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The map label for this gene is nuoL [H]

Identifier: 220904922

GI number: 220904922

Start: 1994188

End: 1996116

Strand: Reverse

Name: nuoL [H]

Synonym: Ddes_1657

Alternate gene names: 220904922

Gene position: 1996116-1994188 (Counterclockwise)

Preceding gene: 220904923

Following gene: 220904921

Centisome position: 69.47

GC content: 56.35

Gene sequence:

>1929_bases
ATGCCCATATACCTCTTGCTTATTCCGCTGTGTCCGCTGCTGGCCTTTGCCGTTACCCTGGTGTGCGGGCGCTGGTGGGG
CAGCCGCGCCCACTGGCTGCCCATCGCAGCCATCGTTGTTTCCCTGTGCTGTTCCATTCTGGCCCTGCGCGATGTCATGA
ACGGCGTTATCGTCAACGCTGATGTGCATAACTGGATAACATCGGGCAATCTGAGCGTGTCTTTCGGTTTTCTTGTGGAC
CAGCTTACGGCAGTTATGCTTATTGTGGTTACCAGTGTCAGCACACTGGTCCACATCTATTCTGTGGGCTACATGAAGGG
CGAGGACGGCTATTACCGCTTTTTCGCCTATCTGGCGCTCTTTTCTTTCTCCATGCTCATGCTGGTGCTGAGCAATAACT
TTTTACAGCTCTTTTTCGGATGGGAGGCTGTAGGGCTTTCATCCTATCTGCTCATCGGCTTTTATTACGAAAAAACCTCG
GCATCGGATGCGGGGAAAAAAGCTTTCATTGTCAACAGGTTCGGCGATTTTGGCTTTTTGCTCGGCCTGTTCTGCATATT
CACGCTTTTCGGCAGCCTGCATTATGATAATGTTTTTGCCCGTGCGGGACTGTTGCAGGGCCTGAGCTATACCATTGGTG
GCATAAGCATTGACGCGGCCACCCTTGTCTGCCTGCTGCTTTTTTGCGGCGCAGCGGGCAAGTCTGCCCAGTTGCCCCTG
CATGTGTGGCTGCCCGATGCCATGGAAGGTCCGACGCCTGTGAGCGCCCTCATTCACGCGGCCACTATGGTCACGGCGGG
GGTCTTTCTGGTCGCCCGCTGTAATGCGTTGTTTTCCCTTTCCCCCACAGCTCTTGGCGTCATTACCGTGGTGGGGGCAC
TTACGGCGCTTTTTGCGGCCACCATTGCCCTCACCCAGACGGACATCAAGCGGGTGGTGGCCTATTCCACCATCAGCCAG
CTGGCTTTCATGTTCATAGGCTGTGGTGTAGGGGCCTATGCGGCGGGCATTTTTCACCTCTTTACCCATGCATTTTTCAA
GGCTCTGCTGTTTCTGGGTTGCGGTTCGGTCATACTGGGCATGCACCATGAGCAGGATATGCGTCGTATGGGCGGGTTAC
GAAAATATATGCCCGTCACCTGCGTCACATTTTTGCTGGCTTCGCTTTCCATTTCCGGCGTACCGGGCCTGGCAGGTTTT
TTTAGCAAGGATGAGATCCTGCTTATGGCTTTCAACGCAGATACCACGGCCGGCTATTTCGCCTGGGGCGTGGGGACCTT
TGTGGCCTTTTTGACGGCTTTTTATTCCTTCCGTCTGTTTTTCAGCATTTTTTATGGTGAATTTCGCGGCACACAGCATC
AGCGCGAGCATTTGCGCGAGTCGCCGCTGGTGGTCACCATACCTTTGCTCCTCCTGGCCTGCGGGGCTGTGGGGGCTGGC
TGGCTGGGCATTCCGCATGTGCTTGGCGGCTCCAACCTCTGGGCCGGTTTTCTTGAGCCGGTTGTGGGGCATCCGCATCT
GCACCTGGATGGCCCGGCGGAGCTTATGCTCATGGGGGCTTCAGTCGTGGCGGGGGTGTGCGGCATCGGTCTTGCGTGGT
TCATGTACCACCGCCAGACTGAATGGCCGGAAAGGGTGGTGCAGAGTTTTCCGCGCCTGTACAGGCTTTTTCTGCACAAG
TACCGTGTGGACGAAATTTACGCGGCCTGTCTGGTGCGTCCGGTCTTGTGGCTGGCTGATCATGTGCTGCTGCGCGTGGT
GGACACCAAGGGGATCGAAGGGGTGGTCAATGGCCTGCCCCGTGCCATCGGCAGGCTTTCTGTCAGGTTGCGCCGTTTTC
AGGACGGGCATGTGGCCCATTATCTGGCCTGGCTGGCCGGAGCCTCGGTGGTGCTTCTGATTGTGCTGCAACTGGGAATT
TTCTCGTAA

Upstream 100 bases:

>100_bases
CAGCGTGCGAGGCCGCCGTGGGGCTGGGCATAGTCATCTGCCTGTTCCGCAGCCGTAGAACGGTGCGCAACGACAACATC
GTCGAGCTTCGGGGGTAACC

Downstream 100 bases:

>100_bases
ACACGGCAGGGAGACAGCATGTCCGTACCCGTACTTTCCTTGCTTATCTTTGTTCCTGTGCTTGGCGGTCTCTCGCTTAT
GCTCCTGCCCAGAGGGCGGG

Product: proton-translocating NADH-quinone oxidoreductase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 642; Mature: 641

Protein sequence:

>642_residues
MPIYLLLIPLCPLLAFAVTLVCGRWWGSRAHWLPIAAIVVSLCCSILALRDVMNGVIVNADVHNWITSGNLSVSFGFLVD
QLTAVMLIVVTSVSTLVHIYSVGYMKGEDGYYRFFAYLALFSFSMLMLVLSNNFLQLFFGWEAVGLSSYLLIGFYYEKTS
ASDAGKKAFIVNRFGDFGFLLGLFCIFTLFGSLHYDNVFARAGLLQGLSYTIGGISIDAATLVCLLLFCGAAGKSAQLPL
HVWLPDAMEGPTPVSALIHAATMVTAGVFLVARCNALFSLSPTALGVITVVGALTALFAATIALTQTDIKRVVAYSTISQ
LAFMFIGCGVGAYAAGIFHLFTHAFFKALLFLGCGSVILGMHHEQDMRRMGGLRKYMPVTCVTFLLASLSISGVPGLAGF
FSKDEILLMAFNADTTAGYFAWGVGTFVAFLTAFYSFRLFFSIFYGEFRGTQHQREHLRESPLVVTIPLLLLACGAVGAG
WLGIPHVLGGSNLWAGFLEPVVGHPHLHLDGPAELMLMGASVVAGVCGIGLAWFMYHRQTEWPERVVQSFPRLYRLFLHK
YRVDEIYAACLVRPVLWLADHVLLRVVDTKGIEGVVNGLPRAIGRLSVRLRRFQDGHVAHYLAWLAGASVVLLIVLQLGI
FS

Sequences:

>Translated_642_residues
MPIYLLLIPLCPLLAFAVTLVCGRWWGSRAHWLPIAAIVVSLCCSILALRDVMNGVIVNADVHNWITSGNLSVSFGFLVD
QLTAVMLIVVTSVSTLVHIYSVGYMKGEDGYYRFFAYLALFSFSMLMLVLSNNFLQLFFGWEAVGLSSYLLIGFYYEKTS
ASDAGKKAFIVNRFGDFGFLLGLFCIFTLFGSLHYDNVFARAGLLQGLSYTIGGISIDAATLVCLLLFCGAAGKSAQLPL
HVWLPDAMEGPTPVSALIHAATMVTAGVFLVARCNALFSLSPTALGVITVVGALTALFAATIALTQTDIKRVVAYSTISQ
LAFMFIGCGVGAYAAGIFHLFTHAFFKALLFLGCGSVILGMHHEQDMRRMGGLRKYMPVTCVTFLLASLSISGVPGLAGF
FSKDEILLMAFNADTTAGYFAWGVGTFVAFLTAFYSFRLFFSIFYGEFRGTQHQREHLRESPLVVTIPLLLLACGAVGAG
WLGIPHVLGGSNLWAGFLEPVVGHPHLHLDGPAELMLMGASVVAGVCGIGLAWFMYHRQTEWPERVVQSFPRLYRLFLHK
YRVDEIYAACLVRPVLWLADHVLLRVVDTKGIEGVVNGLPRAIGRLSVRLRRFQDGHVAHYLAWLAGASVVLLIVLQLGI
FS
>Mature_641_residues
PIYLLLIPLCPLLAFAVTLVCGRWWGSRAHWLPIAAIVVSLCCSILALRDVMNGVIVNADVHNWITSGNLSVSFGFLVDQ
LTAVMLIVVTSVSTLVHIYSVGYMKGEDGYYRFFAYLALFSFSMLMLVLSNNFLQLFFGWEAVGLSSYLLIGFYYEKTSA
SDAGKKAFIVNRFGDFGFLLGLFCIFTLFGSLHYDNVFARAGLLQGLSYTIGGISIDAATLVCLLLFCGAAGKSAQLPLH
VWLPDAMEGPTPVSALIHAATMVTAGVFLVARCNALFSLSPTALGVITVVGALTALFAATIALTQTDIKRVVAYSTISQL
AFMFIGCGVGAYAAGIFHLFTHAFFKALLFLGCGSVILGMHHEQDMRRMGGLRKYMPVTCVTFLLASLSISGVPGLAGFF
SKDEILLMAFNADTTAGYFAWGVGTFVAFLTAFYSFRLFFSIFYGEFRGTQHQREHLRESPLVVTIPLLLLACGAVGAGW
LGIPHVLGGSNLWAGFLEPVVGHPHLHLDGPAELMLMGASVVAGVCGIGLAWFMYHRQTEWPERVVQSFPRLYRLFLHKY
RVDEIYAACLVRPVLWLADHVLLRVVDTKGIEGVVNGLPRAIGRLSVRLRRFQDGHVAHYLAWLAGASVVLLIVLQLGIF
S

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=418, Percent_Identity=39.4736842105263, Blast_Score=269, Evalue=7e-72,
Organism=Escherichia coli, GI1788614, Length=519, Percent_Identity=42.9672447013487, Blast_Score=351, Evalue=7e-98,
Organism=Escherichia coli, GI1788829, Length=342, Percent_Identity=35.672514619883, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI1788831, Length=344, Percent_Identity=31.1046511627907, Blast_Score=132, Evalue=7e-32,
Organism=Escherichia coli, GI1788827, Length=443, Percent_Identity=28.6681715575621, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1788613, Length=480, Percent_Identity=23.75, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI2367154, Length=440, Percent_Identity=23.4090909090909, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI145693160, Length=388, Percent_Identity=23.1958762886598, Blast_Score=76, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 70006; Mature: 69874

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIYLLLIPLCPLLAFAVTLVCGRWWGSRAHWLPIAAIVVSLCCSILALRDVMNGVIVNA
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEC
DVHNWITSGNLSVSFGFLVDQLTAVMLIVVTSVSTLVHIYSVGYMKGEDGYYRFFAYLAL
CHHHHEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHHHHHHHHH
FSFSMLMLVLSNNFLQLFFGWEAVGLSSYLLIGFYYEKTSASDAGKKAFIVNRFGDFGFL
HHHHHHHHHHHCCCEEEHCCHHHHHHHHEEHEEEEEECCCCCCCCCCEEEEECCCHHHHH
LGLFCIFTLFGSLHYDNVFARAGLLQGLSYTIGGISIDAATLVCLLLFCGAAGKSAQLPL
HHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHCCEEHHHHHHHHHHHHHCCCCCCCCCCE
HVWLPDAMEGPTPVSALIHAATMVTAGVFLVARCNALFSLSPTALGVITVVGALTALFAA
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
TIALTQTDIKRVVAYSTISQLAFMFIGCGVGAYAAGIFHLFTHAFFKALLFLGCGSVILG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHC
MHHEQDMRRMGGLRKYMPVTCVTFLLASLSISGVPGLAGFFSKDEILLMAFNADTTAGYF
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCEEEEEECCCCCCHHH
AWGVGTFVAFLTAFYSFRLFFSIFYGEFRGTQHQREHLRESPLVVTIPLLLLACGAVGAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEHHHHHHHHHCCCCC
WLGIPHVLGGSNLWAGFLEPVVGHPHLHLDGPAELMLMGASVVAGVCGIGLAWFMYHRQT
CCCCCHHCCCCCHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EWPERVVQSFPRLYRLFLHKYRVDEIYAACLVRPVLWLADHVLLRVVDTKGIEGVVNGLP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
RAIGRLSVRLRRFQDGHVAHYLAWLAGASVVLLIVLQLGIFS
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PIYLLLIPLCPLLAFAVTLVCGRWWGSRAHWLPIAAIVVSLCCSILALRDVMNGVIVNA
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEC
DVHNWITSGNLSVSFGFLVDQLTAVMLIVVTSVSTLVHIYSVGYMKGEDGYYRFFAYLAL
CHHHHEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHHHHHHHHH
FSFSMLMLVLSNNFLQLFFGWEAVGLSSYLLIGFYYEKTSASDAGKKAFIVNRFGDFGFL
HHHHHHHHHHHCCCEEEHCCHHHHHHHHEEHEEEEEECCCCCCCCCCEEEEECCCHHHHH
LGLFCIFTLFGSLHYDNVFARAGLLQGLSYTIGGISIDAATLVCLLLFCGAAGKSAQLPL
HHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHCCEEHHHHHHHHHHHHHCCCCCCCCCCE
HVWLPDAMEGPTPVSALIHAATMVTAGVFLVARCNALFSLSPTALGVITVVGALTALFAA
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
TIALTQTDIKRVVAYSTISQLAFMFIGCGVGAYAAGIFHLFTHAFFKALLFLGCGSVILG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHC
MHHEQDMRRMGGLRKYMPVTCVTFLLASLSISGVPGLAGFFSKDEILLMAFNADTTAGYF
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCEEEEEECCCCCCHHH
AWGVGTFVAFLTAFYSFRLFFSIFYGEFRGTQHQREHLRESPLVVTIPLLLLACGAVGAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEHHHHHHHHHCCCCC
WLGIPHVLGGSNLWAGFLEPVVGHPHLHLDGPAELMLMGASVVAGVCGIGLAWFMYHRQT
CCCCCHHCCCCCHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EWPERVVQSFPRLYRLFLHKYRVDEIYAACLVRPVLWLADHVLLRVVDTKGIEGVVNGLP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
RAIGRLSVRLRRFQDGHVAHYLAWLAGASVVLLIVLQLGIFS
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]