Click here to switch to the map view.

The map label for this gene is ubiE [C]

Identifier: 220905188

GI number: 220905188

Start: 2319185

End: 2320030

Strand: Direct

Name: ubiE [C]

Synonym: Ddes_1926

Alternate gene names: 220905188

Gene position: 2319185-2320030 (Clockwise)

Preceding gene: 220905187

Following gene: 220905189

Centisome position: 80.71

GC content: 58.51

Gene sequence:

>846_bases
ATGAAATCTGCAGGCAAAGAAACAGACAGGCAGACCATTACAGAAACCGTGCGCTCCGGCTACGCAGCCATTGCCTCCGG
GGCGCAGCGCTCCTGCTGCTCCAACCGCCGGAGCGGTCAGGCTGATCCCGCCAGACTGGCAGAATCACTCGGCTATGACG
CAAAAACTCTTGCCCGCCTCCCCGAGGGGGCCAATATGGGACTTTCGTGCGGTAATCCTGTAGCCCTGGCAGCCCTGCTG
GAAGGACAAACTGTTCTTGATCTGGGCAGCGGCGGCGGCTTTGACGTTTTTCAGGCTGGGGAGCGCGTAAAGGCCTCCGG
CCGTGTCATCGGTGTGGATATGACCCCCGAGATGCTCGCCAAAGCCCGAAAAAACATCGAGTCGTACCGGGAGCTCACCG
GGCTGGACAACGTGGAATTCCGGCTGGGAGAAATCGAGCACCTGCCGGTGGCGGACAACAGCGTGGATGTGGTTTTATCC
AACTGTGTCATCAATCTTTCGCCGGACAAGGCGCAGGTATGGCACGAAATTTTTCGCGTACTGAAGCCGGGCGGCAAGGT
GGCCGTTTCTGATCTGGCGTTGCTCAAGCCGTTGCCCGACAATATCCGCGACATGGCAGCCGCGCTGGTTGGCTGCGTTG
CCGGGGCGGTCCTGATAGATACAAGCGCTGCCCTGCTTGAAAAAACCGGCTTTTCCGGGGTCACACTGACGCCCAAACCA
AGTTATGTGCAAAGCATGCAGGACTGGAACGACCCCCTCTACGCCGAAATAGCCACCAACCTCCCCAAGGGAGAAGATTT
GACGGACTATGTGGTGAGTCTCTCCATTGAAGCCGTCAAACCCTAG

Upstream 100 bases:

>100_bases
ATTCACAACAGATGTGTGATGACAACATTGCCCGTTTATGGGTATGTCTTGCACCAACAAGGCAACATTAGTTGAATAGT
CAAAACATTAAGGATGCATC

Downstream 100 bases:

>100_bases
CAATCAACGCTTCAAATGATTGCTTAACGGTCGGCAAAGCCCCCTACAATCATTTGGCTACAAGGATTTATCTCCAAATC
CTTGTAGAGCATTTCAAGTG

Product: type 11 methyltransferase

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MKSAGKETDRQTITETVRSGYAAIASGAQRSCCSNRRSGQADPARLAESLGYDAKTLARLPEGANMGLSCGNPVALAALL
EGQTVLDLGSGGGFDVFQAGERVKASGRVIGVDMTPEMLAKARKNIESYRELTGLDNVEFRLGEIEHLPVADNSVDVVLS
NCVINLSPDKAQVWHEIFRVLKPGGKVAVSDLALLKPLPDNIRDMAAALVGCVAGAVLIDTSAALLEKTGFSGVTLTPKP
SYVQSMQDWNDPLYAEIATNLPKGEDLTDYVVSLSIEAVKP

Sequences:

>Translated_281_residues
MKSAGKETDRQTITETVRSGYAAIASGAQRSCCSNRRSGQADPARLAESLGYDAKTLARLPEGANMGLSCGNPVALAALL
EGQTVLDLGSGGGFDVFQAGERVKASGRVIGVDMTPEMLAKARKNIESYRELTGLDNVEFRLGEIEHLPVADNSVDVVLS
NCVINLSPDKAQVWHEIFRVLKPGGKVAVSDLALLKPLPDNIRDMAAALVGCVAGAVLIDTSAALLEKTGFSGVTLTPKP
SYVQSMQDWNDPLYAEIATNLPKGEDLTDYVVSLSIEAVKP
>Mature_281_residues
MKSAGKETDRQTITETVRSGYAAIASGAQRSCCSNRRSGQADPARLAESLGYDAKTLARLPEGANMGLSCGNPVALAALL
EGQTVLDLGSGGGFDVFQAGERVKASGRVIGVDMTPEMLAKARKNIESYRELTGLDNVEFRLGEIEHLPVADNSVDVVLS
NCVINLSPDKAQVWHEIFRVLKPGGKVAVSDLALLKPLPDNIRDMAAALVGCVAGAVLIDTSAALLEKTGFSGVTLTPKP
SYVQSMQDWNDPLYAEIATNLPKGEDLTDYVVSLSIEAVKP

Specific function: Methyltransferase Required For The Conversion Of Dimethylmenaquinone (Dmkh2) To Menaquinone (Mkh2) And The Conversion Of 2-Polyprenyl-6-Methoxy-1,4-Benzoquinol (Ddmqh2) To 2-Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol (Dmqh2). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI109389364, Length=167, Percent_Identity=39.5209580838323, Blast_Score=106, Evalue=2e-23,
Organism=Escherichia coli, GI48994983, Length=120, Percent_Identity=32.5, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013216
- InterPro:   IPR005149
- InterPro:   IPR011991 [H]

Pfam domain/function: PF08241 Methyltransf_11; PF03551 PadR [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 29746; Mature: 29746

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSAGKETDRQTITETVRSGYAAIASGAQRSCCSNRRSGQADPARLAESLGYDAKTLARL
CCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHC
PEGANMGLSCGNPVALAALLEGQTVLDLGSGGGFDVFQAGERVKASGRVIGVDMTPEMLA
CCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCHHHHCCCCEECCCCEEEECCCHHHHH
KARKNIESYRELTGLDNVEFRLGEIEHLPVADNSVDVVLSNCVINLSPDKAQVWHEIFRV
HHHHHHHHHHHHHCCCCCEEEECCEEECCCCCCHHHEEEECEEEECCCCHHHHHHHHHHH
LKPGGKVAVSDLALLKPLPDNIRDMAAALVGCVAGAVLIDTSAALLEKTGFSGVTLTPKP
HCCCCCEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCC
SYVQSMQDWNDPLYAEIATNLPKGEDLTDYVVSLSIEAVKP
HHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHEEEEECCC
>Mature Secondary Structure
MKSAGKETDRQTITETVRSGYAAIASGAQRSCCSNRRSGQADPARLAESLGYDAKTLARL
CCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHC
PEGANMGLSCGNPVALAALLEGQTVLDLGSGGGFDVFQAGERVKASGRVIGVDMTPEMLA
CCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCHHHHCCCCEECCCCEEEECCCHHHHH
KARKNIESYRELTGLDNVEFRLGEIEHLPVADNSVDVVLSNCVINLSPDKAQVWHEIFRV
HHHHHHHHHHHHHCCCCCEEEECCEEECCCCCCHHHEEEECEEEECCCCHHHHHHHHHHH
LKPGGKVAVSDLALLKPLPDNIRDMAAALVGCVAGAVLIDTSAALLEKTGFSGVTLTPKP
HCCCCCEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCC
SYVQSMQDWNDPLYAEIATNLPKGEDLTDYVVSLSIEAVKP
HHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2155856 [H]