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The map label for this gene is aroK [H]

Identifier: 220905235

GI number: 220905235

Start: 2376567

End: 2377145

Strand: Direct

Name: aroK [H]

Synonym: Ddes_1973

Alternate gene names: 220905235

Gene position: 2376567-2377145 (Clockwise)

Preceding gene: 220905221

Following gene: 220905236

Centisome position: 82.71

GC content: 60.1

Gene sequence:

>579_bases
ATGCCCGCGCCCTCCCCTGCCGACGCCCCGCCTGCCATGTCTGGCCCAACCAGGCCATCTCCCTGCATAATCCTCATCGG
CATGGCCGGAGCGGGCAAATCCACCGTGGGCGAAGCACTGGCCCGCACGCTTGGCTGGGCCTTTATGGACAGCGATCATC
TTATTGAAGCCGTGTATGCCGCCCGCCTGCAAGATGTTACCGATGCGCTCGGCAAGTCTGCGTTTCTGGATGTGGAGTCC
AGCGTTGTCAGCGCCATAAAGGCCAATCGCACGGTTATTGCCACAGGCGGCAGTGTTGTTTACCGCGAGCAGACCATGCG
ACACCTGGCCTCACTGGGACCGCTGGTTTACCTGGATGTGCCTTTTACCGTGGTGGAAGAACGTATTGCCCGGAATCCGC
AACGCGGCCTTGCCATTGCCCCCGGCCAGACCCTGCGCGACATTTTTCAGGAGCGGGAAGAGCTTTACACCCGCTACGCC
ACATTGCGCTGTCCCGCTGCAGACAAAAATCCACAACAGTGTGTGAACTGGATAGTGCAGCAACTGCCCGCTGAAGTGAC
CATGCCTGACAGGCCGTAA

Upstream 100 bases:

>100_bases
GCCCTGCCGCAAGAGATCTTTACGCTTTTGCCTCTGCCTGCCTTGACAGGTCGCCGCCGCTTAGGCACATTTTCAAAAAA
ATTCCCCATCAGGAGTCGAA

Downstream 100 bases:

>100_bases
CAGCCGTATGCCACGGGACCATACCGTTGCCGTGGCTTTTTTCAACAGCGGCCCTGCCTTTCCCTTCCGGCCGAAGCCCT
ACGCAGCAGGCGGCACGCTG

Product: shikimate kinase

Products: NA

Alternate protein names: SK [H]

Number of amino acids: Translated: 192; Mature: 191

Protein sequence:

>192_residues
MPAPSPADAPPAMSGPTRPSPCIILIGMAGAGKSTVGEALARTLGWAFMDSDHLIEAVYAARLQDVTDALGKSAFLDVES
SVVSAIKANRTVIATGGSVVYREQTMRHLASLGPLVYLDVPFTVVEERIARNPQRGLAIAPGQTLRDIFQEREELYTRYA
TLRCPAADKNPQQCVNWIVQQLPAEVTMPDRP

Sequences:

>Translated_192_residues
MPAPSPADAPPAMSGPTRPSPCIILIGMAGAGKSTVGEALARTLGWAFMDSDHLIEAVYAARLQDVTDALGKSAFLDVES
SVVSAIKANRTVIATGGSVVYREQTMRHLASLGPLVYLDVPFTVVEERIARNPQRGLAIAPGQTLRDIFQEREELYTRYA
TLRCPAADKNPQQCVNWIVQQLPAEVTMPDRP
>Mature_191_residues
PAPSPADAPPAMSGPTRPSPCIILIGMAGAGKSTVGEALARTLGWAFMDSDHLIEAVYAARLQDVTDALGKSAFLDVESS
VVSAIKANRTVIATGGSVVYREQTMRHLASLGPLVYLDVPFTVVEERIARNPQRGLAIAPGQTLRDIFQEREELYTRYAT
LRCPAADKNPQQCVNWIVQQLPAEVTMPDRP

Specific function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate [H]

COG id: COG0703

COG function: function code E; Shikimate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate kinase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=143, Percent_Identity=30.0699300699301, Blast_Score=68, Evalue=5e-12,
Organism=Escherichia coli, GI87082255, Length=169, Percent_Identity=32.5443786982249, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1786587, Length=161, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=5e-14,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000623
- InterPro:   IPR023000 [H]

Pfam domain/function: PF01202 SKI [H]

EC number: =2.7.1.71 [H]

Molecular weight: Translated: 20729; Mature: 20598

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAPSPADAPPAMSGPTRPSPCIILIGMAGAGKSTVGEALARTLGWAFMDSDHLIEAVYA
CCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ARLQDVTDALGKSAFLDVESSVVSAIKANRTVIATGGSVVYREQTMRHLASLGPLVYLDV
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEECCCEEHHHHHHHHHHHHCCEEEEEC
PFTVVEERIARNPQRGLAIAPGQTLRDIFQEREELYTRYATLRCPAADKNPQQCVNWIVQ
CHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
QLPAEVTMPDRP
HCCCCCCCCCCC
>Mature Secondary Structure 
PAPSPADAPPAMSGPTRPSPCIILIGMAGAGKSTVGEALARTLGWAFMDSDHLIEAVYA
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ARLQDVTDALGKSAFLDVESSVVSAIKANRTVIATGGSVVYREQTMRHLASLGPLVYLDV
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEECCCEEHHHHHHHHHHHHCCEEEEEC
PFTVVEERIARNPQRGLAIAPGQTLRDIFQEREELYTRYATLRCPAADKNPQQCVNWIVQ
CHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
QLPAEVTMPDRP
HCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA