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The map label for this gene is lon [H]

Identifier: 220903968

GI number: 220903968

Start: 823352

End: 825793

Strand: Direct

Name: lon [H]

Synonym: Ddes_0694

Alternate gene names: 220903968

Gene position: 823352-825793 (Clockwise)

Preceding gene: 220903967

Following gene: 220903969

Centisome position: 28.65

GC content: 58.03

Gene sequence:

>2442_bases
ATGACTGAATCCGTACGCGGTACTGGAAAACTTGTGGAACTGCCCGTCATGCCTCTGCGTGAGGTGGTCATGTTTCCGCG
CTCCATCATGCCGCTTTTTGTGGGGCGTGAAGCCTCCATCAAGGCCATAGAGGCCGCTCAGGCCAGCTACAGCAAACAGA
TTTTTCTGGTGGCCCAGCTCGAGCCGGAACTGGAAAAACCCGAAGCCGGAGACCTGGCTCCCGTGGGTGTGGTCAGCAAG
GTTCTGCAGATGCTGCGCCTGCCCGACGGCACCATAAAGGTGCTGTTTGAAGGCATGTATCGTGCCGATTGGGAAGACAT
GCACGAAAACGAGCAGTGCGCCGTTGTGCGCGCGGCCCGGCGCGGCGAGGCGCAAAGCCGCCCCGAGGAGCGCGAAGCTC
TTGTGCGCGCAGTGCATGAGGCTCTGGAAGAGTTTGCCAAGGGCAACAAGAAGCTCTCGCAGGAATCTGTGCTTTCCATG
ATGGCGCTGCATGAGCCAGGCCCGCTGGCCGATTCCATTATCCCCAATCTCAAGGTGGACTACCGCAAAAAGCAGCAGGC
CCTGGAGATGGACGACGTGACCGAGCGGCTGGAGCTGGCCTATGAGCTGCTTCACGGTGAGGTGGCGCTGGCCACGGTGG
AAAAGCGCATTAAAAATCGTGTCAAGGTACAGATGGAGCGCAATCAGCGCGAGTATTACCTTAACGAGCAGATCAAGGCC
ATCAACAAGGAAATGGGGCGCGACGACGACCCCCAGGCCGAGGTGGACGAGATAGAGCAAAAGCTCAAGGCGCGCGACAT
GCCCGAAGAAGCGCGCCAGAAAGCCCTTGGCGAAGCCAAAAAACTGCGCAGCATGCCGCCTTCGGCTGCCGAATATACGG
TTGTGCGCAACTATGTGGACTGGATTCTCGATCTGCCGTGGAATGACCTCAAGCAGGTTGATATCAATATCGAAAAGGCC
CGCAATATTCTGGACGGCGACCACTATGGTCTTGAAAAGCCCAAAGAGCGCATCCTTGAATACCTGGCAGTGCAAAAGCT
TTCCCAGGGGCTGAAGGGGCCGATTCTCTGTTTTGTGGGGCCTCCGGGCGTGGGCAAAACGTCTCTGGCGCGGTCTGTGG
CCAAGGCCACAGGGCGGGATTTCGTGCGTCTGTCACTCGGCGGCGTACGCGATGAGGCCGAAATTCGCGGCCACCGCCGT
ACCTATGTGGGCGCGCTGCCGGGCAAGATCATCCAGTCTCTCAAGCGGGTGAAATACAACAATCCGCTCTTCTGCCTGGA
TGAAGTGGACAAGATGACATCCGACTACCGGGGCGACCCGGCATCGGCCCTGCTGGAAGTGTTGGATCCGGAACAGAACC
ATACCTTTATGGACCATTATCTGGACCTGGAATATGACCTGTCCAAGATATTCTTTATCACCACGGCCAACTCGCTGCAC
ACCATTCCCGTGCCTTTGCTGGACCGCATGGAGATAATAGAGCTGAACAGCTACCTTGAAACAGAAAAGCGCCATATCGC
GCGACACTTTCTGCTGCCCCGCCAGATAGAAGAGCACGGACTCAAGGAGAGCAACATCCGGGTTTCGGATAATGCCGTTC
TTGAGATCATCCGTTCCTATACCCGCGAGGCGGGCGTGCGTAACCTTGAGCGCGAAATTGCGGCCCTGTGCCGTAAAACA
GCCATCAAGCTGGTGGAAGAGGAAAATCTGGACAAATGCGTGAACATCTCGTGCCAGAGTCTGCCCTCCATGCTTGGCGT
CAAAAAATACCGGCATGACGAGCGCGAGGCTGAACCGCAGGTGGGCGTGTGCGCCGGGCTTGCCTACAATCAGCGCGGCG
GCGAAATTCTGCTGGTGGAAACAACGCTCATGGCCGGTTCTGGTCAGGTGGTGACCACTGGCAAACTTGGTGAGGTCATG
ACTGAATCGGCCAAGGCCGCGCTTTCCTATGTGCGCTCGCGGGCCGAGGTGCTGGGGCTTGACCCGCGCTTCCACCGCAA
GGTGGATATTCATGTGCATGTACCCTCCGGAGCCACGCCCAAGGACGGTCCCTCGGCAGGCATTACCCTTGCCACGTCAA
TTACCTCGGCCTTGCTGGGCATTCCGGTTCGCAACGATGTGGCCATGACGGGCGAGATATCCTTGCGGGGCCGTGTGCTG
CCCATTGGCGGCCTGCGCGAGAAACTGCTGGCCGCGCGGCGCAGCGGCATCAAAAAAGTGCTTATGCCTCGCGACAATGA
AAAAGACCTCAAGGAAGTGCCGGACGAGGTGCTGAAAGACCTTGAAATTGTTTTTGTGGATCATGTGGATGAAGTGCTGC
CCCATGCCCTGGATGCCGGTGTGGAGGAAATATTCTCCGGCCGGGCCACGGCGCAGCCCATCTGCCGTATCCTGCGGCCC
GAAAAGCATGGCGAAGAAGACAAAAAACAGCCCGCCCAATAA

Upstream 100 bases:

>100_bases
ACGCGGCGACAGAGTGTAACCCGTCTTTACCGTAATCCGCTCTAATCTCCCAAGCTATGGGGCCGTGCCAATGCGGCCCA
CGGCCTTTCAGGGGAAAACT

Downstream 100 bases:

>100_bases
AATCACTTTGGCAACGGCAGAGCATACCTGAAAAGCCCGCGTAAGCGGGCTTTTCAGGTTATGGTTTTAGAGCAATTTCT
GACGGCTGCGTGAGCGAACG

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 813; Mature: 812

Protein sequence:

>813_residues
MTESVRGTGKLVELPVMPLREVVMFPRSIMPLFVGREASIKAIEAAQASYSKQIFLVAQLEPELEKPEAGDLAPVGVVSK
VLQMLRLPDGTIKVLFEGMYRADWEDMHENEQCAVVRAARRGEAQSRPEEREALVRAVHEALEEFAKGNKKLSQESVLSM
MALHEPGPLADSIIPNLKVDYRKKQQALEMDDVTERLELAYELLHGEVALATVEKRIKNRVKVQMERNQREYYLNEQIKA
INKEMGRDDDPQAEVDEIEQKLKARDMPEEARQKALGEAKKLRSMPPSAAEYTVVRNYVDWILDLPWNDLKQVDINIEKA
RNILDGDHYGLEKPKERILEYLAVQKLSQGLKGPILCFVGPPGVGKTSLARSVAKATGRDFVRLSLGGVRDEAEIRGHRR
TYVGALPGKIIQSLKRVKYNNPLFCLDEVDKMTSDYRGDPASALLEVLDPEQNHTFMDHYLDLEYDLSKIFFITTANSLH
TIPVPLLDRMEIIELNSYLETEKRHIARHFLLPRQIEEHGLKESNIRVSDNAVLEIIRSYTREAGVRNLEREIAALCRKT
AIKLVEEENLDKCVNISCQSLPSMLGVKKYRHDEREAEPQVGVCAGLAYNQRGGEILLVETTLMAGSGQVVTTGKLGEVM
TESAKAALSYVRSRAEVLGLDPRFHRKVDIHVHVPSGATPKDGPSAGITLATSITSALLGIPVRNDVAMTGEISLRGRVL
PIGGLREKLLAARRSGIKKVLMPRDNEKDLKEVPDEVLKDLEIVFVDHVDEVLPHALDAGVEEIFSGRATAQPICRILRP
EKHGEEDKKQPAQ

Sequences:

>Translated_813_residues
MTESVRGTGKLVELPVMPLREVVMFPRSIMPLFVGREASIKAIEAAQASYSKQIFLVAQLEPELEKPEAGDLAPVGVVSK
VLQMLRLPDGTIKVLFEGMYRADWEDMHENEQCAVVRAARRGEAQSRPEEREALVRAVHEALEEFAKGNKKLSQESVLSM
MALHEPGPLADSIIPNLKVDYRKKQQALEMDDVTERLELAYELLHGEVALATVEKRIKNRVKVQMERNQREYYLNEQIKA
INKEMGRDDDPQAEVDEIEQKLKARDMPEEARQKALGEAKKLRSMPPSAAEYTVVRNYVDWILDLPWNDLKQVDINIEKA
RNILDGDHYGLEKPKERILEYLAVQKLSQGLKGPILCFVGPPGVGKTSLARSVAKATGRDFVRLSLGGVRDEAEIRGHRR
TYVGALPGKIIQSLKRVKYNNPLFCLDEVDKMTSDYRGDPASALLEVLDPEQNHTFMDHYLDLEYDLSKIFFITTANSLH
TIPVPLLDRMEIIELNSYLETEKRHIARHFLLPRQIEEHGLKESNIRVSDNAVLEIIRSYTREAGVRNLEREIAALCRKT
AIKLVEEENLDKCVNISCQSLPSMLGVKKYRHDEREAEPQVGVCAGLAYNQRGGEILLVETTLMAGSGQVVTTGKLGEVM
TESAKAALSYVRSRAEVLGLDPRFHRKVDIHVHVPSGATPKDGPSAGITLATSITSALLGIPVRNDVAMTGEISLRGRVL
PIGGLREKLLAARRSGIKKVLMPRDNEKDLKEVPDEVLKDLEIVFVDHVDEVLPHALDAGVEEIFSGRATAQPICRILRP
EKHGEEDKKQPAQ
>Mature_812_residues
TESVRGTGKLVELPVMPLREVVMFPRSIMPLFVGREASIKAIEAAQASYSKQIFLVAQLEPELEKPEAGDLAPVGVVSKV
LQMLRLPDGTIKVLFEGMYRADWEDMHENEQCAVVRAARRGEAQSRPEEREALVRAVHEALEEFAKGNKKLSQESVLSMM
ALHEPGPLADSIIPNLKVDYRKKQQALEMDDVTERLELAYELLHGEVALATVEKRIKNRVKVQMERNQREYYLNEQIKAI
NKEMGRDDDPQAEVDEIEQKLKARDMPEEARQKALGEAKKLRSMPPSAAEYTVVRNYVDWILDLPWNDLKQVDINIEKAR
NILDGDHYGLEKPKERILEYLAVQKLSQGLKGPILCFVGPPGVGKTSLARSVAKATGRDFVRLSLGGVRDEAEIRGHRRT
YVGALPGKIIQSLKRVKYNNPLFCLDEVDKMTSDYRGDPASALLEVLDPEQNHTFMDHYLDLEYDLSKIFFITTANSLHT
IPVPLLDRMEIIELNSYLETEKRHIARHFLLPRQIEEHGLKESNIRVSDNAVLEIIRSYTREAGVRNLEREIAALCRKTA
IKLVEEENLDKCVNISCQSLPSMLGVKKYRHDEREAEPQVGVCAGLAYNQRGGEILLVETTLMAGSGQVVTTGKLGEVMT
ESAKAALSYVRSRAEVLGLDPRFHRKVDIHVHVPSGATPKDGPSAGITLATSITSALLGIPVRNDVAMTGEISLRGRVLP
IGGLREKLLAARRSGIKKVLMPRDNEKDLKEVPDEVLKDLEIVFVDHVDEVLPHALDAGVEEIFSGRATAQPICRILRPE
KHGEEDKKQPAQ

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=566, Percent_Identity=48.5865724381625, Blast_Score=542, Evalue=1e-154,
Organism=Homo sapiens, GI21396489, Length=664, Percent_Identity=40.6626506024096, Blast_Score=503, Evalue=1e-142,
Organism=Escherichia coli, GI1786643, Length=766, Percent_Identity=54.0469973890339, Blast_Score=814, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=693, Percent_Identity=39.3939393939394, Blast_Score=496, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17556486, Length=789, Percent_Identity=34.6007604562738, Blast_Score=478, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6319449, Length=669, Percent_Identity=39.4618834080717, Blast_Score=489, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24666867, Length=627, Percent_Identity=44.6570972886762, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI221513036, Length=627, Percent_Identity=44.6570972886762, Blast_Score=531, Evalue=1e-151,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 91148; Mature: 91017

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESVRGTGKLVELPVMPLREVVMFPRSIMPLFVGREASIKAIEAAQASYSKQIFLVAQL
CCCCCCCCCCEEECCCHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEEC
EPELEKPEAGDLAPVGVVSKVLQMLRLPDGTIKVLFEGMYRADWEDMHENEQCAVVRAAR
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHCCCCHHHHHHHHH
RGEAQSRPEEREALVRAVHEALEEFAKGNKKLSQESVLSMMALHEPGPLADSIIPNLKVD
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHCCCCCCH
YRKKQQALEMDDVTERLELAYELLHGEVALATVEKRIKNRVKVQMERNQREYYLNEQIKA
HHHHHHHHCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHEEHHHHCCHHHHHHHHHHH
INKEMGRDDDPQAEVDEIEQKLKARDMPEEARQKALGEAKKLRSMPPSAAEYTVVRNYVD
HHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
WILDLPWNDLKQVDINIEKARNILDGDHYGLEKPKERILEYLAVQKLSQGLKGPILCFVG
HHHCCCCCCHHEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEC
PPGVGKTSLARSVAKATGRDFVRLSLGGVRDEAEIRGHRRTYVGALPGKIIQSLKRVKYN
CCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCCHHEECCCCHHHHHHHHHHCCC
NPLFCLDEVDKMTSDYRGDPASALLEVLDPEQNHTFMDHYLDLEYDLSKIFFITTANSLH
CCEEEHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHCCCEECCCEEEEEEECCCCE
TIPVPLLDRMEIIELNSYLETEKRHIARHFLLPRQIEEHGLKESNIRVSDNAVLEIIRSY
ECCCCHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCEEECHHHHHHHHHHH
TREAGVRNLEREIAALCRKTAIKLVEEENLDKCVNISCQSLPSMLGVKKYRHDEREAEPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHCCHHHCCCC
VGVCAGLAYNQRGGEILLVETTLMAGSGQVVTTGKLGEVMTESAKAALSYVRSRAEVLGL
CEEHCCEEECCCCCEEEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCC
DPRFHRKVDIHVHVPSGATPKDGPSAGITLATSITSALLGIPVRNDVAMTGEISLRGRVL
CCCCCCEEEEEEECCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCCEEEEEEEEECCEEE
PIGGLREKLLAARRSGIKKVLMPRDNEKDLKEVPDEVLKDLEIVFVDHVDEVLPHALDAG
ECCHHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEEIFSGRATAQPICRILRPEKHGEEDKKQPAQ
HHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TESVRGTGKLVELPVMPLREVVMFPRSIMPLFVGREASIKAIEAAQASYSKQIFLVAQL
CCCCCCCCCEEECCCHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEEC
EPELEKPEAGDLAPVGVVSKVLQMLRLPDGTIKVLFEGMYRADWEDMHENEQCAVVRAAR
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHCCCCHHHHHHHHH
RGEAQSRPEEREALVRAVHEALEEFAKGNKKLSQESVLSMMALHEPGPLADSIIPNLKVD
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHCCCCCCH
YRKKQQALEMDDVTERLELAYELLHGEVALATVEKRIKNRVKVQMERNQREYYLNEQIKA
HHHHHHHHCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHEEHHHHCCHHHHHHHHHHH
INKEMGRDDDPQAEVDEIEQKLKARDMPEEARQKALGEAKKLRSMPPSAAEYTVVRNYVD
HHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
WILDLPWNDLKQVDINIEKARNILDGDHYGLEKPKERILEYLAVQKLSQGLKGPILCFVG
HHHCCCCCCHHEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEC
PPGVGKTSLARSVAKATGRDFVRLSLGGVRDEAEIRGHRRTYVGALPGKIIQSLKRVKYN
CCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCCHHEECCCCHHHHHHHHHHCCC
NPLFCLDEVDKMTSDYRGDPASALLEVLDPEQNHTFMDHYLDLEYDLSKIFFITTANSLH
CCEEEHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHCCCEECCCEEEEEEECCCCE
TIPVPLLDRMEIIELNSYLETEKRHIARHFLLPRQIEEHGLKESNIRVSDNAVLEIIRSY
ECCCCHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCEEECHHHHHHHHHHH
TREAGVRNLEREIAALCRKTAIKLVEEENLDKCVNISCQSLPSMLGVKKYRHDEREAEPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHCCHHHCCCC
VGVCAGLAYNQRGGEILLVETTLMAGSGQVVTTGKLGEVMTESAKAALSYVRSRAEVLGL
CEEHCCEEECCCCCEEEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCC
DPRFHRKVDIHVHVPSGATPKDGPSAGITLATSITSALLGIPVRNDVAMTGEISLRGRVL
CCCCCCEEEEEEECCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCCEEEEEEEEECCEEE
PIGGLREKLLAARRSGIKKVLMPRDNEKDLKEVPDEVLKDLEIVFVDHVDEVLPHALDAG
ECCHHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEEIFSGRATAQPICRILRPEKHGEEDKKQPAQ
HHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA