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The map label for this gene is mdtA [H]

Identifier: 220904173

GI number: 220904173

Start: 1048647

End: 1049801

Strand: Reverse

Name: mdtA [H]

Synonym: Ddes_0900

Alternate gene names: 220904173

Gene position: 1049801-1048647 (Counterclockwise)

Preceding gene: 220904175

Following gene: 220904170

Centisome position: 36.53

GC content: 62.86

Gene sequence:

>1155_bases
ATGACGCGCCCTGACAACCGCTTACGCATACCCTTTTTTTTCTGCACACGCCCTGCGCGGACGCTCCGGGCTTCAGGCCT
GCTGCTGGCCCTGGTTCTGGCCCTGCTCCCCGCCCTGAACGGCTGTTCCGGCAATGAGCGGGAAAACTCCGGTCCGGCCC
CGGCTCCCGTGCGCGTAACCCCGGTTATGCGCGCTGATGTGCCGCGTCTGCTGCACGTTGTGGGCAATGTGCGGGCTTCC
GCCTCGGTGGGCGTCAGGCCCAGAGTAGCCGGAGAAATCCAGCAGGTCCACTTTACGGAAGGGCAGGACGTGCAGGAAGG
CCAGCCCCTCATCACCATCGACCCGCGCCCTTTTGAGGCCGCCCTGCGCGAAAAGCGTGGTCTGCTGGCAAAATCACAGG
CCCAGCTGAACAAGGCCCTTGATGACATGGCACGGTACGGCAAGCTGGTGGGCGGCGGCTATGTAAGCCGTGAGGCCTAT
GAGCAGACCGCGACCCAGGCCGCCGCACTGCGCGCTACCGTGCAGTCCGACAAGGCTGCCGTTGAAAGCGCGGCTCTTGA
CCTGTCATACTGTACGGTAGTGGCCCCCATCAGCGGTCGTGTGGGGGCCCTTAATGTGGACAGGGGCAATATGGTGAAAT
CCACGGATGCCGCTCCCGTGGTCACCATCGACACACTTTCGCCCATCTATGTGAGCTTTTCAGTTCCGGAAGCACACCTG
CCCGTGATTCTTGACCGCATGGGCGGTGAGTCCGTCCCGGTTACGGCGACCCCCGCCGGAGGCCAGGCAGAACAGGGGCT
GCTGACCCTGGTGGACAACAGCGTTGACACGCGCACAGGTACTATCCGCCTGCGGGGTACGTTTGAAAACGCCTCCCGCC
GCTTGTGGCCCGGCCAGTTTGTGCAGGTGCAACTTCCCCTCGGCATGGGCAGCAGTGTGCTTACCGTGCCTTCCCGCGCT
GTGCAGTCCGGCCGCGACGAATCCTATGTGTATGTGGTGGACGCCAAAAAAAATGCCGCCTACCGCCCGGTAAAAGTCCT
GTTTGAGCACAATGACGCCAGTGTGGTGGAAGGGTCTGTCTCTGAAGGGGACAAGGTGGTGGTGGAAGGCCAGGTGCGCC
TTGCGCCGGGGCTTCCTGTAAAGGAAGTCGAATAG

Upstream 100 bases:

>100_bases
TTGCTTCACCCTGTGGACACCAGAACCCGCAGGCTTCTGGCACGGCCCGTTTACGGCCGTTCCGCAGCCATGTCCACGCT
TTCTCTTTAAGGATATATCC

Downstream 100 bases:

>100_bases
GGCCGCCGGCAGCAGGTGTGGCGCGTTTCATCGCTTCAGGCGTTTCCGTGCGCCGGACGCCCGGACGCCTCAAAATCTGC
CGTAAACCGCGCGGGTGACT

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MTRPDNRLRIPFFFCTRPARTLRASGLLLALVLALLPALNGCSGNERENSGPAPAPVRVTPVMRADVPRLLHVVGNVRAS
ASVGVRPRVAGEIQQVHFTEGQDVQEGQPLITIDPRPFEAALREKRGLLAKSQAQLNKALDDMARYGKLVGGGYVSREAY
EQTATQAAALRATVQSDKAAVESAALDLSYCTVVAPISGRVGALNVDRGNMVKSTDAAPVVTIDTLSPIYVSFSVPEAHL
PVILDRMGGESVPVTATPAGGQAEQGLLTLVDNSVDTRTGTIRLRGTFENASRRLWPGQFVQVQLPLGMGSSVLTVPSRA
VQSGRDESYVYVVDAKKNAAYRPVKVLFEHNDASVVEGSVSEGDKVVVEGQVRLAPGLPVKEVE

Sequences:

>Translated_384_residues
MTRPDNRLRIPFFFCTRPARTLRASGLLLALVLALLPALNGCSGNERENSGPAPAPVRVTPVMRADVPRLLHVVGNVRAS
ASVGVRPRVAGEIQQVHFTEGQDVQEGQPLITIDPRPFEAALREKRGLLAKSQAQLNKALDDMARYGKLVGGGYVSREAY
EQTATQAAALRATVQSDKAAVESAALDLSYCTVVAPISGRVGALNVDRGNMVKSTDAAPVVTIDTLSPIYVSFSVPEAHL
PVILDRMGGESVPVTATPAGGQAEQGLLTLVDNSVDTRTGTIRLRGTFENASRRLWPGQFVQVQLPLGMGSSVLTVPSRA
VQSGRDESYVYVVDAKKNAAYRPVKVLFEHNDASVVEGSVSEGDKVVVEGQVRLAPGLPVKEVE
>Mature_383_residues
TRPDNRLRIPFFFCTRPARTLRASGLLLALVLALLPALNGCSGNERENSGPAPAPVRVTPVMRADVPRLLHVVGNVRASA
SVGVRPRVAGEIQQVHFTEGQDVQEGQPLITIDPRPFEAALREKRGLLAKSQAQLNKALDDMARYGKLVGGGYVSREAYE
QTATQAAALRATVQSDKAAVESAALDLSYCTVVAPISGRVGALNVDRGNMVKSTDAAPVVTIDTLSPIYVSFSVPEAHLP
VILDRMGGESVPVTATPAGGQAEQGLLTLVDNSVDTRTGTIRLRGTFENASRRLWPGQFVQVQLPLGMGSSVLTVPSRAV
QSGRDESYVYVVDAKKNAAYRPVKVLFEHNDASVVEGSVSEGDKVVVEGQVRLAPGLPVKEVE

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=339, Percent_Identity=34.2182890855457, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1786668, Length=372, Percent_Identity=32.5268817204301, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1789665, Length=375, Percent_Identity=31.7333333333333, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1789929, Length=387, Percent_Identity=29.1989664082687, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI87081796, Length=204, Percent_Identity=26.4705882352941, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87081951, Length=136, Percent_Identity=30.8823529411765, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40947; Mature: 40816

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPDNRLRIPFFFCTRPARTLRASGLLLALVLALLPALNGCSGNERENSGPAPAPVRVT
CCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEE
PVMRADVPRLLHVVGNVRASASVGVRPRVAGEIQQVHFTEGQDVQEGQPLITIDPRPFEA
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCHHH
ALREKRGLLAKSQAQLNKALDDMARYGKLVGGGYVSREAYEQTATQAAALRATVQSDKAA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VESAALDLSYCTVVAPISGRVGALNVDRGNMVKSTDAAPVVTIDTLSPIYVSFSVPEAHL
HHHHHEEEEEEEEEEECCCCEEEEECCCCCEEECCCCCCEEEEECCCEEEEEEECCCCCC
PVILDRMGGESVPVTATPAGGQAEQGLLTLVDNSVDTRTGTIRLRGTFENASRRLWPGQF
CCCEECCCCCCCCEEECCCCCCCCCCEEEEECCCCCCCEEEEEEEEECCCCCCCCCCCCE
VQVQLPLGMGSSVLTVPSRAVQSGRDESYVYVVDAKKNAAYRPVKVLFEHNDASVVEGSV
EEEEECCCCCCCEEECCHHHHHCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCEEECCC
SEGDKVVVEGQVRLAPGLPVKEVE
CCCCEEEEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
TRPDNRLRIPFFFCTRPARTLRASGLLLALVLALLPALNGCSGNERENSGPAPAPVRVT
CCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEE
PVMRADVPRLLHVVGNVRASASVGVRPRVAGEIQQVHFTEGQDVQEGQPLITIDPRPFEA
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCHHH
ALREKRGLLAKSQAQLNKALDDMARYGKLVGGGYVSREAYEQTATQAAALRATVQSDKAA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VESAALDLSYCTVVAPISGRVGALNVDRGNMVKSTDAAPVVTIDTLSPIYVSFSVPEAHL
HHHHHEEEEEEEEEEECCCCEEEEECCCCCEEECCCCCCEEEEECCCEEEEEEECCCCCC
PVILDRMGGESVPVTATPAGGQAEQGLLTLVDNSVDTRTGTIRLRGTFENASRRLWPGQF
CCCEECCCCCCCCEEECCCCCCCCCCEEEEECCCCCCCEEEEEEEEECCCCCCCCCCCCE
VQVQLPLGMGSSVLTVPSRAVQSGRDESYVYVVDAKKNAAYRPVKVLFEHNDASVVEGSV
EEEEECCCCCCCEEECCHHHHHCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCEEECCC
SEGDKVVVEGQVRLAPGLPVKEVE
CCCCEEEEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA