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The map label for this gene is typA [H]

Identifier: 220903740

GI number: 220903740

Start: 558343

End: 560169

Strand: Direct

Name: typA [H]

Synonym: Ddes_0462

Alternate gene names: 220903740

Gene position: 558343-560169 (Clockwise)

Preceding gene: 220903739

Following gene: 220903744

Centisome position: 19.43

GC content: 59.06

Gene sequence:

>1827_bases
ATGCATTATAACGATTCTCTTCGCAACGTTGCTATTATCGCCCACGTTGACCACGGCAAGACCACTCTGGTGGACGCGCT
CTTCAAGCAGGGCGGCGGCCTTCGCGCCGGCCAGCAGATGGACGACCGCGTCATGGACAATATGGACATTGAACGCGAGC
GCGGCATCACCATTGCCGCCAAAAACTGTGCCGTTTCGTGGAACGGCGTCAAGATCAATATCATCGACACCCCGGGCCAC
GCGGACTTCGGCGGTGAGGTGGAACGCTCGCTTTCAATGACCACAGGGGCCATTCTGCTGGTGGACTCTTCTGAAGGTCC
CCTGCCGCAAACCCGTTTTGTGTTGCGCAAAACGCTGGAAGCCGGGCTGCCTGTGGTGGTGGTCATCAACAAGATCGACC
GCAAGGACGCACGGCCCGAAGAAGTGCTGAACGAGATCTACGATCTTTTTATCGACCTGGACGCCAGCGAGGCGCAGCTC
GAGTTTCCCGTGCTCTACGCCATCGGCCGTCAGGGTGTGGCCATGAAAAATATTGACGACGAGCAGAAGGATCTGACCCC
TCTGTTTGAAGCCATACTGAAGCATATTCCCGGTCCGGCGCACGATCCCGGGCAGCCCTTCCAGATGCTGGTGGCTGACC
TTGACTATTCCGACTATCTGGGCCGCCTGGCTGTGGGCCGCATCATGCACGGGCATGTGCACAGCAAGGAAACCCTCGCC
TGCATCGGCGAAAACGGAAAACCGCGCGCTCTGCGGGCCACCAAGCTTCAGGTGTATGACGGCCTGAAGCTTGCCGAGGT
AGAAACCGCCGCCCCCGGCGATATTGTAGTGCTGGCAGGCATTGAAGACGTGACCATCGGCGACACTATCTGCACCAGCA
CCAATCCCCGCGCCCTGCCGCGCATCAGGGTGGATGAGCCGACGGTGGCCATGCGTTTCGGCATCAACACTTCGCCCCTG
GCCGGACGCGAGGGCAAGATTGTGCAGAGCCGCGCCATTCGCGACCGCCTGGAAAAGGAAACCCTGCGCAACGTGGCTGT
GCGCGTGGAAGACACCGCCGACCGCGATGCTTTTCTGGTCAAGGGGCGCGGCGAATTTCAGATGGCTATTCTTATCGAGA
CCATGCGGCGCGAAGGTTTTGAACTTTCCGTGGGCCGCCCCGAGGTAATCCTGCGCAAGGATGAGGACGGCAAGGTTCTT
GAACCCATTGAGCGCCTTTATGTGGACTGCGACGAAGTCTTCATGGGGGTGGTTACGGAAAAGCTGGCCCAGCGCAAAGG
GCGCATGCTCAACTGCGTCAACAACGGCACGGGCCGGGTGCGCCTTGAGTTCACGGTGCCTTCGCGCGGTCTTATCGGGT
ATCGGGATGAATTTCTTACGGATACCAAGGGTACGGGCATCATGAACTCGTATCTTGAAGGCTATGAAGAATGGCGTGGT
GATTTTCCCACGCGTTTTTCCGGCTCCATTGTGGCCGACAGGTCGGGCAGCGCCGTGGCGTATGCCCTTTTTAACCTTGA
GCCGCGCGGCGTGCTTTTTGTGGAGCCGGGCAATCCCGTGTACGAAGGCATGATCGTGGGTGAGCACAATCGCGACAATG
ATATTGACGTGAACGCTACCAAGGAAAAGAAGCTCACCAACATGCGCGCGGCGGGCAAGGATGAAAACGTCATCCTGACG
CCTGTGCGCCGCATGACGCTGGAACACGCCCTGCACTTTGTGCGTGAAGATGAACTGGTGGAAGTGACGCCCCAGTCCAT
CCGTCTGCGCAAAGCGGAGCTTTCAGCCCAGAAGCGCTACCAGATCGCGGGCAGGCGCAAGGGATAA

Upstream 100 bases:

>100_bases
AAATCTGGGCCGCCTCATACGGGCAATGATGACAAAACTTTAAAAAATACGTACAAGCGCAGCCCGGACTCATTTTTTTA
CACTAAAAGGCAAAGCGCCC

Downstream 100 bases:

>100_bases
AAGCATTTCACACGATGCATGCAGACGCGGCAAGGATTTTCAGGAATCCTTGCCGCGAATACGTTGTGGCCTGTTTTCAG
ACGGTTTGCGGCACTGTCAG

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MHYNDSLRNVAIIAHVDHGKTTLVDALFKQGGGLRAGQQMDDRVMDNMDIERERGITIAAKNCAVSWNGVKINIIDTPGH
ADFGGEVERSLSMTTGAILLVDSSEGPLPQTRFVLRKTLEAGLPVVVVINKIDRKDARPEEVLNEIYDLFIDLDASEAQL
EFPVLYAIGRQGVAMKNIDDEQKDLTPLFEAILKHIPGPAHDPGQPFQMLVADLDYSDYLGRLAVGRIMHGHVHSKETLA
CIGENGKPRALRATKLQVYDGLKLAEVETAAPGDIVVLAGIEDVTIGDTICTSTNPRALPRIRVDEPTVAMRFGINTSPL
AGREGKIVQSRAIRDRLEKETLRNVAVRVEDTADRDAFLVKGRGEFQMAILIETMRREGFELSVGRPEVILRKDEDGKVL
EPIERLYVDCDEVFMGVVTEKLAQRKGRMLNCVNNGTGRVRLEFTVPSRGLIGYRDEFLTDTKGTGIMNSYLEGYEEWRG
DFPTRFSGSIVADRSGSAVAYALFNLEPRGVLFVEPGNPVYEGMIVGEHNRDNDIDVNATKEKKLTNMRAAGKDENVILT
PVRRMTLEHALHFVREDELVEVTPQSIRLRKAELSAQKRYQIAGRRKG

Sequences:

>Translated_608_residues
MHYNDSLRNVAIIAHVDHGKTTLVDALFKQGGGLRAGQQMDDRVMDNMDIERERGITIAAKNCAVSWNGVKINIIDTPGH
ADFGGEVERSLSMTTGAILLVDSSEGPLPQTRFVLRKTLEAGLPVVVVINKIDRKDARPEEVLNEIYDLFIDLDASEAQL
EFPVLYAIGRQGVAMKNIDDEQKDLTPLFEAILKHIPGPAHDPGQPFQMLVADLDYSDYLGRLAVGRIMHGHVHSKETLA
CIGENGKPRALRATKLQVYDGLKLAEVETAAPGDIVVLAGIEDVTIGDTICTSTNPRALPRIRVDEPTVAMRFGINTSPL
AGREGKIVQSRAIRDRLEKETLRNVAVRVEDTADRDAFLVKGRGEFQMAILIETMRREGFELSVGRPEVILRKDEDGKVL
EPIERLYVDCDEVFMGVVTEKLAQRKGRMLNCVNNGTGRVRLEFTVPSRGLIGYRDEFLTDTKGTGIMNSYLEGYEEWRG
DFPTRFSGSIVADRSGSAVAYALFNLEPRGVLFVEPGNPVYEGMIVGEHNRDNDIDVNATKEKKLTNMRAAGKDENVILT
PVRRMTLEHALHFVREDELVEVTPQSIRLRKAELSAQKRYQIAGRRKG
>Mature_608_residues
MHYNDSLRNVAIIAHVDHGKTTLVDALFKQGGGLRAGQQMDDRVMDNMDIERERGITIAAKNCAVSWNGVKINIIDTPGH
ADFGGEVERSLSMTTGAILLVDSSEGPLPQTRFVLRKTLEAGLPVVVVINKIDRKDARPEEVLNEIYDLFIDLDASEAQL
EFPVLYAIGRQGVAMKNIDDEQKDLTPLFEAILKHIPGPAHDPGQPFQMLVADLDYSDYLGRLAVGRIMHGHVHSKETLA
CIGENGKPRALRATKLQVYDGLKLAEVETAAPGDIVVLAGIEDVTIGDTICTSTNPRALPRIRVDEPTVAMRFGINTSPL
AGREGKIVQSRAIRDRLEKETLRNVAVRVEDTADRDAFLVKGRGEFQMAILIETMRREGFELSVGRPEVILRKDEDGKVL
EPIERLYVDCDEVFMGVVTEKLAQRKGRMLNCVNNGTGRVRLEFTVPSRGLIGYRDEFLTDTKGTGIMNSYLEGYEEWRG
DFPTRFSGSIVADRSGSAVAYALFNLEPRGVLFVEPGNPVYEGMIVGEHNRDNDIDVNATKEKKLTNMRAAGKDENVILT
PVRRMTLEHALHFVREDELVEVTPQSIRLRKAELSAQKRYQIAGRRKG

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=369, Percent_Identity=30.8943089430894, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI18390331, Length=166, Percent_Identity=36.7469879518072, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI94966754, Length=160, Percent_Identity=37.5, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI25306283, Length=169, Percent_Identity=36.6863905325444, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI19923640, Length=169, Percent_Identity=36.6863905325444, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI25306287, Length=169, Percent_Identity=36.6863905325444, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI4503483, Length=166, Percent_Identity=33.7349397590361, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI34147630, Length=211, Percent_Identity=35.5450236966825, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI217272892, Length=140, Percent_Identity=35, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI217272894, Length=140, Percent_Identity=35, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI310132016, Length=113, Percent_Identity=38.9380530973451, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI310110807, Length=113, Percent_Identity=38.9380530973451, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI310123363, Length=113, Percent_Identity=38.9380530973451, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI53729339, Length=147, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI53729337, Length=147, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI48994988, Length=596, Percent_Identity=51.1744966442953, Blast_Score=617, Evalue=1e-178,
Organism=Escherichia coli, GI1788922, Length=506, Percent_Identity=27.2727272727273, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI1789738, Length=148, Percent_Identity=39.8648648648649, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790835, Length=193, Percent_Identity=27.979274611399, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790412, Length=246, Percent_Identity=29.2682926829268, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1789737, Length=246, Percent_Identity=29.2682926829268, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17557151, Length=320, Percent_Identity=30, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17556745, Length=142, Percent_Identity=41.5492957746479, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17533571, Length=165, Percent_Identity=37.5757575757576, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71988811, Length=130, Percent_Identity=39.2307692307692, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71988819, Length=130, Percent_Identity=39.2307692307692, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17506493, Length=159, Percent_Identity=35.2201257861635, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17552882, Length=134, Percent_Identity=35.0746268656716, Blast_Score=89, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17556456, Length=139, Percent_Identity=37.410071942446, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323320, Length=504, Percent_Identity=26.5873015873016, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324707, Length=163, Percent_Identity=39.2638036809816, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6320593, Length=163, Percent_Identity=39.2638036809816, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6324761, Length=286, Percent_Identity=29.020979020979, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6323098, Length=169, Percent_Identity=36.6863905325444, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322359, Length=148, Percent_Identity=35.1351351351351, Blast_Score=91, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6324166, Length=142, Percent_Identity=35.9154929577465, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324550, Length=145, Percent_Identity=31.0344827586207, Blast_Score=64, Evalue=1e-10,
Organism=Drosophila melanogaster, GI78706572, Length=520, Percent_Identity=25.3846153846154, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI221458488, Length=190, Percent_Identity=35.2631578947368, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24582462, Length=165, Percent_Identity=35.1515151515151, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28574573, Length=137, Percent_Identity=41.6058394160584, Blast_Score=100, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24585711, Length=167, Percent_Identity=34.1317365269461, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24585713, Length=167, Percent_Identity=34.1317365269461, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24585709, Length=167, Percent_Identity=34.1317365269461, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21357743, Length=134, Percent_Identity=35.8208955223881, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281363316, Length=330, Percent_Identity=27.2727272727273, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17864358, Length=330, Percent_Identity=27.2727272727273, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19921738, Length=237, Percent_Identity=29.957805907173, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28572034, Length=146, Percent_Identity=33.5616438356164, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 67593; Mature: 67593

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHYNDSLRNVAIIAHVDHGKTTLVDALFKQGGGLRAGQQMDDRVMDNMDIERERGITIAA
CCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHCCEEEEE
KNCAVSWNGVKINIIDTPGHADFGGEVERSLSMTTGAILLVDSSEGPLPQTRFVLRKTLE
CCEEEEECCEEEEEEECCCCCCCCCHHHHHHEEECCEEEEEECCCCCCCHHHHHHHHHHH
AGLPVVVVINKIDRKDARPEEVLNEIYDLFIDLDASEAQLEFPVLYAIGRQGVAMKNIDD
CCCCEEEEEECCCCCCCCHHHHHHHHHHHEEECCCCCCEEECEEEEEECCCCCEECCCCC
EQKDLTPLFEAILKHIPGPAHDPGQPFQMLVADLDYSDYLGRLAVGRIMHGHVHSKETLA
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHEECCCHHHHHHHHHHHHHHHCCCCCCCEEE
CIGENGKPRALRATKLQVYDGLKLAEVETAAPGDIVVLAGIEDVTIGDTICTSTNPRALP
EECCCCCCCEEEEEEEEEECCCEEEEECCCCCCCEEEEECCCCEECCCEEECCCCCCCCC
RIRVDEPTVAMRFGINTSPLAGREGKIVQSRAIRDRLEKETLRNVAVRVEDTADRDAFLV
EEECCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEE
KGRGEFQMAILIETMRREGFELSVGRPEVILRKDEDGKVLEPIERLYVDCDEVFMGVVTE
ECCCCEEEEHHHHHHHHCCCEEECCCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHH
KLAQRKGRMLNCVNNGTGRVRLEFTVPSRGLIGYRDEFLTDTKGTGIMNSYLEGYEEWRG
HHHHHCCCEEEEEECCCCEEEEEEECCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHCC
DFPTRFSGSIVADRSGSAVAYALFNLEPRGVLFVEPGNPVYEGMIVGEHNRDNDIDVNAT
CCCCCCCCCEEECCCCCEEEEEEEECCCCCEEEECCCCCEEEEEEEECCCCCCCEECCCC
KEKKLTNMRAAGKDENVILTPVRRMTLEHALHFVREDELVEVTPQSIRLRKAELSAQKRY
HHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHCCCCEEEECCHHHEEEHHHHHHHHHH
QIAGRRKG
HCCCCCCC
>Mature Secondary Structure
MHYNDSLRNVAIIAHVDHGKTTLVDALFKQGGGLRAGQQMDDRVMDNMDIERERGITIAA
CCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHCCEEEEE
KNCAVSWNGVKINIIDTPGHADFGGEVERSLSMTTGAILLVDSSEGPLPQTRFVLRKTLE
CCEEEEECCEEEEEEECCCCCCCCCHHHHHHEEECCEEEEEECCCCCCCHHHHHHHHHHH
AGLPVVVVINKIDRKDARPEEVLNEIYDLFIDLDASEAQLEFPVLYAIGRQGVAMKNIDD
CCCCEEEEEECCCCCCCCHHHHHHHHHHHEEECCCCCCEEECEEEEEECCCCCEECCCCC
EQKDLTPLFEAILKHIPGPAHDPGQPFQMLVADLDYSDYLGRLAVGRIMHGHVHSKETLA
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHEECCCHHHHHHHHHHHHHHHCCCCCCCEEE
CIGENGKPRALRATKLQVYDGLKLAEVETAAPGDIVVLAGIEDVTIGDTICTSTNPRALP
EECCCCCCCEEEEEEEEEECCCEEEEECCCCCCCEEEEECCCCEECCCEEECCCCCCCCC
RIRVDEPTVAMRFGINTSPLAGREGKIVQSRAIRDRLEKETLRNVAVRVEDTADRDAFLV
EEECCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEE
KGRGEFQMAILIETMRREGFELSVGRPEVILRKDEDGKVLEPIERLYVDCDEVFMGVVTE
ECCCCEEEEHHHHHHHHCCCEEECCCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHH
KLAQRKGRMLNCVNNGTGRVRLEFTVPSRGLIGYRDEFLTDTKGTGIMNSYLEGYEEWRG
HHHHHCCCEEEEEECCCCEEEEEEECCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHCC
DFPTRFSGSIVADRSGSAVAYALFNLEPRGVLFVEPGNPVYEGMIVGEHNRDNDIDVNAT
CCCCCCCCCEEECCCCCEEEEEEEECCCCCEEEECCCCCEEEEEEEECCCCCCCEECCCC
KEKKLTNMRAAGKDENVILTPVRRMTLEHALHFVREDELVEVTPQSIRLRKAELSAQKRY
HHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHCCCCEEEECCHHHEEEHHHHHHHHHH
QIAGRRKG
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]