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The map label for this gene is gcvT [H]

Identifier: 220904060

GI number: 220904060

Start: 920381

End: 921463

Strand: Direct

Name: gcvT [H]

Synonym: Ddes_0786

Alternate gene names: 220904060

Gene position: 920381-921463 (Clockwise)

Preceding gene: 220904059

Following gene: 220904061

Centisome position: 32.03

GC content: 59.37

Gene sequence:

>1083_bases
ATGTCAGACTTGCGTACCCCGCTGACCTCCTGGCATGAAGCCCAGGGAGCGAAAATGGCCCCCTTTGCGGGCTGGCTCAT
GCCCATTCAGTACGAGGGCATTCTTGCGGAACATCTCCACACCCGGAAACATGCCGGTATTTTTGACATCTGCCATATGG
GAGAATTTCGCATTGAAGGCCCTGGCGCTACAGAGGCCCTGTCGCGCGCCGTAAGCCACAATCTTGAAACCCTGGCCCCC
GGCAAGTGCCGTTATGGTTTTCTGCTCACGGAAAAAGGCGGCGTTCTTGACGACGGCATCATCTACCGTTTCGGGCCTGA
TTCCTTCATGGCCGTGGTCAATGCCGCCTGCGCCCCCGGCGATCTGGCAACCCTGCGCGCCCGCCTGCCTGAAAGTATCA
GGATTACCGACATCTCGGCCGAAACCGGCAAGGTTGACCTGCAAGGCCCGGATTCACTGGACGTGCTTGAAAAGATCATG
GGCGAAAATTTTCATGACCTCGGCTACTTTTCTTTTCGCGAAAGCAAGTGGCAGGGTGTGCCTGTGCTTGTGAGCCGTAC
CGGTTACACTGGTGAACTTGGGTATGAGCTTTATCTGCCCACGGACAAAACCGAGGCTTTCTGGAAAGCCCTGCTGGCCG
ATGAGCGTGTTAAACCTGTCGGCCTTGGCGCTCGCGACACGCTGCGCCTTGAGGCCGGTTTGCCGCTTTACGGGCATGAC
CTTGATGAAGAACATACGCCCGCCGAGGCGGGTATGGCCCGCATGATGACAAGCCAGGCCGACTATGTGGGCAGGGAAGG
GGCACAGACCGTGCGCGAAGTGCTTGTACCCCTGCAGATCGAAGGCCGCCGCGCCGCCCGCCACGGCGATGTGCTGGCGC
TGCCCGGCGGCGAGGCCGTAGGGCGCATCACCAGCGGCTCGTTTGCGCCCTCTTTGGGCTATGTTATTGCTTTTGCCTGG
GTGGCTGCCGCCCATGCGGACAAGGAAGATTTTGTGGTGCGCGCCTCCAGAACGGAACTGCCCGCCAAAAAGGTGGAAAT
TCCCTTCTACAAAGAAGGCACGGCCCGCAAAAAGCTGGTCTGA

Upstream 100 bases:

>100_bases
TCTTGCGGGCATATGTGCGTGCTGTTTGGTGTCCTCCGGGCGCCGCAGCCGATTACGGCACGGCGCAACAAGTTCAACCA
CCCCATATCAAGGAGAAACC

Downstream 100 bases:

>100_bases
TCGCGCGGCGTTCTGCGAACCGCTTGTGGAGCAGACCTGCCGCCCGTCAAATACGTGAAGGCTTGTGCGCCGAGAGGGCG
CGTATTGTTCCCCCCAACTA

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MSDLRTPLTSWHEAQGAKMAPFAGWLMPIQYEGILAEHLHTRKHAGIFDICHMGEFRIEGPGATEALSRAVSHNLETLAP
GKCRYGFLLTEKGGVLDDGIIYRFGPDSFMAVVNAACAPGDLATLRARLPESIRITDISAETGKVDLQGPDSLDVLEKIM
GENFHDLGYFSFRESKWQGVPVLVSRTGYTGELGYELYLPTDKTEAFWKALLADERVKPVGLGARDTLRLEAGLPLYGHD
LDEEHTPAEAGMARMMTSQADYVGREGAQTVREVLVPLQIEGRRAARHGDVLALPGGEAVGRITSGSFAPSLGYVIAFAW
VAAAHADKEDFVVRASRTELPAKKVEIPFYKEGTARKKLV

Sequences:

>Translated_360_residues
MSDLRTPLTSWHEAQGAKMAPFAGWLMPIQYEGILAEHLHTRKHAGIFDICHMGEFRIEGPGATEALSRAVSHNLETLAP
GKCRYGFLLTEKGGVLDDGIIYRFGPDSFMAVVNAACAPGDLATLRARLPESIRITDISAETGKVDLQGPDSLDVLEKIM
GENFHDLGYFSFRESKWQGVPVLVSRTGYTGELGYELYLPTDKTEAFWKALLADERVKPVGLGARDTLRLEAGLPLYGHD
LDEEHTPAEAGMARMMTSQADYVGREGAQTVREVLVPLQIEGRRAARHGDVLALPGGEAVGRITSGSFAPSLGYVIAFAW
VAAAHADKEDFVVRASRTELPAKKVEIPFYKEGTARKKLV
>Mature_359_residues
SDLRTPLTSWHEAQGAKMAPFAGWLMPIQYEGILAEHLHTRKHAGIFDICHMGEFRIEGPGATEALSRAVSHNLETLAPG
KCRYGFLLTEKGGVLDDGIIYRFGPDSFMAVVNAACAPGDLATLRARLPESIRITDISAETGKVDLQGPDSLDVLEKIMG
ENFHDLGYFSFRESKWQGVPVLVSRTGYTGELGYELYLPTDKTEAFWKALLADERVKPVGLGARDTLRLEAGLPLYGHDL
DEEHTPAEAGMARMMTSQADYVGREGAQTVREVLVPLQIEGRRAARHGDVLALPGGEAVGRITSGSFAPSLGYVIAFAWV
AAAHADKEDFVVRASRTELPAKKVEIPFYKEGTARKKLV

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=361, Percent_Identity=32.409972299169, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI257796258, Length=337, Percent_Identity=33.2344213649852, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI257796254, Length=357, Percent_Identity=29.4117647058824, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI257796256, Length=318, Percent_Identity=28.9308176100629, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI24797151, Length=308, Percent_Identity=25.3246753246753, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI197927446, Length=324, Percent_Identity=24.3827160493827, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI21361378, Length=324, Percent_Identity=24.3827160493827, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1789272, Length=371, Percent_Identity=35.5795148247978, Blast_Score=188, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17560118, Length=367, Percent_Identity=33.2425068119891, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71994045, Length=341, Percent_Identity=25.8064516129032, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71994052, Length=341, Percent_Identity=25.8064516129032, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI32563613, Length=312, Percent_Identity=22.4358974358974, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320222, Length=383, Percent_Identity=32.8981723237598, Blast_Score=171, Evalue=1e-43,
Organism=Drosophila melanogaster, GI20129441, Length=373, Percent_Identity=34.0482573726542, Blast_Score=171, Evalue=8e-43,
Organism=Drosophila melanogaster, GI20130091, Length=319, Percent_Identity=27.5862068965517, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 39338; Mature: 39207

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLRTPLTSWHEAQGAKMAPFAGWLMPIQYEGILAEHLHTRKHAGIFDICHMGEFRIEG
CCCCCCCHHHHHHHCCCEECCCCCCEEEEEECCHHHHHHHHHHCCCCHHHCCCCCEEECC
PGATEALSRAVSHNLETLAPGKCRYGFLLTEKGGVLDDGIIYRFGPDSFMAVVNAACAPG
CCHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCEEEEECCHHHHHHHHHCCCCC
DLATLRARLPESIRITDISAETGKVDLQGPDSLDVLEKIMGENFHDLGYFSFRESKWQGV
HHHHHHHHCCCCEEEEEECCCCCEEEECCCCHHHHHHHHHCCCCCCCCEEEECCCCCCCC
PVLVSRTGYTGELGYELYLPTDKTEAFWKALLADERVKPVGLGARDTLRLEAGLPLYGHD
EEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCC
LDEEHTPAEAGMARMMTSQADYVGREGAQTVREVLVPLQIEGRRAARHGDVLALPGGEAV
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCEEECCCCCCCCCCEEEECCCCCE
GRITSGSFAPSLGYVIAFAWVAAAHADKEDFVVRASRTELPAKKVEIPFYKEGTARKKLV
EEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHCCCCEECCCCCCCCCC
>Mature Secondary Structure 
SDLRTPLTSWHEAQGAKMAPFAGWLMPIQYEGILAEHLHTRKHAGIFDICHMGEFRIEG
CCCCCCHHHHHHHCCCEECCCCCCEEEEEECCHHHHHHHHHHCCCCHHHCCCCCEEECC
PGATEALSRAVSHNLETLAPGKCRYGFLLTEKGGVLDDGIIYRFGPDSFMAVVNAACAPG
CCHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCEEEEECCHHHHHHHHHCCCCC
DLATLRARLPESIRITDISAETGKVDLQGPDSLDVLEKIMGENFHDLGYFSFRESKWQGV
HHHHHHHHCCCCEEEEEECCCCCEEEECCCCHHHHHHHHHCCCCCCCCEEEECCCCCCCC
PVLVSRTGYTGELGYELYLPTDKTEAFWKALLADERVKPVGLGARDTLRLEAGLPLYGHD
EEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCC
LDEEHTPAEAGMARMMTSQADYVGREGAQTVREVLVPLQIEGRRAARHGDVLALPGGEAV
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCEEECCCCCCCCCCEEEECCCCCE
GRITSGSFAPSLGYVIAFAWVAAAHADKEDFVVRASRTELPAKKVEIPFYKEGTARKKLV
EEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHCCCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA