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The map label for this gene is rnc [H]

Identifier: 220904300

GI number: 220904300

Start: 1202102

End: 1202833

Strand: Direct

Name: rnc [H]

Synonym: Ddes_1027

Alternate gene names: 220904300

Gene position: 1202102-1202833 (Clockwise)

Preceding gene: 220904296

Following gene: 220904306

Centisome position: 41.83

GC content: 57.1

Gene sequence:

>732_bases
ATGCATAATTTTGACGCTTCATCAGAATACACTTCGTCCAGGGCGCTTGAGCTAGTAAAAAAGCAGCTCGGGCATGGCTT
TATTCGCAAAGACCTGCTGGAACTGGCCCTTACCCACAGCTCATGGGCCAATGAGTGCGGGCCGGGACAGGAACACAACG
AGCGGCAGGAATTTCTTGGAGACGCCGTTCTTGAGCTTTGTGTCTCGTGGGAGCTTTACCGGCGTTTTCCCTCCGCTCGC
GAAGGGGAGCTGACCAAGATGCGTTCCAGCCTTGTCAGCGCTGTAAGCCTTGCGGAAAGAGCGCGTGACATGGGTCTTGA
CAGGCTTTTGAAGTTGGGGCGGGGCGAGGAAAGTCAGGGGGGAAGAAAGCGGGACGCGGTGTTGAGTGACGCTCTTGAAG
CAGTATTGGCTGCCATTTACGAAGACGGTGGCTTTGCCGCGGCGCAAGAGGCCGTAGGCCGCATATTCGCCGATCAGTGG
CCCAGCCGCGCTGGGGACGGCAAGGCCTCTAAAGATTACAAGACCAGACTGCAGGAAGCCTCGCAGCAGCGCTTCGGTCA
GGCTCCGCTATATACGCGCGTGGGCAGTCATGGTCCCGAGCATTCAAAGGTTTTTGAAGTCGCCTTGCGGCTGCCCGACG
GCAGCGAATTTTCGGCCAGCGGCAGCAGTTGTAAAAAAGCTGAACAGCAGGCAGCCCGTATTGCGCTGGAAACTCTTGGA
CACACGGAATAA

Upstream 100 bases:

>100_bases
CTTTGCTCCTGAATGTTAATGGCTTGTAGGTAGGCATTGAAGCAGCGCATGTCAAGGCATTTTCTGTTGCCTTGGCTGCC
GAAAAGACTAAAATACCGCC

Downstream 100 bases:

>100_bases
CATCCGCAAGCGCCCGCCGGGCAACGAAAAGCCGTTGCGACCTGAGGGCTGCTGGGCAGCTTTTTGGGCGTGAAGTGGCT
GTATGGCGCGGGAATGACGC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MHNFDASSEYTSSRALELVKKQLGHGFIRKDLLELALTHSSWANECGPGQEHNERQEFLGDAVLELCVSWELYRRFPSAR
EGELTKMRSSLVSAVSLAERARDMGLDRLLKLGRGEESQGGRKRDAVLSDALEAVLAAIYEDGGFAAAQEAVGRIFADQW
PSRAGDGKASKDYKTRLQEASQQRFGQAPLYTRVGSHGPEHSKVFEVALRLPDGSEFSASGSSCKKAEQQAARIALETLG
HTE

Sequences:

>Translated_243_residues
MHNFDASSEYTSSRALELVKKQLGHGFIRKDLLELALTHSSWANECGPGQEHNERQEFLGDAVLELCVSWELYRRFPSAR
EGELTKMRSSLVSAVSLAERARDMGLDRLLKLGRGEESQGGRKRDAVLSDALEAVLAAIYEDGGFAAAQEAVGRIFADQW
PSRAGDGKASKDYKTRLQEASQQRFGQAPLYTRVGSHGPEHSKVFEVALRLPDGSEFSASGSSCKKAEQQAARIALETLG
HTE
>Mature_243_residues
MHNFDASSEYTSSRALELVKKQLGHGFIRKDLLELALTHSSWANECGPGQEHNERQEFLGDAVLELCVSWELYRRFPSAR
EGELTKMRSSLVSAVSLAERARDMGLDRLLKLGRGEESQGGRKRDAVLSDALEAVLAAIYEDGGFAAAQEAVGRIFADQW
PSRAGDGKASKDYKTRLQEASQQRFGQAPLYTRVGSHGPEHSKVFEVALRLPDGSEFSASGSSCKKAEQQAARIALETLG
HTE

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=194, Percent_Identity=29.3814432989691, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI155030236, Length=194, Percent_Identity=29.3814432989691, Blast_Score=75, Evalue=5e-14,
Organism=Escherichia coli, GI1788920, Length=225, Percent_Identity=36.8888888888889, Blast_Score=124, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17506883, Length=227, Percent_Identity=29.5154185022026, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI193202651, Length=227, Percent_Identity=29.5154185022026, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17137682, Length=201, Percent_Identity=30.8457711442786, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 26697; Mature: 26697

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS50137 DS_RBD ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNFDASSEYTSSRALELVKKQLGHGFIRKDLLELALTHSSWANECGPGQEHNERQEFLG
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
DAVLELCVSWELYRRFPSAREGELTKMRSSLVSAVSLAERARDMGLDRLLKLGRGEESQG
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCC
GRKRDAVLSDALEAVLAAIYEDGGFAAAQEAVGRIFADQWPSRAGDGKASKDYKTRLQEA
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
SQQRFGQAPLYTRVGSHGPEHSKVFEVALRLPDGSEFSASGSSCKKAEQQAARIALETLG
HHHHCCCCCHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
HTE
CCC
>Mature Secondary Structure
MHNFDASSEYTSSRALELVKKQLGHGFIRKDLLELALTHSSWANECGPGQEHNERQEFLG
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
DAVLELCVSWELYRRFPSAREGELTKMRSSLVSAVSLAERARDMGLDRLLKLGRGEESQG
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCC
GRKRDAVLSDALEAVLAAIYEDGGFAAAQEAVGRIFADQWPSRAGDGKASKDYKTRLQEA
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
SQQRFGQAPLYTRVGSHGPEHSKVFEVALRLPDGSEFSASGSSCKKAEQQAARIALETLG
HHHHCCCCCHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
HTE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA