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The map label for this gene is moeA [C]

Identifier: 220905035

GI number: 220905035

Start: 2140685

End: 2142634

Strand: Direct

Name: moeA [C]

Synonym: Ddes_1772

Alternate gene names: 220905035

Gene position: 2140685-2142634 (Clockwise)

Preceding gene: 220905034

Following gene: 220905042

Centisome position: 74.5

GC content: 62.67

Gene sequence:

>1950_bases
ATGAAGCGCAATACCTACCTGACCCTGCTTGCGCCCGAAGAGGCGCGGAAACTCTGGTTCGCGCGTCTTCAGGCAGCTTC
CCGTGCTCTGCCGGAAGAAAACATCCCTCTGACCACAGCCCTGCACCGCGTCCTCAGTCGCCCGGTAGCGGCGCTTCGTT
CTTCGCCCGCCTTTCACGGCGCAGCTATGGACGGCATCGCTGTCAACGCCGAAGACACGTTCAGCGCGTCCGTTCGCAAT
CCCTTGCGCCTCGAACTGGGCAGGCAGGCTCACTGGATCAACACCGGCCACCCCCTGCCGCCGGGTTGCAACGCGGTTAT
TATGGTGGAGCACATCAATACCGAAGGCTCCGGCGAAACCCGGTGGGCGGTGATCGAAAAGGCCGCTTTTCCGTGGCAGC
ATGTACGTAAAATGGGTGAGGATATGGTGGCTACAGAAATCATCCTGCCACCCGGAACGTGCCTTGGGCCGTATGATCTG
GGCGCTCTGGCGGCAGGAGGCGTTCTGCAGGTCCCTGTCTTTGCCCGCCCCCGCGTCACCATAATCCCCAGCGGTTCTGA
AATCGTGCCTCTGGCCCTGGCACGCGAAGAAGACCTGCGTGCCGGACGGGTGCTGCCCGAATTCAATTCCCTGATTTTCT
CGGCCATGATTACAGAAGCCGGGGGTGAATCCGTCACCCTGCCTGTGGTTCCCGACCAGCCGGAGGTCATTGCTGCCGCC
ATAACCGGTGCTCTTGACGCAGATGCCGACATGGTGCTTATCAATGCCGGTTCTTCGGCGGGCAGCCATGATTATACGGC
GCATGTGCTGGAATCTCTGGGCGAGGTGGTCGCGCACGGCATTTCCGTCATGCCCGGCAAACCCACTGTATTGGCCGTAG
TGCGCGGCAAACCCGTTATCGGCGTGCCGGGTTATCCCGTTTCGGCGGGTGTCGCCATGGAGGAATTCGTGCTGCCCCTG
CTGGCGCTCTGGCAAAAACGGCCCGCGCCGGAGCGGGAAAAGGCTACGGCTGTTCCCTGCCATGCCCTGCCCTCGCGCCC
GGGCATGGAGGAGCGCCTGCGCGTAAAACTGGGCCGTGTGGATGGAAATATTATCGCCGTGCCGCTGCCCCGGGGCGCGG
GAACCATCACCAGCCTGAGCCGCGCCGACGGGATCGTGCGTGTTTCGCGCGACAGCGAAGGCTGCGACGCCGGAATGGCC
GTTACCGTAGACCTGCTGCGCCCGCGCAATGCGCTGGACGGCGCGCTTCTTGCCATCGGCAGCCACGACAATACGCTGGA
CCTGCTGGACAGCCTGCTGCGCAAAACCCACCCCCGCTTTCGCCTGACCTCAGCTCATGTGGGTTCTCTGGGCGGCCTCA
TGGCTCTCGGCCGCCGCCAGTGCCATCTGGCAGGCTGCCACCTGCTTGATGCGGAAACCGGTCTGTACAACCGCAGGGCC
ATTGAAAACAATCTTGATGAGCCGATGATCCTGCTGCGCCTTGTGGACAGGGAACAGGGCATTGTTGTGGCTCCGGGCAA
TCCGCTGGGCATCACCGGCATCAGTGATCTGACCAGGGAAGGCACGCGCTTTGTCAATCGCCAGAGGGGCAGCGGAACCC
GCGTACTGCTGGACTACAAGCTGGCCTGCCTGGGCGTGGCCCCTGCGAGCATTTCCGGATACCGTGATGAAGAATACACG
CACATGAACGTAGCTGCCGCCGTGCTCTCCGGCCGGGCCGATGCCGGGCTTGCCGTGCGGGCCGCGGCCAATGCGCTGGG
CCTGCCCTTTGTACCCGTGGGAGTTGAAGAGTACGATCTGGTGATTCCGCGCCGCTTTTACGAAAGCGCGGCCATGCAGG
CGCTGCTGGATGTCGTCCGCGGGCCGGAATTTTTGCAGGCCGTAACGGAAATGGGGGGCTATGGCACGAAAAAGACAGGA
CAGGTCATCTGGGAATACAATGGAAAATAG

Upstream 100 bases:

>100_bases
TGGTCTGCCCGGAAAATCGTGAGGGATTCAGCATGGGCGATATTGTTATGGTGGAACTTTTTCAGTAGTAATAACGCATA
CGCCAAATATGGAGGCCGCC

Downstream 100 bases:

>100_bases
CGCAACCAGCTCTTGAGACAGCCCCTGGCTTATGCCTGGAACAGATACAGCACAATGGGCTGACACCGTATTCTGCAGTT
TATTGTCCAGACCCCGGCCG

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 649; Mature: 649

Protein sequence:

>649_residues
MKRNTYLTLLAPEEARKLWFARLQAASRALPEENIPLTTALHRVLSRPVAALRSSPAFHGAAMDGIAVNAEDTFSASVRN
PLRLELGRQAHWINTGHPLPPGCNAVIMVEHINTEGSGETRWAVIEKAAFPWQHVRKMGEDMVATEIILPPGTCLGPYDL
GALAAGGVLQVPVFARPRVTIIPSGSEIVPLALAREEDLRAGRVLPEFNSLIFSAMITEAGGESVTLPVVPDQPEVIAAA
ITGALDADADMVLINAGSSAGSHDYTAHVLESLGEVVAHGISVMPGKPTVLAVVRGKPVIGVPGYPVSAGVAMEEFVLPL
LALWQKRPAPEREKATAVPCHALPSRPGMEERLRVKLGRVDGNIIAVPLPRGAGTITSLSRADGIVRVSRDSEGCDAGMA
VTVDLLRPRNALDGALLAIGSHDNTLDLLDSLLRKTHPRFRLTSAHVGSLGGLMALGRRQCHLAGCHLLDAETGLYNRRA
IENNLDEPMILLRLVDREQGIVVAPGNPLGITGISDLTREGTRFVNRQRGSGTRVLLDYKLACLGVAPASISGYRDEEYT
HMNVAAAVLSGRADAGLAVRAAANALGLPFVPVGVEEYDLVIPRRFYESAAMQALLDVVRGPEFLQAVTEMGGYGTKKTG
QVIWEYNGK

Sequences:

>Translated_649_residues
MKRNTYLTLLAPEEARKLWFARLQAASRALPEENIPLTTALHRVLSRPVAALRSSPAFHGAAMDGIAVNAEDTFSASVRN
PLRLELGRQAHWINTGHPLPPGCNAVIMVEHINTEGSGETRWAVIEKAAFPWQHVRKMGEDMVATEIILPPGTCLGPYDL
GALAAGGVLQVPVFARPRVTIIPSGSEIVPLALAREEDLRAGRVLPEFNSLIFSAMITEAGGESVTLPVVPDQPEVIAAA
ITGALDADADMVLINAGSSAGSHDYTAHVLESLGEVVAHGISVMPGKPTVLAVVRGKPVIGVPGYPVSAGVAMEEFVLPL
LALWQKRPAPEREKATAVPCHALPSRPGMEERLRVKLGRVDGNIIAVPLPRGAGTITSLSRADGIVRVSRDSEGCDAGMA
VTVDLLRPRNALDGALLAIGSHDNTLDLLDSLLRKTHPRFRLTSAHVGSLGGLMALGRRQCHLAGCHLLDAETGLYNRRA
IENNLDEPMILLRLVDREQGIVVAPGNPLGITGISDLTREGTRFVNRQRGSGTRVLLDYKLACLGVAPASISGYRDEEYT
HMNVAAAVLSGRADAGLAVRAAANALGLPFVPVGVEEYDLVIPRRFYESAAMQALLDVVRGPEFLQAVTEMGGYGTKKTG
QVIWEYNGK
>Mature_649_residues
MKRNTYLTLLAPEEARKLWFARLQAASRALPEENIPLTTALHRVLSRPVAALRSSPAFHGAAMDGIAVNAEDTFSASVRN
PLRLELGRQAHWINTGHPLPPGCNAVIMVEHINTEGSGETRWAVIEKAAFPWQHVRKMGEDMVATEIILPPGTCLGPYDL
GALAAGGVLQVPVFARPRVTIIPSGSEIVPLALAREEDLRAGRVLPEFNSLIFSAMITEAGGESVTLPVVPDQPEVIAAA
ITGALDADADMVLINAGSSAGSHDYTAHVLESLGEVVAHGISVMPGKPTVLAVVRGKPVIGVPGYPVSAGVAMEEFVLPL
LALWQKRPAPEREKATAVPCHALPSRPGMEERLRVKLGRVDGNIIAVPLPRGAGTITSLSRADGIVRVSRDSEGCDAGMA
VTVDLLRPRNALDGALLAIGSHDNTLDLLDSLLRKTHPRFRLTSAHVGSLGGLMALGRRQCHLAGCHLLDAETGLYNRRA
IENNLDEPMILLRLVDREQGIVVAPGNPLGITGISDLTREGTRFVNRQRGSGTRVLLDYKLACLGVAPASISGYRDEEYT
HMNVAAAVLSGRADAGLAVRAAANALGLPFVPVGVEEYDLVIPRRFYESAAMQALLDVVRGPEFLQAVTEMGGYGTKKTG
QVIWEYNGK

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=325, Percent_Identity=30.4615384615385, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI10880983, Length=325, Percent_Identity=30.4615384615385, Blast_Score=112, Evalue=1e-24,
Organism=Escherichia coli, GI1787049, Length=387, Percent_Identity=30.4909560723514, Blast_Score=141, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI25147659, Length=309, Percent_Identity=27.1844660194175, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17136978, Length=334, Percent_Identity=24.8502994011976, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24638841, Length=334, Percent_Identity=24.8502994011976, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 69242; Mature: 69242

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRNTYLTLLAPEEARKLWFARLQAASRALPEENIPLTTALHRVLSRPVAALRSSPAFHG
CCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
AAMDGIAVNAEDTFSASVRNPLRLELGRQAHWINTGHPLPPGCNAVIMVEHINTEGSGET
CCCCCEEECCCCCCHHHCCCCEEEECCCCEEEECCCCCCCCCCCEEEEEEEECCCCCCCE
RWAVIEKAAFPWQHVRKMGEDMVATEIILPPGTCLGPYDLGALAAGGVLQVPVFARPRVT
EEEEEEHHCCCHHHHHHHCCHHEEEEEEECCCCCCCCCCHHHHHCCCEEECCEECCCEEE
IIPSGSEIVPLALAREEDLRAGRVLPEFNSLIFSAMITEAGGESVTLPVVPDQPEVIAAA
EEECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEHEE
ITGALDADADMVLINAGSSAGSHDYTAHVLESLGEVVAHGISVMPGKPTVLAVVRGKPVI
HHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEECCCCCEEEEEECCCCEE
GVPGYPVSAGVAMEEFVLPLLALWQKRPAPEREKATAVPCHALPSRPGMEERLRVKLGRV
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHEEEEEEE
DGNIIAVPLPRGAGTITSLSRADGIVRVSRDSEGCDAGMAVTVDLLRPRNALDGALLAIG
CCCEEEEECCCCCCCHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCEEEEEC
SHDNTLDLLDSLLRKTHPRFRLTSAHVGSLGGLMALGRRQCHLAGCHLLDAETGLYNRRA
CCCCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHCCCCEEEECCEEEECCCCCCCCHH
IENNLDEPMILLRLVDREQGIVVAPGNPLGITGISDLTREGTRFVNRQRGSGTRVLLDYK
HHCCCCCCEEEEEECCCCCCEEEECCCCCEECCHHHHHHHHHHHHHCCCCCCCEEEEEEE
LACLGVAPASISGYRDEEYTHMNVAAAVLSGRADAGLAVRAAANALGLPFVPVGVEEYDL
EEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEHHHHCCCCEEECCCCCEEE
VIPRRFYESAAMQALLDVVRGPEFLQAVTEMGGYGTKKTGQVIWEYNGK
ECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEEECCC
>Mature Secondary Structure
MKRNTYLTLLAPEEARKLWFARLQAASRALPEENIPLTTALHRVLSRPVAALRSSPAFHG
CCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
AAMDGIAVNAEDTFSASVRNPLRLELGRQAHWINTGHPLPPGCNAVIMVEHINTEGSGET
CCCCCEEECCCCCCHHHCCCCEEEECCCCEEEECCCCCCCCCCCEEEEEEEECCCCCCCE
RWAVIEKAAFPWQHVRKMGEDMVATEIILPPGTCLGPYDLGALAAGGVLQVPVFARPRVT
EEEEEEHHCCCHHHHHHHCCHHEEEEEEECCCCCCCCCCHHHHHCCCEEECCEECCCEEE
IIPSGSEIVPLALAREEDLRAGRVLPEFNSLIFSAMITEAGGESVTLPVVPDQPEVIAAA
EEECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEHEE
ITGALDADADMVLINAGSSAGSHDYTAHVLESLGEVVAHGISVMPGKPTVLAVVRGKPVI
HHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEECCCCCEEEEEECCCCEE
GVPGYPVSAGVAMEEFVLPLLALWQKRPAPEREKATAVPCHALPSRPGMEERLRVKLGRV
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHEEEEEEE
DGNIIAVPLPRGAGTITSLSRADGIVRVSRDSEGCDAGMAVTVDLLRPRNALDGALLAIG
CCCEEEEECCCCCCCHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCEEEEEC
SHDNTLDLLDSLLRKTHPRFRLTSAHVGSLGGLMALGRRQCHLAGCHLLDAETGLYNRRA
CCCCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHCCCCEEEECCEEEECCCCCCCCHH
IENNLDEPMILLRLVDREQGIVVAPGNPLGITGISDLTREGTRFVNRQRGSGTRVLLDYK
HHCCCCCCEEEEEECCCCCCEEEECCCCCEECCHHHHHHHHHHHHHCCCCCCCEEEEEEE
LACLGVAPASISGYRDEEYTHMNVAAAVLSGRADAGLAVRAAANALGLPFVPVGVEEYDL
EEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEHHHHCCCCEEECCCCCEEE
VIPRRFYESAAMQALLDVVRGPEFLQAVTEMGGYGTKKTGQVIWEYNGK
ECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]