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The map label for this gene is thyX [H]

Identifier: 220903860

GI number: 220903860

Start: 709285

End: 710088

Strand: Direct

Name: thyX [H]

Synonym: Ddes_0584

Alternate gene names: 220903860

Gene position: 709285-710088 (Clockwise)

Preceding gene: 220903847

Following gene: 220903862

Centisome position: 24.68

GC content: 60.32

Gene sequence:

>804_bases
ATGCTGGATGAAAAATTTACCGGAAACGGCAAGGTCGTGCTACTGGCCGGCGGCGGCAAAATCTATACAGACATCGCGGC
GCGCTTTGTGCGTAGCGAGAGGGACCTTGAAGACATTGTGGCTTCGCCCTATTCCAAAAAAATAGTGGAGAACATCCTGT
CATCGGGGCACAGGGCCGCGCTGGAGTTTGATTTTTTCATTTTCGGCCTTGAGGGCTACTCCCGTGTGACCGAAACCCAG
CTTGTGCGCAAGCGTCTGGCCTCTTACCTTATCAAGTCGGGCCGGGCGGAGCTTGGCGGCAAGCGCCGTTATTCTGTGGT
GTACCCTCGCGGCGTGGCGGAGTTCACCGCGCCGGTGACCCTGCCCGGCGGCGCAACGGTGAACCTGAGTGGGCGCGACC
TCGCCGATCTCGGCCGTCAATGGTATGAGGCGGGGCTTGATGCGGACCTGCCGGAAGAAGATCTGCGTTATCTCAAGCCG
CAGGCTACGGAGTTCAAGGCTATTGTGGGCATGAATGCCCACGCTCTGCTGGACTGGTTTTCCATCCGCTGCTGCCGTAA
CGCCCAGCACGAAATACGGCACCTTGCCTGGCAGATGCTGCGCCTGTGCCGCAAGGCTGCCCCCGATCTTTTCGCAGGGG
CCGGACCCAACTGCGTACAACTGGGCTATTGTCCGGAAAATGCCCTTCAGAATGCCCGCTGTAGAGGCCGCATCATTACC
AAGGACGAGGCCATGGCCTTGCTGCGCTCTGCCCGGGGGGCCGCAGCCGCACCTCCGGCTCAGGATGAGTTTGCAGGAGA
CTAG

Upstream 100 bases:

>100_bases
GTATCTATGGATGCCCTTGTGATTTTGTGTTCTTCTTGCCGTGGCTTCCTGTTTCGCTTATGCTTGATGCGCGCACGCAA
TTTTGCGGCAAGGAGTTGAA

Downstream 100 bases:

>100_bases
GCCTCGCGCCTGTGTGCTTTTTTTGCTGGCTGTGGCAAAAGAACTTTTTGCTTCGGTCGGGTGCAGCAAGAGCAGACTTT
TGGGAAAAATTCTTTTGCCT

Product: thymidylate synthase complementing protein ThyX

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MLDEKFTGNGKVVLLAGGGKIYTDIAARFVRSERDLEDIVASPYSKKIVENILSSGHRAALEFDFFIFGLEGYSRVTETQ
LVRKRLASYLIKSGRAELGGKRRYSVVYPRGVAEFTAPVTLPGGATVNLSGRDLADLGRQWYEAGLDADLPEEDLRYLKP
QATEFKAIVGMNAHALLDWFSIRCCRNAQHEIRHLAWQMLRLCRKAAPDLFAGAGPNCVQLGYCPENALQNARCRGRIIT
KDEAMALLRSARGAAAAPPAQDEFAGD

Sequences:

>Translated_267_residues
MLDEKFTGNGKVVLLAGGGKIYTDIAARFVRSERDLEDIVASPYSKKIVENILSSGHRAALEFDFFIFGLEGYSRVTETQ
LVRKRLASYLIKSGRAELGGKRRYSVVYPRGVAEFTAPVTLPGGATVNLSGRDLADLGRQWYEAGLDADLPEEDLRYLKP
QATEFKAIVGMNAHALLDWFSIRCCRNAQHEIRHLAWQMLRLCRKAAPDLFAGAGPNCVQLGYCPENALQNARCRGRIIT
KDEAMALLRSARGAAAAPPAQDEFAGD
>Mature_267_residues
MLDEKFTGNGKVVLLAGGGKIYTDIAARFVRSERDLEDIVASPYSKKIVENILSSGHRAALEFDFFIFGLEGYSRVTETQ
LVRKRLASYLIKSGRAELGGKRRYSVVYPRGVAEFTAPVTLPGGATVNLSGRDLADLGRQWYEAGLDADLPEEDLRYLKP
QATEFKAIVGMNAHALLDWFSIRCCRNAQHEIRHLAWQMLRLCRKAAPDLFAGAGPNCVQLGYCPENALQNARCRGRIIT
KDEAMALLRSARGAAAAPPAQDEFAGD

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 29410; Mature: 29410

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDEKFTGNGKVVLLAGGGKIYTDIAARFVRSERDLEDIVASPYSKKIVENILSSGHRAA
CCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHCCCCCEE
LEFDFFIFGLEGYSRVTETQLVRKRLASYLIKSGRAELGGKRRYSVVYPRGVAEFTAPVT
EEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCCEEEEEECCCCHHHHCCCEE
LPGGATVNLSGRDLADLGRQWYEAGLDADLPEEDLRYLKPQATEFKAIVGMNAHALLDWF
CCCCCEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHCCCHHHHHHHH
SIRCCRNAQHEIRHLAWQMLRLCRKAAPDLFAGAGPNCVQLGYCPENALQNARCRGRIIT
HHHHHHCHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCEEEECCCCHHHHHCCCCCCEEEC
KDEAMALLRSARGAAAAPPAQDEFAGD
HHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLDEKFTGNGKVVLLAGGGKIYTDIAARFVRSERDLEDIVASPYSKKIVENILSSGHRAA
CCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHCCCCCEE
LEFDFFIFGLEGYSRVTETQLVRKRLASYLIKSGRAELGGKRRYSVVYPRGVAEFTAPVT
EEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCCEEEEEECCCCHHHHCCCEE
LPGGATVNLSGRDLADLGRQWYEAGLDADLPEEDLRYLKPQATEFKAIVGMNAHALLDWF
CCCCCEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHCCCHHHHHHHH
SIRCCRNAQHEIRHLAWQMLRLCRKAAPDLFAGAGPNCVQLGYCPENALQNARCRGRIIT
HHHHHHCHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCEEEECCCCHHHHHCCCCCCEEEC
KDEAMALLRSARGAAAAPPAQDEFAGD
HHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA