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The map label for this gene is rhtB [H]

Identifier: 220904874

GI number: 220904874

Start: 1934406

End: 1935038

Strand: Direct

Name: rhtB [H]

Synonym: Ddes_1609

Alternate gene names: 220904874

Gene position: 1934406-1935038 (Clockwise)

Preceding gene: 220904873

Following gene: 220904875

Centisome position: 67.32

GC content: 60.03

Gene sequence:

>633_bases
ATGCTGACCGTGGATGTTGCTCTGGCGTTTTTCGCCGCCTCCCTTCTTCTTGGCATCGCCCCCGGGCCGGACAATATTTT
TGTGCTCACGCAGTCCGCAGTTTACGGCGCAGGCGCAGGTGTGGTCACCACTCTGGGGCTGGTCACCGGTCTCTGCGTGC
ACACGGCTGCCGTGGCGCTGGGGGTGGCCGCCATCTTTCAAAGCTCCCCGATGGCTTTTACCCTGCTCAAGACCGTGGGC
GCGGCCTACCTGCTGTGGCTTGCCTGGCTTTCTTTCAGGGCCGGAGCTTCACTGGCGCTTACCGGAGGCGGCGGAACACC
CTTTCCCGGTTATGCGGCCCTGTACCGGCGCGGCATTGTCATGAATGTGACCAATCCCAAGGTTTCACTCTTCTTTCTGG
CTTTTTTGCCCCAGTTCTGCGATCCCTCCAGAGGCAGTGTGGCCCTGCAGGTTCTTGGTCTGGGTCTTTTATTCATGCTG
GCAACCCTTATGGTTTTTTTCAGCGTTGCCCTGCTTGGCGGCAGGCTGGCCCTGTGGTTCAACAAGGCCCCCGGCGGGCA
GATACTCATACACCGCGCTGCAGGCCTTGTTTTTGCGGGTTTGGCCCTGCTTCTGCTGTTCAGCGGCAAATAG

Upstream 100 bases:

>100_bases
CCTGCGCATGCATGGCCGATGCCCTGCGCCTTGAACGTGCGGTCAAAGCCCGCCCGCGCCACAAAAAAAAATCCTACCTG
CTGCACGGAGATGCCGAACA

Downstream 100 bases:

>100_bases
CCGGAACAGGCAGGCGGCAGCAATAGCGGCGGTCCTTCGCTTGCAGGCGGCGGCTTGCGTTCAGTGAAATGGCAGTGGAT
ATTGCTGGCGCCAGACAAGA

Product: lysine exporter LysE/YggA

Products: homoserine lactone [Periplasm]; Proton [Cytoplasm]; homoserine [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MLTVDVALAFFAASLLLGIAPGPDNIFVLTQSAVYGAGAGVVTTLGLVTGLCVHTAAVALGVAAIFQSSPMAFTLLKTVG
AAYLLWLAWLSFRAGASLALTGGGGTPFPGYAALYRRGIVMNVTNPKVSLFFLAFLPQFCDPSRGSVALQVLGLGLLFML
ATLMVFFSVALLGGRLALWFNKAPGGQILIHRAAGLVFAGLALLLLFSGK

Sequences:

>Translated_210_residues
MLTVDVALAFFAASLLLGIAPGPDNIFVLTQSAVYGAGAGVVTTLGLVTGLCVHTAAVALGVAAIFQSSPMAFTLLKTVG
AAYLLWLAWLSFRAGASLALTGGGGTPFPGYAALYRRGIVMNVTNPKVSLFFLAFLPQFCDPSRGSVALQVLGLGLLFML
ATLMVFFSVALLGGRLALWFNKAPGGQILIHRAAGLVFAGLALLLLFSGK
>Mature_210_residues
MLTVDVALAFFAASLLLGIAPGPDNIFVLTQSAVYGAGAGVVTTLGLVTGLCVHTAAVALGVAAIFQSSPMAFTLLKTVG
AAYLLWLAWLSFRAGASLALTGGGGTPFPGYAALYRRGIVMNVTNPKVSLFFLAFLPQFCDPSRGSVALQVLGLGLLFML
ATLMVFFSVALLGGRLALWFNKAPGGQILIHRAAGLVFAGLALLLLFSGK

Specific function: Conducts the efflux of homoserine and homoserine lactone [H]

COG id: COG1280

COG function: function code E; Putative threonine efflux protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rht family [H]

Homologues:

Organism=Escherichia coli, GI48994979, Length=197, Percent_Identity=31.9796954314721, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1788099, Length=136, Percent_Identity=28.6764705882353, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786522, Length=115, Percent_Identity=32.1739130434783, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004778
- InterPro:   IPR001123 [H]

Pfam domain/function: PF01810 LysE [H]

EC number: NA

Molecular weight: Translated: 21652; Mature: 21652

Theoretical pI: Translated: 10.45; Mature: 10.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTVDVALAFFAASLLLGIAPGPDNIFVLTQSAVYGAGAGVVTTLGLVTGLCVHTAAVAL
CEEHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHH
GVAAIFQSSPMAFTLLKTVGAAYLLWLAWLSFRAGASLALTGGGGTPFPGYAALYRRGIV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHCCEE
MNVTNPKVSLFFLAFLPQFCDPSRGSVALQVLGLGLLFMLATLMVFFSVALLGGRLALWF
EEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEE
NKAPGGQILIHRAAGLVFAGLALLLLFSGK
ECCCCCEEEEHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLTVDVALAFFAASLLLGIAPGPDNIFVLTQSAVYGAGAGVVTTLGLVTGLCVHTAAVAL
CEEHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHH
GVAAIFQSSPMAFTLLKTVGAAYLLWLAWLSFRAGASLALTGGGGTPFPGYAALYRRGIV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHCCEE
MNVTNPKVSLFFLAFLPQFCDPSRGSVALQVLGLGLLFMLATLMVFFSVALLGGRLALWF
EEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEE
NKAPGGQILIHRAAGLVFAGLALLLLFSGK
ECCCCCEEEEHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; homoserine [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + homoserine lactone [Cytoplasm] = Proton [Cytoplasm] + homoserine lactone [Periplasm] Proton [Periplasm] + homoserine [Cytoplasm] = Proton [Cytoplasm] + homoserine [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]