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The map label for this gene is tlpC [H]

Identifier: 220904218

GI number: 220904218

Start: 1100742

End: 1102769

Strand: Direct

Name: tlpC [H]

Synonym: Ddes_0945

Alternate gene names: 220904218

Gene position: 1100742-1102769 (Clockwise)

Preceding gene: 220904217

Following gene: 220904223

Centisome position: 38.31

GC content: 57.3

Gene sequence:

>2028_bases
ATGCGCATAACGCTCACGCACAAGTATGTGGGTTCGCTATTCGGCGCTCTGATTACCTGCTGTGGGGTAGTGTTGTTTGT
TTCCATCTATTTTATGAAGGTCCCCATTGAAGATGAGCTGGATAAGGGCATCCGCCGCATGCAGAATATCATTCTGGAGG
CCAACGAGGTCACCAGCAAGCGCTTTGCGCAAAGCGCCGCCCTTATTGCCAGCGACAGCAGCATGATACAGGCCATTGCG
CACAAGGATCATGCGCTGGCCCGAGAGTTGGGCGAAAAAAGCATGAAAATGGCCGGGTCGGACTTCATGACCATTACTGA
TGAGTCCGGCAAGGTCATCGCCCGTGGTCACTCCGATAAATACGGCGACAGTGTGACCAATCAGGAAACCGTGGTTATTG
CCCTCAAGGGGCAGCCCGCAGCGGCTGTTGTGGCAGGCACCATTGTGCCGTTCACAATCCGGGCCAGTCAGCCTGTGGTT
TATGAGGGGCGGGTAGTGGGGTCCATTTCCATCGGCACCTCTCTGGTCACCCCTGCCTATCTTGACTGGCTCAAGCAGCT
TTCGGGAGTTAACGTCACCATTTTCAAGGGCGATACCCGGGTGATGACCACGATCGTGAATGACGGGCAGCGGGCTGTGG
GCACAAAGCTGCAATCGCCGGAAATTATCGACGCCGTGCTGAAAAAGGGAGAGGTTTACTACACCCACAACACCATTCTT
GGGGTAGACTACAACTCTGCTTACTGGCCGGTCAAAGACGCTAATAACCAGATCATCGGCATGTGGTTTGTGGGCATGCC
CATGAGCGACCTGCAAAAGCTTGAGCACGAAGCAGTGGACAAGGCCATTCTGGTGGCCTGTGGCCTGCTTGTGGTGCAGC
TTACCCTGTCGGTGATTCTGGGGTTGCGTGTCAGCGCGCCGGTGGGCAAGATCACCCGCTACGCCCTTGGCGTGGCCGAA
GGCAAGAAAGACCTCACCCTTGATGTTTACAGCAAGGACGATATGGGCCAACTGGCCAATGCCTTGCGCCATATGGAAGA
AAACCTGCGCCGCCTGGTTCAGGATGCAAGCGAAAAGGCCGAACAGGCACGCCTGATGGGCGAAGAAGCGCAGCAGGCTA
TGGAAGAGGCCAAGCAGGCCCAGGCCCAGGCTGAAATTGCCAGGCGTGAAGGCATGATAAGCGCTGCGGGCCAGATAGAG
GGCGTGGTTGAACGCCTTAATGCTTCCATAAACGACATTGCTGAACAGGTGGACAATACCGGCGGCGCGTTGAGCCACGC
CGTGGCCAGGCTGGCGGAAACCGCGACAGCTATGGAAGAAATGAATTCCACCGTGCTTGAGGTTGCCAAAAATGCCGGCG
GCGCTGCGGATGTTTCGGCCTCGGCCAAGCTCAAGGCCCAGGCAGGCTCCGAAGTGGTATACAAGGCCGTGGACGGCATA
CAGGAAGTGCAGCGCCAGTCCCTGGCTCTCAAGGATGGCATGACCCAGCTTGACGAGCATGCCAGGGCCATTAACCAGAT
CATGAGCGTCATTTCCGACATTGCCGACCAGACCAACCTGCTGGCGCTTAACGCGGCCATTGAAGCGGCCCGTGCGGGTG
ACGCCGGCAGGGGATTTGCCGTTGTGGCCGACGAGGTACGCAAGCTGGCAGAAAAAACCATGGCTTCAACCACAGATGTG
GGCAATGCCATTCGCGCCATCCAGCAAAGCGCCTCGCAGAGCATTCAGGAAGTGGAGCTGGCCGTGCACAACATCGCCTC
CGCCACAGACTTTTCCAACAAGTCCGGCGAAGCGTTGCAGGAAATCGTGGGCATGGTGGATCAGACCGCGGACGAAGTGC
GCGCCATTGCCACCGCCAGCGAGCAGCAGTCCGCTACCAGCGAAGAGATCAACAGGTCCATCGCTGATGTGAACCACATT
GCCGCCACAACCTCTGAATCCATGCAGCTGGCCATGACCGAGCTTGAAGCCCTGCGCAAGCAGGCCCACAGCCTGGTAGA
ACTGATTGAACACATGAAAAAAGCCTAA

Upstream 100 bases:

>100_bases
TATTGCTCTTTTTTGTAAAAAAACTCTGCCATGTGGCAGAGGACAGCGTTTTGTGAATCATATATATTTATAAAATAACT
TTTTGTTGCAAGGAGGGGGC

Downstream 100 bases:

>100_bases
CGGCGTCAGGGGCCATGCGGCCTCATAAAAAAGATGCGAGCGCCCCCTCCGTTTGTGCGGAAGGGGCGCTCATTTTTTCT
GTACAGGCGGGGCGCTTTTC

Product: methyl-accepting chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 675; Mature: 675

Protein sequence:

>675_residues
MRITLTHKYVGSLFGALITCCGVVLFVSIYFMKVPIEDELDKGIRRMQNIILEANEVTSKRFAQSAALIASDSSMIQAIA
HKDHALARELGEKSMKMAGSDFMTITDESGKVIARGHSDKYGDSVTNQETVVIALKGQPAAAVVAGTIVPFTIRASQPVV
YEGRVVGSISIGTSLVTPAYLDWLKQLSGVNVTIFKGDTRVMTTIVNDGQRAVGTKLQSPEIIDAVLKKGEVYYTHNTIL
GVDYNSAYWPVKDANNQIIGMWFVGMPMSDLQKLEHEAVDKAILVACGLLVVQLTLSVILGLRVSAPVGKITRYALGVAE
GKKDLTLDVYSKDDMGQLANALRHMEENLRRLVQDASEKAEQARLMGEEAQQAMEEAKQAQAQAEIARREGMISAAGQIE
GVVERLNASINDIAEQVDNTGGALSHAVARLAETATAMEEMNSTVLEVAKNAGGAADVSASAKLKAQAGSEVVYKAVDGI
QEVQRQSLALKDGMTQLDEHARAINQIMSVISDIADQTNLLALNAAIEAARAGDAGRGFAVVADEVRKLAEKTMASTTDV
GNAIRAIQQSASQSIQEVELAVHNIASATDFSNKSGEALQEIVGMVDQTADEVRAIATASEQQSATSEEINRSIADVNHI
AATTSESMQLAMTELEALRKQAHSLVELIEHMKKA

Sequences:

>Translated_675_residues
MRITLTHKYVGSLFGALITCCGVVLFVSIYFMKVPIEDELDKGIRRMQNIILEANEVTSKRFAQSAALIASDSSMIQAIA
HKDHALARELGEKSMKMAGSDFMTITDESGKVIARGHSDKYGDSVTNQETVVIALKGQPAAAVVAGTIVPFTIRASQPVV
YEGRVVGSISIGTSLVTPAYLDWLKQLSGVNVTIFKGDTRVMTTIVNDGQRAVGTKLQSPEIIDAVLKKGEVYYTHNTIL
GVDYNSAYWPVKDANNQIIGMWFVGMPMSDLQKLEHEAVDKAILVACGLLVVQLTLSVILGLRVSAPVGKITRYALGVAE
GKKDLTLDVYSKDDMGQLANALRHMEENLRRLVQDASEKAEQARLMGEEAQQAMEEAKQAQAQAEIARREGMISAAGQIE
GVVERLNASINDIAEQVDNTGGALSHAVARLAETATAMEEMNSTVLEVAKNAGGAADVSASAKLKAQAGSEVVYKAVDGI
QEVQRQSLALKDGMTQLDEHARAINQIMSVISDIADQTNLLALNAAIEAARAGDAGRGFAVVADEVRKLAEKTMASTTDV
GNAIRAIQQSASQSIQEVELAVHNIASATDFSNKSGEALQEIVGMVDQTADEVRAIATASEQQSATSEEINRSIADVNHI
AATTSESMQLAMTELEALRKQAHSLVELIEHMKKA
>Mature_675_residues
MRITLTHKYVGSLFGALITCCGVVLFVSIYFMKVPIEDELDKGIRRMQNIILEANEVTSKRFAQSAALIASDSSMIQAIA
HKDHALARELGEKSMKMAGSDFMTITDESGKVIARGHSDKYGDSVTNQETVVIALKGQPAAAVVAGTIVPFTIRASQPVV
YEGRVVGSISIGTSLVTPAYLDWLKQLSGVNVTIFKGDTRVMTTIVNDGQRAVGTKLQSPEIIDAVLKKGEVYYTHNTIL
GVDYNSAYWPVKDANNQIIGMWFVGMPMSDLQKLEHEAVDKAILVACGLLVVQLTLSVILGLRVSAPVGKITRYALGVAE
GKKDLTLDVYSKDDMGQLANALRHMEENLRRLVQDASEKAEQARLMGEEAQQAMEEAKQAQAQAEIARREGMISAAGQIE
GVVERLNASINDIAEQVDNTGGALSHAVARLAETATAMEEMNSTVLEVAKNAGGAADVSASAKLKAQAGSEVVYKAVDGI
QEVQRQSLALKDGMTQLDEHARAINQIMSVISDIADQTNLLALNAAIEAARAGDAGRGFAVVADEVRKLAEKTMASTTDV
GNAIRAIQQSASQSIQEVELAVHNIASATDFSNKSGEALQEIVGMVDQTADEVRAIATASEQQSATSEEINRSIADVNHI
AATTSESMQLAMTELEALRKQAHSLVELIEHMKKA

