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The map label for this gene is wecB [H]

Identifier: 220904288

GI number: 220904288

Start: 1188433

End: 1189551

Strand: Direct

Name: wecB [H]

Synonym: Ddes_1015

Alternate gene names: 220904288

Gene position: 1188433-1189551 (Clockwise)

Preceding gene: 220904287

Following gene: 220904289

Centisome position: 41.36

GC content: 55.05

Gene sequence:

>1119_bases
ATGAAAAAGGTACTTGTTATCGCCGGTACGCGCCCCGAAGCCGTCAAGCTGGCACCGCTGGTACACGAACTGCGCCGCAG
GCCGGATGATTTTACGGTTCACCTGTGCTCCAGTGGTCAGCATCAGACCATGCTGGAGCAAACACTGGCCGATTTTGATC
TCAAGCCGGATTCTTCGCTCCAGGTCATGACAGGCAATCAAAGTCTTGCGGGGCTTAGTGCTCGCCTTTTTTCTGAGGTG
GACGGCCTGCTTGACAGGCTCGCTCCTGATGTGGTGCTTGTGCAGGGCGATACAACGACAGTTCAGGTTTCGGCTCTGAG
CGCGTTTTACAGGCATATTCCTGTTGGACATGTGGAGGCAGGTTTGCGTACCTGGAACCTGAACTCTCCTTTTCCTGAAG
AGTTGAACCGTCGCGTGGTTGCTCTTGCAGTGCGCTGGCACTACGCGCCCACGGAACTTGCCAGACAAAACTTGCTGGCA
GAGCGCATCAGGCCGGAAAGCGTCATCGTTACGGGCAATACCGTTATTGATGCGCTGCACATGACGCTTGCCGCTTCCCG
CCGTCATCCGCCGGCTCTGCCGCCTCGTGTTGAGGCTGTTCTGGCGCAAAAAAATCCGGTTATTCTGGTTACAGGTCACC
GGAGGGAAAGTTTTGGTGAAGGTTTTCGGCGTATTTGCGCGGCCCTGAAAAATATTGCCCTCGCCCTGCCTCATATGTGG
ATCGTCTTTCCCGTGCATCTGAATCCGCATGTTCATGGCCCGGTTACTGAAATGTTGGGTGGCGTCCCCAATATTTTACT
GGAAGCGCCGCTGCCCTATACGGCGTTTGTGCGCCTGATGGATGCCTGCACACTGATTCTTACAGACTCCGGTGGGATAC
AGGAAGAAGGCCCGTCACTGAGCAAGCCTGTTCTCATCATGAGAGACACCACCGAGCGGCCCGAAGGCGTGGAGGCCGGA
GTCAACAGGCTGGTGGGAACGGACTCGCAACGCATTTTTGATGAAGTGCTCGGTCTTGTGGGTAATCCATCACACATTGC
TGCAATGCAAAACGCTGTAAACCCCTATGGTGATGGCAAGGCGGCAAAACGTATCGCCGACCACCTGAAAATGCAATAA

Upstream 100 bases:

>100_bases
TTGTTGAAAGCATTGCGGCTAACCTGCCCTATGAAAACCGCCGGGACGGCCTGTTTTTCGGGTTGTCTGCTGTCCGCACA
AAGGCATAGTGGTTACGCCT

Downstream 100 bases:

>100_bases
TATATTTTGTTAATACATTGCTGTGTGTATTGCGTTGTGCATAAGAGCGGAGGTTTTATATGCCGGCTTCTCCAACTGAC
ATGATTCTGAAAAAACTCCA

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MKKVLVIAGTRPEAVKLAPLVHELRRRPDDFTVHLCSSGQHQTMLEQTLADFDLKPDSSLQVMTGNQSLAGLSARLFSEV
DGLLDRLAPDVVLVQGDTTTVQVSALSAFYRHIPVGHVEAGLRTWNLNSPFPEELNRRVVALAVRWHYAPTELARQNLLA
ERIRPESVIVTGNTVIDALHMTLAASRRHPPALPPRVEAVLAQKNPVILVTGHRRESFGEGFRRICAALKNIALALPHMW
IVFPVHLNPHVHGPVTEMLGGVPNILLEAPLPYTAFVRLMDACTLILTDSGGIQEEGPSLSKPVLIMRDTTERPEGVEAG
VNRLVGTDSQRIFDEVLGLVGNPSHIAAMQNAVNPYGDGKAAKRIADHLKMQ

Sequences:

>Translated_372_residues
MKKVLVIAGTRPEAVKLAPLVHELRRRPDDFTVHLCSSGQHQTMLEQTLADFDLKPDSSLQVMTGNQSLAGLSARLFSEV
DGLLDRLAPDVVLVQGDTTTVQVSALSAFYRHIPVGHVEAGLRTWNLNSPFPEELNRRVVALAVRWHYAPTELARQNLLA
ERIRPESVIVTGNTVIDALHMTLAASRRHPPALPPRVEAVLAQKNPVILVTGHRRESFGEGFRRICAALKNIALALPHMW
IVFPVHLNPHVHGPVTEMLGGVPNILLEAPLPYTAFVRLMDACTLILTDSGGIQEEGPSLSKPVLIMRDTTERPEGVEAG
VNRLVGTDSQRIFDEVLGLVGNPSHIAAMQNAVNPYGDGKAAKRIADHLKMQ
>Mature_372_residues
MKKVLVIAGTRPEAVKLAPLVHELRRRPDDFTVHLCSSGQHQTMLEQTLADFDLKPDSSLQVMTGNQSLAGLSARLFSEV
DGLLDRLAPDVVLVQGDTTTVQVSALSAFYRHIPVGHVEAGLRTWNLNSPFPEELNRRVVALAVRWHYAPTELARQNLLA
ERIRPESVIVTGNTVIDALHMTLAASRRHPPALPPRVEAVLAQKNPVILVTGHRRESFGEGFRRICAALKNIALALPHMW
IVFPVHLNPHVHGPVTEMLGGVPNILLEAPLPYTAFVRLMDACTLILTDSGGIQEEGPSLSKPVLIMRDTTERPEGVEAG
VNRLVGTDSQRIFDEVLGLVGNPSHIAAMQNAVNPYGDGKAAKRIADHLKMQ

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=375, Percent_Identity=50.9333333333333, Blast_Score=343, Evalue=1e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 40721; Mature: 40721

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVLVIAGTRPEAVKLAPLVHELRRRPDDFTVHLCSSGQHQTMLEQTLADFDLKPDSSL
CCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCE
QVMTGNQSLAGLSARLFSEVDGLLDRLAPDVVLVQGDTTTVQVSALSAFYRHIPVGHVEA
EEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEHHHHHHHHHHCCCCHHHC
GLRTWNLNSPFPEELNRRVVALAVRWHYAPTELARQNLLAERIRPESVIVTGNTVIDALH
CCEEECCCCCCHHHHCCEEEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEECHHHHHHHH
MTLAASRRHPPALPPRVEAVLAQKNPVILVTGHRRESFGEGFRRICAALKNIALALPHMW
HHHHHHCCCCCCCCHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEE
IVFPVHLNPHVHGPVTEMLGGVPNILLEAPLPYTAFVRLMDACTLILTDSGGIQEEGPSL
EEEEEEECCCCCCCHHHHHCCCCCEEEECCCCHHHHHHHHHHHEEEEECCCCCCCCCCCC
SKPVLIMRDTTERPEGVEAGVNRLVGTDSQRIFDEVLGLVGNPSHIAAMQNAVNPYGDGK
CCCEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCH
AAKRIADHLKMQ
HHHHHHHHHCCC
>Mature Secondary Structure
MKKVLVIAGTRPEAVKLAPLVHELRRRPDDFTVHLCSSGQHQTMLEQTLADFDLKPDSSL
CCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCE
QVMTGNQSLAGLSARLFSEVDGLLDRLAPDVVLVQGDTTTVQVSALSAFYRHIPVGHVEA
EEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEHHHHHHHHHHCCCCHHHC
GLRTWNLNSPFPEELNRRVVALAVRWHYAPTELARQNLLAERIRPESVIVTGNTVIDALH
CCEEECCCCCCHHHHCCEEEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEECHHHHHHHH
MTLAASRRHPPALPPRVEAVLAQKNPVILVTGHRRESFGEGFRRICAALKNIALALPHMW
HHHHHHCCCCCCCCHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEE
IVFPVHLNPHVHGPVTEMLGGVPNILLEAPLPYTAFVRLMDACTLILTDSGGIQEEGPSL
EEEEEEECCCCCCCHHHHHCCCCCEEEECCCCHHHHHHHHHHHEEEEECCCCCCCCCCCC
SKPVLIMRDTTERPEGVEAGVNRLVGTDSQRIFDEVLGLVGNPSHIAAMQNAVNPYGDGK
CCCEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCH
AAKRIADHLKMQ
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]