCGGCCAGCGCGAGCTGATCATCGGCGACCGCCAGACCGGTAAAACCGCCGTTTGCCTCGACGCCATCCTGGCGCAGAA
AGAAACGGGCATCCACTGCTTCTACGTGGCCATCGGCCAGAAGAAGTCTTCGGTGGCCCTGGTGGCCGACACGCTGCGCC
GTCACGGTGCGCTTGAGTACACCACCATCATTTCCGCCACCGCGTCCGATCCCGCGCCGCTGCAGTACATTGCGGCCTAC
ACGGGCTGCACCATGGCGGAGTACTACCGCGACAGCGGCAAACACGCGCTCATCATTTATGACGACCTTTCCAAGCAGGC
CGTGGCCTATCGCCAGATGTCCCTGCTGCTCCGCCGTCCTCCGGGACGTGAAGCCTTCCCCGGCGACGTCTTCTACCTGC
ACTCGCGCCTGCTCGAACGCGCGGCCAAGGTAAACGACAGCCTCGGTGCGGGTTCACTGACGGCTCTGCCCATCATTGAA
ACCCAGGCTGGCGACGTGTCCGCGTACATCCCCACCAACGTGATCTCCATCACCGACGGTCAGGTGTACCTTGAGCCCAA
CCTTTTCAACGCCGGTGTGCGCCCGGCCATTAACGTGGGTCTTTCCGTGTCCCGCGTAGGTGGCGCGGCGCAGATCAAGG
CCATGAAGCAGGTGGCGGGCACCATGCGCCTGGACCTTGCCCAGTACCGCGAACTGGCGGCCTTCGCCCAGTTCGGCTCG
GACCTGGACAAGGGGACAAAAGCCAAGCTCGACCGTGGCGCGCGCCTGGTGGAACTGCTCAAGCAGCCCCAGTACCAGCC
CATGCCTTCCAATGAACAGGTCGCTTCCATCTACGCCGCTACCCGCGGCCATATGGATGACGTGCCGGTGGAAGACATCC
GCCGTTTTGAGGCCGCCCTGCTCACCTTCCTGCGCGACACCAGGAAGGACGTGCTGGACGCCATTAAAGAAAAGCAAGTC
ATTGACGAGGCTGTGGAAAAAGCGCTTACCGAGGCTATTGCCGCCTTCAAGCAGGGCTGGACGGCCTAG

Upstream 100 bases:

>100_bases
AGGGGGGATGGTGCTCAAAATGGGTGACCGGGTGCTGGACGCAAGTCTGCGCGCGCAATTGGGTATCCTTCGGGAGACTT
TCAAGAGGGGTGAATAGCAC

Downstream 100 bases:

>100_bases
GGGCCCCCAATATCCGGGAGAAAAGCATGCCTTCACTCAAAGACGTAAAAATGAAGATCGTGGGGGTCGGTAAGACCAAG
CAGATCACCAAGGCCATGAA

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MQIKAEEISKIIEDQIQNYEQRVEMSETGTVLYVGDGIARVYGVQNAMSMELLEFPGGIMGMVLNLEEDNVGVALLGSDV
GIKEGDPVKRTGKIFSVPVGDGVMGRVLNPLGEPIDGLGPIDAAEVRPVEIKAPGIIARKSVHEPMPTGLKAIDAMTPIG
RGQRELIIGDRQTGKTAVCLDAILAQKETGIHCFYVAIGQKKSSVALVADTLRRHGALEYTTIISATASDPAPLQYIAAY
TGCTMAEYYRDSGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAFPGDVFYLHSRLLERAAKVNDSLGAGSLTALPIIE
TQAGDVSAYIPTNVISITDGQVYLEPNLFNAGVRPAINVGLSVSRVGGAAQIKAMKQVAGTMRLDLAQYRELAAFAQFGS
DLDKGTKAKLDRGARLVELLKQPQYQPMPSNEQVASIYAATRGHMDDVPVEDIRRFEAALLTFLRDTRKDVLDAIKEKQV
IDEAVEKALTEAIAAFKQGWTA

Sequences:

>Translated_502_residues
MQIKAEEISKIIEDQIQNYEQRVEMSETGTVLYVGDGIARVYGVQNAMSMELLEFPGGIMGMVLNLEEDNVGVALLGSDV
GIKEGDPVKRTGKIFSVPVGDGVMGRVLNPLGEPIDGLGPIDAAEVRPVEIKAPGIIARKSVHEPMPTGLKAIDAMTPIG
RGQRELIIGDRQTGKTAVCLDAILAQKETGIHCFYVAIGQKKSSVALVADTLRRHGALEYTTIISATASDPAPLQYIAAY
TGCTMAEYYRDSGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAFPGDVFYLHSRLLERAAKVNDSLGAGSLTALPIIE
TQAGDVSAYIPTNVISITDGQVYLEPNLFNAGVRPAINVGLSVSRVGGAAQIKAMKQVAGTMRLDLAQYRELAAFAQFGS
DLDKGTKAKLDRGARLVELLKQPQYQPMPSNEQVASIYAATRGHMDDVPVEDIRRFEAALLTFLRDTRKDVLDAIKEKQV
IDEAVEKALTEAIAAFKQGWTA
>Mature_502_residues
MQIKAEEISKIIEDQIQNYEQRVEMSETGTVLYVGDGIARVYGVQNAMSMELLEFPGGIMGMVLNLEEDNVGVALLGSDV
GIKEGDPVKRTGKIFSVPVGDGVMGRVLNPLGEPIDGLGPIDAAEVRPVEIKAPGIIARKSVHEPMPTGLKAIDAMTPIG
RGQRELIIGDRQTGKTAVCLDAILAQKETGIHCFYVAIGQKKSSVALVADTLRRHGALEYTTIISATASDPAPLQYIAAY
TGCTMAEYYRDSGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAFPGDVFYLHSRLLERAAKVNDSLGAGSLTALPIIE
TQAGDVSAYIPTNVISITDGQVYLEPNLFNAGVRPAINVGLSVSRVGGAAQIKAMKQVAGTMRLDLAQYRELAAFAQFGS
DLDKGTKAKLDRGARLVELLKQPQYQPMPSNEQVASIYAATRGHMDDVPVEDIRRFEAALLTFLRDTRKDVLDAIKEKQV
IDEAVEKALTEAIAAFKQGWTA

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=504, Percent_Identity=61.7063492063492, Blast_Score=627, Evalue=1e-179,
Organism=Homo sapiens, GI4757810, Length=504, Percent_Identity=61.7063492063492, Blast_Score=627, Evalue=1e-179,
Organism=Homo sapiens, GI19913428, Length=295, Percent_Identity=30.1694915254237, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI19913426, Length=295, Percent_Identity=29.4915254237288, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI32189394, Length=409, Percent_Identity=25.4278728606357, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI19913424, Length=257, Percent_Identity=27.2373540856031, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1790172, Length=513, Percent_Identity=55.1656920077973, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI1790170, Length=471, Percent_Identity=26.1146496815287, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1788251, Length=326, Percent_Identity=28.2208588957055, Blast_Score=104, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71988063, Length=498, Percent_Identity=62.6506024096386, Blast_Score=635, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988080, Length=498, Percent_Identity=62.6506024096386, Blast_Score=633, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988074, Length=498, Percent_Identity=58.433734939759, Blast_Score=576, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI17570191, Length=322, Percent_Identity=27.639751552795, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17510931, Length=371, Percent_Identity=26.6846361185984, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25144756, Length=405, Percent_Identity=24.4444444444444, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71988068, Length=73, Percent_Identity=52.0547945205479, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=60, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17565854, Length=256, Percent_Identity=25.78125, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6319370, Length=498, Percent_Identity=60.2409638554217, Blast_Score=622, Evalue=1e-179,
Organism=Saccharomyces cerevisiae, GI6319603, Length=334, Percent_Identity=28.7425149700599, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6322581, Length=449, Percent_Identity=25.3897550111359, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6320016, Length=155, Percent_Identity=32.258064516129, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24658560, Length=501, Percent_Identity=61.6766467065868, Blast_Score=623, Evalue=1e-179,
Organism=Drosophila melanogaster, GI281361666, Length=294, Percent_Identity=29.2517006802721, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646341, Length=294, Percent_Identity=29.2517006802721, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17136796, Length=294, Percent_Identity=29.2517006802721, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24638766, Length=444, Percent_Identity=25.4504504504505, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28574560, Length=425, Percent_Identity=24.9411764705882, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI20129479, Length=256, Percent_Identity=27.34375, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583988, Length=255, Percent_Identity=25.4901960784314, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583986, Length=255, Percent_Identity=25.4901960784314, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583984, Length=255, Percent_Identity=25.4901960784314, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583992, Length=255, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_DESDA (B8J437)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002480760.1
- GeneID:   7285902
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_2186
- HOGENOM:   HBG565875
- ProtClustDB:   PRK09281
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 54328; Mature: 54328

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIKAEEISKIIEDQIQNYEQRVEMSETGTVLYVGDGIARVYGVQNAMSMELLEFPGGIM
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCEE
GMVLNLEEDNVGVALLGSDVGIKEGDPVKRTGKIFSVPVGDGVMGRVLNPLGEPIDGLGP
EEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCC
IDAAEVRPVEIKAPGIIARKSVHEPMPTGLKAIDAMTPIGRGQRELIIGDRQTGKTAVCL
CCCCCCCEEEEECCCEEEHHHCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHH
DAILAQKETGIHCFYVAIGQKKSSVALVADTLRRHGALEYTTIISATASDPAPLQYIAAY
HHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHHHH
TGCTMAEYYRDSGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAFPGDVFYLHSRLLER
HCCHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
AAKVNDSLGAGSLTALPIIETQAGDVSAYIPTNVISITDGQVYLEPNLFNAGVRPAINVG
HHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEECCCCCCCCCCCHHHCC
LSVSRVGGAAQIKAMKQVAGTMRLDLAQYRELAAFAQFGSDLDKGTKAKLDRGARLVELL
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHH
KQPQYQPMPSNEQVASIYAATRGHMDDVPVEDIRRFEAALLTFLRDTRKDVLDAIKEKQV
HCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDEAVEKALTEAIAAFKQGWTA
HHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQIKAEEISKIIEDQIQNYEQRVEMSETGTVLYVGDGIARVYGVQNAMSMELLEFPGGIM
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCEE
GMVLNLEEDNVGVALLGSDVGIKEGDPVKRTGKIFSVPVGDGVMGRVLNPLGEPIDGLGP
EEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCC
IDAAEVRPVEIKAPGIIARKSVHEPMPTGLKAIDAMTPIGRGQRELIIGDRQTGKTAVCL
CCCCCCCEEEEECCCEEEHHHCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHH
DAILAQKETGIHCFYVAIGQKKSSVALVADTLRRHGALEYTTIISATASDPAPLQYIAAY
HHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHHHH
TGCTMAEYYRDSGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAFPGDVFYLHSRLLER
HCCHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
AAKVNDSLGAGSLTALPIIETQAGDVSAYIPTNVISITDGQVYLEPNLFNAGVRPAINVG
HHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEECCCCCCCCCCCHHHCC
LSVSRVGGAAQIKAMKQVAGTMRLDLAQYRELAAFAQFGSDLDKGTKAKLDRGARLVELL
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHH
KQPQYQPMPSNEQVASIYAATRGHMDDVPVEDIRRFEAALLTFLRDTRKDVLDAIKEKQV
HCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDEAVEKALTEAIAAFKQGWTA
HHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA