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The map label for this gene is purH [H]

Identifier: 220904153

GI number: 220904153

Start: 1029722

End: 1030312

Strand: Reverse

Name: purH [H]

Synonym: Ddes_0880

Alternate gene names: 220904153

Gene position: 1030312-1029722 (Counterclockwise)

Preceding gene: 220904157

Following gene: 220904152

Centisome position: 35.86

GC content: 58.38

Gene sequence:

>591_bases
ATGGACATCTTGCCCATTCGCCGTGCCATTCTGAGCGTTACGGACAAAAGCGGCCTTGTGGATTTTGCCACCTTTCTGAC
TGCCCGCGGGGTAGAGCTTGTCTCTACCGGCGGCACGCAGAAGGCACTGGAGGCGGCGGGCCTGCCCGTCACCGCAGTGA
GCACGGTTACCGGATTTCCCGAAATTCTCGGGGGCCGGGTAAAAACCCTGCACCCCAAGATCCATGCCGGAATCCTGGCA
AACAAGGACGAAGAATCCCACATGCAGACCCTGTCTGAAAAAGGCATACGCCCCTTTGACATGGTTTGCGTCAACCTCTA
CGACTTTGCAGGAGCTGTGGAGCGCAAACTCTCCCTTGAAGAAGCCGTGGAGGAGATCGACATCGGCGGCCCCTGTATGC
TGCGTGCCGCTGCCAAGAACTTTCACAGCATTCTTGTGCTGCCTTCGCCCCAGTGGTACCCCACTGCCATGGATGAAATG
CGCAGCCACGACAATGCCGTGAGCCTGGAATTCCGCCAGACCATGGCCTCAAGAGCTTTTGAAGCCACCTCGCGCTACGA
CGCCCTCATCACGTCCTATCTGCGCCCGTAA

Upstream 100 bases:

>100_bases
TGCGCAAACACGCATTTTACTGTAATAACTCAGATGGGTCACATTTATGCCGTGCCGGACTTTCCGGCGCGTAAGCCCAC
GAAATTTTAGGAGTCGCTTC

Downstream 100 bases:

>100_bases
CCACCATCAGGCAGGGCGGCCCCGGGCCGCCCTGTTTTTTTCAGCCGTGGCCCGCCAGCATGCGGGCCAGAGCGAAAAGC
GCACCATTGCGCCAGGAGCA

Product: IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase [H]

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MDILPIRRAILSVTDKSGLVDFATFLTARGVELVSTGGTQKALEAAGLPVTAVSTVTGFPEILGGRVKTLHPKIHAGILA
NKDEESHMQTLSEKGIRPFDMVCVNLYDFAGAVERKLSLEEAVEEIDIGGPCMLRAAAKNFHSILVLPSPQWYPTAMDEM
RSHDNAVSLEFRQTMASRAFEATSRYDALITSYLRP

Sequences:

>Translated_196_residues
MDILPIRRAILSVTDKSGLVDFATFLTARGVELVSTGGTQKALEAAGLPVTAVSTVTGFPEILGGRVKTLHPKIHAGILA
NKDEESHMQTLSEKGIRPFDMVCVNLYDFAGAVERKLSLEEAVEEIDIGGPCMLRAAAKNFHSILVLPSPQWYPTAMDEM
RSHDNAVSLEFRQTMASRAFEATSRYDALITSYLRP
>Mature_196_residues
MDILPIRRAILSVTDKSGLVDFATFLTARGVELVSTGGTQKALEAAGLPVTAVSTVTGFPEILGGRVKTLHPKIHAGILA
NKDEESHMQTLSEKGIRPFDMVCVNLYDFAGAVERKLSLEEAVEEIDIGGPCMLRAAAKNFHSILVLPSPQWYPTAMDEM
RSHDNAVSLEFRQTMASRAFEATSRYDALITSYLRP

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family [H]

Homologues:

Organism=Homo sapiens, GI20127454, Length=195, Percent_Identity=49.2307692307692, Blast_Score=164, Evalue=5e-41,
Organism=Escherichia coli, GI1790439, Length=191, Percent_Identity=50.7853403141361, Blast_Score=194, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI71985564, Length=188, Percent_Identity=46.2765957446808, Blast_Score=156, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6323056, Length=190, Percent_Identity=45.2631578947368, Blast_Score=158, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6323768, Length=190, Percent_Identity=44.7368421052632, Blast_Score=157, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24649832, Length=188, Percent_Identity=44.6808510638298, Blast_Score=154, Evalue=4e-38,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607 [H]

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS [H]

EC number: =2.1.2.3; =3.5.4.10 [H]

Molecular weight: Translated: 21408; Mature: 21408

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDILPIRRAILSVTDKSGLVDFATFLTARGVELVSTGGTQKALEAAGLPVTAVSTVTGFP
CCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHCCCCEEHHHHHHCCH
EILGGRVKTLHPKIHAGILANKDEESHMQTLSEKGIRPFDMVCVNLYDFAGAVERKLSLE
HHHCCCCEEECCHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
EAVEEIDIGGPCMLRAAAKNFHSILVLPSPQWYPTAMDEMRSHDNAVSLEFRQTMASRAF
HHHHHHCCCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHCCCCEEEHHHHHHHHHHHH
EATSRYDALITSYLRP
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDILPIRRAILSVTDKSGLVDFATFLTARGVELVSTGGTQKALEAAGLPVTAVSTVTGFP
CCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHCCCCEEHHHHHHCCH
EILGGRVKTLHPKIHAGILANKDEESHMQTLSEKGIRPFDMVCVNLYDFAGAVERKLSLE
HHHCCCCEEECCHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
EAVEEIDIGGPCMLRAAAKNFHSILVLPSPQWYPTAMDEMRSHDNAVSLEFRQTMASRAF
HHHHHHCCCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHCCCCEEEHHHHHHHHHHHH
EATSRYDALITSYLRP
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA