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The map label for this gene is mtaD

Identifier: 220905193

GI number: 220905193

Start: 2324847

End: 2326169

Strand: Direct

Name: mtaD

Synonym: Ddes_1931

Alternate gene names: 220905193

Gene position: 2324847-2326169 (Clockwise)

Preceding gene: 220905189

Following gene: 220905194

Centisome position: 80.91

GC content: 61.22

Gene sequence:

>1323_bases
ATGCGCCCCTGCCAGACACTTGTTCACGCCGCCCTCATTGTCACTCAGGACAAAGAACGCCGCATTCTTGAAAACGCCAG
CATGGCCGTTACAGACGGCATCGTGGCCGATCTCGGCCCGCGTCATGAAATGATCACCTGCTGGCAGCCTCGCCACGAAG
CCGATTTCGGCCGGTGCCTGTTGCTGCCGGGCCTTGTCAATGCCCATACGCATTCGGCCATGACCTTTTTGCGCGGCCTG
GCCGATGACATGCCCCTTATGGACTGGCTCAACAAGCGCATCTTTCCGGTGGAGCAAAAGCTCACGCCCGAAATCGTGCG
CCTTGGCAGCCTTATGGGCTATGCGGAGATGCTGCGCACCGGCACAACAGCCTGCGTGGATATGTACATTTTTGAAAAAG
AGGCCATGGCTGCTGCGGATCAAGCCGGGCTGCGCTGCCTGGGGGGCGAGGTGGTTTTTGCCTTTCCTTCCGCCGCCTTT
CCCGGCCCGGAGGCGGCCCTCGAGGAAACCCGCGCCCTGGCACAAAAATACGCGGGGCATCCCAGACTGAGCATAGCCGT
CAACCCGCACAGCGTTTACACCACGACGCCAGAAATACTCGCCGCCTGCCGCGACCTTGCCCGCGAGCTGGCCCTGCCGC
TTCACATGCATCTGGCCGAAACAGCCGAAGAAACACAGATATGCCTGCATGCGCACGGTAAAAGGCCCGTGGCCTGCTGC
CGCAGCCTTGAGCTGCTGGATGGCCCCTGCACGCTGGCCCATGTGGTGGACGTCACCCCGGACGAACTGGACTTCCTGGC
CCAAAGGGGCGCGGTGGCGGTCCATAATATTTCCTCAAACATGAAGCTTGCCTCCGGCGCATCCCCCGTACCCGCCATGC
TTGAGCGGGGCATGCCCGTCGCCTTGGGAACAGACGGAGCCGCCAGCAACAACCGGCTTAACATGTTTACCGAAATGGGT
CGTGCCGCCCTGCTGCACAAGCTCACCGGCATGGATCCTACCCTTCTGCCGGCCCAGACCGTGCTGGACATGGCCACTCT
TGGCGGAGCGGCCGCCATGCACGACAACCGCCTGGGCAGCCTGGCCGTGGGCAAGGCGGCGGACTGCGTGGCCCTGGACC
TTGCGGCCCCCAATATGCAACCCCTGTACAATGCCGTTTCACACCTTGTTTACGCTGCCACCGGCATGGAAAACCGTATG
ACGATGATTGCCGGAGAAATTGTTTATGAGGATGGAAAATTTACCCGTTTCGACTATGACGCCCTGTGCCGCGAAATGAC
CTCCATACGTGACTTTGTACGCCGTCAGGCCGGTTTGGCCTGA

Upstream 100 bases:

>100_bases
TGTCACGCACGGGATAAGGATGCATGCCACACAGGAACTTGCATCCCGTAGCTGACGGGGCTACAGAATATTTTTTCGCA
AACGCCGCACAGGAGTTGCC

Downstream 100 bases:

>100_bases
CCCGCCCACGCGGGGCGGCAGGGCCGCATTTCCGGCCCGGGGCATGGGGCATATCCGCCCTGGCCGCCGCTGCCAGGAAA
TTCTCGCCTCTCGCCTCTTG

Product: amidohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MRPCQTLVHAALIVTQDKERRILENASMAVTDGIVADLGPRHEMITCWQPRHEADFGRCLLLPGLVNAHTHSAMTFLRGL
ADDMPLMDWLNKRIFPVEQKLTPEIVRLGSLMGYAEMLRTGTTACVDMYIFEKEAMAAADQAGLRCLGGEVVFAFPSAAF
PGPEAALEETRALAQKYAGHPRLSIAVNPHSVYTTTPEILAACRDLARELALPLHMHLAETAEETQICLHAHGKRPVACC
RSLELLDGPCTLAHVVDVTPDELDFLAQRGAVAVHNISSNMKLASGASPVPAMLERGMPVALGTDGAASNNRLNMFTEMG
RAALLHKLTGMDPTLLPAQTVLDMATLGGAAAMHDNRLGSLAVGKAADCVALDLAAPNMQPLYNAVSHLVYAATGMENRM
TMIAGEIVYEDGKFTRFDYDALCREMTSIRDFVRRQAGLA

Sequences:

>Translated_440_residues
MRPCQTLVHAALIVTQDKERRILENASMAVTDGIVADLGPRHEMITCWQPRHEADFGRCLLLPGLVNAHTHSAMTFLRGL
ADDMPLMDWLNKRIFPVEQKLTPEIVRLGSLMGYAEMLRTGTTACVDMYIFEKEAMAAADQAGLRCLGGEVVFAFPSAAF
PGPEAALEETRALAQKYAGHPRLSIAVNPHSVYTTTPEILAACRDLARELALPLHMHLAETAEETQICLHAHGKRPVACC
RSLELLDGPCTLAHVVDVTPDELDFLAQRGAVAVHNISSNMKLASGASPVPAMLERGMPVALGTDGAASNNRLNMFTEMG
RAALLHKLTGMDPTLLPAQTVLDMATLGGAAAMHDNRLGSLAVGKAADCVALDLAAPNMQPLYNAVSHLVYAATGMENRM
TMIAGEIVYEDGKFTRFDYDALCREMTSIRDFVRRQAGLA
>Mature_440_residues
MRPCQTLVHAALIVTQDKERRILENASMAVTDGIVADLGPRHEMITCWQPRHEADFGRCLLLPGLVNAHTHSAMTFLRGL
ADDMPLMDWLNKRIFPVEQKLTPEIVRLGSLMGYAEMLRTGTTACVDMYIFEKEAMAAADQAGLRCLGGEVVFAFPSAAF
PGPEAALEETRALAQKYAGHPRLSIAVNPHSVYTTTPEILAACRDLARELALPLHMHLAETAEETQICLHAHGKRPVACC
RSLELLDGPCTLAHVVDVTPDELDFLAQRGAVAVHNISSNMKLASGASPVPAMLERGMPVALGTDGAASNNRLNMFTEMG
RAALLHKLTGMDPTLLPAQTVLDMATLGGAAAMHDNRLGSLAVGKAADCVALDLAAPNMQPLYNAVSHLVYAATGMENRM
TMIAGEIVYEDGKFTRFDYDALCREMTSIRDFVRRQAGLA

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family

Homologues:

Organism=Homo sapiens, GI4758426, Length=344, Percent_Identity=24.7093023255814, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI1789249, Length=413, Percent_Identity=26.1501210653753, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI87082177, Length=427, Percent_Identity=25.2927400468384, Blast_Score=89, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17540282, Length=353, Percent_Identity=24.3626062322946, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6319963, Length=339, Percent_Identity=28.023598820059, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24643849, Length=397, Percent_Identity=26.9521410579345, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTAD_DESDA (B8J2Q8)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002480505.1
- ProteinModelPortal:   B8J2Q8
- GeneID:   7285647
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_1931
- HOGENOM:   HBG668170
- ProtClustDB:   CLSK705430
- HAMAP:   MF_01281
- InterPro:   IPR006680
- InterPro:   IPR011059

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.4.28

Molecular weight: Translated: 47626; Mature: 47626

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: BINDING 98-98 BINDING 190-190 BINDING 220-220 BINDING 305-305

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
8.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
8.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPCQTLVHAALIVTQDKERRILENASMAVTDGIVADLGPRHEMITCWQPRHEADFGRCL
CCHHHHHHHHHHHEECCHHHHHHHCCCHHHHCCHHHCCCCCCCEEEEECCCCCCCCCCEE
LLPGLVNAHTHSAMTFLRGLADDMPLMDWLNKRIFPVEQKLTPEIVRLGSLMGYAEMLRT
ECCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHC
GTTACVDMYIFEKEAMAAADQAGLRCLGGEVVFAFPSAAFPGPEAALEETRALAQKYAGH
CCHHHHHHHHHHHHHHHHHHHHCCEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCC
PRLSIAVNPHSVYTTTPEILAACRDLARELALPLHMHLAETAEETQICLHAHGKRPVACC
CEEEEEECCCEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEECCCCCHHHHH
RSLELLDGPCTLAHVVDVTPDELDFLAQRGAVAVHNISSNMKLASGASPVPAMLERGMPV
HHHHHCCCCEEEEEEECCCCHHHHHHHHCCCEEEEECCCCCEECCCCCCCHHHHHCCCCE
ALGTDGAASNNRLNMFTEMGRAALLHKLTGMDPTLLPAQTVLDMATLGGAAAMHDNRLGS
EECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHCCCCCCC
LAVGKAADCVALDLAAPNMQPLYNAVSHLVYAATGMENRMTMIAGEIVYEDGKFTRFDYD
EECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHEEEEEEEEECCCEEEECHH
ALCREMTSIRDFVRRQAGLA
HHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRPCQTLVHAALIVTQDKERRILENASMAVTDGIVADLGPRHEMITCWQPRHEADFGRCL
CCHHHHHHHHHHHEECCHHHHHHHCCCHHHHCCHHHCCCCCCCEEEEECCCCCCCCCCEE
LLPGLVNAHTHSAMTFLRGLADDMPLMDWLNKRIFPVEQKLTPEIVRLGSLMGYAEMLRT
ECCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHC
GTTACVDMYIFEKEAMAAADQAGLRCLGGEVVFAFPSAAFPGPEAALEETRALAQKYAGH
CCHHHHHHHHHHHHHHHHHHHHCCEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCC
PRLSIAVNPHSVYTTTPEILAACRDLARELALPLHMHLAETAEETQICLHAHGKRPVACC
CEEEEEECCCEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEECCCCCHHHHH
RSLELLDGPCTLAHVVDVTPDELDFLAQRGAVAVHNISSNMKLASGASPVPAMLERGMPV
HHHHHCCCCEEEEEEECCCCHHHHHHHHCCCEEEEECCCCCEECCCCCCCHHHHHCCCCE
ALGTDGAASNNRLNMFTEMGRAALLHKLTGMDPTLLPAQTVLDMATLGGAAAMHDNRLGS
EECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHCCCCCCC
LAVGKAADCVALDLAAPNMQPLYNAVSHLVYAATGMENRMTMIAGEIVYEDGKFTRFDYD
EECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHEEEEEEEEECCCEEEECHH
ALCREMTSIRDFVRRQAGLA
HHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA