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The map label for this gene is ilvC

Identifier: 220905167

GI number: 220905167

Start: 2293546

End: 2294547

Strand: Direct

Name: ilvC

Synonym: Ddes_1905

Alternate gene names: 220905167

Gene position: 2293546-2294547 (Clockwise)

Preceding gene: 220905166

Following gene: 220905168

Centisome position: 79.82

GC content: 58.68

Gene sequence:

>1002_bases
ATGAAAGTTTATTACGATCAGGATGCCGACCTTAATCTCCTGAAGGATAAAACCGTCGCCATCATCGGTTACGGCAGCCA
GGGCCACGCCCACGCCCAGAACCTGCGCGATTCCGGCGTCAAGGTTGTGGTGGGCCAGCGCCCCGGCGGCGCCAACTACG
AACTGGCCAAGGAACACGGCTTCAATCCTGTTTCCGCCGCTGAAGCCGCCGCCCAGGCCGACCTGATTATGCTTCTGCTG
CCCGACGAAGTGCAGGCTGCCGTTTACGAAAACGACATCAAGCCCAACCTTGCCAAGGGCAAGGCCCTGCTGTTCGCCCA
CGGCTTCAACATCCACTTCGGGCAGATCCAGCCGCCCAAGGATGTGGACGTGTTCCTCATCGCGCCCAAGGGACCGGGCC
ATCTGGTGCGCCGCACCTACACCGAGGGCGGCGGCGTACCCTGCCTCGTGGCCATTGAGCAGGACGCTACCGGAAAAGCC
CTTCAGATGGCCCTGGCCTATGCCAAGGGTGTTGGCGGCGCGCGCTCCGGCGTGATTGAAACCACCTTCCGTGAAGAGAC
TGAAACCGACCTTTTCGGTGAACAGGCCGTGCTGTGCGGCGGTGTTTCCGCCCTGATCAAGGCCGGCTTTGAAACCCTGG
TAGAAGCCGGTTACCAGCCCGAAATGGCCTACTTCGAATGCCTGCACGAAATGAAACTTATCGTGGACCTCATGTACGAA
GGCGGCCTTTCGCGCATGCGCTACTCCATCAGCAATACCGCTGAATACGGCGACTATGTCACCGGTCCCCGCCTTGTCAC
CGATGAAGTGAAAAAAGAAATGAAGGCCGTGCTCAAGGACATCCAGAGCGGCGTATTCGCGCGCAACTTCATTCTTGAAG
CCCGCGCCAAGTACCCCATGTTCCTTACCACCCGCCGCAATGAATCCGAGCACCAGATTGAAAAAGTGGGCAAAGAGCTG
CGCAGCATGATGCCCTGGCTCAAGAAAGACAAAAAAGACTAG

Upstream 100 bases:

>100_bases
CAACAACGCCCGGCGCTTATGTCCAGGCCCCACGTTCTTTCCCACCGGTGGAAAGAAATACAATTTTGTTTAACCGTGAG
TGATCTCAGAGGAAGTTCAG

Downstream 100 bases:

>100_bases
AACGGATCAACTTTGAAATATGGAGTATTTCAAAGTTGCCATTCTGCCGGAAAATGCAGTTTCCGGCAGAATCCACGCTG
TGTTACGATGCGCTGTACGG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MKVYYDQDADLNLLKDKTVAIIGYGSQGHAHAQNLRDSGVKVVVGQRPGGANYELAKEHGFNPVSAAEAAAQADLIMLLL
PDEVQAAVYENDIKPNLAKGKALLFAHGFNIHFGQIQPPKDVDVFLIAPKGPGHLVRRTYTEGGGVPCLVAIEQDATGKA
LQMALAYAKGVGGARSGVIETTFREETETDLFGEQAVLCGGVSALIKAGFETLVEAGYQPEMAYFECLHEMKLIVDLMYE
GGLSRMRYSISNTAEYGDYVTGPRLVTDEVKKEMKAVLKDIQSGVFARNFILEARAKYPMFLTTRRNESEHQIEKVGKEL
RSMMPWLKKDKKD

Sequences:

>Translated_333_residues
MKVYYDQDADLNLLKDKTVAIIGYGSQGHAHAQNLRDSGVKVVVGQRPGGANYELAKEHGFNPVSAAEAAAQADLIMLLL
PDEVQAAVYENDIKPNLAKGKALLFAHGFNIHFGQIQPPKDVDVFLIAPKGPGHLVRRTYTEGGGVPCLVAIEQDATGKA
LQMALAYAKGVGGARSGVIETTFREETETDLFGEQAVLCGGVSALIKAGFETLVEAGYQPEMAYFECLHEMKLIVDLMYE
GGLSRMRYSISNTAEYGDYVTGPRLVTDEVKKEMKAVLKDIQSGVFARNFILEARAKYPMFLTTRRNESEHQIEKVGKEL
RSMMPWLKKDKKD
>Mature_333_residues
MKVYYDQDADLNLLKDKTVAIIGYGSQGHAHAQNLRDSGVKVVVGQRPGGANYELAKEHGFNPVSAAEAAAQADLIMLLL
PDEVQAAVYENDIKPNLAKGKALLFAHGFNIHFGQIQPPKDVDVFLIAPKGPGHLVRRTYTEGGGVPCLVAIEQDATGKA
LQMALAYAKGVGGARSGVIETTFREETETDLFGEQAVLCGGVSALIKAGFETLVEAGYQPEMAYFECLHEMKLIVDLMYE
GGLSRMRYSISNTAEYGDYVTGPRLVTDEVKKEMKAVLKDIQSGVFARNFILEARAKYPMFLTTRRNESEHQIEKVGKEL
RSMMPWLKKDKKD

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=323, Percent_Identity=34.0557275541796, Blast_Score=148, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6323387, Length=332, Percent_Identity=35.8433734939759, Blast_Score=160, Evalue=2e-40,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_DESDA (B8J2E2)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002480479.1
- ProteinModelPortal:   B8J2E2
- GeneID:   7285620
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_1905
- HOGENOM:   HBG286525
- ProtClustDB:   PRK05479
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36591; Mature: 36591

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVYYDQDADLNLLKDKTVAIIGYGSQGHAHAQNLRDSGVKVVVGQRPGGANYELAKEHG
CEEEECCCCCCEEECCCEEEEEEECCCCCHHHHHHHCCCCEEEEECCCCCCCCCHHHHCC
FNPVSAAEAAAQADLIMLLLPDEVQAAVYENDIKPNLAKGKALLFAHGFNIHFGQIQPPK
CCCHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCCCCCCCCEEEEEECCEEEECCCCCCC
DVDVFLIAPKGPGHLVRRTYTEGGGVPCLVAIEQDATGKALQMALAYAKGVGGARSGVIE
CCEEEEECCCCCCHHHEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCEE
TTFREETETDLFGEQAVLCGGVSALIKAGFETLVEAGYQPEMAYFECLHEMKLIVDLMYE
EHHHCCHHHHHCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GGLSRMRYSISNTAEYGDYVTGPRLVTDEVKKEMKAVLKDIQSGVFARNFILEARAKYPM
CCHHHHEEHHCCCHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCE
FLTTRRNESEHQIEKVGKELRSMMPWLKKDKKD
EEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKVYYDQDADLNLLKDKTVAIIGYGSQGHAHAQNLRDSGVKVVVGQRPGGANYELAKEHG
CEEEECCCCCCEEECCCEEEEEEECCCCCHHHHHHHCCCCEEEEECCCCCCCCCHHHHCC
FNPVSAAEAAAQADLIMLLLPDEVQAAVYENDIKPNLAKGKALLFAHGFNIHFGQIQPPK
CCCHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCCCCCCCCEEEEEECCEEEECCCCCCC
DVDVFLIAPKGPGHLVRRTYTEGGGVPCLVAIEQDATGKALQMALAYAKGVGGARSGVIE
CCEEEEECCCCCCHHHEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCEE
TTFREETETDLFGEQAVLCGGVSALIKAGFETLVEAGYQPEMAYFECLHEMKLIVDLMYE
EHHHCCHHHHHCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GGLSRMRYSISNTAEYGDYVTGPRLVTDEVKKEMKAVLKDIQSGVFARNFILEARAKYPM
CCHHHHEEHHCCCHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCE
FLTTRRNESEHQIEKVGKELRSMMPWLKKDKKD
EEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA