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The map label for this gene is pyrH [H]

Identifier: 220903797

GI number: 220903797

Start: 630507

End: 631220

Strand: Reverse

Name: pyrH [H]

Synonym: Ddes_0520

Alternate gene names: 220903797

Gene position: 631220-630507 (Counterclockwise)

Preceding gene: 220903798

Following gene: 220903796

Centisome position: 21.97

GC content: 58.68

Gene sequence:

>714_bases
ATGTCACTGACATACAAGCGAGTTCTGCTCAAACTGAGCGGCGAAGCCCTTGCGGGGTCCAACAAGACCGGTATCAATCC
CGACACCGTGGCGGAAATATGCCGCGAAATCGGCACGGTGCTTGCCATGGGTGTGGAAATGGCCCTGGTAATCGGCGGCG
GCAATATTTTTCGCGGGCTTTCCGGCTCGGCCAAAGGTATGGAGCGTTCATCGGCAGACTATATGGGCATGCTGGCTACG
GTGCTGAACGCCCTGGCCGTACAGGATATGCTGGAAAAACAAGGCTATCCCACCCGCGTGCTTTCGGCCATCACCATGCA
GGAAGTGTGCGAGCCCTTCATTCGCCGCCGCGCCCTGCGCCATATGGAAAAAGGCCGTGTGGTCATCTGTGCCGCCGGAA
CGGGCAATCCCTATTTCACCACCGATACCACGGCAGTGCTGCGCGGCATGGAACTCAAGTGTGATGCCATCATCAAGGCC
ACCAAGGTTGACGGCATCTACGACAAAGATCCCACCAAGCACAGCGATGCCGTAAAGTTTGACACCATCAGCTACGATGA
AACCCTGGCCCGTCACCTGGGCGTCATGGATGCCACGGCCTTTGCCCTGGTGCGCGACAACAATGTGCCCATCATTGTCT
GCCGCATGTTCGGCGGCGACATCCAGCGTGCCGTCATGGGCGAACCGGTGGGGACCATCGTGCGCAACTGCTGA

Upstream 100 bases:

>100_bases
CCCGGGGAGGCCCGGTCCCGTTTTTTCACGCCCGCGTACTGCGGCGCTCCACAGCACAACGGCCCTCATACGGGCCTCCC
ATCCAGATGAAGGCGGATAC

Downstream 100 bases:

>100_bases
TGCAGATGTGCGTCATGTTTGTCGCATTGCTGCGGAAAACCCGGCTGCGGGCAGGCGCATATCCGCCCGGAAAAACGGAC
GAGGCCCCGCAAGCACAGGC

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MSLTYKRVLLKLSGEALAGSNKTGINPDTVAEICREIGTVLAMGVEMALVIGGGNIFRGLSGSAKGMERSSADYMGMLAT
VLNALAVQDMLEKQGYPTRVLSAITMQEVCEPFIRRRALRHMEKGRVVICAAGTGNPYFTTDTTAVLRGMELKCDAIIKA
TKVDGIYDKDPTKHSDAVKFDTISYDETLARHLGVMDATAFALVRDNNVPIIVCRMFGGDIQRAVMGEPVGTIVRNC

Sequences:

>Translated_237_residues
MSLTYKRVLLKLSGEALAGSNKTGINPDTVAEICREIGTVLAMGVEMALVIGGGNIFRGLSGSAKGMERSSADYMGMLAT
VLNALAVQDMLEKQGYPTRVLSAITMQEVCEPFIRRRALRHMEKGRVVICAAGTGNPYFTTDTTAVLRGMELKCDAIIKA
TKVDGIYDKDPTKHSDAVKFDTISYDETLARHLGVMDATAFALVRDNNVPIIVCRMFGGDIQRAVMGEPVGTIVRNC
>Mature_236_residues
SLTYKRVLLKLSGEALAGSNKTGINPDTVAEICREIGTVLAMGVEMALVIGGGNIFRGLSGSAKGMERSSADYMGMLATV
LNALAVQDMLEKQGYPTRVLSAITMQEVCEPFIRRRALRHMEKGRVVICAAGTGNPYFTTDTTAVLRGMELKCDAIIKAT
KVDGIYDKDPTKHSDAVKFDTISYDETLARHLGVMDATAFALVRDNNVPIIVCRMFGGDIQRAVMGEPVGTIVRNC

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=231, Percent_Identity=45.4545454545455, Blast_Score=213, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 25599; Mature: 25468

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
8.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTYKRVLLKLSGEALAGSNKTGINPDTVAEICREIGTVLAMGVEMALVIGGGNIFRGL
CCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHCCC
SGSAKGMERSSADYMGMLATVLNALAVQDMLEKQGYPTRVLSAITMQEVCEPFIRRRALR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
HMEKGRVVICAAGTGNPYFTTDTTAVLRGMELKCDAIIKATKVDGIYDKDPTKHSDAVKF
HHHCCCEEEEEECCCCCEEECCHHHHHCCCCCCHHHHEEEHHCCCCCCCCCCCCCCCEEE
DTISYDETLARHLGVMDATAFALVRDNNVPIIVCRMFGGDIQRAVMGEPVGTIVRNC
ECCCHHHHHHHHHCHHHHHEEEEEECCCCCEEEEEECCCHHHHHHHCCCHHHHHHCC
>Mature Secondary Structure 
SLTYKRVLLKLSGEALAGSNKTGINPDTVAEICREIGTVLAMGVEMALVIGGGNIFRGL
CCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHCCC
SGSAKGMERSSADYMGMLATVLNALAVQDMLEKQGYPTRVLSAITMQEVCEPFIRRRALR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
HMEKGRVVICAAGTGNPYFTTDTTAVLRGMELKCDAIIKATKVDGIYDKDPTKHSDAVKF
HHHCCCEEEEEECCCCCEEECCHHHHHCCCCCCHHHHEEEHHCCCCCCCCCCCCCCCEEE
DTISYDETLARHLGVMDATAFALVRDNNVPIIVCRMFGGDIQRAVMGEPVGTIVRNC
ECCCHHHHHHHHHCHHHHHEEEEEECCCCCEEEEEECCCHHHHHHHCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA