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The map label for this gene is uvrC [H]

Identifier: 220903857

GI number: 220903857

Start: 702956

End: 705019

Strand: Reverse

Name: uvrC [H]

Synonym: Ddes_0581

Alternate gene names: 220903857

Gene position: 705019-702956 (Counterclockwise)

Preceding gene: 220903858

Following gene: 220903856

Centisome position: 24.54

GC content: 62.45

Gene sequence:

>2064_bases
ATGCAAAAGCCAGAACCAGCCAGCATTCCTCTTTCTCCCGGCGTTTACCTGTACAAGGATGAGCGGGGACGCATCATTTA
CGTGGGCAAAGCCCGTATTCTGCGCCGCCGTGTGCTCTCCTACTTCAGGGCCGAAGGCTTGCCCACCAAGACAAAAGCCA
TGCTTTCTCATGCCGGAAGTATAGAGTACCTCACCACAACAACGGAAAAAGAGGCCCTGCTTCTGGAATCGAGCCTCATC
AAAAAGCACAGGCCCCGCTATAATATCGTTTTGCGGGACGACAAACAGTATGTACTGTTTCGGCTCAACCCCAAGCACCC
TTTTCCGCGTCTTGAAGTTGTACGCCAGGCAAGGCGAGACGGTGCACGCTACTTCGGCCCGTTCACTTCCGCCCTGTCTG
CCCGCGAAACCTGGAAACTCATACACCGGGCCTTTGCCCTGCGCCGCTGCTCCGACAGGGCCATGAAAAACCGTGTGCGC
GCCTGCCTGTATCATTTTATGGGGCAATGCCCCGCCCCGTGTATGGACCTGGTAACTCCGCAGCAATACAATGAAAACGT
GCGTAAAGTCTGCGATCTTCTGCAAGGCCGTGCGGCCCCCCTGCTGGATAGTCTGCGCGAGGCTATGGAGCAGGCCTCGG
AAGATCTGGAGTTTGAAAAAGCCGCAGTGCTGCGTGACCAGATCCGCGCTGTGGAGCGCACGGTGGAGCGGCAGGCTGCC
GTTTTGCCCGGCGGCGGTGATATGGATGCTGTTGGCCTTTACCAGGCGGAGAAAGGCCTTGCTCTGGGCATAGTCTTTGT
CCGCGGCGGTGCCGTCACGGACGGGCGCGCCTTCTACTGGCCGGGCCTGACATTTGAAGACGCCCCCGAACTGCTCTGGA
GCTTTGTAAGCCAGTATTACAGTCAGATCACGCCGCCGCCGCGCATACTGCTGCCCTGGCTGCCGCCCGATACAGAACGC
GTGGAGGACGCGGAAGATAGCGAGAGTACGGGCGAAGGCATAAACGCTGGTGCTGGCACACAAGCTGCCCCGCTGACGCC
CATACCGTCAGGGACAGGCGCTGACCTTCCTCCGGTTGCGGCAAGTCCCCCTGCGGACGCGTCTAGCCCGCCTTCCGGGC
CATCATCTGTCCCGCATTCTGATCCGGATGACGCTCTGCCTTCTGTTCCGGCCGCCGTGCTTTCCTCCGCCCCCCTGACC
GGGCGCGAACTGCTGGAGCAGACCCTGGCCGACCGCCGGGACGGCGCGGTGCGCATTGTGCCGCCACAGCATGCCGGAGA
CAACCAGCTGGTGGACATGGCCCAGTCCAACGCCCGCGAGGAAGCGCGCCGCCAGGAGCAGAAATCTGAAATGAACATTC
TGGACAGGCTGGCCCGCGCCCTGCACCTTTCCGGGCCGCCCAGCCGCATCGAATGTGTGGACGTGTCACATACCGGCGGC
CGCCAGACCCGTGTGGGTATGGTGGTTTTTGAAGACGGCCAGCCCGCGCGCCCGCAGTACCGCACCTACAGCATGCCCGA
CAGCGGTGACGACTACGCCACCCTGTACGCCTGGGTTGCCCGCAGGCTTGAAAGCGGCCCTCCCTGGCCCGACCTGCTGC
TTATTGACGGCGGCCGTGGGCAGTTGCGCACTATACAGCGCGCCCTTGAAGAAGCGGGCCAGCCCGACCTTTTCGCACTG
GCGGCCATTGCCAAAGCCAGAGATGAGCAGGGCCACGCCGACCGCCGCGCGGGCAATGTGGCCGACCGCATTTTTGTACC
CAACCGCGCCAATGCCCTGCCCCTGCGCGAAGGCGGCCAGGAGTTGCTTTTTCTGCAAAACATTCGTGATACAACCCACC
GTTTCGCCATCGGCCGCCACCGCAAGGCCCGGCGTGGAGCAGCCCTTGCAGGCGAACTCATGCGTCTGCCCGGCGTTGGC
CCGGCCACGGCGCGCCTTTTGTGGGACCATTTCGGCAGTGTGGAGGCCATGTGTGCCGCCACGCAGGAAGATCTGCGCAA
AATTCCTGGCATTGGCCCGGCCAAGGCCTCAATGCTGCTGGAAAAACTGTCCGGTCTGCGCTAG

Upstream 100 bases:

>100_bases
GCCTGCGCAAAAAACTGCACAAAAAAGCTATTGTATCGCCCCCCCATGGCGAACGCCGGTTCACGCAGCGGTCAGAGCAC
TATCAACGTAAAATTTATCT

Downstream 100 bases:

>100_bases
CCGGTTGCCGTTTTTGCGCGCATTTCCCGCACAGGCCGGGGCAGCTTCGCTGCACAGTACTACACAGCGCTGCCCGGACC
TCTCTGTTGCCTCCACCCGT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 687; Mature: 687

Protein sequence:

>687_residues
MQKPEPASIPLSPGVYLYKDERGRIIYVGKARILRRRVLSYFRAEGLPTKTKAMLSHAGSIEYLTTTTEKEALLLESSLI
KKHRPRYNIVLRDDKQYVLFRLNPKHPFPRLEVVRQARRDGARYFGPFTSALSARETWKLIHRAFALRRCSDRAMKNRVR
ACLYHFMGQCPAPCMDLVTPQQYNENVRKVCDLLQGRAAPLLDSLREAMEQASEDLEFEKAAVLRDQIRAVERTVERQAA
VLPGGGDMDAVGLYQAEKGLALGIVFVRGGAVTDGRAFYWPGLTFEDAPELLWSFVSQYYSQITPPPRILLPWLPPDTER
VEDAEDSESTGEGINAGAGTQAAPLTPIPSGTGADLPPVAASPPADASSPPSGPSSVPHSDPDDALPSVPAAVLSSAPLT
GRELLEQTLADRRDGAVRIVPPQHAGDNQLVDMAQSNAREEARRQEQKSEMNILDRLARALHLSGPPSRIECVDVSHTGG
RQTRVGMVVFEDGQPARPQYRTYSMPDSGDDYATLYAWVARRLESGPPWPDLLLIDGGRGQLRTIQRALEEAGQPDLFAL
AAIAKARDEQGHADRRAGNVADRIFVPNRANALPLREGGQELLFLQNIRDTTHRFAIGRHRKARRGAALAGELMRLPGVG
PATARLLWDHFGSVEAMCAATQEDLRKIPGIGPAKASMLLEKLSGLR

Sequences:

>Translated_687_residues
MQKPEPASIPLSPGVYLYKDERGRIIYVGKARILRRRVLSYFRAEGLPTKTKAMLSHAGSIEYLTTTTEKEALLLESSLI
KKHRPRYNIVLRDDKQYVLFRLNPKHPFPRLEVVRQARRDGARYFGPFTSALSARETWKLIHRAFALRRCSDRAMKNRVR
ACLYHFMGQCPAPCMDLVTPQQYNENVRKVCDLLQGRAAPLLDSLREAMEQASEDLEFEKAAVLRDQIRAVERTVERQAA
VLPGGGDMDAVGLYQAEKGLALGIVFVRGGAVTDGRAFYWPGLTFEDAPELLWSFVSQYYSQITPPPRILLPWLPPDTER
VEDAEDSESTGEGINAGAGTQAAPLTPIPSGTGADLPPVAASPPADASSPPSGPSSVPHSDPDDALPSVPAAVLSSAPLT
GRELLEQTLADRRDGAVRIVPPQHAGDNQLVDMAQSNAREEARRQEQKSEMNILDRLARALHLSGPPSRIECVDVSHTGG
RQTRVGMVVFEDGQPARPQYRTYSMPDSGDDYATLYAWVARRLESGPPWPDLLLIDGGRGQLRTIQRALEEAGQPDLFAL
AAIAKARDEQGHADRRAGNVADRIFVPNRANALPLREGGQELLFLQNIRDTTHRFAIGRHRKARRGAALAGELMRLPGVG
PATARLLWDHFGSVEAMCAATQEDLRKIPGIGPAKASMLLEKLSGLR
>Mature_687_residues
MQKPEPASIPLSPGVYLYKDERGRIIYVGKARILRRRVLSYFRAEGLPTKTKAMLSHAGSIEYLTTTTEKEALLLESSLI
KKHRPRYNIVLRDDKQYVLFRLNPKHPFPRLEVVRQARRDGARYFGPFTSALSARETWKLIHRAFALRRCSDRAMKNRVR
ACLYHFMGQCPAPCMDLVTPQQYNENVRKVCDLLQGRAAPLLDSLREAMEQASEDLEFEKAAVLRDQIRAVERTVERQAA
VLPGGGDMDAVGLYQAEKGLALGIVFVRGGAVTDGRAFYWPGLTFEDAPELLWSFVSQYYSQITPPPRILLPWLPPDTER
VEDAEDSESTGEGINAGAGTQAAPLTPIPSGTGADLPPVAASPPADASSPPSGPSSVPHSDPDDALPSVPAAVLSSAPLT
GRELLEQTLADRRDGAVRIVPPQHAGDNQLVDMAQSNAREEARRQEQKSEMNILDRLARALHLSGPPSRIECVDVSHTGG
RQTRVGMVVFEDGQPARPQYRTYSMPDSGDDYATLYAWVARRLESGPPWPDLLLIDGGRGQLRTIQRALEEAGQPDLFAL
AAIAKARDEQGHADRRAGNVADRIFVPNRANALPLREGGQELLFLQNIRDTTHRFAIGRHRKARRGAALAGELMRLPGVG
PATARLLWDHFGSVEAMCAATQEDLRKIPGIGPAKASMLLEKLSGLR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=338, Percent_Identity=39.3491124260355, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1788037, Length=209, Percent_Identity=32.5358851674641, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 75666; Mature: 75666

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKPEPASIPLSPGVYLYKDERGRIIYVGKARILRRRVLSYFRAEGLPTKTKAMLSHAGS
CCCCCCCCCCCCCCEEEEECCCCCEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
IEYLTTTTEKEALLLESSLIKKHRPRYNIVLRDDKQYVLFRLNPKHPFPRLEVVRQARRD
CEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHC
GARYFGPFTSALSARETWKLIHRAFALRRCSDRAMKNRVRACLYHFMGQCPAPCMDLVTP
CCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCC
QQYNENVRKVCDLLQGRAAPLLDSLREAMEQASEDLEFEKAAVLRDQIRAVERTVERQAA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHE
VLPGGGDMDAVGLYQAEKGLALGIVFVRGGAVTDGRAFYWPGLTFEDAPELLWSFVSQYY
ECCCCCCCCCEEHEECCCCCEEEEEEEECCCEECCCEEEECCCCCCHHHHHHHHHHHHHH
SQITPPPRILLPWLPPDTERVEDAEDSESTGEGINAGAGTQAAPLTPIPSGTGADLPPVA
HHCCCCCCEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
ASPPADASSPPSGPSSVPHSDPDDALPSVPAAVLSSAPLTGRELLEQTLADRRDGAVRIV
CCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEE
PPQHAGDNQLVDMAQSNAREEARRQEQKSEMNILDRLARALHLSGPPSRIECVDVSHTGG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
RQTRVGMVVFEDGQPARPQYRTYSMPDSGDDYATLYAWVARRLESGPPWPDLLLIDGGRG
CCEEEEEEEECCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCC
QLRTIQRALEEAGQPDLFALAAIAKARDEQGHADRRAGNVADRIFVPNRANALPLREGGQ
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHCCCCHHEEECCCCCCCCCCCCCCC
ELLFLQNIRDTTHRFAIGRHRKARRGAALAGELMRLPGVGPATARLLWDHFGSVEAMCAA
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHH
TQEDLRKIPGIGPAKASMLLEKLSGLR
HHHHHHHCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQKPEPASIPLSPGVYLYKDERGRIIYVGKARILRRRVLSYFRAEGLPTKTKAMLSHAGS
CCCCCCCCCCCCCCEEEEECCCCCEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
IEYLTTTTEKEALLLESSLIKKHRPRYNIVLRDDKQYVLFRLNPKHPFPRLEVVRQARRD
CEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHC
GARYFGPFTSALSARETWKLIHRAFALRRCSDRAMKNRVRACLYHFMGQCPAPCMDLVTP
CCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCC
QQYNENVRKVCDLLQGRAAPLLDSLREAMEQASEDLEFEKAAVLRDQIRAVERTVERQAA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHE
VLPGGGDMDAVGLYQAEKGLALGIVFVRGGAVTDGRAFYWPGLTFEDAPELLWSFVSQYY
ECCCCCCCCCEEHEECCCCCEEEEEEEECCCEECCCEEEECCCCCCHHHHHHHHHHHHHH
SQITPPPRILLPWLPPDTERVEDAEDSESTGEGINAGAGTQAAPLTPIPSGTGADLPPVA
HHCCCCCCEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
ASPPADASSPPSGPSSVPHSDPDDALPSVPAAVLSSAPLTGRELLEQTLADRRDGAVRIV
CCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEE
PPQHAGDNQLVDMAQSNAREEARRQEQKSEMNILDRLARALHLSGPPSRIECVDVSHTGG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
RQTRVGMVVFEDGQPARPQYRTYSMPDSGDDYATLYAWVARRLESGPPWPDLLLIDGGRG
CCEEEEEEEECCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCC
QLRTIQRALEEAGQPDLFALAAIAKARDEQGHADRRAGNVADRIFVPNRANALPLREGGQ
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHCCCCHHEEECCCCCCCCCCCCCCC
ELLFLQNIRDTTHRFAIGRHRKARRGAALAGELMRLPGVGPATARLLWDHFGSVEAMCAA
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHH
TQEDLRKIPGIGPAKASMLLEKLSGLR
HHHHHHHCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA