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The map label for this gene is nuoD1 [H]

Identifier: 220904927

GI number: 220904927

Start: 1998980

End: 2000131

Strand: Reverse

Name: nuoD1 [H]

Synonym: Ddes_1662

Alternate gene names: 220904927

Gene position: 2000131-1998980 (Counterclockwise)

Preceding gene: 220904928

Following gene: 220904926

Centisome position: 69.61

GC content: 59.98

Gene sequence:

>1152_bases
ATGGGACCGCAGCATCCGGCCACACACGGCGTTTTGCGGGTGGACCTTGAGCTTGAGGGCGAAACCATCGTGCATTGCGA
CCCGCAGGTCGGGTATCTGCACCGGGGATTTGAAAAACTGGCGGAAAAGTTCACCTATGCCCAGGCCCTGACGCTTACGG
ACCGACTGGACTATATCGCGGCCATGTCCAACAACACAGGCTATTGCCTGGCGGTGGAAAAGCTGCTGGGTATTGAAGCG
CCCCTGCGCGCCCGGTACATCCGCACCATTGCCTGCGAAATGTCGCGCATCAGTTCACATTTGCTGTGGCTTGCCACCCA
CGCCCTGGATATCGGGGCCATGACGGTTTTTCTTTACTGCTTCCGTGAGCGCGAAATGCTGCTCAATCTTTTTGAAGACC
TGTGCGGCGCGCGGCTTACCCTGACGTATCCGCGCATCGGCGGTGTGCGGCAGGACGTGAGCGGCAGGTTCATGAGCGGC
CTTCAGGATTTTGTAAACATTTTCCCCGGCCGTATTGTGGAATACGAGACCCTGCTGGATACCAACCGCATCTGGCTCAA
GCGCACCGTTGGCGTGGGCAAGGTCAGCGCGGATGAAGCCCTGTCGTTGGGTCTTACCGGGGCCTGTCTGCGCGGTTCCG
GCGTGGATTATGACGTGCGCCGCCATGCGCCCTATGATGCGTATGCCCTGCTGGACTTTGCAGTTCCTCTGGGTGCTGAC
GGGGATATCTACGCCCGTTATCGCTGTCGTATGGAGGAACTGCGCCAGTCTACGCACATTCTGCAGCAGTGCATCGACGC
CATGCCTCCCGGCCCCACGCTGGCCGAAGACTCCCCGGATCTGCTCATGCCGCCGTCACGCTGGCACGGCACGCCCGAAA
CCACCCTTTACGGCGGTGGGCTGCGCGCCGTTATGCGTGACAGAAATATCTACATGGCGGGCGATGTATTTGTATCCACA
GAAGTCCCCAAGGGAGAACTGGGTTTCTACTTCATCTCCAACGGCAGCAGCCGCCCGTACCGCATGCATGTACGTGCGCC
GTCTTTCATACACATCGGCGCGCTGGCAAGCATCGCCAGGGGCGGGCTTATCGCCGACCTGATCGCAAATATCGGAAGTC
TGGACGTGGTGCTGGGCGAATCGGACCGCTGA

Upstream 100 bases:

>100_bases
GGAACTGAGCGGTCTTGAGCAGAGCGATATTGCCTGCGTCAACTGCCTTGACGACAACGATTTTGACGACGCAGATTTTG
ACGACCGCACCAGCCTGCGC

Downstream 100 bases:

>100_bases
AGCCCGACGCGGCATGCCCGCGTACGCCCGGCGGCTTGTAGGCGCAACATGACAAAACGGGTCTGAAACAGGACAAGCCA
TATGGACATACTGCTTATTC

Product: NADH dehydrogenase I subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D 1; NDH-1 subunit D 1 [H]

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MGPQHPATHGVLRVDLELEGETIVHCDPQVGYLHRGFEKLAEKFTYAQALTLTDRLDYIAAMSNNTGYCLAVEKLLGIEA
PLRARYIRTIACEMSRISSHLLWLATHALDIGAMTVFLYCFREREMLLNLFEDLCGARLTLTYPRIGGVRQDVSGRFMSG
LQDFVNIFPGRIVEYETLLDTNRIWLKRTVGVGKVSADEALSLGLTGACLRGSGVDYDVRRHAPYDAYALLDFAVPLGAD
GDIYARYRCRMEELRQSTHILQQCIDAMPPGPTLAEDSPDLLMPPSRWHGTPETTLYGGGLRAVMRDRNIYMAGDVFVST
EVPKGELGFYFISNGSSRPYRMHVRAPSFIHIGALASIARGGLIADLIANIGSLDVVLGESDR

Sequences:

>Translated_383_residues
MGPQHPATHGVLRVDLELEGETIVHCDPQVGYLHRGFEKLAEKFTYAQALTLTDRLDYIAAMSNNTGYCLAVEKLLGIEA
PLRARYIRTIACEMSRISSHLLWLATHALDIGAMTVFLYCFREREMLLNLFEDLCGARLTLTYPRIGGVRQDVSGRFMSG
LQDFVNIFPGRIVEYETLLDTNRIWLKRTVGVGKVSADEALSLGLTGACLRGSGVDYDVRRHAPYDAYALLDFAVPLGAD
GDIYARYRCRMEELRQSTHILQQCIDAMPPGPTLAEDSPDLLMPPSRWHGTPETTLYGGGLRAVMRDRNIYMAGDVFVST
EVPKGELGFYFISNGSSRPYRMHVRAPSFIHIGALASIARGGLIADLIANIGSLDVVLGESDR
>Mature_382_residues
GPQHPATHGVLRVDLELEGETIVHCDPQVGYLHRGFEKLAEKFTYAQALTLTDRLDYIAAMSNNTGYCLAVEKLLGIEAP
LRARYIRTIACEMSRISSHLLWLATHALDIGAMTVFLYCFREREMLLNLFEDLCGARLTLTYPRIGGVRQDVSGRFMSGL
QDFVNIFPGRIVEYETLLDTNRIWLKRTVGVGKVSADEALSLGLTGACLRGSGVDYDVRRHAPYDAYALLDFAVPLGADG
DIYARYRCRMEELRQSTHILQQCIDAMPPGPTLAEDSPDLLMPPSRWHGTPETTLYGGGLRAVMRDRNIYMAGDVFVSTE
VPKGELGFYFISNGSSRPYRMHVRAPSFIHIGALASIARGGLIADLIANIGSLDVVLGESDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=389, Percent_Identity=44.987146529563, Blast_Score=347, Evalue=2e-95,
Organism=Homo sapiens, GI260898743, Length=383, Percent_Identity=44.3864229765013, Blast_Score=335, Evalue=4e-92,
Organism=Escherichia coli, GI145693162, Length=384, Percent_Identity=39.84375, Blast_Score=282, Evalue=3e-77,
Organism=Escherichia coli, GI1789076, Length=384, Percent_Identity=27.8645833333333, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788832, Length=384, Percent_Identity=28.3854166666667, Blast_Score=122, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17568379, Length=383, Percent_Identity=46.2140992167102, Blast_Score=356, Evalue=1e-98,
Organism=Caenorhabditis elegans, GI17555284, Length=383, Percent_Identity=45.9530026109661, Blast_Score=355, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24638644, Length=389, Percent_Identity=47.3007712082262, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI221459469, Length=388, Percent_Identity=45.360824742268, Blast_Score=346, Evalue=1e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 42451; Mature: 42320

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPQHPATHGVLRVDLELEGETIVHCDPQVGYLHRGFEKLAEKFTYAQALTLTDRLDYIA
CCCCCCCCCCEEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
AMSNNTGYCLAVEKLLGIEAPLRARYIRTIACEMSRISSHLLWLATHALDIGAMTVFLYC
EECCCCCEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FREREMLLNLFEDLCGARLTLTYPRIGGVRQDVSGRFMSGLQDFVNIFPGRIVEYETLLD
HHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHC
TNRIWLKRTVGVGKVSADEALSLGLTGACLRGSGVDYDVRRHAPYDAYALLDFAVPLGAD
CCCEEEEEECCCCCCCHHHHHHCCCCCEEECCCCCCCHHHCCCCCCHHHHEEECCCCCCC
GDIYARYRCRMEELRQSTHILQQCIDAMPPGPTLAEDSPDLLMPPSRWHGTPETTLYGGG
CCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCC
LRAVMRDRNIYMAGDVFVSTEVPKGELGFYFISNGSSRPYRMHVRAPSFIHIGALASIAR
CEEEEECCCEEEECCEEEECCCCCCCEEEEEEECCCCCCEEEEECCCCEEEHHHHHHHHC
GGLIADLIANIGSLDVVLGESDR
CCHHHHHHHCCCCEEEEECCCCC
>Mature Secondary Structure 
GPQHPATHGVLRVDLELEGETIVHCDPQVGYLHRGFEKLAEKFTYAQALTLTDRLDYIA
CCCCCCCCCEEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
AMSNNTGYCLAVEKLLGIEAPLRARYIRTIACEMSRISSHLLWLATHALDIGAMTVFLYC
EECCCCCEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FREREMLLNLFEDLCGARLTLTYPRIGGVRQDVSGRFMSGLQDFVNIFPGRIVEYETLLD
HHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHC
TNRIWLKRTVGVGKVSADEALSLGLTGACLRGSGVDYDVRRHAPYDAYALLDFAVPLGAD
CCCEEEEEECCCCCCCHHHHHHCCCCCEEECCCCCCCHHHCCCCCCHHHHEEECCCCCCC
GDIYARYRCRMEELRQSTHILQQCIDAMPPGPTLAEDSPDLLMPPSRWHGTPETTLYGGG
CCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCC
LRAVMRDRNIYMAGDVFVSTEVPKGELGFYFISNGSSRPYRMHVRAPSFIHIGALASIAR
CEEEEECCCEEEECCEEEECCCCCCCEEEEEEECCCCCCEEEEECCCCEEEHHHHHHHHC
GGLIADLIANIGSLDVVLGESDR
CCHHHHHHHCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA