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The map label for this gene is map [H]

Identifier: 220903955

GI number: 220903955

Start: 811579

End: 812373

Strand: Direct

Name: map [H]

Synonym: Ddes_0681

Alternate gene names: 220903955

Gene position: 811579-812373 (Clockwise)

Preceding gene: 220903954

Following gene: 220903956

Centisome position: 28.24

GC content: 58.24

Gene sequence:

>795_bases
ATGAAGAAATATCACGGCGCGTACATCAAGAATGAGCGTGAAATCGGCTGCCTGCGCGAAGCTAACCGCATGGTCGCCAA
CGTTCTTGATGCCGTGGGCGACATGGTGGCTCCCGGCCTTCCCACTATGCGCCTTGAAGAGCTGGCGCGCGATATGTGCG
CCGATTACAAGGTCAAACCGGCCTTTTTGGGCTACTGCGGCTATCCATATGCCCTGTGCTGCTCGGTCAACGAGCAGGTG
GTGCATGGTTTTCCTTCCGGGCGGCTGCTTGAGGAAGGGGATATTGTCAGTGTGGATATGGGCGTAGTCTTTGAAGGCTT
TGTTGGCGATGCGGCACGCACCTTTCCTGTGGGCAAGGTGAGCGACGAAGCCAGAAAACTCATGCGGATTACCGAGGAAA
GCCTCTATGTCGGCATTGAGCAGGCGCGGGCAGGCAATGATGTGTATAACATCGGCGCCGCCGTGCAGGATTATGTGGAA
GCCGCAGGTTTTAACGTAGTGCGGCGTTTTGTGGGGCACGGCGTGGGCGCCAAGATGCACGAAAAGCCCGAGGTGCCCAA
CTTCAGGCCCGGCATGCGCGGGCTGACCCTGCAAAACGGCATGGTGATAGCCATTGAACCAATGGTCACCATGGGGACCT
ACGAGGTCGACATACTTGACGACCAGTGGACTGCGGTGACGCGCGACGGCCTTTGGGCCGCGCACTTCGAACACAGTGTT
GCCATTACGCCGTCCGGGCCGCAAATCCTCAGCATCTCGGATCGTGGACTCAACCGGCACACCATCGAAGGTTGA

Upstream 100 bases:

>100_bases
TTATGAATCAGGTGGAATCGCATATGATTTCCAGCCAGTATCAGGGCCTGATGGCCAAGGCGCGCAAAAGCGGCCGGCTG
TAACCAACGGGTGATGGAGT

Downstream 100 bases:

>100_bases
CAGAACAGGTAAAGCCGGATAAAGATTTCCGTTCACGTCCTTTTGTTTGGAGGACGTCGGTCAGCCGTCTGTGCGGCCTG
TGCCGGTATGCCGGAGACTT

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MKKYHGAYIKNEREIGCLREANRMVANVLDAVGDMVAPGLPTMRLEELARDMCADYKVKPAFLGYCGYPYALCCSVNEQV
VHGFPSGRLLEEGDIVSVDMGVVFEGFVGDAARTFPVGKVSDEARKLMRITEESLYVGIEQARAGNDVYNIGAAVQDYVE
AAGFNVVRRFVGHGVGAKMHEKPEVPNFRPGMRGLTLQNGMVIAIEPMVTMGTYEVDILDDQWTAVTRDGLWAAHFEHSV
AITPSGPQILSISDRGLNRHTIEG

Sequences:

>Translated_264_residues
MKKYHGAYIKNEREIGCLREANRMVANVLDAVGDMVAPGLPTMRLEELARDMCADYKVKPAFLGYCGYPYALCCSVNEQV
VHGFPSGRLLEEGDIVSVDMGVVFEGFVGDAARTFPVGKVSDEARKLMRITEESLYVGIEQARAGNDVYNIGAAVQDYVE
AAGFNVVRRFVGHGVGAKMHEKPEVPNFRPGMRGLTLQNGMVIAIEPMVTMGTYEVDILDDQWTAVTRDGLWAAHFEHSV
AITPSGPQILSISDRGLNRHTIEG
>Mature_264_residues
MKKYHGAYIKNEREIGCLREANRMVANVLDAVGDMVAPGLPTMRLEELARDMCADYKVKPAFLGYCGYPYALCCSVNEQV
VHGFPSGRLLEEGDIVSVDMGVVFEGFVGDAARTFPVGKVSDEARKLMRITEESLYVGIEQARAGNDVYNIGAAVQDYVE
AAGFNVVRRFVGHGVGAKMHEKPEVPNFRPGMRGLTLQNGMVIAIEPMVTMGTYEVDILDDQWTAVTRDGLWAAHFEHSV
AITPSGPQILSISDRGLNRHTIEG

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=241, Percent_Identity=36.9294605809129, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI40385867, Length=243, Percent_Identity=34.9794238683128, Blast_Score=162, Evalue=3e-40,
Organism=Escherichia coli, GI1786364, Length=250, Percent_Identity=40.4, Blast_Score=196, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI71996291, Length=238, Percent_Identity=36.5546218487395, Blast_Score=164, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6323273, Length=248, Percent_Identity=32.258064516129, Blast_Score=155, Evalue=5e-39,
Organism=Drosophila melanogaster, GI21355531, Length=248, Percent_Identity=36.2903225806452, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI24583427, Length=243, Percent_Identity=32.5102880658436, Blast_Score=157, Evalue=5e-39,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28958; Mature: 28958

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKYHGAYIKNEREIGCLREANRMVANVLDAVGDMVAPGLPTMRLEELARDMCADYKVKP
CCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCH
AFLGYCGYPYALCCSVNEQVVHGFPSGRLLEEGDIVSVDMGVVFEGFVGDAARTFPVGKV
HEEECCCCCEEEEECCCHHHHHCCCCCCEECCCCEEEEECCEEEECCCCCCHHHCCCCCC
SDEARKLMRITEESLYVGIEQARAGNDVYNIGAAVQDYVEAAGFNVVRRFVGHGVGAKMH
CHHHHHHHHHHHHHHHEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
EKPEVPNFRPGMRGLTLQNGMVIAIEPMVTMGTYEVDILDDQWTAVTRDGLWAAHFEHSV
CCCCCCCCCCCCCCEEECCCEEEEEECEEEECEEEEEEECCCCEEEECCCEEEEECCCEE
AITPSGPQILSISDRGLNRHTIEG
EECCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MKKYHGAYIKNEREIGCLREANRMVANVLDAVGDMVAPGLPTMRLEELARDMCADYKVKP
CCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCH
AFLGYCGYPYALCCSVNEQVVHGFPSGRLLEEGDIVSVDMGVVFEGFVGDAARTFPVGKV
HEEECCCCCEEEEECCCHHHHHCCCCCCEECCCCEEEEECCEEEECCCCCCHHHCCCCCC
SDEARKLMRITEESLYVGIEQARAGNDVYNIGAAVQDYVEAAGFNVVRRFVGHGVGAKMH
CHHHHHHHHHHHHHHHEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
EKPEVPNFRPGMRGLTLQNGMVIAIEPMVTMGTYEVDILDDQWTAVTRDGLWAAHFEHSV
CCCCCCCCCCCCCCEEECCCEEEEEECEEEECEEEEEEECCCCEEEECCCEEEEECCCEE
AITPSGPQILSISDRGLNRHTIEG
EECCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792842; 7559358 [H]