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The map label for this gene is hepT [H]

Identifier: 220905174

GI number: 220905174

Start: 2301795

End: 2302760

Strand: Direct

Name: hepT [H]

Synonym: Ddes_1912

Alternate gene names: 220905174

Gene position: 2301795-2302760 (Clockwise)

Preceding gene: 220905173

Following gene: 220905175

Centisome position: 80.11

GC content: 63.46

Gene sequence:

>966_bases
ATGATTCAACTCAAAGCACGCATTGCCCTGGAACTTCCGGCCATCAACCGCGCCCTTGACCGGGCTGTGGAGGTATTGCC
CGAACCGGTACGTCCGGTAACGCGGCACATTTTTGAAGCCGGGGGCAAACGTCTGCGCCCGCTTCTCACCGTGCTGACCG
CCCGCCTGCTCGGGCATGACCGTGAAGACATACACGACCTTGCCGTCACCCTTGAAATGCTGCATGCGGCCACCCTCCTG
CACGACGATGTGCTGGACAATGCCATGAGCCGCCGGGGCAAACCCGCCGCCCACACCCTGTACAATGTGTCCAGCGTGAT
CCTCGCGGGCGATGCCCTGCTGGCCGAGGCCAACGCGCAGGTGGCCCGGCGCGGCGACCCGCGCCTTACGCGCTGCTTTT
CCGAGGCCACCAGCCGTACGGCCGCAGGTGAGATACTTGAAATTGCTGCTCAGGGCCGCGTGGATACAAGCGCCGGGCAT
TACGAAGAAATCGTACGCGGCAAGACAGCGTGGCTCATCCGCGCCGCCTGTGAGATGGGCGCACTGGCCGCCGAAGCTGA
TGAGGCGAGCGTGGCTGCGGCTGCGGCCTACGGCGAAAACCTGGGCATGGCCTTTCAGATGGTGGACGATGCGCTGGACT
TTGCGCCCGAAAGCGCCACAGGCAAACCCACAGGCGGTGATGTGCGCGAGGGCAAGCTGACGCCGCCCCTGCGTCTTTAC
CGCGACAGCCTGAACGATGCAGAACGCGAAGCCTTTGACGCGGCGTTTGCCGGCTTTGCCATGAGCGCGGCCGATGCCGA
ATCCGTTGCCCTGCGCATACGCGAGGCCGGTTTTGACACGGCAGTGCGCCGCCAGGCCGACACTTTTCTTGATGCGGCCA
GGCGTGCCCTGCATAGCCTGCCCGACAGACCAGAGCGCAAGGTCATGCTTAAAATGACCGACTATGTGCGCGACAGAAAA
AAATAA

Upstream 100 bases:

>100_bases
ACAAGGTGGGTCCCCGCGCCAGAGAGGAAAAAGATTTTCCCGGCGCATTGCGAGCCCTTGCCCAGGTGCTACCCGCCCTT
AACCTCATCTGAGTAGTGAA

Downstream 100 bases:

>100_bases
GCTGTAACCGTACGAGGAAGCACCAATGCTCTACCGGGTGGAAACCGGCCTGCACGCCGGACTGGACGATACACAAGGCC
GCAAAACGGCCCAGCACCTG

Product: polyprenyl synthetase

Products: NA

Alternate protein names: HEPPP synthase subunit 2 [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MIQLKARIALELPAINRALDRAVEVLPEPVRPVTRHIFEAGGKRLRPLLTVLTARLLGHDREDIHDLAVTLEMLHAATLL
HDDVLDNAMSRRGKPAAHTLYNVSSVILAGDALLAEANAQVARRGDPRLTRCFSEATSRTAAGEILEIAAQGRVDTSAGH
YEEIVRGKTAWLIRAACEMGALAAEADEASVAAAAAYGENLGMAFQMVDDALDFAPESATGKPTGGDVREGKLTPPLRLY
RDSLNDAEREAFDAAFAGFAMSAADAESVALRIREAGFDTAVRRQADTFLDAARRALHSLPDRPERKVMLKMTDYVRDRK
K

Sequences:

>Translated_321_residues
MIQLKARIALELPAINRALDRAVEVLPEPVRPVTRHIFEAGGKRLRPLLTVLTARLLGHDREDIHDLAVTLEMLHAATLL
HDDVLDNAMSRRGKPAAHTLYNVSSVILAGDALLAEANAQVARRGDPRLTRCFSEATSRTAAGEILEIAAQGRVDTSAGH
YEEIVRGKTAWLIRAACEMGALAAEADEASVAAAAAYGENLGMAFQMVDDALDFAPESATGKPTGGDVREGKLTPPLRLY
RDSLNDAEREAFDAAFAGFAMSAADAESVALRIREAGFDTAVRRQADTFLDAARRALHSLPDRPERKVMLKMTDYVRDRK
K
>Mature_321_residues
MIQLKARIALELPAINRALDRAVEVLPEPVRPVTRHIFEAGGKRLRPLLTVLTARLLGHDREDIHDLAVTLEMLHAATLL
HDDVLDNAMSRRGKPAAHTLYNVSSVILAGDALLAEANAQVARRGDPRLTRCFSEATSRTAAGEILEIAAQGRVDTSAGH
YEEIVRGKTAWLIRAACEMGALAAEADEASVAAAAAYGENLGMAFQMVDDALDFAPESATGKPTGGDVREGKLTPPLRLY
RDSLNDAEREAFDAAFAGFAMSAADAESVALRIREAGFDTAVRRQADTFLDAARRALHSLPDRPERKVMLKMTDYVRDRK
K

Specific function: Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7) [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=216, Percent_Identity=32.8703703703704, Blast_Score=125, Evalue=7e-29,
Organism=Escherichia coli, GI1789578, Length=309, Percent_Identity=29.7734627831715, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI1786623, Length=257, Percent_Identity=33.0739299610895, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17505681, Length=326, Percent_Identity=28.2208588957055, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6319475, Length=216, Percent_Identity=28.7037037037037, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24651612, Length=214, Percent_Identity=35.5140186915888, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI281365769, Length=216, Percent_Identity=28.2407407407407, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24660002, Length=216, Percent_Identity=28.2407407407407, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014119
- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.30 [H]

Molecular weight: Translated: 34872; Mature: 34872

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQLKARIALELPAINRALDRAVEVLPEPVRPVTRHIFEAGGKRLRPLLTVLTARLLGHD
CEEEEEEHEEECHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
REDIHDLAVTLEMLHAATLLHDDVLDNAMSRRGKPAAHTLYNVSSVILAGDALLAEANAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHCCHH
VARRGDPRLTRCFSEATSRTAAGEILEIAAQGRVDTSAGHYEEIVRGKTAWLIRAACEMG
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHH
ALAAEADEASVAAAAAYGENLGMAFQMVDDALDFAPESATGKPTGGDVREGKLTPPLRLY
HHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHH
RDSLNDAEREAFDAAFAGFAMSAADAESVALRIREAGFDTAVRRQADTFLDAARRALHSL
HHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
PDRPERKVMLKMTDYVRDRKK
CCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIQLKARIALELPAINRALDRAVEVLPEPVRPVTRHIFEAGGKRLRPLLTVLTARLLGHD
CEEEEEEHEEECHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
REDIHDLAVTLEMLHAATLLHDDVLDNAMSRRGKPAAHTLYNVSSVILAGDALLAEANAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHCCHH
VARRGDPRLTRCFSEATSRTAAGEILEIAAQGRVDTSAGHYEEIVRGKTAWLIRAACEMG
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHH
ALAAEADEASVAAAAAYGENLGMAFQMVDDALDFAPESATGKPTGGDVREGKLTPPLRLY
HHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHH
RDSLNDAEREAFDAAFAGFAMSAADAESVALRIREAGFDTAVRRQADTFLDAARRALHSL
HHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
PDRPERKVMLKMTDYVRDRKK
CCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7629164 [H]