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The map label for this gene is era

Identifier: 220903650

GI number: 220903650

Start: 450519

End: 451442

Strand: Direct

Name: era

Synonym: Ddes_0371

Alternate gene names: 220903650

Gene position: 450519-451442 (Clockwise)

Preceding gene: 220903648

Following gene: 220903651

Centisome position: 15.68

GC content: 60.39

Gene sequence:

>924_bases
ATGACCGACCTGCACTACCGTTGCGGATGGGTGGCTCTCATGGGTCCGCCCAATGCCGGCAAATCAACACTGCTCAATGC
CCTTCTGGGGCAGAAGGTGACCATTGTCACGCCCAAGCCGCAGACCACGCGCAACCAGATTGTGGGCATCCTCACCGATG
ACGATGCCCAGACCATTTTTATGGATACCCCGGGCCTTACCCAGGTGCGCGGGCGGCTGAGCAAGACCATGATCCAGGCT
GTATGGCAGAGCCTGAACCAGGCCGACATCATCATGCCCGTGCTGGACGCCCATCTCTACATCCGCCACCCCGAATTTCT
TGATCGTGACCTCGCCCCGGTGGCCCAGGCCCTTGCCAGCGAAGAGCGCCCGATGATCGTCGTGGTTAACAAGGTGGACC
TGTTCGGTGATAAAAGCCGCATGTTGCCCCTGCTGACCCGGCTGCATGAAATGTGGCCGAGAGCCGATATCTTTCCCATT
TCTGCGCTGCACAAGGACGGGCTTGCCGACCTGGTGGAGCTTATCCGCAAAAAACTGCCCAAGGGCCAGGCCCAGTTCCC
CGAAGACCAGATATCCACCGCGCCCCTGCGCTTCATGACGGCCGAAATTGTCCGCGAAAAGCTTTTCATGCACCTGCGGC
AGGAGGTTCCTTACTCCGTGGCCGTGGACGTGGAAAGCTGGGAAGAGGATGAAGAACGCGGGCAGACCGTCATTCATGCC
ACCATCTACGTGGCCCGGCCCATGCACAAAGCTATGGTCATCGGGCGCGCCGGGCAGTCCATCAAGGCCATCGGCACTGA
AGCCCGCAAGGACATTCAGGAACTCGTGGGCGGCAAGGTGCATCTGGAACTGTGGGTCAAGGTGCGCGAGCACTGGACGG
AAGACACGGCCTTTCTGCGCGACCTGGGCCTTATGGCGGAGTAG

Upstream 100 bases:

>100_bases
AGCCCGCTTTGTGCGGGCGGCATGCACTTGAACACAGCCCCTTGAAAAACTTTGCGCCCCTTGTGCGCAGCGTAGGCCGG
TTGTCCGGCCAGGAGACGTA

Downstream 100 bases:

>100_bases
GGTATGGAACTGCTGGATCGCTATCACCGCGTGCTGGAAAGGCTGGACGCCGCCTGTGCCGCTGCCGGGCGGCCCAGGGA
AGAAGTCTCGCTTGTTGCCG

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MTDLHYRCGWVALMGPPNAGKSTLLNALLGQKVTIVTPKPQTTRNQIVGILTDDDAQTIFMDTPGLTQVRGRLSKTMIQA
VWQSLNQADIIMPVLDAHLYIRHPEFLDRDLAPVAQALASEERPMIVVVNKVDLFGDKSRMLPLLTRLHEMWPRADIFPI
SALHKDGLADLVELIRKKLPKGQAQFPEDQISTAPLRFMTAEIVREKLFMHLRQEVPYSVAVDVESWEEDEERGQTVIHA
TIYVARPMHKAMVIGRAGQSIKAIGTEARKDIQELVGGKVHLELWVKVREHWTEDTAFLRDLGLMAE

Sequences:

>Translated_307_residues
MTDLHYRCGWVALMGPPNAGKSTLLNALLGQKVTIVTPKPQTTRNQIVGILTDDDAQTIFMDTPGLTQVRGRLSKTMIQA
VWQSLNQADIIMPVLDAHLYIRHPEFLDRDLAPVAQALASEERPMIVVVNKVDLFGDKSRMLPLLTRLHEMWPRADIFPI
SALHKDGLADLVELIRKKLPKGQAQFPEDQISTAPLRFMTAEIVREKLFMHLRQEVPYSVAVDVESWEEDEERGQTVIHA
TIYVARPMHKAMVIGRAGQSIKAIGTEARKDIQELVGGKVHLELWVKVREHWTEDTAFLRDLGLMAE
>Mature_306_residues
TDLHYRCGWVALMGPPNAGKSTLLNALLGQKVTIVTPKPQTTRNQIVGILTDDDAQTIFMDTPGLTQVRGRLSKTMIQAV
WQSLNQADIIMPVLDAHLYIRHPEFLDRDLAPVAQALASEERPMIVVVNKVDLFGDKSRMLPLLTRLHEMWPRADIFPIS
ALHKDGLADLVELIRKKLPKGQAQFPEDQISTAPLRFMTAEIVREKLFMHLRQEVPYSVAVDVESWEEDEERGQTVIHAT
IYVARPMHKAMVIGRAGQSIKAIGTEARKDIQELVGGKVHLELWVKVREHWTEDTAFLRDLGLMAE

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain

Homologues:

Organism=Homo sapiens, GI24307899, Length=328, Percent_Identity=29.8780487804878, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI193082988, Length=172, Percent_Identity=31.3953488372093, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI193082991, Length=172, Percent_Identity=31.3953488372093, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1788919, Length=299, Percent_Identity=42.4749163879599, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI87082120, Length=173, Percent_Identity=31.7919075144509, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI2367268, Length=140, Percent_Identity=32.8571428571429, Blast_Score=62, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24646434, Length=316, Percent_Identity=25.6329113924051, Blast_Score=95, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ERA_DESDA (B8J3P9)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002478962.1
- GeneID:   7284028
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_0371
- HOGENOM:   HBG561652
- ProtClustDB:   PRK00089
- GO:   GO:0005737
- HAMAP:   MF_00367
- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- TIGRFAMs:   TIGR00436
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1; SSF54814 KH_prok

EC number: NA

Molecular weight: Translated: 34675; Mature: 34544

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLHYRCGWVALMGPPNAGKSTLLNALLGQKVTIVTPKPQTTRNQIVGILTDDDAQTIF
CCCCCEECCEEEEECCCCCCHHHHHHHHHCCEEEEECCCCCCCCCCEEEEEECCCCCEEE
MDTPGLTQVRGRLSKTMIQAVWQSLNQADIIMPVLDAHLYIRHPEFLDRDLAPVAQALAS
ECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCEEEEECHHHHCCHHHHHHHHHHC
EERPMIVVVNKVDLFGDKSRMLPLLTRLHEMWPRADIFPISALHKDGLADLVELIRKKLP
CCCCEEEEEECEECCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHCC
KGQAQFPEDQISTAPLRFMTAEIVREKLFMHLRQEVPYSVAVDVESWEEDEERGQTVIHA
CCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHCCCHHHHCCEEEEE
TIYVARPMHKAMVIGRAGQSIKAIGTEARKDIQELVGGKVHLELWVKVREHWTEDTAFLR
EEEECCHHHHHHEECCCCCHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHCCHHHHHHH
DLGLMAE
HHCCCCC
>Mature Secondary Structure 
TDLHYRCGWVALMGPPNAGKSTLLNALLGQKVTIVTPKPQTTRNQIVGILTDDDAQTIF
CCCCEECCEEEEECCCCCCHHHHHHHHHCCEEEEECCCCCCCCCCEEEEEECCCCCEEE
MDTPGLTQVRGRLSKTMIQAVWQSLNQADIIMPVLDAHLYIRHPEFLDRDLAPVAQALAS
ECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCEEEEECHHHHCCHHHHHHHHHHC
EERPMIVVVNKVDLFGDKSRMLPLLTRLHEMWPRADIFPISALHKDGLADLVELIRKKLP
CCCCEEEEEECEECCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHCC
KGQAQFPEDQISTAPLRFMTAEIVREKLFMHLRQEVPYSVAVDVESWEEDEERGQTVIHA
CCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHCCCHHHHCCEEEEE
TIYVARPMHKAMVIGRAGQSIKAIGTEARKDIQELVGGKVHLELWVKVREHWTEDTAFLR
EEEECCHHHHHHEECCCCCHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHCCHHHHHHH
DLGLMAE
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA