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The map label for this gene is aroP [H]

Identifier: 220903917

GI number: 220903917

Start: 779566

End: 780945

Strand: Direct

Name: aroP [H]

Synonym: Ddes_0642

Alternate gene names: 220903917

Gene position: 779566-780945 (Clockwise)

Preceding gene: 220903915

Following gene: 220903918

Centisome position: 27.13

GC content: 54.93

Gene sequence:

>1380_bases
ATGAAAAAAGAAACACCAGAGCTTCACCGTGCCTTGAAGAACAGGCACATCCAGTTGATCGCCCTTGGCGGGGCCATTGG
CACGGGCCTTTTTCTCGGATCTGCGGGAACCATCCAGATGGCCGGGCCGGCTGTCATACTGAGTTACGCCATTGGTGGTT
TTATCGCCTTTCTCATTATGCGCCAGCTTGGCGAGATGATGGCGCAAGAGCCTGTGGCCGGCTCTTTCAGCAATCTTGCC
TACAAATACTGGGGCGAGTTTCCTGGTCTTCTTTCCGGCTGGAACTACTGGATTCTTTATGTTCTGGTGGGCATGTCCGA
ACTGACGGCCGTGGCTGTTTATGTGCAGTACTGGTTTCCCGGCATTGAGCCGTGGCAGACCACGGCTTTTTTCTTTATTC
TCATCAATGTGGTCAACCTGGCGCAGGTTGGCGTTTTTGGCGAAATGGAGTTCTGGTTTGCTTCCATCAAGGTGGCGGCC
ATTGTGGCCATGATCGCCCTGGGGACGTTTCTGCTTGCCACCGGGGGGGCCGGACCCGATGCCAAAGTAAGCAATCTTTG
GGAGTATGGCGGCTTTTTTGCCAGGGGTTGGGGGGGCGTGTTTACCTCGCTTGCGGTGGTGAGCTTTTCTTTCGGCGGGC
TTGAGCTTGTGGGCATAGCTGCGGCGGAAACTTCTGATCCGCAAAAAACCATTCCCAAGGCCGTCAACCAGCTCATCTAC
CGAATCCTGATCTTCTACATCGGCGCGCTTACCGTGCTTCTGGCGTTGCACCCCTGGAACCAGCTTGGCGCTTCCGTTGA
CAAAAGCCAGTGGGCCGAGGCCATGGTCGCCAGCCCCTTTGTGCAGATTTTTGACCTCATAGGTATTCCTTCTGCTGCGC
ACGTGCTCAACTTTGTGGTGCTGACTGCGGCCCTTTCCGTATATAACAGCTGTGTCTACTGTAACAGCCGCATGCTTTAC
GGCCTGGCGCTTCAGGGCAACGCGCCCAAGGTTCTGGCCGCTGTGAGCGCCAGGGGGGTTCCGGTTTATGCGCTGATGAT
TTCTTCCGGCGCAACCCTGCTGTGCGTATTGCTGAACTTCATTATGCCCGCCAAGGCCCTTGGCGTGCTTATGGCCCTGG
TGGTGACGGCTCTTGTGATCAACTGGGCCATGATAAGCCTGACCCACCTGAGATTCAGGGCCGCCAAGATAAAGGCCGGA
GAAAAGATAGTTTTCAGGGCATTCTGGCATCCCTGGTCCAACTACCTCTGTCTTGTCTTTATGATGGTAGTGTTTGTAGT
GCTGGTGCAGATAGACATGGCCGTTTCTGTTTATGTGGCTCCCATCTGGCTGTTCTTCGTGTGGCTGGGCTACAAGATGA
AGAAGCACTATACGCAGTAG

Upstream 100 bases:

>100_bases
CGTAAAGGCTGCGGCGGAGCAGCCGCCATGTGCCGGCGTCTTTTCAAAGTTTCATAATCCTGATATGCCTTGCCGAATCA
TTTTAACACACGAGCCGGCT

Downstream 100 bases:

>100_bases
CGCCGCTTCAGTTTTTCGGCTTTGCGGGCGCCTCTCACGAGGTGGCCGCAAAGCCCCTCTTTTCAGGCTGCCTGTTTTTG
CGAAAGGTCCCTTTCCATTG

Product: amino acid permease-associated protein

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MKKETPELHRALKNRHIQLIALGGAIGTGLFLGSAGTIQMAGPAVILSYAIGGFIAFLIMRQLGEMMAQEPVAGSFSNLA
YKYWGEFPGLLSGWNYWILYVLVGMSELTAVAVYVQYWFPGIEPWQTTAFFFILINVVNLAQVGVFGEMEFWFASIKVAA
IVAMIALGTFLLATGGAGPDAKVSNLWEYGGFFARGWGGVFTSLAVVSFSFGGLELVGIAAAETSDPQKTIPKAVNQLIY
RILIFYIGALTVLLALHPWNQLGASVDKSQWAEAMVASPFVQIFDLIGIPSAAHVLNFVVLTAALSVYNSCVYCNSRMLY
GLALQGNAPKVLAAVSARGVPVYALMISSGATLLCVLLNFIMPAKALGVLMALVVTALVINWAMISLTHLRFRAAKIKAG
EKIVFRAFWHPWSNYLCLVFMMVVFVVLVQIDMAVSVYVAPIWLFFVWLGYKMKKHYTQ

Sequences:

>Translated_459_residues
MKKETPELHRALKNRHIQLIALGGAIGTGLFLGSAGTIQMAGPAVILSYAIGGFIAFLIMRQLGEMMAQEPVAGSFSNLA
YKYWGEFPGLLSGWNYWILYVLVGMSELTAVAVYVQYWFPGIEPWQTTAFFFILINVVNLAQVGVFGEMEFWFASIKVAA
IVAMIALGTFLLATGGAGPDAKVSNLWEYGGFFARGWGGVFTSLAVVSFSFGGLELVGIAAAETSDPQKTIPKAVNQLIY
RILIFYIGALTVLLALHPWNQLGASVDKSQWAEAMVASPFVQIFDLIGIPSAAHVLNFVVLTAALSVYNSCVYCNSRMLY
GLALQGNAPKVLAAVSARGVPVYALMISSGATLLCVLLNFIMPAKALGVLMALVVTALVINWAMISLTHLRFRAAKIKAG
EKIVFRAFWHPWSNYLCLVFMMVVFVVLVQIDMAVSVYVAPIWLFFVWLGYKMKKHYTQ
>Mature_459_residues
MKKETPELHRALKNRHIQLIALGGAIGTGLFLGSAGTIQMAGPAVILSYAIGGFIAFLIMRQLGEMMAQEPVAGSFSNLA
YKYWGEFPGLLSGWNYWILYVLVGMSELTAVAVYVQYWFPGIEPWQTTAFFFILINVVNLAQVGVFGEMEFWFASIKVAA
IVAMIALGTFLLATGGAGPDAKVSNLWEYGGFFARGWGGVFTSLAVVSFSFGGLELVGIAAAETSDPQKTIPKAVNQLIY
RILIFYIGALTVLLALHPWNQLGASVDKSQWAEAMVASPFVQIFDLIGIPSAAHVLNFVVLTAALSVYNSCVYCNSRMLY
GLALQGNAPKVLAAVSARGVPVYALMISSGATLLCVLLNFIMPAKALGVLMALVVTALVINWAMISLTHLRFRAAKIKAG
EKIVFRAFWHPWSNYLCLVFMMVVFVVLVQIDMAVSVYVAPIWLFFVWLGYKMKKHYTQ

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=359, Percent_Identity=25.6267409470752, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1786302, Length=459, Percent_Identity=59.6949891067538, Blast_Score=545, Evalue=1e-156,
Organism=Escherichia coli, GI1786789, Length=456, Percent_Identity=56.7982456140351, Blast_Score=529, Evalue=1e-151,
Organism=Escherichia coli, GI48994972, Length=464, Percent_Identity=42.4568965517241, Blast_Score=340, Evalue=8e-95,
Organism=Escherichia coli, GI1790653, Length=451, Percent_Identity=39.4678492239468, Blast_Score=328, Evalue=5e-91,
Organism=Escherichia coli, GI1786602, Length=464, Percent_Identity=40.0862068965517, Blast_Score=310, Evalue=2e-85,
Organism=Escherichia coli, GI87081915, Length=397, Percent_Identity=38.2871536523929, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1789017, Length=431, Percent_Identity=36.6589327146172, Blast_Score=263, Evalue=1e-71,
Organism=Escherichia coli, GI1788480, Length=476, Percent_Identity=35.7142857142857, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI87081708, Length=436, Percent_Identity=35.7798165137615, Blast_Score=241, Evalue=7e-65,
Organism=Escherichia coli, GI87081869, Length=174, Percent_Identity=25.2873563218391, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=437, Percent_Identity=32.0366132723112, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6324924, Length=483, Percent_Identity=30.2277432712215, Blast_Score=203, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6321053, Length=427, Percent_Identity=30.9133489461358, Blast_Score=202, Evalue=9e-53,
Organism=Saccharomyces cerevisiae, GI6324553, Length=405, Percent_Identity=34.8148148148148, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6324061, Length=437, Percent_Identity=32.2654462242563, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6322892, Length=439, Percent_Identity=33.2574031890661, Blast_Score=199, Evalue=9e-52,
Organism=Saccharomyces cerevisiae, GI6324990, Length=483, Percent_Identity=31.4699792960663, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6319824, Length=436, Percent_Identity=29.1284403669725, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6320251, Length=486, Percent_Identity=28.8065843621399, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6320717, Length=407, Percent_Identity=29.97542997543, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6319608, Length=437, Percent_Identity=29.5194508009153, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6324059, Length=481, Percent_Identity=30.7692307692308, Blast_Score=171, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6321629, Length=411, Percent_Identity=31.1435523114355, Blast_Score=169, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6319542, Length=479, Percent_Identity=28.6012526096033, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6322967, Length=415, Percent_Identity=29.1566265060241, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6319543, Length=438, Percent_Identity=29.9086757990868, Blast_Score=160, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6324981, Length=406, Percent_Identity=29.8029556650246, Blast_Score=147, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6320364, Length=498, Percent_Identity=26.1044176706827, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24667468, Length=281, Percent_Identity=27.4021352313167, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24666159, Length=367, Percent_Identity=22.3433242506812, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI221512776, Length=367, Percent_Identity=22.3433242506812, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24668806, Length=437, Percent_Identity=23.1121281464531, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21356285, Length=437, Percent_Identity=23.1121281464531, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24668802, Length=437, Percent_Identity=23.1121281464531, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI161077963, Length=426, Percent_Identity=25.1173708920188, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50139; Mature: 50139

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKETPELHRALKNRHIQLIALGGAIGTGLFLGSAGTIQMAGPAVILSYAIGGFIAFLIM
CCCCCHHHHHHHHCCCEEEEEECCHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHH
RQLGEMMAQEPVAGSFSNLAYKYWGEFPGLLSGWNYWILYVLVGMSELTAVAVYVQYWFP
HHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
GIEPWQTTAFFFILINVVNLAQVGVFGEMEFWFASIKVAAIVAMIALGTFLLATGGAGPD
CCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AKVSNLWEYGGFFARGWGGVFTSLAVVSFSFGGLELVGIAAAETSDPQKTIPKAVNQLIY
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHH
RILIFYIGALTVLLALHPWNQLGASVDKSQWAEAMVASPFVQIFDLIGIPSAAHVLNFVV
HHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LTAALSVYNSCVYCNSRMLYGLALQGNAPKVLAAVSARGVPVYALMISSGATLLCVLLNF
HHHHHHHHHHHHEECCCEEEEEEECCCCCHHHHHHHCCCCEEEEEEECCCHHHHHHHHHH
IMPAKALGVLMALVVTALVINWAMISLTHLRFRAAKIKAGEKIVFRAFWHPWSNYLCLVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCHHHHHHHHH
MMVVFVVLVQIDMAVSVYVAPIWLFFVWLGYKMKKHYTQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKETPELHRALKNRHIQLIALGGAIGTGLFLGSAGTIQMAGPAVILSYAIGGFIAFLIM
CCCCCHHHHHHHHCCCEEEEEECCHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHH
RQLGEMMAQEPVAGSFSNLAYKYWGEFPGLLSGWNYWILYVLVGMSELTAVAVYVQYWFP
HHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
GIEPWQTTAFFFILINVVNLAQVGVFGEMEFWFASIKVAAIVAMIALGTFLLATGGAGPD
CCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AKVSNLWEYGGFFARGWGGVFTSLAVVSFSFGGLELVGIAAAETSDPQKTIPKAVNQLIY
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHH
RILIFYIGALTVLLALHPWNQLGASVDKSQWAEAMVASPFVQIFDLIGIPSAAHVLNFVV
HHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LTAALSVYNSCVYCNSRMLYGLALQGNAPKVLAAVSARGVPVYALMISSGATLLCVLLNF
HHHHHHHHHHHHEECCCEEEEEEECCCCCHHHHHHHCCCCEEEEEEECCCHHHHHHHHHH
IMPAKALGVLMALVVTALVINWAMISLTHLRFRAAKIKAGEKIVFRAFWHPWSNYLCLVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCHHHHHHHHH
MMVVFVVLVQIDMAVSVYVAPIWLFFVWLGYKMKKHYTQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]