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The map label for this gene is nrdZ [H]

Identifier: 220905096

GI number: 220905096

Start: 2209995

End: 2212340

Strand: Reverse

Name: nrdZ [H]

Synonym: Ddes_1833

Alternate gene names: 220905096

Gene position: 2212340-2209995 (Counterclockwise)

Preceding gene: 220905097

Following gene: 220905095

Centisome position: 76.99

GC content: 58.57

Gene sequence:

>2346_bases
ATGCTTGCAATGCCCAAAAATCTGCCCCATCCGCAACTGAAGCCCAATACCGAAGTTGTTTTGCAAAAGCGCTATCTGCG
TAAAAATCTGGACGGCAAAATCATCGAAGCGCCGCGCGATCTTTTCTGGCGCGTGGCCGCCGCTATTGCAGCCCAGGAAG
AAAACTATAAAAATTCGAGCCGTACGCCGAACCAACTGGCCCGTGATTTTTACGACCTCATGACCAGCTGGAAATTTCTG
CCCAATTCGCCCACCCTCATGAATGCCGGTACGGAACTGGGGCAGCTTTCGGCCTGCTTTGTGCTGCCCGTGGGCGACTC
CATTGAAGAAATTTTTGACGCCGTCAAATACGCCGCCATGATACACAAGTCCGGCGGTGGCACGGGCTTTTCCTTTTCCC
GCCTACGGCCCAAAGATAGCCGCGTAGGCTCCACCGGGGGCGTGGCGTCCGGCCCGGTATCCTTTTTGCGCATCTTTAAT
ACCGCCACTGAACAGATAAAGCAGGGCGGCACACGGCGCGGGGCCAATATGGGCATTCTGCGGGTGGATCATCCGGACAT
TCTGGAATTCATCCGGGCCAAGGAAAAAGAGGGAGAGTTCAATAACTTCAATCTTTCCGTCGGATTGACAGAATCTTTCA
TGCAGGCCGTGGAAAACGACGAGCAGTATGACCTTGTTTCGCCCAATAACGGCGAAGTCATGAAGCGTCTGCCCGCGCGT
GATGTTTTTGACCTTCTGGTGCGCAAGGCGTGGCAGTCCGGCGATCCGGGTATTGTTTTTCTGGACCGCATCAATCGCGA
CAATCCCACGCCTGATCAAGGCGAGATCGAATCCACCAACCCTTGCGGCGAGCAGCCGCTTTTGCCCTTTGAGGCGTGCA
ATCTGGGGTCCATCAATCTTTCGTGCTTTCATGTGCCGGGGCATGAGAACAGTGCTGACCCCGCTGCGGGCATTGATTGG
GACGAACTGCGCCGCGTGGTGCATCTGTCTGTGCGTTTTCTTGACAACGTCATCGATGCTTCGCGTTTTCCGCTTGACCG
CATTGGCGAAACTGTACGCAAAAACCGCAAGATCGGTCTGGGCGTTATGGGCTTTGCGGACCTGCTCTTTCAGCTCGGCG
TGCCCTATGACTCGCAGCAGGGCCTTGATCTTGGCGAGCGCATCATGGCCTTTGTGCAGGGAGAAGGGCACAGGGCATCG
GCGGAACTGGCTCTGGAGCGCGGGCCTTTCCCGGCCTACGGATCTTCTGTGTTTGCCCGCAAGAAACTCGGGCCTTACCG
CAACGCCACGGTAACCACCATTGCGCCCACGGGTACGTTGTCGATCATCGCGGGGTGCTCGTCCGGCGTGGAGCCGCTTT
TTGCCCTTTGCTTTACCCGTAATATTCTGGACGGCGAGCGCCTGGTGGAGATCAATCCGCATTTTGAGGCAGCGCTGGAA
TCCGGAGGCCTGTTCAGCCATGAGCTGATGGATGCCGTAGTAGCCAAAGGCTCCATTCAGGATATGGACTATCTGCCTGC
CCCGCTGCGCAAGACTTTTGTGACCGCTATGGATATTGCGCCCCAGTGGCATCTGCGCATGCAGGCGGCCTTTCAGCGGC
ATACGGACAATGCCGTGTCCAAAACCGTCAACCTGTCCAACAGCGCAACAGAGCAGGACATCCGCGAAATTTACTGGCTG
GCCTATCAGGAAGGCTGCAAGGGCGTCACCGTATACCGCGACGGCTGCAAGAGCATTCAGGTGCTGGCTACCGGCGAAGG
GCAGAAAAAAATGGACAGCGGCTCCGCTGAAGTGGCGGGCGGCAGTGCCCAGAGCGGGCATGCGTCCGAGCATGCAGACC
ATCGGGCTGGCGCGCATGCGGTTGCGGCAGACGGCCCCATTGCCGCCGTGCCGTCACTGGTGCGCAAGCGGCCGGATGAG
GTTCAGGGCTTCACCCGCAAGGTGCAGACGGGTCTTGGGGCCATGTATCTTACGGTGAACGAGGTGGACGGCAGACCTTT
TGAAGTGTTCGCCACCATCGGCAAGTCCGGGCGTTCCATCACGGCCAAGGCAGAGGCCATCGGGCGGCTCGTGTCCCTTG
CGCTGCGCTCCGGCGTGCATGTGCGTGACGTGGTGGCGCAGATCAAGGGCATCGGCGGCGAGCATCCTGTATTTCGGGGC
AAGGGGCTGCTGCTGTCCATACCCGATGCCATCGCCTGGGTGCTGGAGCAGCGCTATCTCAAGGACGAAGTGGTGGATAC
AGTCAGTGATATTGCCGTCAGCCGTTGCCCGGACTGTGGCGAAAAGCTGGTATTTCAGGAAGGCTGCCTCATTTGCCCGG
CCTGCGGCTTTTCCCGCTGCGGCTAG

Upstream 100 bases:

>100_bases
GCTTTGACGGCTTTTATTTGTTCCGTAAGCGTGTATAGTGGCTTTTGGCCCGCAGGGCCGTTTTCACTCATTGTAACTTC
AAGAAAAGGTTACTGCTCCC

Downstream 100 bases:

>100_bases
AGCAGTTTAACTTTTAGATTGCTCTGACGGCTGCGTGAGGAGACGTTCACTACGGAGGCGCAAAGGCTTCAGCCGCAAGC
CCCCCGGTACCGGCTGAAGC

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 781; Mature: 781

Protein sequence:

>781_residues
MLAMPKNLPHPQLKPNTEVVLQKRYLRKNLDGKIIEAPRDLFWRVAAAIAAQEENYKNSSRTPNQLARDFYDLMTSWKFL
PNSPTLMNAGTELGQLSACFVLPVGDSIEEIFDAVKYAAMIHKSGGGTGFSFSRLRPKDSRVGSTGGVASGPVSFLRIFN
TATEQIKQGGTRRGANMGILRVDHPDILEFIRAKEKEGEFNNFNLSVGLTESFMQAVENDEQYDLVSPNNGEVMKRLPAR
DVFDLLVRKAWQSGDPGIVFLDRINRDNPTPDQGEIESTNPCGEQPLLPFEACNLGSINLSCFHVPGHENSADPAAGIDW
DELRRVVHLSVRFLDNVIDASRFPLDRIGETVRKNRKIGLGVMGFADLLFQLGVPYDSQQGLDLGERIMAFVQGEGHRAS
AELALERGPFPAYGSSVFARKKLGPYRNATVTTIAPTGTLSIIAGCSSGVEPLFALCFTRNILDGERLVEINPHFEAALE
SGGLFSHELMDAVVAKGSIQDMDYLPAPLRKTFVTAMDIAPQWHLRMQAAFQRHTDNAVSKTVNLSNSATEQDIREIYWL
AYQEGCKGVTVYRDGCKSIQVLATGEGQKKMDSGSAEVAGGSAQSGHASEHADHRAGAHAVAADGPIAAVPSLVRKRPDE
VQGFTRKVQTGLGAMYLTVNEVDGRPFEVFATIGKSGRSITAKAEAIGRLVSLALRSGVHVRDVVAQIKGIGGEHPVFRG
KGLLLSIPDAIAWVLEQRYLKDEVVDTVSDIAVSRCPDCGEKLVFQEGCLICPACGFSRCG

Sequences:

>Translated_781_residues
MLAMPKNLPHPQLKPNTEVVLQKRYLRKNLDGKIIEAPRDLFWRVAAAIAAQEENYKNSSRTPNQLARDFYDLMTSWKFL
PNSPTLMNAGTELGQLSACFVLPVGDSIEEIFDAVKYAAMIHKSGGGTGFSFSRLRPKDSRVGSTGGVASGPVSFLRIFN
TATEQIKQGGTRRGANMGILRVDHPDILEFIRAKEKEGEFNNFNLSVGLTESFMQAVENDEQYDLVSPNNGEVMKRLPAR
DVFDLLVRKAWQSGDPGIVFLDRINRDNPTPDQGEIESTNPCGEQPLLPFEACNLGSINLSCFHVPGHENSADPAAGIDW
DELRRVVHLSVRFLDNVIDASRFPLDRIGETVRKNRKIGLGVMGFADLLFQLGVPYDSQQGLDLGERIMAFVQGEGHRAS
AELALERGPFPAYGSSVFARKKLGPYRNATVTTIAPTGTLSIIAGCSSGVEPLFALCFTRNILDGERLVEINPHFEAALE
SGGLFSHELMDAVVAKGSIQDMDYLPAPLRKTFVTAMDIAPQWHLRMQAAFQRHTDNAVSKTVNLSNSATEQDIREIYWL
AYQEGCKGVTVYRDGCKSIQVLATGEGQKKMDSGSAEVAGGSAQSGHASEHADHRAGAHAVAADGPIAAVPSLVRKRPDE
VQGFTRKVQTGLGAMYLTVNEVDGRPFEVFATIGKSGRSITAKAEAIGRLVSLALRSGVHVRDVVAQIKGIGGEHPVFRG
KGLLLSIPDAIAWVLEQRYLKDEVVDTVSDIAVSRCPDCGEKLVFQEGCLICPACGFSRCG
>Mature_781_residues
MLAMPKNLPHPQLKPNTEVVLQKRYLRKNLDGKIIEAPRDLFWRVAAAIAAQEENYKNSSRTPNQLARDFYDLMTSWKFL
PNSPTLMNAGTELGQLSACFVLPVGDSIEEIFDAVKYAAMIHKSGGGTGFSFSRLRPKDSRVGSTGGVASGPVSFLRIFN
TATEQIKQGGTRRGANMGILRVDHPDILEFIRAKEKEGEFNNFNLSVGLTESFMQAVENDEQYDLVSPNNGEVMKRLPAR
DVFDLLVRKAWQSGDPGIVFLDRINRDNPTPDQGEIESTNPCGEQPLLPFEACNLGSINLSCFHVPGHENSADPAAGIDW
DELRRVVHLSVRFLDNVIDASRFPLDRIGETVRKNRKIGLGVMGFADLLFQLGVPYDSQQGLDLGERIMAFVQGEGHRAS
AELALERGPFPAYGSSVFARKKLGPYRNATVTTIAPTGTLSIIAGCSSGVEPLFALCFTRNILDGERLVEINPHFEAALE
SGGLFSHELMDAVVAKGSIQDMDYLPAPLRKTFVTAMDIAPQWHLRMQAAFQRHTDNAVSKTVNLSNSATEQDIREIYWL
AYQEGCKGVTVYRDGCKSIQVLATGEGQKKMDSGSAEVAGGSAQSGHASEHADHRAGAHAVAADGPIAAVPSLVRKRPDE
VQGFTRKVQTGLGAMYLTVNEVDGRPFEVFATIGKSGRSITAKAEAIGRLVSLALRSGVHVRDVVAQIKGIGGEHPVFRG
KGLLLSIPDAIAWVLEQRYLKDEVVDTVSDIAVSRCPDCGEKLVFQEGCLICPACGFSRCG

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=586, Percent_Identity=27.6450511945392, Blast_Score=225, Evalue=1e-58,
Organism=Escherichia coli, GI1789030, Length=606, Percent_Identity=26.5676567656766, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI2367133, Length=512, Percent_Identity=24.609375, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17555242, Length=612, Percent_Identity=26.6339869281046, Blast_Score=225, Evalue=9e-59,
Organism=Saccharomyces cerevisiae, GI6320914, Length=676, Percent_Identity=26.3313609467456, Blast_Score=206, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6322123, Length=642, Percent_Identity=26.791277258567, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI17352481, Length=612, Percent_Identity=26.1437908496732, Blast_Score=213, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 85086; Mature: 85086

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAMPKNLPHPQLKPNTEVVLQKRYLRKNLDGKIIEAPRDLFWRVAAAIAAQEENYKNSS
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHCCCCCC
RTPNQLARDFYDLMTSWKFLPNSPTLMNAGTELGQLSACFVLPVGDSIEEIFDAVKYAAM
CCHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHH
IHKSGGGTGFSFSRLRPKDSRVGSTGGVASGPVSFLRIFNTATEQIKQGGTRRGANMGIL
HCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
RVDHPDILEFIRAKEKEGEFNNFNLSVGLTESFMQAVENDEQYDLVSPNNGEVMKRLPAR
ECCCHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHCCCCCEECCCCCCCHHHHHCCHH
DVFDLLVRKAWQSGDPGIVFLDRINRDNPTPDQGEIESTNPCGEQPLLPFEACNLGSINL
HHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCEEE
SCFHVPGHENSADPAAGIDWDELRRVVHLSVRFLDNVIDASRFPLDRIGETVRKNRKIGL
EEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCE
GVMGFADLLFQLGVPYDSQQGLDLGERIMAFVQGEGHRASAELALERGPFPAYGSSVFAR
EHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCHHHHH
KKLGPYRNATVTTIAPTGTLSIIAGCSSGVEPLFALCFTRNILDGERLVEINPHFEAALE
HHCCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHHHHH
SGGLFSHELMDAVVAKGSIQDMDYLPAPLRKTFVTAMDIAPQWHLRMQAAFQRHTDNAVS
CCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHH
KTVNLSNSATEQDIREIYWLAYQEGCKGVTVYRDGCKSIQVLATGEGQKKMDSGSAEVAG
HEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEECCCCHHCCCCCCEECC
GSAQSGHASEHADHRAGAHAVAADGPIAAVPSLVRKRPDEVQGFTRKVQTGLGAMYLTVN
CCCCCCCCHHHHHHHCCCCEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEE
EVDGRPFEVFATIGKSGRSITAKAEAIGRLVSLALRSGVHVRDVVAQIKGIGGEHPVFRG
CCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEC
KGLLLSIPDAIAWVLEQRYLKDEVVDTVSDIAVSRCPDCGEKLVFQEGCLICPACGFSRC
CCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEECCCCCCCC
G
C
>Mature Secondary Structure
MLAMPKNLPHPQLKPNTEVVLQKRYLRKNLDGKIIEAPRDLFWRVAAAIAAQEENYKNSS
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHCCCCCC
RTPNQLARDFYDLMTSWKFLPNSPTLMNAGTELGQLSACFVLPVGDSIEEIFDAVKYAAM
CCHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHH
IHKSGGGTGFSFSRLRPKDSRVGSTGGVASGPVSFLRIFNTATEQIKQGGTRRGANMGIL
HCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
RVDHPDILEFIRAKEKEGEFNNFNLSVGLTESFMQAVENDEQYDLVSPNNGEVMKRLPAR
ECCCHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHCCCCCEECCCCCCCHHHHHCCHH
DVFDLLVRKAWQSGDPGIVFLDRINRDNPTPDQGEIESTNPCGEQPLLPFEACNLGSINL
HHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCEEE
SCFHVPGHENSADPAAGIDWDELRRVVHLSVRFLDNVIDASRFPLDRIGETVRKNRKIGL
EEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCE
GVMGFADLLFQLGVPYDSQQGLDLGERIMAFVQGEGHRASAELALERGPFPAYGSSVFAR
EHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCHHHHH
KKLGPYRNATVTTIAPTGTLSIIAGCSSGVEPLFALCFTRNILDGERLVEINPHFEAALE
HHCCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHHHHH
SGGLFSHELMDAVVAKGSIQDMDYLPAPLRKTFVTAMDIAPQWHLRMQAAFQRHTDNAVS
CCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHH
KTVNLSNSATEQDIREIYWLAYQEGCKGVTVYRDGCKSIQVLATGEGQKKMDSGSAEVAG
HEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEECCCCHHCCCCCCEECC
GSAQSGHASEHADHRAGAHAVAADGPIAAVPSLVRKRPDEVQGFTRKVQTGLGAMYLTVN
CCCCCCCCHHHHHHHCCCCEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEE
EVDGRPFEVFATIGKSGRSITAKAEAIGRLVSLALRSGVHVRDVVAQIKGIGGEHPVFRG
CCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEC
KGLLLSIPDAIAWVLEQRYLKDEVVDTVSDIAVSRCPDCGEKLVFQEGCLICPACGFSRC
CCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEECCCCCCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]