Specific function: Receptor For The Attractant L-Serine And Related Amino Acids. Is Also Responsible For Chemotaxis Away From A Wide Range Of Repellents, Including Leucine, Indole, And Weak Acids. Chemotactic-Signal Transducers Respond To Changes In The Concentration Of At

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI2367378, Length=360, Percent_Identity=30.2777777777778, Blast_Score=122, Evalue=1e-28,
Organism=Escherichia coli, GI1788195, Length=334, Percent_Identity=28.4431137724551, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1788194, Length=237, Percent_Identity=32.9113924050633, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1787690, Length=242, Percent_Identity=30.9917355371901, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1789453, Length=391, Percent_Identity=24.8081841432225, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 72350; Mature: 72350

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRITLTHKYVGSLFGALITCCGVVLFVSIYFMKVPIEDELDKGIRRMQNIILEANEVTSK
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RFAQSAALIASDSSMIQAIAHKDHALARELGEKSMKMAGSDFMTITDESGKVIARGHSDK
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEECCCCCC
YGDSVTNQETVVIALKGQPAAAVVAGTIVPFTIRASQPVVYEGRVVGSISIGTSLVTPAY
CCCCCCCCCEEEEEECCCCCHHHHHHHHEEEEEECCCCEEECCEEEEEEECCHHHHHHHH
LDWLKQLSGVNVTIFKGDTRVMTTIVNDGQRAVGTKLQSPEIIDAVLKKGEVYYTHNTIL
HHHHHHHCCCEEEEEECCCEEEEEECCCCCHHHCCCCCCCHHHHHHHHCCCEEEEECEEE
GVDYNSAYWPVKDANNQIIGMWFVGMPMSDLQKLEHEAVDKAILVACGLLVVQLTLSVIL
EECCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLRVSAPVGKITRYALGVAEGKKDLTLDVYSKDDMGQLANALRHMEENLRRLVQDASEKA
HCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EQARLMGEEAQQAMEEAKQAQAQAEIARREGMISAAGQIEGVVERLNASINDIAEQVDNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCC
GGALSHAVARLAETATAMEEMNSTVLEVAKNAGGAADVSASAKLKAQAGSEVVYKAVDGI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCHHHHHHHHHHH
QEVQRQSLALKDGMTQLDEHARAINQIMSVISDIADQTNLLALNAAIEAARAGDAGRGFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCHH
VVADEVRKLAEKTMASTTDVGNAIRAIQQSASQSIQEVELAVHNIASATDFSNKSGEALQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
EIVGMVDQTADEVRAIATASEQQSATSEEINRSIADVNHIAATTSESMQLAMTELEALRK
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
QAHSLVELIEHMKKA
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MRITLTHKYVGSLFGALITCCGVVLFVSIYFMKVPIEDELDKGIRRMQNIILEANEVTSK
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RFAQSAALIASDSSMIQAIAHKDHALARELGEKSMKMAGSDFMTITDESGKVIARGHSDK
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEECCCCCC
YGDSVTNQETVVIALKGQPAAAVVAGTIVPFTIRASQPVVYEGRVVGSISIGTSLVTPAY
CCCCCCCCCEEEEEECCCCCHHHHHHHHEEEEEECCCCEEECCEEEEEEECCHHHHHHHH
LDWLKQLSGVNVTIFKGDTRVMTTIVNDGQRAVGTKLQSPEIIDAVLKKGEVYYTHNTIL
HHHHHHHCCCEEEEEECCCEEEEEECCCCCHHHCCCCCCCHHHHHHHHCCCEEEEECEEE
GVDYNSAYWPVKDANNQIIGMWFVGMPMSDLQKLEHEAVDKAILVACGLLVVQLTLSVIL
EECCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLRVSAPVGKITRYALGVAEGKKDLTLDVYSKDDMGQLANALRHMEENLRRLVQDASEKA
HCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EQARLMGEEAQQAMEEAKQAQAQAEIARREGMISAAGQIEGVVERLNASINDIAEQVDNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCC
GGALSHAVARLAETATAMEEMNSTVLEVAKNAGGAADVSASAKLKAQAGSEVVYKAVDGI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCHHHHHHHHHHH
QEVQRQSLALKDGMTQLDEHARAINQIMSVISDIADQTNLLALNAAIEAARAGDAGRGFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCHH
VVADEVRKLAEKTMASTTDVGNAIRAIQQSASQSIQEVELAVHNIASATDFSNKSGEALQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
EIVGMVDQTADEVRAIATASEQQSATSEEINRSIADVNHIAATTSESMQLAMTELEALRK
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
QAHSLVELIEHMKKA
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7921238; 7704255; 8969502; 9384377 [H]