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The map label for this gene is dxr [H]

Identifier: 220903793

GI number: 220903793

Start: 626203

End: 627534

Strand: Reverse

Name: dxr [H]

Synonym: Ddes_0516

Alternate gene names: 220903793

Gene position: 627534-626203 (Counterclockwise)

Preceding gene: 220903794

Following gene: 220903792

Centisome position: 21.84

GC content: 64.86

Gene sequence:

>1332_bases
ATGGCACATCTCTGGCCGGGTCAGGGCGGCCCTTCCATAGACTATATCTCCGGTCCGCCGGACGACGCGTGGCGCGATAC
ATGGCCGCGCAGTCTGGTCATTCTCGGCTCCACGGGGTCCATTGGCTGCAGTGCCCTCGCTGTTGTTGAAAGCCACCCAC
AGGCCTTCCGCGTTGAGGGGCTGGCCTGCGCCCGCCAGGTGGAACTGCTGGCAAAACAGGCCAACCGCTGGCGCCCTTCG
CACCTCGCAGTGCTTGATGAAGATGCCGCCGCCAGACTCAAGGCCCTGCTGCCTTCCGGCTATTCCCCCCGCATCCTGAC
CGGGCGTGAAGGCTATGCCGAACTTGCCGCCCTGCCCGAGGCCCGCACGGTGCTGTCGGCACAGGTGGGCGCCGCCGGAC
TTGCCGGAACCCTGGCCGCCGCCCTGGCGGGCAAGATCATCTGCCTTGCCAACAAGGAATCCCTTGTGCTGGCAGGCGAT
CTGGTGCGCCGCATCTGCGCCCGCACGGGAGCCGTCGTACTACCTGTGGACTCAGAGCATAACGCCATATTTCAATGCCT
CGCAGGGCGCGGGCAGGAAGTGCGCCGCCTCATTCTCACTGCCAGCGGCGGCCCTTTCCGTGGCCGGTCACTCGAAGACC
TGCGCCACATCACACCGGCCCAGGCCCTCAAGCATCCCAACTGGAGCATGGGCGCAAAAATAAGCATCGATTCGGCCACC
CTCATGAACAAGGGGCTTGAGGTCATTGAGGCATATCACCTCTACGGCGCGGCTCCCGAGCGCATAAAAGTGCTGGTGCA
CCCCCAGTCCGTCATCCATTCGCTGGTGGAACTGGAGGACGGAACCCAACTGGCACAGCTTGGCACAGCGGACATGCGCC
TTGCCATCGCCAACTGCCTGCTGTGGCCGCGCTGTCTGCCTGTGGGCGTGCCGCCCCTTGACCTTACCGCCGCGGCCCTC
ACCTTTCACGAACCGGACAGCGGCGTTTTTCCCTGTCTTGAACTGGCCCGCCGTTCTCTCGCCTTGCGTGGAGGGCGTTG
TGTAGTCATGAATGCGGCCAACGAGGCCGCCGTGGAACTTTTTCTTGAAGGCGGCTGCGCCTTTCTTGACATCCCCCGGC
TGATAGAAGCGGCTCTGACGGCGCACAGCGCCACAGAACCCGGCAATCAGTCTTTCTGCGCCCCGCTGCATCAGGATATG
CCCCCGGCCCCGGCCGGTATGGCCGCCCTGCAAAGCGAGGCCCATACCCTGGCGGAGCGCATCACGCAGCTTGACAGCCA
GAGCCGCGAGCTGGTGCGCAAGCTGGCCCGCGACGGAGAATCCGCATGCTGA

Upstream 100 bases:

>100_bases
GCCGCTTGATTTTTTTGCCAGCGTACCTATTTTTTCTTATGGGCAAGCCGCCTGCCCATAAAACAGCATTTCTACACGGC
GGCACCCACAGGATGCAGAC

Downstream 100 bases:

>100_bases
CGACCATTATAGCAGTCACCCTTGTTCTTGGCGGCCTCATCTTTTTTCACGAGCTGGGGCATTTTGCCGTGGCCCGTGGA
TTCGGCATGGGTGTTTCCAC

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MAHLWPGQGGPSIDYISGPPDDAWRDTWPRSLVILGSTGSIGCSALAVVESHPQAFRVEGLACARQVELLAKQANRWRPS
HLAVLDEDAAARLKALLPSGYSPRILTGREGYAELAALPEARTVLSAQVGAAGLAGTLAAALAGKIICLANKESLVLAGD
LVRRICARTGAVVLPVDSEHNAIFQCLAGRGQEVRRLILTASGGPFRGRSLEDLRHITPAQALKHPNWSMGAKISIDSAT
LMNKGLEVIEAYHLYGAAPERIKVLVHPQSVIHSLVELEDGTQLAQLGTADMRLAIANCLLWPRCLPVGVPPLDLTAAAL
TFHEPDSGVFPCLELARRSLALRGGRCVVMNAANEAAVELFLEGGCAFLDIPRLIEAALTAHSATEPGNQSFCAPLHQDM
PPAPAGMAALQSEAHTLAERITQLDSQSRELVRKLARDGESAC

Sequences:

>Translated_443_residues
MAHLWPGQGGPSIDYISGPPDDAWRDTWPRSLVILGSTGSIGCSALAVVESHPQAFRVEGLACARQVELLAKQANRWRPS
HLAVLDEDAAARLKALLPSGYSPRILTGREGYAELAALPEARTVLSAQVGAAGLAGTLAAALAGKIICLANKESLVLAGD
LVRRICARTGAVVLPVDSEHNAIFQCLAGRGQEVRRLILTASGGPFRGRSLEDLRHITPAQALKHPNWSMGAKISIDSAT
LMNKGLEVIEAYHLYGAAPERIKVLVHPQSVIHSLVELEDGTQLAQLGTADMRLAIANCLLWPRCLPVGVPPLDLTAAAL
TFHEPDSGVFPCLELARRSLALRGGRCVVMNAANEAAVELFLEGGCAFLDIPRLIEAALTAHSATEPGNQSFCAPLHQDM
PPAPAGMAALQSEAHTLAERITQLDSQSRELVRKLARDGESAC
>Mature_442_residues
AHLWPGQGGPSIDYISGPPDDAWRDTWPRSLVILGSTGSIGCSALAVVESHPQAFRVEGLACARQVELLAKQANRWRPSH
LAVLDEDAAARLKALLPSGYSPRILTGREGYAELAALPEARTVLSAQVGAAGLAGTLAAALAGKIICLANKESLVLAGDL
VRRICARTGAVVLPVDSEHNAIFQCLAGRGQEVRRLILTASGGPFRGRSLEDLRHITPAQALKHPNWSMGAKISIDSATL
MNKGLEVIEAYHLYGAAPERIKVLVHPQSVIHSLVELEDGTQLAQLGTADMRLAIANCLLWPRCLPVGVPPLDLTAAALT
FHEPDSGVFPCLELARRSLALRGGRCVVMNAANEAAVELFLEGGCAFLDIPRLIEAALTAHSATEPGNQSFCAPLHQDMP
PAPAGMAALQSEAHTLAERITQLDSQSRELVRKLARDGESAC

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=372, Percent_Identity=47.0430107526882, Blast_Score=289, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 47021; Mature: 46889

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHLWPGQGGPSIDYISGPPDDAWRDTWPRSLVILGSTGSIGCSALAVVESHPQAFRVEG
CCCCCCCCCCCCCCCCCCCCCCHHHCCCCCEEEEEECCCCCCHHEEEEECCCCCCEEHHH
LACARQVELLAKQANRWRPSHLAVLDEDAAARLKALLPSGYSPRILTGREGYAELAALPE
HHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCCCCCCCEEECCCCHHHHHHCCH
ARTVLSAQVGAAGLAGTLAAALAGKIICLANKESLVLAGDLVRRICARTGAVVLPVDSEH
HHHHHHHHHCCCHHHHHHHHHHHCCEEEEECCCCEEEHHHHHHHHHHHCCCEEEEECCCC
NAIFQCLAGRGQEVRRLILTASGGPFRGRSLEDLRHITPAQALKHPNWSMGAKISIDSAT
HHHHHHHHCCCHHHEEEEEEECCCCCCCCCHHHHHHCCHHHHHCCCCCCCCCEEEECHHH
LMNKGLEVIEAYHLYGAAPERIKVLVHPQSVIHSLVELEDGTQLAQLGTADMRLAIANCL
HHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHH
LWPRCLPVGVPPLDLTAAALTFHEPDSGVFPCLELARRSLALRGGRCVVMNAANEAAVEL
HHHHHCCCCCCCCCHHEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCHHEEEE
FLEGGCAFLDIPRLIEAALTAHSATEPGNQSFCAPLHQDMPPAPAGMAALQSEAHTLAER
HCCCCCCEECHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHH
ITQLDSQSRELVRKLARDGESAC
HHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AHLWPGQGGPSIDYISGPPDDAWRDTWPRSLVILGSTGSIGCSALAVVESHPQAFRVEG
CCCCCCCCCCCCCCCCCCCCCHHHCCCCCEEEEEECCCCCCHHEEEEECCCCCCEEHHH
LACARQVELLAKQANRWRPSHLAVLDEDAAARLKALLPSGYSPRILTGREGYAELAALPE
HHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCCCCCCCEEECCCCHHHHHHCCH
ARTVLSAQVGAAGLAGTLAAALAGKIICLANKESLVLAGDLVRRICARTGAVVLPVDSEH
HHHHHHHHHCCCHHHHHHHHHHHCCEEEEECCCCEEEHHHHHHHHHHHCCCEEEEECCCC
NAIFQCLAGRGQEVRRLILTASGGPFRGRSLEDLRHITPAQALKHPNWSMGAKISIDSAT
HHHHHHHHCCCHHHEEEEEEECCCCCCCCCHHHHHHCCHHHHHCCCCCCCCCEEEECHHH
LMNKGLEVIEAYHLYGAAPERIKVLVHPQSVIHSLVELEDGTQLAQLGTADMRLAIANCL
HHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHH
LWPRCLPVGVPPLDLTAAALTFHEPDSGVFPCLELARRSLALRGGRCVVMNAANEAAVEL
HHHHHCCCCCCCCCHHEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCHHEEEE
FLEGGCAFLDIPRLIEAALTAHSATEPGNQSFCAPLHQDMPPAPAGMAALQSEAHTLAER
HCCCCCCEECHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHH
ITQLDSQSRELVRKLARDGESAC
HHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA