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The map label for this gene is mltA [H]

Identifier: 220903881

GI number: 220903881

Start: 732376

End: 733452

Strand: Direct

Name: mltA [H]

Synonym: Ddes_0606

Alternate gene names: 220903881

Gene position: 732376-733452 (Clockwise)

Preceding gene: 220903879

Following gene: 220903889

Centisome position: 25.49

GC content: 58.31

Gene sequence:

>1077_bases
ATGTGTCTTCTGCTCGGGGCCTGCGGCAAAAAGGTGGCCCCGCCTTCTCCAGAACCCGTGGGACCGCCCGTGGCTTTTGA
AAGCCCGGAATTTTTTGTAAGCTGCCTGAAGCCTGTCAATCAGGACCTGACCAGCTGGAAAGATATGGCTCCTACCGTGC
GCAAGTCTTTGCGCTATGTCAACAGCAAGCCCGCCACGGCCATTGCCGTGCAACGCCCGGGGTTGACCGTGACCTGGGGC
GAGCTTTCGCGCACGTTGACCCGGCTGCAGGAGCTTTTGCCCCGTCTGGACAGGGAACCGGAGCTTTTTCTGGCAAATTT
CCGCTGGGTGGAAGTGCCTGACGGCATAAAATATTCGGGCTATTACGAACCTGTGGTGCGCGCCAGTCGCACACGCAAGC
CAGGGTATACCCAGGCCATCTACGGGTTGCCGCCGGACCTCAAAAAGGTGGCGGCCAAGCGCGGGCGCTACTATGACCGT
CGCACCATTGAAGAAAAACAGATACTGGCCGGCAAAGGCCTGGAGCTGGCCTGGGCCGCCGACCCCGTGGACGTATTTTT
TCTGGAAATTCAGGGTTCAGGCCGACTGGTTTTTGACGACGGAACCCAGGCCTATATCAACTATGCGGGTCAGAACGGCC
ACAAGTATAAAAGTTCCGGACGCATCATGCGTGAAAAGGGCCTGCTCCGGGAAGGGCATATATTTGAGCAGCGCCAGTGG
TTCAAGGATAATCCGCAGCGTGTGCGCGAGATACTGAACGAAAACCCCAGCTATGTCTTTTTTCGGTACGGAACCCGGGG
ACCAACCGGGGCCACGGGGCAGGTGGTGGACGAGTGGCTGTCGCTGGCTACGGACCGCACCTTCATCCCTTTGGGCTCTG
TTGTGGCTTACGGCGTGAACATTCCTGACCAGCAGCGCGGCAAGGTCCCGCTGCGCGGTATCGGCTTTGCCCAGGATGTG
GGGGGCGCCATCAAGAAAAACCGTATAGACGTGTTTTGTGGCGGTGAGGAAAGAGGCAATTATGTGGCCAGTCATCTGGA
TGCCAGAGGCCCGGCCTGGGTATTGCTGGCAAAATAA

Upstream 100 bases:

>100_bases
CTTCATGCACGCGAATGCTCCTTGTTTATATGCACCTTGCACTTGTGGCGCGGTCGACCGGCCCTGTGGGGTCAGACCGG
TTCTGGCGGCGCTGCTGCTC

Downstream 100 bases:

>100_bases
AAAACGGACGTCTTGGGCCGGTTGAGGCAAAGCCCGTTTGCAGCCGGGGGAGCATTATCCCCAGGCTGCAAACGGGCTTT
TGTATGCTTGAATGTTTTCA

Product: MltA domain-containing protein

Products: Muramic Acid Residue [C]

Alternate protein names: Mlt38; Murein hydrolase A [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MCLLLGACGKKVAPPSPEPVGPPVAFESPEFFVSCLKPVNQDLTSWKDMAPTVRKSLRYVNSKPATAIAVQRPGLTVTWG
ELSRTLTRLQELLPRLDREPELFLANFRWVEVPDGIKYSGYYEPVVRASRTRKPGYTQAIYGLPPDLKKVAAKRGRYYDR
RTIEEKQILAGKGLELAWAADPVDVFFLEIQGSGRLVFDDGTQAYINYAGQNGHKYKSSGRIMREKGLLREGHIFEQRQW
FKDNPQRVREILNENPSYVFFRYGTRGPTGATGQVVDEWLSLATDRTFIPLGSVVAYGVNIPDQQRGKVPLRGIGFAQDV
GGAIKKNRIDVFCGGEERGNYVASHLDARGPAWVLLAK

Sequences:

>Translated_358_residues
MCLLLGACGKKVAPPSPEPVGPPVAFESPEFFVSCLKPVNQDLTSWKDMAPTVRKSLRYVNSKPATAIAVQRPGLTVTWG
ELSRTLTRLQELLPRLDREPELFLANFRWVEVPDGIKYSGYYEPVVRASRTRKPGYTQAIYGLPPDLKKVAAKRGRYYDR
RTIEEKQILAGKGLELAWAADPVDVFFLEIQGSGRLVFDDGTQAYINYAGQNGHKYKSSGRIMREKGLLREGHIFEQRQW
FKDNPQRVREILNENPSYVFFRYGTRGPTGATGQVVDEWLSLATDRTFIPLGSVVAYGVNIPDQQRGKVPLRGIGFAQDV
GGAIKKNRIDVFCGGEERGNYVASHLDARGPAWVLLAK
>Mature_358_residues
MCLLLGACGKKVAPPSPEPVGPPVAFESPEFFVSCLKPVNQDLTSWKDMAPTVRKSLRYVNSKPATAIAVQRPGLTVTWG
ELSRTLTRLQELLPRLDREPELFLANFRWVEVPDGIKYSGYYEPVVRASRTRKPGYTQAIYGLPPDLKKVAAKRGRYYDR
RTIEEKQILAGKGLELAWAADPVDVFFLEIQGSGRLVFDDGTQAYINYAGQNGHKYKSSGRIMREKGLLREGHIFEQRQW
FKDNPQRVREILNENPSYVFFRYGTRGPTGATGQVVDEWLSLATDRTFIPLGSVVAYGVNIPDQQRGKVPLRGIGFAQDV
GGAIKKNRIDVFCGGEERGNYVASHLDARGPAWVLLAK

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=248, Percent_Identity=33.8709677419355, Blast_Score=119, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 40062; Mature: 40062

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCLLLGACGKKVAPPSPEPVGPPVAFESPEFFVSCLKPVNQDLTSWKDMAPTVRKSLRYV
CEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NSKPATAIAVQRPGLTVTWGELSRTLTRLQELLPRLDREPELFLANFRWVEVPDGIKYSG
CCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCEECC
YYEPVVRASRTRKPGYTQAIYGLPPDLKKVAAKRGRYYDRRTIEEKQILAGKGLELAWAA
CHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHCCCHHHHHCCHHHHHHCCCCEEEEEC
DPVDVFFLEIQGSGRLVFDDGTQAYINYAGQNGHKYKSSGRIMREKGLLREGHIFEQRQW
CCEEEEEEEEECCCEEEEECCCEEEEEECCCCCCEECCCCCEEHHCCCCCCCCHHHHHHH
FKDNPQRVREILNENPSYVFFRYGTRGPTGATGQVVDEWLSLATDRTFIPLGSVVAYGVN
HCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEECCHHHEECCC
IPDQQRGKVPLRGIGFAQDVGGAIKKNRIDVFCGGEERGNYVASHLDARGPAWVLLAK
CCCCCCCCCCCCCCCCHHHHCCHHHCCCEEEEECCCCCCCCHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MCLLLGACGKKVAPPSPEPVGPPVAFESPEFFVSCLKPVNQDLTSWKDMAPTVRKSLRYV
CEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NSKPATAIAVQRPGLTVTWGELSRTLTRLQELLPRLDREPELFLANFRWVEVPDGIKYSG
CCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCEECC
YYEPVVRASRTRKPGYTQAIYGLPPDLKKVAAKRGRYYDRRTIEEKQILAGKGLELAWAA
CHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHCCCHHHHHCCHHHHHHCCCCEEEEEC
DPVDVFFLEIQGSGRLVFDDGTQAYINYAGQNGHKYKSSGRIMREKGLLREGHIFEQRQW
CCEEEEEEEEECCCEEEEECCCEEEEEECCCCCCEECCCCCEEHHCCCCCCCCHHHHHHH
FKDNPQRVREILNENPSYVFFRYGTRGPTGATGQVVDEWLSLATDRTFIPLGSVVAYGVN
HCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEECCHHHEECCC
IPDQQRGKVPLRGIGFAQDVGGAIKKNRIDVFCGGEERGNYVASHLDARGPAWVLLAK
CCCCCCCCCCCCCCCCHHHHCCHHHCCCEEEEECCCCCCCCHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]