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The map label for this gene is moeA [C]

Identifier: 220905034

GI number: 220905034

Start: 2139372

End: 2140652

Strand: Direct

Name: moeA [C]

Synonym: Ddes_1771

Alternate gene names: 220905034

Gene position: 2139372-2140652 (Clockwise)

Preceding gene: 220905033

Following gene: 220905035

Centisome position: 74.45

GC content: 61.9

Gene sequence:

>1281_bases
ATGAAAGCTTTTTTGACCTTGCAGTCCGTGGAATCCGTTCTTGAACACATCCACCAGTTTCCTGTGCTTGAATATGAAAA
CGTTTCTCTGGACAACGCCCTTGGCCGCCGCCTGGCACACGATTTTTGCGCTCCGGAAAACCTGCCCGGCTTTAACCGCT
CAACCATGGATGGATACGCCGTGCGGGCGCGCGATGTGTTTGGCGCACAGGAGGGCAGCCCCGCCCTCGTGGAATGTGTG
GGCGACTGCCCTATGGGGGCAAAGCCCGATCTGACGCTTGCAGAAGGTCAGGCTGCCCGCATAGCTACCGGCGGCATGCT
GCCCGAAGGCGCGGATTGTGTGGTTATGGTGGAGTATTCCCGCCCTGCGGGCGGCAAACTGGTGGAGCTTACCCGCAGCC
AGGCTCCCGGCGACAATGTTATTTTCCATAATGACGATGCAAGCACGGGCGACAGGCTTTTGCCTGCGGGGCATTGTCTT
CGCCCGCAGGATATCGGCCTTCTGGCAGCCTTTGGTGCCACCGGTGTTGCAGTGCGGCGCAAACCGCGCGTAGCCGTGCT
TTCCACCGGCGATGAAATTGTTTCCGCCACAGAAACACCGCCGCCGGGCAAAATCCGCGATATCAATGCCCACAGCATCA
CTGCCCTGTGCTGTCAGGCCGGGGGCCGTGCCTCACGGGCAGGGCTTGTGCGCGACAATGCGCGCGAGCTTGAAACAGCT
CTTGCCGGCCTTGCGGCCGCACATGACATCATCGTTGTTTCAGGCGGCTCATCGGCTGGCGCGCGCGATCATACTGTCGA
GGTTTTCGCCGCTCTGCCCCAAAGCGAAATCATAACGCACGGTGTCGCTCTCAGCCCCGGCAAGCCCTTCATCCTGGCCC
GCGCCGGCATAGACGGACGCACCGTCTGCCTCATGGGCCTGCCCGGCCATACAGTCAGCGCGCTCATCTGTGCGCGGGTT
TTTCTCGTTCCTCTGCTGCACCACCTTCAGGGCGGGACCGGGACGGAAATAGCCGCCTGTGTTCCGGCAGTGCTGAGCCG
CTCCATTGCTTCCGCCCAAGGCCGCCGCGACTACCTGCGAGTACGCCTGCAGCCCTTGCCCGCAACCTCCCCCTCCTCTT
CTGGCGCCACACGCGGACAGGCCCTGTACACCGCCGAACCGATAACGGGGGCTTCCGGCCTGATCACGGGTCTTGCCGCG
GCAGACGGCCTGCTGGTCTGCCCGGAAAATCGTGAGGGATTCAGCATGGGCGATATTGTTATGGTGGAACTTTTTCAGTA
G

Upstream 100 bases:

>100_bases
TGTATGCTCCCGCCAGTTGCGCAAAAGCCGCACCACTCAATCGTTTCTGTTGCACATCAAAGCGGCGGGCAATATTGGAA
ACGCAGTCCGGAGGCCAGGC

Downstream 100 bases:

>100_bases
TAATAACGCATACGCCAAATATGGAGGCCGCCATGAAGCGCAATACCTACCTGACCCTGCTTGCGCCCGAAGAGGCGCGG
AAACTCTGGTTCGCGCGTCT

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MKAFLTLQSVESVLEHIHQFPVLEYENVSLDNALGRRLAHDFCAPENLPGFNRSTMDGYAVRARDVFGAQEGSPALVECV
GDCPMGAKPDLTLAEGQAARIATGGMLPEGADCVVMVEYSRPAGGKLVELTRSQAPGDNVIFHNDDASTGDRLLPAGHCL
RPQDIGLLAAFGATGVAVRRKPRVAVLSTGDEIVSATETPPPGKIRDINAHSITALCCQAGGRASRAGLVRDNARELETA
LAGLAAAHDIIVVSGGSSAGARDHTVEVFAALPQSEIITHGVALSPGKPFILARAGIDGRTVCLMGLPGHTVSALICARV
FLVPLLHHLQGGTGTEIAACVPAVLSRSIASAQGRRDYLRVRLQPLPATSPSSSGATRGQALYTAEPITGASGLITGLAA
ADGLLVCPENREGFSMGDIVMVELFQ

Sequences:

>Translated_426_residues
MKAFLTLQSVESVLEHIHQFPVLEYENVSLDNALGRRLAHDFCAPENLPGFNRSTMDGYAVRARDVFGAQEGSPALVECV
GDCPMGAKPDLTLAEGQAARIATGGMLPEGADCVVMVEYSRPAGGKLVELTRSQAPGDNVIFHNDDASTGDRLLPAGHCL
RPQDIGLLAAFGATGVAVRRKPRVAVLSTGDEIVSATETPPPGKIRDINAHSITALCCQAGGRASRAGLVRDNARELETA
LAGLAAAHDIIVVSGGSSAGARDHTVEVFAALPQSEIITHGVALSPGKPFILARAGIDGRTVCLMGLPGHTVSALICARV
FLVPLLHHLQGGTGTEIAACVPAVLSRSIASAQGRRDYLRVRLQPLPATSPSSSGATRGQALYTAEPITGASGLITGLAA
ADGLLVCPENREGFSMGDIVMVELFQ
>Mature_426_residues
MKAFLTLQSVESVLEHIHQFPVLEYENVSLDNALGRRLAHDFCAPENLPGFNRSTMDGYAVRARDVFGAQEGSPALVECV
GDCPMGAKPDLTLAEGQAARIATGGMLPEGADCVVMVEYSRPAGGKLVELTRSQAPGDNVIFHNDDASTGDRLLPAGHCL
RPQDIGLLAAFGATGVAVRRKPRVAVLSTGDEIVSATETPPPGKIRDINAHSITALCCQAGGRASRAGLVRDNARELETA
LAGLAAAHDIIVVSGGSSAGARDHTVEVFAALPQSEIITHGVALSPGKPFILARAGIDGRTVCLMGLPGHTVSALICARV
FLVPLLHHLQGGTGTEIAACVPAVLSRSIASAQGRRDYLRVRLQPLPATSPSSSGATRGQALYTAEPITGASGLITGLAA
ADGLLVCPENREGFSMGDIVMVELFQ

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=421, Percent_Identity=32.0665083135392, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI66932975, Length=421, Percent_Identity=32.0665083135392, Blast_Score=167, Evalue=2e-41,
Organism=Escherichia coli, GI1787049, Length=344, Percent_Identity=32.5581395348837, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI25147659, Length=316, Percent_Identity=32.5949367088608, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17562606, Length=330, Percent_Identity=28.7878787878788, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI17136978, Length=336, Percent_Identity=30.3571428571429, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24638841, Length=336, Percent_Identity=30.3571428571429, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44282; Mature: 44282

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAFLTLQSVESVLEHIHQFPVLEYENVSLDNALGRRLAHDFCAPENLPGFNRSTMDGYA
CCCEEEHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEE
VRARDVFGAQEGSPALVECVGDCPMGAKPDLTLAEGQAARIATGGMLPEGADCVVMVEYS
EEEHHHCCCCCCCCHHHHEECCCCCCCCCCCEEECCCEEEEEECCCCCCCCCEEEEEEEC
RPAGGKLVELTRSQAPGDNVIFHNDDASTGDRLLPAGHCLRPQDIGLLAAFGATGVAVRR
CCCCCEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEC
KPRVAVLSTGDEIVSATETPPPGKIRDINAHSITALCCQAGGRASRAGLVRDNARELETA
CCCEEEEECCCHHEECCCCCCCCCEEECCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
LAGLAAAHDIIVVSGGSSAGARDHTVEVFAALPQSEIITHGVALSPGKPFILARAGIDGR
HHHHHHCCEEEEEECCCCCCCCCCEEEEEECCCHHHHHHCCEEECCCCCEEEEECCCCCC
TVCLMGLPGHTVSALICARVFLVPLLHHLQGGTGTEIAACVPAVLSRSIASAQGRRDYLR
EEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEE
VRLQPLPATSPSSSGATRGQALYTAEPITGASGLITGLAAADGLLVCPENREGFSMGDIV
EEEEECCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCEE
MVELFQ
EEEEEC
>Mature Secondary Structure
MKAFLTLQSVESVLEHIHQFPVLEYENVSLDNALGRRLAHDFCAPENLPGFNRSTMDGYA
CCCEEEHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEE
VRARDVFGAQEGSPALVECVGDCPMGAKPDLTLAEGQAARIATGGMLPEGADCVVMVEYS
EEEHHHCCCCCCCCHHHHEECCCCCCCCCCCEEECCCEEEEEECCCCCCCCCEEEEEEEC
RPAGGKLVELTRSQAPGDNVIFHNDDASTGDRLLPAGHCLRPQDIGLLAAFGATGVAVRR
CCCCCEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEC
KPRVAVLSTGDEIVSATETPPPGKIRDINAHSITALCCQAGGRASRAGLVRDNARELETA
CCCEEEEECCCHHEECCCCCCCCCEEECCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
LAGLAAAHDIIVVSGGSSAGARDHTVEVFAALPQSEIITHGVALSPGKPFILARAGIDGR
HHHHHHCCEEEEEECCCCCCCCCCEEEEEECCCHHHHHHCCEEECCCCCEEEEECCCCCC
TVCLMGLPGHTVSALICARVFLVPLLHHLQGGTGTEIAACVPAVLSRSIASAQGRRDYLR
EEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEE
VRLQPLPATSPSSSGATRGQALYTAEPITGASGLITGLAAADGLLVCPENREGFSMGDIV
EEEEECCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCEE
MVELFQ
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]