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The map label for this gene is apeA [H]

Identifier: 220905005

GI number: 220905005

Start: 2106796

End: 2108181

Strand: Direct

Name: apeA [H]

Synonym: Ddes_1741

Alternate gene names: 220905005

Gene position: 2106796-2108181 (Clockwise)

Preceding gene: 220905004

Following gene: 220905006

Centisome position: 73.32

GC content: 59.09

Gene sequence:

>1386_bases
ATGGAAAAGACTCTGGCCTACAAACCCCAAAACGCCTGGGAAGGCGCGGACGCCAAGACGCGCAAAGAAATGGAAGCCCT
GGCTGTTCGCTATATGGATTTTCTTACGCACTGCAAAACAGAACGCGAAACAGTGAAATATGTGCGCCAGCGCCTGGCGG
AACACGGCTATACTGAAGACTTCAATGCTGACCGCATTATGCGGCCCATGCGTGGCAAAGCCATTTTTGCGGCAAGGCGT
GGCGTGCTGCCGCTGGAGCAGGGGCTTGCCCTCATTGCCGCCCATACCGACACGCCGCGCCTGGACTTCAAACAGCGCCC
GCTCATTGAGCAGCCCGGCGTTGCTCAGGCAAAAACACACTATTACGGCGGCATACGAAAATATCAATGGCTGGCGCGCC
CTCTGGCGCTGCATGGCGTGGTGGTGCGCGGCGACGGCTCTGTCGTTGAAGTTACCATTGGCGAAAAAGCCGGGGAACCT
GTGTTCTGCATTGCCGACCTTCTGCCCCATCTGGCCCAGAAGCAGGTTACCCAGACCGTCAGCGATGCGTTTGAAGCCGA
AAAGCTCAACATCATTCTTGGGCACAGCCCCAAGGCCGCAGGCAAGGGCAAAAAAGAAGACGCCCCCAAAGAACCGGTAA
AGGCGCAACTTCTTGAAATTCTGAATAAAAAATACGGCATTACCGAAGAGGATCTCATCACAGCCGAACTTCAGGCCGTT
CCCGCCGGGCCGGCCCGCTTTGTGGGTTTTGACAAGGCTCTGGTAGGCGGCTACGGGCAGGATGACCGCATCTGCGTCTT
TGCAGCCCTTGAAGCCCTGCTGGAGGCCGAAGCCACAGGCCGGAGCATGGCCGTCATTTTTTGGGACAAGGAAGAAATCG
GTTCGGACGGGGCCACCGGCGCGGCCTCACGCTTTTTTCAGTATTGCGTGGAAGACCTGGCCCGCGCCTGGGCGCCGGAT
GTGCCTGCATCCCGTGTTTTTATGGAAACCCGCGCCCTGTCCGCCGACGTGCAGGCAGCCCTGGACCCCGATTTTCAGGA
AGTGCACGAAAAACAGAATGCTGCCCAGATGGGCTACGGTCCCTGTTTTTCCAAGTTCACAGGCTCACGCGGCAAGTACG
GGGCCAGCGAGGCCGATGCAGAGTTTTTCGGCGCGCTGCGCAATCTTTACAACAGCATAAGCATTCCCTGGCAGGCGGCG
GAACTCGGCCGCGTGGACCACGGCGGCGGCGGCACGGTGGCTCTTTTTCTTGCCGCCTACGGCATGCACGTCATTGACCT
CGGCCCTGCGGTCCTGTCCATGCACAGCCCCTTTGAGCTGGCAAGCTGCGCCGACCTGCATACTACGGTGCGGGCATACC
GGGCCTTTTTTGAATCAGCCGTCTAG

Upstream 100 bases:

>100_bases
GCGCGAGGCTCTGGCTTTGGCCGCAAAAGAGATTATATAGGCGGTACTGACCGCAAAAATGACAGGCCTGCCGTTCGGGC
AGGCCGTAAAGGAAAACAGC

Downstream 100 bases:

>100_bases
GGCCGTTTCACTGTAAAACACTCCCACCCGATGCCGGGCCTACCATACACACAGGGCAGACCTGCCCGCACAAGGCCCGG
CGGCATCGCTCTACTCCTTG

Product: putative aminopeptidase 1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MEKTLAYKPQNAWEGADAKTRKEMEALAVRYMDFLTHCKTERETVKYVRQRLAEHGYTEDFNADRIMRPMRGKAIFAARR
GVLPLEQGLALIAAHTDTPRLDFKQRPLIEQPGVAQAKTHYYGGIRKYQWLARPLALHGVVVRGDGSVVEVTIGEKAGEP
VFCIADLLPHLAQKQVTQTVSDAFEAEKLNIILGHSPKAAGKGKKEDAPKEPVKAQLLEILNKKYGITEEDLITAELQAV
PAGPARFVGFDKALVGGYGQDDRICVFAALEALLEAEATGRSMAVIFWDKEEIGSDGATGAASRFFQYCVEDLARAWAPD
VPASRVFMETRALSADVQAALDPDFQEVHEKQNAAQMGYGPCFSKFTGSRGKYGASEADAEFFGALRNLYNSISIPWQAA
ELGRVDHGGGGTVALFLAAYGMHVIDLGPAVLSMHSPFELASCADLHTTVRAYRAFFESAV

Sequences:

>Translated_461_residues
MEKTLAYKPQNAWEGADAKTRKEMEALAVRYMDFLTHCKTERETVKYVRQRLAEHGYTEDFNADRIMRPMRGKAIFAARR
GVLPLEQGLALIAAHTDTPRLDFKQRPLIEQPGVAQAKTHYYGGIRKYQWLARPLALHGVVVRGDGSVVEVTIGEKAGEP
VFCIADLLPHLAQKQVTQTVSDAFEAEKLNIILGHSPKAAGKGKKEDAPKEPVKAQLLEILNKKYGITEEDLITAELQAV
PAGPARFVGFDKALVGGYGQDDRICVFAALEALLEAEATGRSMAVIFWDKEEIGSDGATGAASRFFQYCVEDLARAWAPD
VPASRVFMETRALSADVQAALDPDFQEVHEKQNAAQMGYGPCFSKFTGSRGKYGASEADAEFFGALRNLYNSISIPWQAA
ELGRVDHGGGGTVALFLAAYGMHVIDLGPAVLSMHSPFELASCADLHTTVRAYRAFFESAV
>Mature_461_residues
MEKTLAYKPQNAWEGADAKTRKEMEALAVRYMDFLTHCKTERETVKYVRQRLAEHGYTEDFNADRIMRPMRGKAIFAARR
GVLPLEQGLALIAAHTDTPRLDFKQRPLIEQPGVAQAKTHYYGGIRKYQWLARPLALHGVVVRGDGSVVEVTIGEKAGEP
VFCIADLLPHLAQKQVTQTVSDAFEAEKLNIILGHSPKAAGKGKKEDAPKEPVKAQLLEILNKKYGITEEDLITAELQAV
PAGPARFVGFDKALVGGYGQDDRICVFAALEALLEAEATGRSMAVIFWDKEEIGSDGATGAASRFFQYCVEDLARAWAPD
VPASRVFMETRALSADVQAALDPDFQEVHEKQNAAQMGYGPCFSKFTGSRGKYGASEADAEFFGALRNLYNSISIPWQAA
ELGRVDHGGGGTVALFLAAYGMHVIDLGPAVLSMHSPFELASCADLHTTVRAYRAFFESAV

Specific function: Unknown

COG id: COG1362

COG function: function code E; Aspartyl aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M18 family [H]

Homologues:

Organism=Homo sapiens, GI156416028, Length=471, Percent_Identity=26.5392781316348, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17552916, Length=463, Percent_Identity=23.110151187905, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321905, Length=470, Percent_Identity=25.3191489361702, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6322746, Length=467, Percent_Identity=24.8394004282655, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022983
- InterPro:   IPR001948 [H]

Pfam domain/function: PF02127 Peptidase_M18 [H]

EC number: NA

Molecular weight: Translated: 50473; Mature: 50473

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTLAYKPQNAWEGADAKTRKEMEALAVRYMDFLTHCKTERETVKYVRQRLAEHGYTED
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCC
FNADRIMRPMRGKAIFAARRGVLPLEQGLALIAAHTDTPRLDFKQRPLIEQPGVAQAKTH
CCHHHHHHHHCCCEEEHHHCCCCCHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHH
YYGGIRKYQWLARPLALHGVVVRGDGSVVEVTIGEKAGEPVFCIADLLPHLAQKQVTQTV
HHCCHHHHHHHHHHHHHCEEEEECCCCEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHH
SDAFEAEKLNIILGHSPKAAGKGKKEDAPKEPVKAQLLEILNKKYGITEEDLITAELQAV
HHHHHHHHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
PAGPARFVGFDKALVGGYGQDDRICVFAALEALLEAEATGRSMAVIFWDKEEIGSDGATG
CCCCHHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECHHHHCCCCCCH
AASRFFQYCVEDLARAWAPDVPASRVFMETRALSADVQAALDPDFQEVHEKQNAAQMGYG
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
PCFSKFTGSRGKYGASEADAEFFGALRNLYNSISIPWQAAELGRVDHGGGGTVALFLAAY
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHH
GMHVIDLGPAVLSMHSPFELASCADLHTTVRAYRAFFESAV
CCHHEECCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKTLAYKPQNAWEGADAKTRKEMEALAVRYMDFLTHCKTERETVKYVRQRLAEHGYTED
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCC
FNADRIMRPMRGKAIFAARRGVLPLEQGLALIAAHTDTPRLDFKQRPLIEQPGVAQAKTH
CCHHHHHHHHCCCEEEHHHCCCCCHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHH
YYGGIRKYQWLARPLALHGVVVRGDGSVVEVTIGEKAGEPVFCIADLLPHLAQKQVTQTV
HHCCHHHHHHHHHHHHHCEEEEECCCCEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHH
SDAFEAEKLNIILGHSPKAAGKGKKEDAPKEPVKAQLLEILNKKYGITEEDLITAELQAV
HHHHHHHHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
PAGPARFVGFDKALVGGYGQDDRICVFAALEALLEAEATGRSMAVIFWDKEEIGSDGATG
CCCCHHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECHHHHCCCCCCH
AASRFFQYCVEDLARAWAPDVPASRVFMETRALSADVQAALDPDFQEVHEKQNAAQMGYG
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
PCFSKFTGSRGKYGASEADAEFFGALRNLYNSISIPWQAAELGRVDHGGGGTVALFLAAY
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHH
GMHVIDLGPAVLSMHSPFELASCADLHTTVRAYRAFFESAV
CCHHEECCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]