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The map label for this gene is hisB [H]

Identifier: 220905072

GI number: 220905072

Start: 2184194

End: 2184790

Strand: Direct

Name: hisB [H]

Synonym: Ddes_1809

Alternate gene names: 220905072

Gene position: 2184194-2184790 (Clockwise)

Preceding gene: 220905071

Following gene: 220905073

Centisome position: 76.01

GC content: 62.65

Gene sequence:

>597_bases
ATGACCACCGCCCCGCGCACTTCTACGCAGGCGCGCACCAGCGCCGAAACCGACATCCGCCTTGAACTGAATCTGGACGG
TCAGGGCAAGACAGACATCCGAACCGGATTCGGCCTGCTGGACCATATGCTCACCCTCACGTTCTTCTGGGCAGGCATGG
ACCTGACCCTTGTCTGCGAGGGTGACATGCAGGTGGACGCTCACCACACGGCCGAGGACGTGGGCATGACCCTTGGCAAG
GCCCTGCTCGAAGCCCTGGGGGACAGGGCGGGCATTGCCCGCGTGGGTTACGGCCGTGTGCCTATGGACGAGGCCCTTGC
GGAAGTTACCGTTGACCTTTCAGGCCGCCCCTGGCTTGAGTGGCGTGGCGACGAACTGTTGCCCCCCGTACTCGCCGGGG
AGGAAAAAGACCTCTGGCGTGAATACTATAAAGCCCTTGCCAGCGGCGCGCGCTGCAATCTGCATGTGGACATGCGCTAC
GGCAAAAACGGGCATCATTTGCTGGAATCCGCCGCCAAGGGCCTGGGCCTTGCCCTGGCTCATGCAGTGCGTCGGCACGG
CACAACCATACGCAGCACCAAGGGAGGTCTTGATTAA

Upstream 100 bases:

>100_bases
GCAAACCCAAAACTGAAAAAGATGCCGATGACGGCGGGCAGGAAAAGACAGACGCAGACGCTGCATCGGATGCAAAAACC
GCCAACGCCTCGGAGAAAGC

Downstream 100 bases:

>100_bases
TGCATAACCGCCTGAATATACTGCTTCTCGTCATACTGAGTCTTGCCGTGGTCCTGGGCGCGTGCAGCAAGCGCCCGCGC
AGTACCGCCGATGTGCCGCG

Product: Imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 198; Mature: 197

Protein sequence:

>198_residues
MTTAPRTSTQARTSAETDIRLELNLDGQGKTDIRTGFGLLDHMLTLTFFWAGMDLTLVCEGDMQVDAHHTAEDVGMTLGK
ALLEALGDRAGIARVGYGRVPMDEALAEVTVDLSGRPWLEWRGDELLPPVLAGEEKDLWREYYKALASGARCNLHVDMRY
GKNGHHLLESAAKGLGLALAHAVRRHGTTIRSTKGGLD

Sequences:

>Translated_198_residues
MTTAPRTSTQARTSAETDIRLELNLDGQGKTDIRTGFGLLDHMLTLTFFWAGMDLTLVCEGDMQVDAHHTAEDVGMTLGK
ALLEALGDRAGIARVGYGRVPMDEALAEVTVDLSGRPWLEWRGDELLPPVLAGEEKDLWREYYKALASGARCNLHVDMRY
GKNGHHLLESAAKGLGLALAHAVRRHGTTIRSTKGGLD
>Mature_197_residues
TTAPRTSTQARTSAETDIRLELNLDGQGKTDIRTGFGLLDHMLTLTFFWAGMDLTLVCEGDMQVDAHHTAEDVGMTLGKA
LLEALGDRAGIARVGYGRVPMDEALAEVTVDLSGRPWLEWRGDELLPPVLAGEEKDLWREYYKALASGARCNLHVDMRYG
KNGHHLLESAAKGLGLALAHAVRRHGTTIRSTKGGLD

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=197, Percent_Identity=37.5634517766497, Blast_Score=130, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6324776, Length=178, Percent_Identity=39.8876404494382, Blast_Score=118, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21595; Mature: 21464

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00954 IGP_DEHYDRATASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAPRTSTQARTSAETDIRLELNLDGQGKTDIRTGFGLLDHMLTLTFFWAGMDLTLVCE
CCCCCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
GDMQVDAHHTAEDVGMTLGKALLEALGDRAGIARVGYGRVPMDEALAEVTVDLSGRPWLE
CCEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHEEECCCCCCCEE
WRGDELLPPVLAGEEKDLWREYYKALASGARCNLHVDMRYGKNGHHLLESAAKGLGLALA
ECCCCCCCHHHCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHH
HAVRRHGTTIRSTKGGLD
HHHHHCCCEEECCCCCCC
>Mature Secondary Structure 
TTAPRTSTQARTSAETDIRLELNLDGQGKTDIRTGFGLLDHMLTLTFFWAGMDLTLVCE
CCCCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
GDMQVDAHHTAEDVGMTLGKALLEALGDRAGIARVGYGRVPMDEALAEVTVDLSGRPWLE
CCEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHEEECCCCCCCEE
WRGDELLPPVLAGEEKDLWREYYKALASGARCNLHVDMRYGKNGHHLLESAAKGLGLALA
ECCCCCCCHHHCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHH
HAVRRHGTTIRSTKGGLD
HHHHHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA